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  1. Book: Minimierung von Risiken bei Planung und langfristigem Betrieb tiefengeothermischer Anlagen im bayrischen Molassebecken

    Frank, Nadine
    Institution SWM Services GmbH, Emmy-Noether-Str. 2, 80992, Muenchen, DE
    Keywords Kenngroesse ; Materialpruefung ; Monitoring ; Planung ; Tiefengeothermie ; Filter ; Risikominderung ; Anlagenbetrieb ; Langzeitverhalten ; Wirtschaftlichkeit ; Thermalquelle ; Erdwaermenutzung ; Anlagenoptimierung ; Entgasung ; Werkstoffkunde ; Modellierung ; Prognosemodell ; Wasseruntersuchung ; Wasserinhaltsstoff ; Probenahmestelle ; Korrosion ; Partikel ; Betriebsdaten ; Korrosionsfestigkeit ; Geothermiebohrung ; Wasserfilter ; Prospektion ; Lagerstaettenerkundung ; Vergleichsuntersuchung ; Bayern
    Document type Book
    Remark project start: 02/01/2011 project end: 01/31/2014 grant ID: 0325280A
    Database Environmental research database (UFORDAT) of the German Federal Environment Agency (UBA)

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  2. Article ; Online: DAMPs Released from Proinflammatory Macrophages Induce Inflammation in Cardiomyocytes via Activation of TLR4 and TNFR.

    Neu, Carolina / Thiele, Yvonne / Horr, Fabienne / Beckers, Christian / Frank, Nadine / Marx, Gernot / Martin, Lukas / Kraemer, Sandra / Zechendorf, Elisabeth

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: Cardiac dysfunction is a life-threatening complication in sepsis. Upon infection and cardiac stress, the cardiac macrophage population expands. Recruited macrophages exhibit a predominantly proinflammatory phenotype and release danger-associated ... ...

    Abstract Cardiac dysfunction is a life-threatening complication in sepsis. Upon infection and cardiac stress, the cardiac macrophage population expands. Recruited macrophages exhibit a predominantly proinflammatory phenotype and release danger-associated molecular patterns (DAMPs) that contribute to cardiac dysfunction. However, the underlying pathomechanisms are highly complex and not fully understood. Here, we utilized an indirect macrophage-cardiomyocyte co-culture model to study the effects of proinflammatory macrophages on the activation of different cardiac receptors (TLR3, TLR4, and TNFR) and their role in cardiac inflammation and caspase-3/7 activation. The stimulation of cardiomyocytes with conditioned medium of LPS-stimulated macrophages resulted in elevated IL-6 protein concentrations and relative IL-6 and TNFα mRNA levels. Conditioned medium from LPS-stimulated macrophages also induced NFκB translocation and increased caspase-3/7 activation in cardiomyocytes. Analyzing the role of different cardiac receptors, we found that TLR4 and TNFR inhibition reduces cardiac inflammation and that the inhibition of TNFR prevents NFκB translocation into the nuclei of cardiomyocytes, induced by exposure to conditioned medium of proinflammatory macrophages. Moreover, we demonstrated that TLR3 inhibition reduces macrophage-mediated caspase-3/7 activation. Our results suggest that the immune response of macrophages under inflammatory conditions leads to the release of DAMPs, such as eRNA and cytokines, which in turn induce cardiomyocyte dysfunction. Thus, the data obtained in this study contribute to a better understanding of the pathophysiological mechanisms of cardiac dysfunction.
    Language English
    Publishing date 2022-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232415522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Potential Association between Ribonuclease 1 Dynamics in the Blood and the Outcome in COVID-19 Patients.

    Zechendorf, Elisabeth / Beckers, Christian / Frank, Nadine / Kraemer, Sandra / Neu, Carolina / Breuer, Thomas / Dreher, Michael / Dahl, Edgar / Marx, Gernot / Martin, Lukas / Simon, Tim-Philipp

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: The COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus is the most recent and well-known outbreak of a coronavirus. RNase 1 is a small endogenous antimicrobial polypeptide that possesses antiviral activity against viral diseases. In this study, ... ...

    Abstract The COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus is the most recent and well-known outbreak of a coronavirus. RNase 1 is a small endogenous antimicrobial polypeptide that possesses antiviral activity against viral diseases. In this study, we investigated a potential association between ribonuclease 1 and the outcome in COVID-19 patients and the impact of increased and decreased RNase 1 levels serum during the course of the disease. Therefore, two patient populations, Cohort A (
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Potential Impact of Heparanase Activity and Endothelial Damage in COVID-19 Disease.

    Zechendorf, Elisabeth / Schröder, Katharina / Stiehler, Lara / Frank, Nadine / Beckers, Christian / Kraemer, Sandra / Dreher, Michael / Kersten, Alexander / Thiemermann, Christoph / Marx, Gernot / Simon, Tim-Philipp / Martin, Lukas

    Journal of clinical medicine

    2022  Volume 11, Issue 18

    Abstract: SARS-CoV-2 was first detected in 2019 in Wuhan, China. It has been found to be the most pathogenic virus among coronaviruses and is associated with endothelial damage resulting in respiratory failure. Determine whether heparanase and heparan sulfate ... ...

