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  1. Article: Helping children tolerate the cardiac ICU: where do we start?

    Frank, Deborah U

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2014  Volume 15, Issue 8, Page(s) 768–769

    MeSH term(s) Analgesics/therapeutic use ; Decision Making ; Humans ; Hypnotics and Sedatives/therapeutic use ; Intensive Care Units, Pediatric ; Nurse's Role
    Chemical Substances Analgesics ; Hypnotics and Sedatives
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000000206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SNAP Is Medicine for Food Insecurity.

    Frank, Deborah A / Bruce, Charlotte / Ochoa, Eduardo

    Pediatrics

    2020  Volume 146, Issue 3

    MeSH term(s) Academic Performance ; Academies and Institutes ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Developmental Disabilities/etiology ; Economic Recession ; Emigrants and Immigrants/legislation & jurisprudence ; Food Assistance/economics ; Food Assistance/legislation & jurisprudence ; Food Supply/economics ; Food Supply/legislation & jurisprudence ; Food Supply/statistics & numerical data ; Hospitalization ; Humans ; Pandemics ; Pediatrics ; Pneumonia, Viral/epidemiology ; Public Assistance/legislation & jurisprudence ; SARS-CoV-2 ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-002105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Failure to Thrive or Growth Faltering: Medical, Developmental/Behavioral, Nutritional, and Social Dimensions.

    Tang, Margot N / Adolphe, Soukaina / Rogers, Stephen R / Frank, Deborah A

    Pediatrics in review

    2021  Volume 42, Issue 11, Page(s) 590–603

    MeSH term(s) Failure to Thrive/diagnosis ; Failure to Thrive/etiology ; Failure to Thrive/therapy ; Humans ; Infant ; Malnutrition ; Weight Loss
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2020-001883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reduced health care utilization among young children of immigrants after Donald Trump's election and proposed public charge rule.

    Ettinger de Cuba, Stephanie / Miller, Daniel P / Raifman, Julia / Cutts, Diana B / Bovell-Ammon, Allison / Frank, Deborah A / Jones, David K

    Health affairs scholar

    2023  Volume 1, Issue 2, Page(s) qxad023

    Abstract: Widespread fear among immigrants from hostile 2016 presidential campaign rhetoric decreased social and health care service enrollment (chilling effect). Health care utilization effects among immigrant families with young children are unknown. We examined ...

    Abstract Widespread fear among immigrants from hostile 2016 presidential campaign rhetoric decreased social and health care service enrollment (chilling effect). Health care utilization effects among immigrant families with young children are unknown. We examined whether former President Trump's election had chilling effects on well-child visit (WCV) schedule adherence, hospitalizations, and emergency department (ED) visits among children of immigrant vs US-born mothers in 3 US cities. Cross-sectional surveys of children <4 years receiving care in hospitals were linked to 2015-2018 electronic health records. We applied difference-in-difference analysis with a 12-month pre/post-election study period. Trump's election was associated with a 5-percentage-point decrease (-0.05; 95% CI: -0.08, -0.02) in WCV adherence for children of immigrant vs US-born mothers with no difference in hospitalizations or ED visits. Secondary analyses extending the treatment period to a leaked draft of proposed changes to public charge rules also showed significantly decreased WCV adherence among children of immigrant vs US-born mothers. Findings indicate likely missed opportunities for American Academy of Pediatrics-recommended early childhood vaccinations, health and developmental screenings, and family support. Policies and rhetoric promoting immigrant inclusion create a more just and equitable society for all US children.
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article
    ISSN 2976-5390
    ISSN (online) 2976-5390
    DOI 10.1093/haschl/qxad023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Women's responses to unemployment of their spouse. Implications for psychiatric nurses.

    Frank, Deborah I

    Journal of psychosocial nursing and mental health services

    2010  Volume 48, Issue 8, Page(s) 28–33

    Abstract: The current economic recession has resulted in extremely high rates of unemployment, with the majority of those losing jobs being men. There is much research exploring how men respond to unemployment, but little examines how wives experience this crisis. ...

