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  1. Article ; Online: Ultrasound Pressure-Dependent Cytokine and Immune Cell Response Lost in Aged Muscle.

    Dunham, Chelsey L / Frank, Joseph A

    Ultrasound in medicine & biology

    2024  Volume 50, Issue 4, Page(s) 494–501

    Abstract: Objective: Therapeutic ultrasound remains a highly discussed topic in physical therapy due to uncertainty between treatment regimens and biological benefits. Its impact on aged populations, who are vulnerable to insufficient healing after muscle injury ... ...

    Abstract Objective: Therapeutic ultrasound remains a highly discussed topic in physical therapy due to uncertainty between treatment regimens and biological benefits. Its impact on aged populations, who are vulnerable to insufficient healing after muscle injury because of sarcopenia, is understudied. Despite the coupling between muscle inflammation and regeneration, research on the immune response after therapeutic ultrasound is limited. The objective of this study was to evaluate structure, inflammatory cytokine signaling and immune cell infiltration after therapeutic ultrasound in young and aging murine muscle.
    Methods: Young (6-week-old) and Adult (52-week-old) male and female mouse non-injured gastrocnemii were treated with either low-intensity pulsed ultrasound at 2 W/cm
    Results: Low-intensity pulsed ultrasound induced an early, transient inflammatory response where interleukin (IL)-15 and macrophages (M2 > M1) were increased 1 hour post-sonication. High-intensity pulsed focused ultrasound caused a late, extended immune response where monocyte chemoattractant protein 1 (MCP-1), neutrophils, monocytes and macrophages (M1 > M2) were increased 24 hours post-sonication. Notably, these changes manifested solely in Young gastrocnemius. The Adult gastrocnemius exhibited decreased cytokine expression (IL-1α, IL-6, IL-15, macrophage colony-stimulating factor [M-CSF]) and no alteration in immune cell recruitment post-sonication. There was no damage to muscle structure.
    Conclusion: Therapeutic ultrasound induced a pressure-dependent inflammatory response that can augment or mitigate intrinsic muscle cytokine signaling and cell recruitment in adolescent or aged muscle, respectively.
    MeSH term(s) Male ; Female ; Mice ; Animals ; Cytokines/metabolism ; Monocytes/metabolism ; Macrophages/metabolism ; Muscle, Skeletal/metabolism ; Immunity
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2023.12.009
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    Zs.A 963: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Sensitivity of the Evapotranspiration Deficit Index to Its Parameters and Different Temporal Scales

    Frank Joseph Wambura

    Hydrology, Vol 8, Iss 1, p

    2021  Volume 26

    Abstract: Sound estimates of drought characteristics are very important for planning intervention measures in drought-prone areas. Due to data scarcity, many studies are increasingly using less data-intensive approaches, such as the evapotranspiration deficit ... ...

    Abstract Sound estimates of drought characteristics are very important for planning intervention measures in drought-prone areas. Due to data scarcity, many studies are increasingly using less data-intensive approaches, such as the evapotranspiration deficit index (ETDI), in estimations of agricultural droughts. However, little is known about the sensitivity of this specific ETDI formula to its parameters, and to data at different temporal scales. In this study, a general ETDI formula, homologous to the specific ETDI formula, was introduced and used to test the sensitivity of the ETDI to its parameters and to data at different temporal scales. The tests used time series of remotely sensed evapotranspiration data in the Ruvu River basin in Tanzania. The parameter sensitivity tests revealed that ETDI is sensitive to its parameters, and different parameter combinations resulted in different drought characteristics. The temporal scale sensitivity test showed that drought characteristics, such as the number of drought events and the total drought durations, decreased as the temporal scale increased. Thus, an inappropriate temporal scale may lead to the misrepresentation of drought characteristics. To reduce uncertainty and increase the accuracy of ETDI-based agricultural drought characteristics, ETDI requires parameter calibration and the use of data with small temporal scales, respectively. These findings are useful for improving estimations of ETDI-based agricultural droughts.
    Keywords agricultural drought ; drought characteristics ; evapotranspiration deficit index ; parameter sensitivity ; temporal scale sensitivity ; water stress anomaly ; Science ; Q
    Subject code 550
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  3. Article ; Online: Potential of rainfall data hybridization in a data-scarce region

    Frank Joseph Wambura

    Scientific African, Vol 8, Iss , Pp e00449- (2020)

    2020  

    Abstract: Many impact assessment studies have been using reanalysis precipitation data as an alternative to observed rainfall data even where few rainfall records are available. For that reason, this study investigated fit-to-observations and fit-for-purpose of ... ...

