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Book ; Online ; Thesis: In-vivo-Testung des "Vascular Disrupting Agents" DMXAA am Modell für neuroendokrine und Nebennieren-Tumore

Frantsev, Roman [Verfasser]

2010

Author's details	vorgelegt von Roman Frantsev
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Long-term outcomes of semi-implantable functional electrical stimulation for central drop foot.

Buentjen, Lars / Kupsch, Andreas / Galazky, Imke / Frantsev, Roman / Heinze, Hans-Jochen / Voges, Jürgen / Hausmann, Janet / Sweeney-Reed, Catherine M

Journal of neuroengineering and rehabilitation

2019 Volume 16, Issue 1, Page(s) 72

Abstract: Background: Central drop foot is a common problem in patients with stroke or multiple sclerosis (MS). For decades, it has been treated with orthotic devices, keeping the ankle in a fixed position. It has been shown recently that semi-implantable ... ...

Abstract	Background: Central drop foot is a common problem in patients with stroke or multiple sclerosis (MS). For decades, it has been treated with orthotic devices, keeping the ankle in a fixed position. It has been shown recently that semi-implantable functional electrical stimulation (siFES) of the peroneal nerve can lead to a greater gait velocity increase than orthotic devices immediately after being switched on. Little is known, however, about long-term outcomes over 12 months, and the relationship between quality of life (QoL) and gait speed using siFES has never been reported applying a validated tool. We provide here a report of short (3 months) and long-term (12 months) outcomes for gait speed and QoL. Methods: Forty-five consecutive patients (91% chronic stroke, 9% MS) with central drop foot received siFES (Actigait®). A 10 m walking test was carried out on day 1 of stimulation (T1), in stimulation ON and OFF conditions, and repeated after 3 (T2) and 12 (T3) months. A 36-item Short Form questionnaire was applied at all three time points. Results: We found a main effect of stimulation on both maximum (p < 0.001) and comfortable gait velocity (p < 0.001) and a main effect of time (p = 0.015) only on maximum gait velocity. There were no significant interactions. Mean maximum gait velocity across the three assessment time points was 0.13 m/s greater with stimulation ON than OFF, and mean comfortable gait velocity was 0.083 m/s faster with stimulation ON than OFF. The increase in maximum gait velocity over time was 0.096 m/s, with post hoc testing revealing a significant increase from T1 to T2 (p = 0.012), which was maintained but not significantly further increased at T3. QoL scores showed a main effect of time (p < 0.001), with post hoc testing revealing an increase from T1 to T2 (p < 0.001), which was maintained at T3 (p < 0.001). Finally, overall absolute QoL scores correlated with the absolute maximum and comfortable gait speeds at T2 and T3, and the increase in overall QoL scores correlated with the increase in comfortable gait velocity from T1 to T3. Pain was reduced at T2 (p < 0.001) and was independent of gait speed but correlated with overall QoL (p < 0.001). Conclusions: Peroneal siFES increased maximal and comfortable gait velocity and QoL, with the greatest increase in both over the first three months, which was maintained at one year, suggesting that 3 months is an adequate follow-up time. Pain after 3 months correlated with QoL and was independent of gait velocity, suggesting pain as an independent outcome measure in siFES for drop foot.
MeSH term(s)	Adult ; Electric Stimulation Therapy/instrumentation ; Electrodes, Implanted ; Female ; Gait Disorders, Neurologic/etiology ; Gait Disorders, Neurologic/physiopathology ; Gait Disorders, Neurologic/therapy ; Humans ; Male ; Middle Aged ; Multiple Sclerosis/complications ; Multiple Sclerosis/physiopathology ; Quality of Life ; Retrospective Studies ; Stroke/complications ; Stroke/physiopathology ; Stroke Rehabilitation/instrumentation ; Stroke Rehabilitation/methods ; Treatment Outcome
Language	English
Publishing date	2019-06-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1743-0003
ISSN (online)	1743-0003
DOI	10.1186/s12984-019-0542-8
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Article ; Online: The role of the Sylvian fissure configuration and the vascular anatomy on different bleeding patterns in ruptured middle cerebral artery aneurysms.

