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  1. Article ; Online: Artificial intelligence for recurrence in patients with venous thromboembolism: towards a new era.

    Franco-Moreno, A / Muñoz-Rivas, N / Ruiz-Giardín, J-M / de Ancos-Aracil, C

    Revista clinica espanola

    2023  Volume 223, Issue 7, Page(s) 456–459

    MeSH term(s) Humans ; Venous Thromboembolism/prevention & control ; Artificial Intelligence ; Risk Factors ; Anticoagulants ; Patients ; Recurrence
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-06-16
    Publishing country Spain
    Document type Letter
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rceng.2023.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Systematic review of clinical trials on antithrombotic therapy with factor XI inhibitors.

    Franco-Moreno, A / Muñoz-Rivas, N / Torres-Macho, J / Bustamante-Fermosel, A / Ancos-Aracil, C L / Madroñal-Cerezo, E

    Revista clinica espanola

    2024  Volume 224, Issue 3, Page(s) 167–177

    Abstract: Introduction and objective: Data from phase 2 clinical trials suggest that factor XI inhibitors may exhibit a more favorable efficacy/safety profile compared to current antithrombotic therapies. The aim of this systematic review is to analyze the ... ...

    Abstract Introduction and objective: Data from phase 2 clinical trials suggest that factor XI inhibitors may exhibit a more favorable efficacy/safety profile compared to current antithrombotic therapies. The aim of this systematic review is to analyze the available evidence derived from these studies.
    Methods: A literature search in the PubMed, Cochrane Library, Scopus, EMBASE databases, and clinical trial registration platforms Clinical Trials and Cochrane Central Register of Controlled was conducted. In accordance with the PRISMA statement, results were reported.
    Results: A total of 18 completed or ongoing clinical trials addressing multiple scenarios, including atrial fibrillation, stroke, myocardial infarction, and venous thromboembolism, were identified. Evidence from 8 studies with available results was analyzed. Phase 2 studies with factor XI inhibitors, overall, demonstrated an acceptable efficacy and safety profile. The benefit-risk balance, in terms of reducing venous thromboembolism in patients undergoing total knee arthroplasty, was more favorable. For this scenario, factor XI inhibitors showed a 50% reduction in the overall rate of thrombotic complications and a 60% reduction in the rate of bleeding compared to enoxaparin. Modest results in studies involving patients with atrial fibrillation, stroke, and myocardial infarction were observed.
    Conclusions: Factor XI inhibitors offer new prospects in antithrombotic treatment and prophylaxis. Ongoing phase 3 studies will help define the most suitable drugs and indications.
    MeSH term(s) Humans ; Anticoagulants/therapeutic use ; Fibrinolytic Agents/therapeutic use ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Factor XI ; Atrial Fibrillation/drug therapy ; Stroke/drug therapy ; Stroke/prevention & control ; Myocardial Infarction/drug therapy ; Myocardial Infarction/prevention & control
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Factor XI (9013-55-2)
    Language English
    Publishing date 2024-02-01
    Publishing country Spain
    Document type Systematic Review ; Journal Article ; Review
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rceng.2024.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prediction of pulmonary embolism in patients with SARS-CoV-2 infection.

    Franco-Moreno, Anabel / Brown-Lavalle, David / Bustamante-Fermosel, Ana

    Medicina clinica (English ed.)

    2023  Volume 160, Issue 3, Page(s) 137–138

    Language English
    Publishing date 2023-01-06
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2022.09.011
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  4. Article ; Online: Predicción del desarrollo de embolia pulmonar en pacientes con infección por SARS-CoV-2.

    Franco-Moreno, Anabel / Brown-Lavalle, David / Bustamante-Fermosel, Ana

    Medicina clinica

    2022  Volume 160, Issue 3, Page(s) 137–138

    Title translation Prediction of pulmonary embolism in patients with SARS-CoV-2 infection.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/etiology
    Language Spanish
    Publishing date 2022-10-24
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.09.013
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  5. Article ; Online: Tromboembolismo pulmonar y COVID-19: un cambio de paradigma.

    Franco-Moreno, A / Muñoz-Rivas, N / Mestre-Gómez, B / Torres-Macho, J

    Revista clinica espanola

    2020  Volume 220, Issue 7, Page(s) 459–461

    Title translation Pulmonary embolism and COVID-19: A paradigm change.
    Language Spanish
    Publishing date 2020-05-21
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 123597-7
    ISSN 1578-1860 ; 0014-2565 ; 0014-2565
    ISSN (online) 1578-1860 ; 0014-2565
    ISSN 0014-2565
    DOI 10.1016/j.rce.2020.05.006
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  6. Article ; Online: Pulmonary embolism and COVID-19: A paradigm change.

