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Article ; Online: Chemoprevention in oral leukoplakia: challenges and current landscape.

Palma, Victor de Mello / Koerich Laureano, Natalia / Frank, Luiza Abrahão / Rados, Pantelis Varvaki / Visioli, Fernanda

Frontiers in oral health

2023 Volume 4, Page(s) 1191347

Abstract: Oral potentially malignant disorders have the potential to transform into oral cancer. Oral leukoplakia is a prevalent OPMD with a 9.8% malignant transformation rate. The standard management for OL involves surgical excision, but its efficacy in ... ...

Abstract	Oral potentially malignant disorders have the potential to transform into oral cancer. Oral leukoplakia is a prevalent OPMD with a 9.8% malignant transformation rate. The standard management for OL involves surgical excision, but its efficacy in preventing clinical recurrence and malignant transformation is limited. Therefore, alternative strategies such as chemoprevention modalities have emerged as a promising approach to inhibit the carcinogenesis process. The aim of this review was to identify human studies that investigated the effectiveness of chemopreventive agents in preventing the progression of oral leukoplakia and to provide guidance for future research. Several systemic and topical agents have been evaluated for their potential chemopreventive effects in oral leukoplakia. Systemic agents that have been investigated include vitamin A, lycopene, celecoxib, green tea extract, ZengShengPing, Bowman Birk inhibitor, beta-carotene, curcumin, erlotinib, and metformin. In addition, topical agents tested include bleomycin, isotretinoin, ONYX-015 mouthwash, ketorolac, and dried black raspberry. Despite numerous agents that have already been tested, evidence supporting their effectiveness is limited. To improve the search for an ideal chemopreventive agent for oral leukoplakia, we propose several strategies that can be implemented. Oral leukoplakia chemoprevention presents a promising opportunity for decreasing the incidence of oral cancer. Identifying new chemopreventive agents and biomarkers for predicting treatment response should be a focus of future research.
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-4842
ISSN (online)	2673-4842
DOI	10.3389/froh.2023.1191347
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Article ; Online: Evaluation of an Efficient and Skin-Adherent Semisolid Sunscreen Nanoformulation.

Frank, Luiza Abrahão / Gazzi, Rafaela Pletsch / Pohlmann, Adriana Raffin / Guterres, Silvia Stanisçuaski / Contri, Renata Vidor

Skin pharmacology and physiology

2022 Volume 35, Issue 5, Page(s) 291–298

Abstract: Introduction: Sunscreens are substances applied on the skin surface to protect the skin from the harmful effects of UV light. Nanoparticles can increase the retention time of the sunscreen on the skin surface and its efficacy, by acting as physical ... ...

Abstract	Introduction: Sunscreens are substances applied on the skin surface to protect the skin from the harmful effects of UV light. Nanoparticles can increase the retention time of the sunscreen on the skin surface and its efficacy, by acting as physical barriers. The present investigation aimed to evaluate the influence of the chitosan coating of benzophenone-3-loaded lipid-core nanocapsules (CH-LCN) on the skin adhesion and photoprotective effect of the sunscreen. Methods: CH-LNC were obtained by the interfacial deposition of preformed polymer. A suitable semisolid formulation was obtained by using hydroxyethyl cellulose as the gel-forming polymer. Skin adhesion experiments were performed in vitro by applying the formulation on porcine skin and keeping it under water at 32 °C for up to 60 min. Photoprotective effect was analyzed in vitro by the capacity of the formulations to protect a photo unstable substance (resveratrol) from degradation under UV light. Results: CH-LNC presented size of around 150 nm, with low polydispersity, positive zeta potential, due to chitosan, and benzophenone-3 encapsulation efficiency of close to 100% (3 mg/mL). The proposed gel presented suitable consistence and pH for skin application and benzophenone-3 concentration of around 3 mg/g. Although coated and uncoated lipid-core nanocapsules increased benzophenone-3 skin adhesion after 10 min of water immersion, only the nanoparticles coated with chitosan were able to do so after 60 min. The chitosan coating of the nanocapsules increased the photoprotection of the sunscreen under UVA and UVB light after 60 min of exposure, probably due to the film-forming properties of chitosan. Conclusion: The chitosan coating of CH-LCN increased the skin adhesion and the photoprotective effect of the sunscreen.
MeSH term(s)	Animals ; Benzophenones ; Cellulose/pharmacology ; Chitosan/chemistry ; Chitosan/pharmacology ; Lipids ; Nanocapsules/chemistry ; Polymers/chemistry ; Resveratrol ; Sunscreening Agents/chemistry ; Sunscreening Agents/pharmacology ; Swine ; Water
Chemical Substances	Benzophenones ; Lipids ; Nanocapsules ; Polymers ; Sunscreening Agents ; Water (059QF0KO0R) ; Cellulose (9004-34-6) ; Chitosan (9012-76-4) ; oxybenzone (95OOS7VE0Y) ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2131931-5
ISSN	1660-5535 ; 1660-5527
ISSN (online)	1660-5535
ISSN	1660-5527
DOI	10.1159/000525176
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Article ; Online: The management of osteoarthritis symptomatology through nanotechnology: a patent review.

Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny De Araujo / Rajkumar, Gomathi / Frank, Luiza Abrahão / Serafini, Mairim Russo

Journal of microencapsulation

2023 Volume 40, Issue 7, Page(s) 475–490

Abstract: Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for ... ...

Abstract	Osteoarthritis is considered a degenerative joint disease that is characterised by inflammation, chronic pain, and functional limitation. The increasing development of nanotechnology in drug delivery systems has provided new ideas and methods for osteoarthritis therapy. This review aimed to evaluate patents that have developed innovations, therapeutic strategies, and alternatives using nanotechnology in osteoarthritis treatment. The results show patents deposited from 2015 to November 2021 in the online databases European Patent Office and World Intellectual Property Organisation. A total of 651 patents were identified for preliminary assessment and 16 were selected for full reading and discussion. The evaluated patents are focused on the intraarticular route, oral route, and topical route for osteoarthritis treatment. The intraarticular route presented a higher patent number, followed by the oral and topical routes, respectively. The development of new technologies allows us to envision a promising and positive future in osteoarthritis treatment.
MeSH term(s)	Humans ; Drug Delivery Systems ; Nanotechnology ; Osteoarthritis/drug therapy
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652048.2023.2258955
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Zs.A 2267: Show issues

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Article ; Online: Is imiquimod a promising drug to treat oral mucosa diseases? A scoping review and new perspectives.

de Mello Palma, Victor / Frank, Luiza Abrahão / Balinha, Daiana Moraes / Rados, Pantelis Varvaki / Pohlmann, Adriana Raffin / Guterres, Silvia Stanisçuaski / Visioli, Fernanda

British journal of clinical pharmacology

2023 Volume 90, Issue 2, Page(s) 427–439

Abstract: Imiquimod (IMQ) is a chemotherapeutic and immunostimulant drug that is applied topically, demonstrating antitumor and antiviral activities. The objective of this review was to compile data on the off-label use of IMQ in oral mucosal diseases. IMQ has ... ...

Abstract	Imiquimod (IMQ) is a chemotherapeutic and immunostimulant drug that is applied topically, demonstrating antitumor and antiviral activities. The objective of this review was to compile data on the off-label use of IMQ in oral mucosal diseases. IMQ has exhibited effectiveness in the treatment of various oral mucosal conditions, including oral carcinogenic lesions, neoplasms, HPV-related lesions and autoimmune disorders. Although IMQ holds promise as a potential strategy for addressing oral mucosal lesions, it is important to note that significant side effects have been frequently reported. Nonetheless, it is crucial to develop and test new technological systems, such as the combination of nanotechnology with innovative drug delivery platforms. These advancements aim to minimize side effects and prolong the drug's contact time with the mucosa, preventing its removal by salivary flow.
MeSH term(s)	Humans ; Imiquimod/therapeutic use ; Pharmaceutical Preparations ; Mouth Mucosa ; Drug Delivery Systems
Chemical Substances	Imiquimod (P1QW714R7M) ; Pharmaceutical Preparations
Language	English
Publishing date	2023-10-29
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15923
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Zs.A 1118: Show issues

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Article ; Online: Devices for osteoarthritis symptoms treatment: a patent review.

Santos, Mariana Mendonça / Santos, Anamaria Mendonça / Carvalho Nascimento, José Adão / Santana, Cláudio Carvalho / Oliveira, Ana Maria Santos / Cezar, Silvia Vitoria Silva / Santos, Alcimary Bispo / Frank, Luiza Abrahão / Serafini, Mairim Russo

Expert review of medical devices

2024 Volume 21, Issue 1-2, Page(s) 91–107

Abstract: Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, ... ...