    Abstract The current economic recession has resulted in extremely high rates of unemployment, with the majority of those losing jobs being men. There is much research exploring how men respond to unemployment, but little examines how wives experience this crisis. Although nearly half of the workforce is now female, many women are co-providers, not sole providers. This article uses a historical perspective within a framework of role theory to help psychiatric nurse clinicians understand the possible responses of women who seek counseling after their spouses become unemployed. Counseling interventions are suggested, and an individual example is presented. Directions for future research are noted.
    MeSH term(s) Adaptation, Psychological ; Adult ; Communication ; Counseling ; Economic Recession ; Family Conflict/psychology ; Female ; Gender Identity ; Humans ; Male ; Nurse Practitioners ; Psychiatric Nursing ; Social Support ; Spouses/psychology ; Unemployment/psychology ; Workload/psychology
    Language English
    Publishing date 2010-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 225817-1
    ISSN 1938-2413 ; 0279-3695
    ISSN (online) 1938-2413
    ISSN 0279-3695
    DOI 10.3928/02793695-20100701-03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Network-based predictions of in vivo cardiac hypertrophy.

    Frank, Deborah U / Sutcliffe, Matthew D / Saucerman, Jeffrey J

    Journal of molecular and cellular cardiology

    2018  Volume 121, Page(s) 180–189

    Abstract: Cardiac hypertrophy is a common response of cardiac myocytes to stress and a predictor of heart failure. While in vitro cell culture studies have identified numerous molecular mechanisms driving hypertrophy, it is unclear to what extent these mechanisms ... ...

    Abstract Cardiac hypertrophy is a common response of cardiac myocytes to stress and a predictor of heart failure. While in vitro cell culture studies have identified numerous molecular mechanisms driving hypertrophy, it is unclear to what extent these mechanisms can be integrated into a consistent framework predictive of in vivo phenotypes. To address this question, we investigate the degree to which an in vitro-based, manually curated computational model of the hypertrophy signaling network is able to predict in vivo hypertrophy of 52 cardiac-specific transgenic mice. After minor revisions motivated by in vivo literature, the model concordantly predicts the qualitative responses of 78% of output species and 69% of signaling intermediates within the network model. Analysis of four double-transgenic mouse models reveals that the computational model robustly predicts hypertrophic responses in mice subjected to multiple, simultaneous perturbations. Thus the model provides a framework with which to mechanistically integrate data from multiple laboratories and experimental systems to predict molecular regulation of cardiac hypertrophy.
    MeSH term(s) Angiotensin II/genetics ; Angiotensin II/metabolism ; Animals ; Cardiomegaly/genetics ; Cardiomegaly/physiopathology ; Computational Biology ; Disease Models, Animal ; Heart Failure/genetics ; Heart Failure/physiopathology ; Humans ; Mice ; Mice, Transgenic ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Signal Transduction/genetics
    Chemical Substances Angiotensin II (11128-99-7)
    Language English
    Publishing date 2018-07-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2018.07.243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: PFTAIRE Kinase L63 Interactor 1A (Pif1A Protein) Is Required for Actin Cone Movement during Spermatid Individualization in

    Pravder, Harrison D / Grabowska, Dorota / Roychoudhury, Kaushik / Zhang, Betty / Frank, Deborah / Zakrzewski, Przemysław / Lenartowska, Marta / Miller, Kathryn G

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: A useful model for determining the mechanisms by which actin and actin binding proteins control cellular architecture is ... ...

    Abstract A useful model for determining the mechanisms by which actin and actin binding proteins control cellular architecture is the
    MeSH term(s) Actins/genetics ; Actins/metabolism ; Animals ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Male ; Spermatids/metabolism ; Spermatogenesis/genetics ; Testis/metabolism
    Chemical Substances Actins ; Drosophila Proteins
    Language English
    Publishing date 2022-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Changes in Economic Hardships Arising During the COVID-19 Pandemic: Differences by Nativity and Race

    Bovell-Ammon, Allison / Ettinger de Cuba, Stephanie / Lê-Scherban, Félice / Rateau, Lindsey / Heeren, Timothy / Cantave, Cerlyn / Green, Kaye-Alese / Frank, Deborah A. / Cutts, Diana / Ochoa, Eduardo / Sandel, Megan

    J Immigrant Minority Health. 2023 Apr., v. 25, no. 2, p. 483-488

    2023  , Page(s) 483–488

    Abstract: Hardships in early childhood impact health. Few longitudinal studies have examined pandemic-related hardships among families with young children by race/ethnicity or nativity. We used prospective longitudinal data from 1,165 caregivers of children < 4 ... ...