    Abstract SARS-CoV-2 was first detected in 2019 in Wuhan, China. It has been found to be the most pathogenic virus among coronaviruses and is associated with endothelial damage resulting in respiratory failure. Determine whether heparanase and heparan sulfate fragments, biomarkers of endothelial function, can assist in the risk stratification and clinical management of critically ill COVID-19 patients admitted to the intensive care unit. We investigated 53 critically ill patients with severe COVID-19 admitted between March and April 2020 to the University Hospital RWTH Aachen. Heparanase activity and serum levels of both heparanase and heparan sulfate were measured on day one (day of diagnosis) and day three in patients with COVID-19. The patients were classified into four groups according to the severity of ARDS. When compared to baseline data (day one), heparanase activity increased and the heparan sulfate serum levels decreased with increasing severity of ARDS. The heparanase activity significantly correlated with the lactate concentration on day one (
    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11185261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: EU(7)-PIM - eine europäische Screening-Liste zur Identifizierung potenziell unangemessener Arzneimitteltherapien bei älteren Patienten

    Lipp, Hans-Peter / Frank, Nadine / Kuret, Anna

    Krankenhauspharmazie

    2016  Volume 37, Issue 12, Page(s) 537

    Language German
    Document type Article
    ZDB-ID 138842-3
    ISSN 0173-7597
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Slack K

    Ehinger, Rebekka / Kuret, Anna / Matt, Lucas / Frank, Nadine / Wild, Katharina / Kabagema-Bilan, Clement / Bischof, Helmut / Malli, Roland / Ruth, Peter / Bausch, Anne E / Lukowski, Robert

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2021  Volume 35, Issue 5, Page(s) e21568

    Abstract: The neuronal ... ...

    Abstract The neuronal Na
    Language English
    Publishing date 2021-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202002308RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

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  7. Article: The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair.

    Zechendorf, Elisabeth / Gombert, Alexander / Bülow, Tanja / Frank, Nadine / Beckers, Christian / Peine, Arne / Kotelis, Drosos / Jacobs, Michael J / Marx, Gernot / Martin, Lukas

    Journal of clinical medicine

    2020  Volume 9, Issue 10

    Abstract: Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of ...

    Abstract Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (
    Language English
    Publishing date 2020-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9103292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effect of Long-Term Polytrauma on Ventilator-Induced Diaphragmatic Dysfunction in a Piglet Model.

    Breuer, Thomas / Bruells, Christian S / Horst, Klemens / Thiele, Christoph / Hildebrand, Frank / Linnartz, Stephan / Siegberg, Tom / Frank, Nadine / Gayan-Ramirez, Ghislaine / Martin, Lukas / Ostareck, Dirk H / Marx, Gernot / Simon, Tim-Philipp

    Shock (Augusta, Ga.)

    2018  Volume 52, Issue 4, Page(s) 443–448

    Abstract: Introduction: Mechanical ventilation is known to activate oxidative stress and proteolytic pathways in the diaphragm. Trauma by inducing inflammation and activating proteolytic pathways may potentiate the effects of mechanical ventilation on the ... ...

    Abstract Introduction: Mechanical ventilation is known to activate oxidative stress and proteolytic pathways in the diaphragm. Trauma by inducing inflammation and activating proteolytic pathways may potentiate the effects of mechanical ventilation on the diaphragm. In a blunt chest trauma with concomitant injuries we tested the hypothesis that trauma via inflammation further activates the proteolytic pathways and worsens atrophy in the diaphragm.
    Material and methods: Piglets were separated into two groups and underwent 72 h of mechanical ventilation. One group received a polytrauma (PT) by unilateral femur fracture, blunt chest trauma with lung contusion, laparotomy with standardized liver incision, and a predefined hemorrhagic shock. The second mechanically ventilated group (MV) did not receive any trauma. A non-ventilated group (Con) served as control.Diaphragmatic fiber dimensions, Western Blot analyses of proteolytic pathways, and lipid peroxidation and messenger ribonucleic acid (mRNA) levels of cytokines and nuclear factor kappa b subunit p65 were measured.
    Results: Active Caspase-3 was significantly increased in MV (P = 0.019), and in PT (P = 0.02) compared with Con. Nuclear factor kappa b subunit p65, was upregulated in PT (P = 0.010) compared with Con. IL-6 mRNA increased significantly in PT compared with Con (P = 0.0024) but did not differ between Con and MV.
    Conclusion: Trauma and mechanical ventilation induced proteolysis and atrophy in the diaphragm, but only polytrauma induced an inflammatory response in the diaphragm. The additional traumatic inflammatory stimulus did not increase the levels of the prementioned variables. These data underline that inflammation is not a major contributor to ventilator-induced diaphragmatic dysfunction.
    Trial registry number: AZ 84-02.04.2014.A265 (Landesamt für Natur-, Umwelt- und Verbraucherschutz, LANUV NRW, Germany).
    MeSH term(s) Animals ; Cytokines/metabolism ; Diaphragm/injuries ; Diaphragm/metabolism ; Diaphragm/pathology ; Disease Models, Animal ; Lipid Peroxidation ; Multiple Trauma/metabolism ; Multiple Trauma/pathology ; Multiple Trauma/therapy ; Respiration, Artificial/adverse effects ; Swine ; Time Factors ; Transcription Factor RelA/metabolism
    Chemical Substances Cytokines ; Transcription Factor RelA
    Language English
    Publishing date 2018-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1185432-7
    ISSN 1540-0514 ; 1073-2322
    ISSN (online) 1540-0514
    ISSN 1073-2322
    DOI 10.1097/SHK.0000000000001272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3985: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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