Abstract	Introduction: Osteoarthritis is a musculoskeletal disease that can lead to the loss and inability of those affected to perform normal daily functions, which leads to a decrease in quality of life. The main symptoms of osteoarthritis are tenderness, joint pain, stiffness, crepitus, limited movement, and local inflammation. Areas covered: The selected patents were deposited from 2010 to April 2022 involving 57 documents that were in line with the study objective in the final selection. The patents were classified in years, country, and applicants. Also, the therapeutic fields that presented the most documents were electrical stimulation, phototherapy, and ultrasound, followed by magnetic, electromagnetic, and thermotherapy. Therefore, the most current therapies used in the documents are already on the market. Expert opinion: Although the OA is cureless, non-surgical treatments are classified as the primary management approach for this disease. The pharmacological and non-pharmacological therapies are employed to reduce its prevalence and ensure the effectiveness of treatments. A strategy for relieving OA symptoms is non-pharmacological treatment, which can be based on exercise and patient education, combined with other alternative therapies. These therapies are used as supplements to the main OA treatments, enhancing the effectiveness of treatment outcomes.
MeSH term(s)	Humans ; Quality of Life ; Osteoarthritis/therapy ; Hyperthermia, Induced ; Inflammation ; Exercise
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2250857-0
ISSN	1745-2422 ; 1743-4440
ISSN (online)	1745-2422
ISSN	1743-4440
DOI	10.1080/17434440.2023.2298729
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Article ; Online: Dermatological applications of the flavonoid phloretin.

Anunciato Casarini, Talita Pizza / Frank, Luiza Abrahão / Pohlmann, Adriana Raffin / Guterres, Silvia Stanisçuaski

European journal of pharmacology

2020 Volume 889, Page(s) 173593

Abstract: Botanical molecules are known to have the ability to counteract ultraviolet radiation-induced skin damage. The interest in the development of natural compound-based products for the prevention of solar ultraviolet radiation-induced skin photoaging, ... ...

Abstract	Botanical molecules are known to have the ability to counteract ultraviolet radiation-induced skin damage. The interest in the development of natural compound-based products for the prevention of solar ultraviolet radiation-induced skin photoaging, melasma, and photocarcinogenesis has been increasing. Recently, the flavonoid phloretin has attracted the attention of researchers in the dermatological field for application in cosmetics and therapeutics. In addition to its antioxidant activity, phloretin has been shown to have properties such as anti-aging and depigmenting effects. In this study, we review the dermatological treatments with phloretin for conditions such as melasma, photoaging, acne, and melanoma. Phloretin has been shown to inhibit elastase and matrix metalloproteinase-1 activity, to reduce cellular tyrosinase activity and melanin content, and induce apoptosis in B16 mouse melanoma 4A5 cells. An in vivo study showed that phloretin, applied topically to the dorsal skin of mice, suppressed the 12-O-tetradecanoylphorbol 13-acetate-induced expression of COX-2, a critical molecular target of many chemopreventive, as well as anti-inflammatory agents. Phloretin can penetrate the skin; nevertheless, its penetration profile in different skin layers has not yet been evaluated. Despite its health benefits, phloretin application has been limited because of its photoinstability and poor aqueous solubility, among other limitations. Therefore, we reviewed the recent advances in pharmaceutical applications such as the use of nanotechnology, in order to improve the cutaneous availability of phloretin. In this review, we also focus on the oral application, product development challenges, and recent progress and future research directions on phloretin.
MeSH term(s)	Administration, Cutaneous ; Administration, Oral ; Animals ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/chemistry ; Dermatologic Agents/metabolism ; Drug Delivery Systems/trends ; Humans ; Nanotechnology/trends ; Phloretin/administration & dosage ; Phloretin/chemistry ; Phloretin/metabolism ; Skin/drug effects ; Skin/metabolism ; Skin/radiation effects ; Ultraviolet Rays/adverse effects
Chemical Substances	Dermatologic Agents ; Phloretin (S5J5OE47MK)
Language	English
Publishing date	2020-09-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2020.173593
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Article ; Online: Antibacterial drugs and cyclodextrin inclusion complexes: a patent review.

