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  1. Article ; Online: Adolescent BMI trajectory and associations with adult metabolic syndrome and offspring obesity.

    Frank, Darren M / Bradshaw, Patrick T / Mujahid, Mahasin / Epel, Elissa / Lararia, Barbara A

    Obesity (Silver Spring, Md.)

    2023  Volume 31, Issue 7, Page(s) 1924–1932

    Abstract: Objective: This study examined the association of adolescent BMI trajectory with adult metabolic syndrome (MetSyn) and with intergenerational obesity.: Methods: This study used data from the National Heart, Lung, and Blood Institute (NHLBI) Growth ... ...

    Abstract Objective: This study examined the association of adolescent BMI trajectory with adult metabolic syndrome (MetSyn) and with intergenerational obesity.
    Methods: This study used data from the National Heart, Lung, and Blood Institute (NHLBI) Growth and Health Study (1987-1997). Data from the 20-year follow-up (2016-2019) study were included from the original participants (N = 624) and their children (N = 645). Adolescent BMI trajectories were identified using latent trajectory modeling. Mediation analysis using logistic regression models was performed to estimate confounder-adjusted odds ratios (OR) and 95% CI between adolescent BMI trajectory and adult MetSyn. Using similar methods, the association between BMI trajectory and offspring obesity was examined.
    Results: Latent trajectory modeling identified four patterns: "weight loss then gain" (N = 62); "persistently normal" (N = 374); "persistently high BMI" (N = 127); and "weight gain then loss" (N = 61). Women who had a persistently high BMI trajectory had twice the odds of having children who met the definition for obesity compared with the persistently normal group, adjusting for adult BMI (OR: 2.76; 95% CI: 1.39-5.46). None of the trajectory groups was associated with adult MetSyn compared with the persistently normal group.
    Conclusions: Intermittent adolescent obesity may not confer MetSyn risk during adulthood. However, maternal adolescent BMI trajectories that are persistently high may increase the odds of intergenerational obesity among offspring.
    MeSH term(s) Child ; Adult ; Adolescent ; Humans ; Female ; Metabolic Syndrome/epidemiology ; Pediatric Obesity/epidemiology ; Body Mass Index ; Longitudinal Studies ; Weight Gain ; Risk Factors
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Trends in Laboratory-Confirmed SARS-CoV-2 Reinfections and Associated Hospitalizations and Deaths Among Adults Aged ≥18 Years - 18 U.S. Jurisdictions, September 2021-December 2022.

    Ma, Kevin C / Dorabawila, Vajeera / León, Tomás M / Henry, Hannah / Johnson, Amelia G / Rosenberg, Eli / Mansfield, Joshua A / Midgley, Claire M / Plumb, Ian D / Aiken, Julia / Khanani, Quratul Ain / Auche, Steven / Bayoumi, Nagla S / Bennett, Sarah A / Bernu, Carmen / Chang, Carolyn / Como-Sabetti, Kathryn J / Cueto, Kevin / Cunningham, Spencer /
    Eddy, Meredith / Falender, Rebecca A / Fleischauer, Aaron / Frank, Darren M / Harrington, Pauline / Hoskins, Mikhail / Howsare, Adam / Ingaiza, Lucy M / Islam, Aras S / Jensen, Shelli A / Jones, Jefferson M / Kambach, Grace / Kanishka, Fnu / Levin, Yuriy / Masarik, John F / Meyer, Stephanie D / Milroy, Lauren / Morris, Keeley J / Olmstead, John / Olsen, Nina S / Omoike, Enaholo / Patel, Komal / Pettinger, Amanda / Pike, Melissa A / Reed, Isaiah G / Slocum, Elizabeth / Sutton, Melissa / Tilakaratne, Buddhi P / Vest, Hailey / Vostok, Johanna / Wang, Jennifer S / Watson-Lewis, Lydia / Wienkes, Haley N / Hagen, Melissa Briggs / Silk, Benjamin J / Scobie, Heather M

    MMWR. Morbidity and mortality weekly report

    2023  Volume 72, Issue 25, Page(s) 683–689

    Abstract: Although reinfections with SARS-CoV-2 have occurred in the United States with increasing frequency, U.S. epidemiologic trends in reinfections and associated severe outcomes have not been characterized. Weekly counts of SARS-CoV-2 reinfections, total ... ...

    Abstract Although reinfections with SARS-CoV-2 have occurred in the United States with increasing frequency, U.S. epidemiologic trends in reinfections and associated severe outcomes have not been characterized. Weekly counts of SARS-CoV-2 reinfections, total infections, and associated hospitalizations and deaths reported by 18 U.S. jurisdictions during September 5, 2021-December 31, 2022, were analyzed overall, by age group, and by five periods of SARS-CoV-2 variant predominance (Delta and Omicron [BA.1, BA.2, BA.4/BA.5, and BQ.1/BQ.1.1]). Among reported reinfections, weekly trends in the median intervals between infections and frequencies of predominant variants during previous infections were calculated. As a percentage of all infections, reinfections increased substantially from the Delta (2.7%) to the Omicron BQ.1/BQ.1.1 (28.8%) periods; during the same periods, increases in the percentages of reinfections among COVID-19-associated hospitalizations (from 1.9% [Delta] to 17.0% [Omicron BQ.1/BQ.1.1]) and deaths (from 1.2% [Delta] to 12.3% [Omicron BQ.1/BQ.1.1]) were also substantial. Percentages of all COVID-19 cases, hospitalizations, and deaths that were reinfections were consistently higher across variant periods among adults aged 18-49 years compared with those among adults aged ≥50 years. The median interval between infections ranged from 269 to 411 days by week, with a steep decline at the start of the BA.4/BA.5 period, when >50% of reinfections occurred among persons previously infected during the Alpha variant period or later. To prevent severe COVID-19 outcomes, including those following reinfection, CDC recommends staying up to date with COVID-19 vaccination and receiving timely antiviral treatments, when eligible.
    MeSH term(s) Adolescent ; Adult ; Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Vaccines ; Hospitalization/trends ; Reinfection/epidemiology ; SARS-CoV-2 ; Hospital Mortality
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7225a3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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