    Franco-Moreno, A / Muñoz-Rivas, N / Mestre-Gómez, B / Torres-Macho, J

    Revista clinica espanola

    2020  Volume 220, Issue 7, Page(s) 459–461

    Title translation Tromboembolismo pulmonar y COVID-19: un cambio de paradigma.
    Keywords covid19
    Language Spanish
    Publishing date 2020-05-21
    Publishing country Spain
    Document type Letter
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2020.05.006
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  7. Article ; Online: Effect of corticosteroids in patients with COVID-19 early stage pneumonia and risk of disease progression: An uncharted territory.

    Franco-Moreno, Anabel / Acedo-Gutiérrez, María Soledad / Romero-Pareja, Rodolfo / Torres-Macho, Juan

    Drug discoveries & therapeutics

    2022  Volume 16, Issue 1, Page(s) 47–48

    Abstract: Corticosteroids are one of the few drugs that have shown a reduction in mortality in coronavirus disease 2019 (COVID-19). In the RECOVERY trial, the use of dexamethasone reduced 28-day mortality compared to standard care in hospitalized patients with ... ...

    Abstract Corticosteroids are one of the few drugs that have shown a reduction in mortality in coronavirus disease 2019 (COVID-19). In the RECOVERY trial, the use of dexamethasone reduced 28-day mortality compared to standard care in hospitalized patients with suspected or confirmed COVID-19 requiring supplemental oxygen or invasive mechanical ventilation. No benefit in patients not requiring respiratory support at randomization was observed. However, we believe that the use of corticosteroids in patients with COVID-19 pneumonia might not be subject to a decision based solely on oxygen needs. Evidence has shown that 30% of COVID-19 patients in its initial phases will progress to acute respiratory distress syndrome, particularly patients in whom laboratory inflammatory biomarkers associated with COVID-19 disease progression are detected. We postulated that corticosteroids in patients with COVID-19 in its initial phases and risk of progressing to severe disease might lead to a decrease in the development of acute respiratory distress syndrome, and thereby reduce death.
    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; COVID-19/drug therapy ; Disease Progression ; Humans ; Respiration, Artificial ; Risk
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2022-03-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2568828-5
    ISSN 1881-784X ; 1881-784X
    ISSN (online) 1881-784X
    ISSN 1881-784X
    DOI 10.5582/ddt.2022.01008
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  8. Article ; Online: Prediction of Venous Thromboembolism in Patients With Cancer Using Machine Learning Approaches: A Systematic Review and Meta-Analysis.

    Franco-Moreno, Anabel / Madroñal-Cerezo, Elena / Muñoz-Rivas, Nuria / Torres-Macho, Juan / Ruiz-Giardín, José Manuel / Ancos-Aracil, Cristina L

    JCO clinical cancer informatics

    2023  Volume 7, Page(s) e2300060

    Abstract: Purpose: Recent studies have suggested that machine learning (ML) could be used to predict venous thromboembolism (VTE) in cancer patients with high accuracy.: Methods: We aimed to evaluate the performance of ML in predicting VTE events in patients ... ...

    Abstract Purpose: Recent studies have suggested that machine learning (ML) could be used to predict venous thromboembolism (VTE) in cancer patients with high accuracy.
    Methods: We aimed to evaluate the performance of ML in predicting VTE events in patients with cancer. PubMed, Web of Science, and EMBASE to identify studies were searched.
    Results: Seven studies involving 12,249 patients with cancer were included. The combined results of the different ML models demonstrated good accuracy in the prediction of VTE. In the training set, the global pooled sensitivity was 0.87, the global pooled specificity was 0.87, and the AUC was 0.91, and in the test set 0.65, 0.84, and 0.80, respectively.
    Conclusion: The prediction ML models showed good performance to predict VTE. External validation to determine the result's reproducibility is necessary.
    MeSH term(s) Humans ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/etiology ; Reproducibility of Results ; Neoplasms/complications ; Machine Learning ; Patients
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2473-4276
    ISSN (online) 2473-4276
    DOI 10.1200/CCI.23.00060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: CHEDDAR score versus YEARS algorithm for suspected pulmonary embolism in SARS-CoV-2-infected patients: A comparison of two strategies.

    Franco-Moreno, Anabel / Izquierdo-Martínez, Aida / Pagai-Valcárcel, Idoia / Torres-Macho, Juan / de Ancos-Aracil, Cristina Lucía

    European journal of internal medicine

    2023  Volume 119, Page(s) 129–131

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Pulmonary Embolism/diagnostic imaging ; Decision Support Techniques ; Algorithms
    Language English
    Publishing date 2023-09-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.09.008
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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  10. Article ; Online: Correction: Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review.

    Fernández-de-Las-Peñas, César / Torres-Macho, Juan / Catahay, Jesus Alfonso / Macasaet, Raymart / Velasco, Jacqueline Veronica / Macapagal, Sharina / Caldararo, Mario / Henry, Brandon Michael / Lippi, Giuseppe / Franco-Moreno, Ana / Notarte, Kin Israel

    Infection

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-024-02208-x
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