Santos, Anamaria Mendonça / Carvalho Santana Júnior, Cláudio / Nascimento Júnior, José Adão Carvalho / Andrade, Tatianny de Araujo / Shanmugam, Saravanan / Thangaraj, Parimelazhagan / Frank, Luiza Abrahão / Serafini, Mairim Russo

Expert opinion on drug delivery

2023 Volume 20, Issue 3, Page(s) 349–366

Abstract: Introduction: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need ... ...

Abstract	Introduction: Bacterial antibiotic resistance occurs when bacteria mutate and escape the effect of antibiotics, which makes the antibiotics no longer effective in treating infections. New solutions for bacterial infections are a persistent need including the identification of drugs with better pharmacological profiles, more potent, and safer. Cyclodextrins inclusion complexes have been able to improve the physicochemical and pharmacological properties of the formulation molecules, resulting in new alternatives with better efficacy. Areas covered: The patents analyzed in the review used treatments based on antibiotics already on the market, natural products, and synthesized molecules composed of the formulation with cyclodextrins. The combination between cyclodextrin and nanostructures also were presented in the patents review process. Moreover, inclusion complexes have been an alternative in developing treatment mainly in China by the pharmaceutical industries in several countries such as Germany, Hungary, the United States of America, Japan and China. Expert opinion: This review is broad and complete since it considers the first patent involving cyclodextrins and antibacterial drugs. Therefore, the various inclusion complexes and antibacterial drugs alternatives presented in this review offer therapeutic options to fight bacterial infections. If shown to be effective, these drugs may be extremely important in the current clinical practice.
MeSH term(s)	Cyclodextrins/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Solubility
Chemical Substances	Cyclodextrins ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2167286-6
ISSN	1744-7593 ; 1742-5247
ISSN (online)	1744-7593
ISSN	1742-5247
DOI	10.1080/17425247.2023.2175815
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Article ; Online: Mapping of New Pharmacological Alternatives in the Face of the Emergence of Antibiotic Resistance in COVID-19 Patents Treated for Opportunistic Respiratory Bacterial Pathogens.

Santos, Anamaria Mendonça / Santos, Mariana Mendonça / Nascimento Júnior, José Adão Carvalho / Brito, João Rafael Lisboa Rêgo / de Araújo Andrade, Tatianny / Frank, Luiza Abrahão / Serafini, Mairim Russo

Recent advances in anti-infective drug discovery

2022 Volume 17, Issue 1, Page(s) 34–53

Abstract: Background: The increase in bacterial resistance against antibiotics is thought to be another type of pandemic after COVID-19. Emergency treatment based on antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella ... ...

Abstract	Background: The increase in bacterial resistance against antibiotics is thought to be another type of pandemic after COVID-19. Emergency treatment based on antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella pneumoniae, are the most affected by the indiscriminate use of antibiotics, since they are resistant to most antibiotics currently available on the market. Objective: This review aimed to evaluate patents of new drugs and formulations, for the treatment of infections caused by Klebsiella pneumoniae. Methods: The present patent review was carried out through a specialized search database Espacenet. The selection was based on the criteria of patents published from 2010 to May 2021, in any language, and containing the keywords in title or abstract. Also, a research was performed on the PubMed database, using the inclusion criteria. Results: Twenty-two patents were selected for the analysis according to the aim of the study. The advance of new patents has been mostly observed in the World Intellectual Property Organization, China, and United States. The results showed that the main approach was the drug association, followed by drug carriers, new isolated products, and vaccines. Conclusion: It has been observed that few studies use new drug alternatives for the treatment, probably due to the higher cost of the development and lack of investments. The effectiveness and safety of these therapies depend on the acceptance, the correct prescription, and rational use of medicines. Therefore, this review can further develop new treatments as alternatives against Klebsiella pneumoniae and pneumonia caused by it.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria ; COVID-19/drug therapy ; Drug Carriers ; Drug Resistance, Microbial ; Humans ; Klebsiella pneumoniae
Chemical Substances	Anti-Bacterial Agents ; Drug Carriers
Language	English
Publishing date	2022-05-20
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	2772-4352
ISSN (online)	2772-4352
DOI	10.2174/1574891X16666220518142347
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Article ; Online: Innovative hydrogel containing polymeric nanocapsules loaded with phloretin: Enhanced skin penetration and adhesion.