    Abstract Hardships in early childhood impact health. Few longitudinal studies have examined pandemic-related hardships among families with young children by race/ethnicity or nativity. We used prospective longitudinal data from 1,165 caregivers of children < 4 years surveyed in English and Spanish face-to-face in 5 urban hospitals 1/2018 to 3/2020 (pre-pandemic) and again by telephone 9/2020 to 3/2021 (during pandemic). Caregivers reported hardships (household food insecurity [HFI], child food insecurity [CFI]), behind on rent [BOR]) and maternal race/ethnicity and nativity. During the pandemic vs pre-pandemic, families with immigrant mothers had greater increases in HFI [aOR = 2.15 (CI 1.49–3.09)] than families with US-born mothers [aOR = 1.44 (CI 1.09–1.90)] and greater increases in BOR [families with immigrant mothers aOR = 4.09 (CI 2.78–6.01) vs. families with US-born mothers aOR = 2.19 (CI 1.68–2.85)]. CFI increases for all groups did not vary by nativity nor race/ethnicity. HFI and BOR increases during COVID were significantly greater in families with Latina mothers and those with immigrant mothers than other groups.
    Keywords COVID-19 infection ; Latinos ; caregivers ; childhood ; children ; food security ; pandemic ; telephones
    Language English
    Dates of publication 2023-04
    Size p. 483-488
    Publishing place Springer US
    Document type Article ; Online
    ZDB-ID 2220162-2
    ISSN 1557-1920 ; 1557-1912
    ISSN (online) 1557-1920
    ISSN 1557-1912
    DOI 10.1007/s10903-022-01410-z
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Association Between Material Hardship in Families With Young Children and Federal Relief Program Participation by Race and Ethnicity and Maternal Nativity.

    Lê-Scherban, Félice / Ettinger de Cuba, Stephanie / Bovell-Ammon, Allison / Coleman, Sharon / Rateau, Lindsey / Cutts, Diana / Black, Maureen / Heeren, Timothy / Frank, Deborah A

    JAMA health forum

    2023  Volume 4, Issue 4, Page(s) e230508

    Abstract: Importance: Even brief periods of hardship during early childhood may have lifelong consequences. Prior cross-sectional research limited to respondents with English proficiency and internet access during the COVID-19 crisis documented families with ... ...