    Abstract Many impact assessment studies have been using reanalysis precipitation data as an alternative to observed rainfall data even where few rainfall records are available. For that reason, this study investigated fit-to-observations and fit-for-purpose of hybrid rainfall data using four strategically located rainfall stations in the Wami-Ruvu basin, Tanzania. Hybrid rainfall data were generated by randomly filling 15% to 70% hypothetical missing data in the observed records at the rainfall stations with reanalysis precipitation data from nearby grids. Fit-to-observations was used to evaluate the performance of the whole time series of hybrid rainfall data in mimicking that of observed rainfall data at the stations. Fit-for-purpose was used to evaluate the performance of trend and seasonal components of the whole time series of hybrid rainfall data in mimicking those of the whole time series of observed rainfall data at the stations. The findings showed that hybrid rainfall data are superior to reanalysis precipitation data in mimicking observed rainfall data. The findings also revealed that in most cases, trend and seasonal components have greater performances than the whole time series at high degrees of hybridization. Therefore, hybridization of rainfall data is highly encouraged especially in data-scarce regions.
    Keywords Data scarcity ; Fit-for-purpose ; Fit-to-observations ; Hybrid rainfall ; Reanalysis precipitation ; Wami-Ruvu basin ; Science ; Q
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  4. Article ; Online: Uncertainty of drought information in a data-scarce tropical river basin

    Frank Joseph Wambura

    Journal of Hydrology: Regional Studies, Vol 32, Iss , Pp 100760- (2020)

    2020  

    Abstract: Study region: The Wami River basin in east-central Tanzania features the Eastern Arc Mountains and dichotomous climate regimes. Study focus: Drought characteristics are vital in planning and managing water resources in river basins. However, the ... ...

    Abstract Study region: The Wami River basin in east-central Tanzania features the Eastern Arc Mountains and dichotomous climate regimes. Study focus: Drought characteristics are vital in planning and managing water resources in river basins. However, the estimation of drought characteristics from the evapotranspiration deficit index (ETDI) is susceptible to the uncertainty associated with alternative datasets from hydrological models and remote sensing images. Thus, this study investigated scenario uncertainty in ETDI-based drought characteristics in the river basin using evapotranspiration and potential evapotranspiration data from a classical Soil and Water Assessment Tool (SWAT) and the Moderate Resolution Imaging Spectroradiometer (MODIS) images between the years 2000 and 2010. New hydrological insights: The findings showed a substantial scenario uncertainty in drought duration, severity, and intensity at various locations in the river basin. Localized severe MODIS-based overall drought intensity (MODIS-ODI) in the middle of the basin was attributed to prolonged low rainfall amounts. In the downstream, localized severe SWAT-based overall drought intensity (SWAT-ODI) was attributed to an imperfection of the SWAT model in simulating the true hydrologic cycle of the river basin. However, at the basin level, both SWAT-ODI and MODIS-ODI between the years 2000 and 2010 were moderate. These findings can be used as the baseline information in improving drought estimation in the river basin. Moreover, this study also demonstrates the importance of assessing scenario uncertainty in drought characterization.
    Keywords Drought ; Evapotranspiration deficit index ; MODIS ; Scenario uncertainty ; SWAT ; Wami River basin ; Physical geography ; GB3-5030 ; Geology ; QE1-996.5
    Subject code 550
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book: Advances in multiple sclerosis

    Frank, Joseph A.

    (Neuroimaging clinics of North America ; 10,4)

    2000  

    Author's details Joseph A. Frank, guest ed
    Series title Neuroimaging clinics of North America ; 10,4
    Collection
    Language English
    Size X S., S. 611 - 840 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013056006
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 1309 -10,4- verfügbar in Königswinter Königswinter

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  6. Book: Refractive surgery

    Goes, Frank Joseph

    (Instant clinical diagnosis in ophthalmology)

    2010  

    Title variant Instant clinical diagnosis in ophthalmology refractive surgery
    Author's details ed. Frank Jozef Goes
    Series title Instant clinical diagnosis in ophthalmology
    Keywords Eye--Refractive errors--Surgery
    Subject code 617.755
    Language English
    Size XXII, 589 S. : zahlr. Ill., graph. Darst., 24 cm
    Publisher Japee Brothers u.a.
    Publishing place New Dellhi u.a.
    Publishing country India
    Document type Book
    HBZ-ID HT016943131
    ISBN 978-0-07-174947-3 ; 0-07-174947-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 3355 order for loan Magazin

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  7. Article ; Online: The enigmatic strabismus of Albrecht Dürer.