Casarini, Talita Pizza Anunciato / Frank, Luiza Abrahão / Benin, Tainara / Onzi, Giovana / Pohlmann, Adriana Raffin / Guterres, Silvia Stanisçuaski

Materials science & engineering. C, Materials for biological applications

2020 Volume 120, Page(s) 111681

Abstract: Dermatological applications of phloretin are restricted by its poor aqueous solubility. Nanotechnology has been proposed as strategy to increase the apparent drug solubility in aqueous media. This study aimed to develop, characterize, and evaluate the ... ...

Abstract	Dermatological applications of phloretin are restricted by its poor aqueous solubility. Nanotechnology has been proposed as strategy to increase the apparent drug solubility in aqueous media. This study aimed to develop, characterize, and evaluate the antitumoral effects and safety of polymeric nanocapsules containing phloretin (NCPhl). Further, to incorporate NC-Phl in an innovative semi-solid formulation (HG-NCPhl) to evaluate its performance using porcine skin model. NC-Phl was prepared and the effects in MRC5, HACAT, and SK-mel28 cells were evaluated. Hydrogels were prepared with Lecigel ® and characterized for their nanotechnological properties, adhesion (in vitro washability), and penetration/permeation studies in porcine skin. NC-Phl had a cytotoxic effect against Sk-Mel-28 cells and the population doubling time was increased upon treatment with NC-Phl for longer culture periods; notably when cells were treated for 72 h and then followed for 7 days after the treatment was removed (p < 0.05). HG-NC-Phl was considered adhesive and had a higher capacity to penetrate all skin layers compared with HG-Phl (p < 0.05). The innovative hydrogel HGNC-Phl promoted a drug-reservoir in the stratum corneum and higher penetration of the flavonoid into the epidermis. Therefore, this approach can be considered as a platform to establish versatile dermatological solutions for both cosmeceutics and melanoma therapy.
MeSH term(s)	Animals ; Hydrogels ; Nanocapsules ; Phloretin/pharmacology ; Polymers ; Skin ; Swine
Chemical Substances	Hydrogels ; Nanocapsules ; Polymers ; Phloretin (S5J5OE47MK)
Language	English
Publishing date	2020-10-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2020.111681
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Article ; Online: Technological Scenario for Masks in Patent Database During Covid-19 Pandemic.

de Araújo Andrade, Tatianny / Nascimento Junior, José Adão Carvalho / Santos, Anamaria Mendonça / Borges, Lysandro Pinto / Quintans-Júnior, Lucindo José / Walker, Cristiani Isabel Banderó / Frank, Luiza Abrahão / Serafini, Mairim Russo

AAPS PharmSciTech

2021 Volume 22, Issue 2, Page(s) 72

Abstract: Since January 2020, the World Health Organization announces COVID-19 outbreak a case of public health emergency of international interest, and declaring it a pandemic on March. Due to the high transmission of this disease, rate precautions have been ... ...

Abstract	Since January 2020, the World Health Organization announces COVID-19 outbreak a case of public health emergency of international interest, and declaring it a pandemic on March. Due to the high transmission of this disease, rate precautions have been implemented, such as the use of masks by the population, personal protective equipment (PPE), and safety protocols, mainly to health workers. Thus, we performed a patent review to evaluate the current patents related to the protective mask. The review was carried out in the patent database in the period of May 2019 to May 2020. After the process of screening and eligibility, 563 patents were selected for our analysis according to the aim of the study which used masks such as a PPE against dust particles and pathogens, mostly when it is about airborne transmission, such as viruses and bacteria. Here, an overview of the main materials used in the mask manufacturing and their efficiency was described. The results of the review showed that most of the masks used cotton, nylon, silver fiber fabrics, among others as fabrics to develop the masks. It also makes an analysis of masks composed of nanotechnology which provide high filtration efficiency. Moreover, the review also brought possibilities of masking the population, which already have been done in countries such as China and Korea and ways of sterilization for reuse of PPE during COVID-19 outbreak. Thus, this review can further researchers in the developing of masks to decrease the spread of a pandemic disease. Graphical abstract.
MeSH term(s)	COVID-19 ; Databases, Factual ; Humans ; Masks ; Pandemics ; Patients ; Personal Protective Equipment
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2052070-0
ISSN	1530-9932 ; 1530-9932
ISSN (online)	1530-9932
ISSN	1530-9932
DOI	10.1208/s12249-021-01918-x
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