    Abstract Importance: Even brief periods of hardship during early childhood may have lifelong consequences. Prior cross-sectional research limited to respondents with English proficiency and internet access during the COVID-19 crisis documented families with young children that struggled to afford basic needs like food and rent. Few studies have examined experiences of families with young children by race and ethnicity and maternal nativity.
    Objective: To examine the association of COVID-19 relief programs with the mitigation of household food insecurity among families with young children, as well as being behind on rent and disparities in program receipt.
    Design, setting, and participants: This cohort study used data from the ongoing repeat cross-sectional Children's HealthWatch study comprising families surveyed at baseline (January 1, 2018, to March 20, 2020) and during the COVID-19 crisis (September 1, 2020, to June 30, 2021). Baseline questionnaires were administered face to face to caregivers of children aged 48 months or younger in English or Spanish in emergency departments or primary care clinics in 5 US cities. The follow-up questionnaires were administered via telephone.
    Exposures: Supplemental Nutrition Assistance Program (SNAP) participation or receipt of at least 1 Economic Impact Payment (EIP; ie, stimulus check) during the COVID-19 crisis.
    Main outcomes and measures: The primary outcomes were household food insecurity (assessed via the US Household Food Security Survey Module: Six-Item Short Form) and being behind on rent. Logistic and binomial regression models were used to calculate adjusted odds ratios (aORs) and unadjusted and adjusted prevalence ratios (PRs).
    Results: Of 1396 caregiver-child dyads (20.3% response rate), race and ethnicity data were available for 1357 caregivers: 514 (37.9%) were Black, non-Latino; 558 (41.1%) were Latino; 230 (16.9%) were White, non-Latino; and 55 (4.1%) were of other non-Latino race or ethnicity. Among 1390 responses with nonmissing data, 417 children (30.0%) had an immigrant mother, and among 1388 responses, 1238 (33.5%) were publicly insured. During the crisis, 467 of 1395 respondents (33.5%) reported household food insecurity, and 567 of 1391 respondents (40.8%) reported being behind on rent. Families with immigrant mothers had lower odds of EIP and SNAP participation than families with US-born mothers (eg, aOR, 0.07 [95% CI, 0.05-0.12] for both EIP and SNAP vs neither), despite being more likely to report household food insecurity (adjusted PR [aPR], 1.48 [95% CI, 1.28-1.71]) and being behind on rent (aPR, 1.14 [95% CI, 1.00-1.30]). Families with Black (unadjusted PR [uPR], 1.40 [95% CI, 1.08-1.82]) or Latino (uPR, 1.54 [95% CI, 1.19-1.98]) caregivers or caregivers of other race and ethnicity (uPR, 1.67 [1.12-2.49]) were also more likely than families with White, non-Latino caregivers to experience household food insecurity or being behind on rent (families with Black caregivers: uPR, 2.02 [95% CI, 1.58-2.58]; families with Latino caregivers: 1.68 [95% CI, 1.30-2.16]; families with caregivers of other race or ethnicity: uPR, 1.94 [95% CI, 1.34-2.80]). Adjustment for covariates and differential participation in relief programs did not entirely account for these disparities.
    Conclusions and relevance: The results of this cohort study suggest that the COVID-19 crisis exacerbated preexisting inequities in food insecurity and difficulty paying rent according to race and ethnicity and maternal nativity and that equity-focused policy changes are needed to ensure that all children and their families in the US can afford basic needs for optimal health.
    MeSH term(s) Female ; Humans ; Child, Preschool ; Ethnicity ; Cohort Studies ; Cross-Sectional Studies ; Poverty ; COVID-19/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2023.0508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of Food Insecurity with Children's Behavioral, Emotional, and Academic Outcomes: A Systematic Review.

    Shankar, Priya / Chung, Rainjade / Frank, Deborah A

    Journal of developmental and behavioral pediatrics : JDBP

    2017  Volume 38, Issue 2, Page(s) 135–150

    Abstract: Objective: Food Insecurity (FI) occurs in 21% of families with children and adolescents in the United States, but the potential developmental and behavioral implications of this prevalent social determinant of health have not been comprehensively ... ...

    Abstract Objective: Food Insecurity (FI) occurs in 21% of families with children and adolescents in the United States, but the potential developmental and behavioral implications of this prevalent social determinant of health have not been comprehensively elucidated. This systematic review aims to examine the association between FI and childhood developmental and behavioral outcomes in western industrialized countries.
    Method: This review provides a critical summary of 23 peer reviewed articles from developed countries on the associations between FI and adverse childhood developmental behavioral outcomes including early cognitive development, academic performance, inattention, externalizing behaviors, and depression in 4 groups-infants and toddlers, preschoolers, school age, and adolescents. Various approaches to measuring food insecurity are delineated. Potential confounding and mediating variables of this association are compared across studies. Alternate explanatory mechanisms of observed effects and need for further research are discussed.
    Results: This review demonstrates that household FI, even at marginal levels, is associated with children's behavioral, academic, and emotional problems from infancy to adolescence across western industrialized countries - even after controlling for confounders.
    Conclusions: While the American Academy of Pediatrics already recommends routine screening for food insecurity during health maintenance visits, the evidence summarized here should encourage developmental behavioral health providers to screen for food insecurity in their practices and intervene when possible. Conversely, children whose families are identified as food insecure in primary care settings warrant enhanced developmental behavioral assessment and possible intervention.
    MeSH term(s) Achievement ; Adolescent ; Child ; Child Behavior ; Child Development ; Child, Preschool ; Food Supply ; Humans ; Infant ; Malnutrition ; Poverty
    Language English
    Publishing date 2017-01-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603379-9
    ISSN 1536-7312 ; 0196-206X
    ISSN (online) 1536-7312
    ISSN 0196-206X
    DOI 10.1097/DBP.0000000000000383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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