    Goes, Frank Joseph

    Strabismus

    2019  Volume 27, Issue 1, Page(s) 35–38

    Abstract: The author discusses several of Albrecht Dürer's selfportraits. In some portraits his eyes are straight and in some others a divergent squint is present. Did Dürer do this on purpose or whas the squint indeed intermittently present? Analysis of the ... ...

    Abstract The author discusses several of Albrecht Dürer's selfportraits. In some portraits his eyes are straight and in some others a divergent squint is present. Did Dürer do this on purpose or whas the squint indeed intermittently present? Analysis of the portrait of his mother gave the explanation.
    MeSH term(s) Austria ; Famous Persons ; History, 15th Century ; History, 16th Century ; Humans ; Medicine in the Arts ; Paintings/history ; Portraits as Topic/history ; Strabismus/history
    Language English
    Publishing date 2019-02-13
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1149100-0
    ISSN 1744-5132 ; 0927-3972
    ISSN (online) 1744-5132
    ISSN 0927-3972
    DOI 10.1080/09273972.2019.1560977
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    Zs.A 5485: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Book: Multifocal IOLs

    Goes, Frank Joseph

    2009  

    Author's details ed. Frank Joseph Goes
    Language English
    Size XVI, 235 S. : zahlr. Ill., graph. Darst.
    Publisher Jaypee u.a.
    Publishing place New Delhi
    Publishing country India
    Document type Book
    HBZ-ID HT016079068
    ISBN 978-0-07-163432-8 ; 0-07-163432-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4531 order for loan Magazin

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  9. Article ; Online: Ending the pandemic of inaccessibility in dermatology.

    Yardman-Frank, Joseph Michael / Nambudiri, Vinod

    Clinics in dermatology

    2023  Volume 41, Issue 2, Page(s) 280–283

    Abstract: Dermatology in the United States is among the global leaders in advancing scientific discovery and practicing evidence-based medicine; however, many patients face limited access to dermatologic care due to a national shortage of dermatologists, provider ... ...

    Abstract Dermatology in the United States is among the global leaders in advancing scientific discovery and practicing evidence-based medicine; however, many patients face limited access to dermatologic care due to a national shortage of dermatologists, provider clustering, and the interplay of sociodemographic and socioeconomic factors. These intertwined barriers have created a landscape where race, ethnicity, insurance subtype, education, and socioeconomic status negatively impact access to dermatologic services. Leveraging the utilization of technology and community engagement provides inroads to improve access to care. We outline how teleconsultations, telementoring, specialty care extension for community health outcomes (Project ECHO), community health centers, donated specialty care models, and community health workers can be bolstered to create more equitable access to care.
    MeSH term(s) Humans ; United States ; Dermatology ; Pandemics ; Social Class ; Ethnicity ; Health Services Accessibility
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2023.04.003
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    Se 972: Show issues Location:
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  10. Article ; Online: Semántica de los términos del cuerpo humano en quechua

    Frank Joseph Domínguez Chenguayen / Manuel Eulogio Conde Marcos

    Tesis (Lima), Vol 15, Iss 21, Pp 319-

    metáfora, metonimia e interacción conceptual

    2022  Volume 333

    Abstract: En el quechua Ayacucho-Chanca, los términos corpóreos evocan distintos dominios o marcos conceptuales. El objetivo de este trabajo consiste en esclarecer la naturaleza del comportamiento polisémico de dichos términos corpóreos. Teóricamente se parte de ... ...

    Abstract En el quechua Ayacucho-Chanca, los términos corpóreos evocan distintos dominios o marcos conceptuales. El objetivo de este trabajo consiste en esclarecer la naturaleza del comportamiento polisémico de dichos términos corpóreos. Teóricamente se parte de un conjunto de principios que rigen el fenómeno de la polisemia en el marco de la lingüística cognitiva. Metodológicamente, la data ha sido obtenida a partir de un proceso de elicitación. Los resultados permiten reafirmar la metáfora y la metonimia como procedimientos necesarios, pero (a la vez) insuficientes para explicar la generación de nuevos sentidos. La explicación requiere también de un proceso interaccional.
    Keywords polisemia ; términos del cuerpo humano ; quechua ; metáfora ; metonimia ; History of scholarship and learning. The humanities ; AZ20-999 ; Literature (General) ; PN1-6790 ; Arts in general ; NX1-820
    Language Spanish
    Publishing date 2022-12-01T00:00:00Z
    Publisher Universidad Nacional Mayor de San Marcos, Facultad de Letras y Ciencias Humanas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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