Neyazi, Belal / Siblini, Ali / Frantsev, Roman / Özkan, Neriman / Sandalcioglu, I Erol / Sure, Ulrich / Maslehaty, Homajoun

Clinical neurology and neurosurgery

2019 Volume 189, Page(s) 105572

Abstract: Objective: Ruptured middle cerebral artery (MCA) aneurysms are one of the causes of subarachnoid (SAH) or intracerebral hemorrhage (ICH) but the factors associated with the bleeding type are unknown. The aim of the study was to analyze the association ... ...

Abstract	Objective: Ruptured middle cerebral artery (MCA) aneurysms are one of the causes of subarachnoid (SAH) or intracerebral hemorrhage (ICH) but the factors associated with the bleeding type are unknown. The aim of the study was to analyze the association of the morphological variations of the Sylvian fissure (SF) and vascular parameters on occurrence of different bleeding patterns in patients with ruptured MCA aneurysms. Patients and methods: The data of consecutive 202 patients with ruptured MCA aneurysm of two centers were included for analysis. Patients were divided into three groups: Group 1 with SAH, Group 2 with accompanying ICH and Group 3 with intrasylvian hemorrhage (ISH). The SF was divided into five types according to the previously described classification. Analyzed vascular parameters were aneurysm size, localization, presence of a daughter aneurysm, shape, and angulation of the aneurysm sac. Results: A total of 202 patients (141 female, 61 male, mean age 52.4 yr) were included in this study. 67 patients (33.2%) had a SAH, 122 (60.4%) an ICH and 13 (6.4%) presented with ISH. Statistical analysis showed a significant association of narrow and twisted SF types 4 and 5 (p < 0.001) and temporal angulation of the aneurysm (p = 0.030) for occurrence of ICH. All other vascular parameters showed no significant association for any kind of hemorrhage. Conclusion: Our results allow the conclusion that the complex SF types 4 and 5, as well as the temporal angulation of the aneurysm sac are associated with the occurrence of ICH in ruptured MCA aneurysms.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anatomic Variation ; Aneurysm, Ruptured/diagnostic imaging ; Angiography, Digital Subtraction ; Cerebral Angiography ; Cerebral Hemorrhage/diagnostic imaging ; Computed Tomography Angiography ; Female ; Frontal Lobe/anatomy & histology ; Frontal Lobe/diagnostic imaging ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Male ; Middle Aged ; Middle Cerebral Artery/diagnostic imaging ; Subarachnoid Hemorrhage/diagnostic imaging ; Temporal Lobe/anatomy & histology ; Temporal Lobe/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-10-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	193107-6
ISSN	1872-6968 ; 0303-8467
ISSN (online)	1872-6968
ISSN	0303-8467
DOI	10.1016/j.clineuro.2019.105572
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Article ; Online: Successful multimodal treatment of a gigantic choroid plexus carcinoma (CPC) in an 8-year-old girl.

Maslehaty, Homajoun / Frantsev, Roman / Teuber-Hanselmann, Sarah / Tippelt, Stephan / Sure, Ulrich

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2017 Volume 33, Issue 11, Page(s) 1875–1877

MeSH term(s)	Carcinoma/diagnostic imaging ; Carcinoma/pathology ; Carcinoma/therapy ; Child ; Choroid Plexus/diagnostic imaging ; Choroid Plexus/pathology ; Choroid Plexus/surgery ; Choroid Plexus Neoplasms/diagnostic imaging ; Choroid Plexus Neoplasms/pathology ; Choroid Plexus Neoplasms/therapy ; Female ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging
Language	English
Publishing date	2017
Publishing country	Germany
Document type	Case Reports ; Letter
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-017-3590-z
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Conference proceedings: Influence of morphological vascular parameters and the anatomical variations of the Sylvian Fissure on the bleeding pattern of ruptured middle cerebral artery aneurysms

Maslehaty, Homajoun / Frantsev, Roman / Kleist, Bernadette / Hütter, Bernd Otto / Sure, Ulrich / Müller, Oliver M.

2017 , Page(s) P 213

Event/congress	68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); Magdeburg; ; Society of British Neurological Surgeons; 2017
Keywords	Medizin, Gesundheit
Publishing date	2017-06-09
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/17dgnc776
Database	German Medical Science

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Conference proceedings: Ruptured middle cerebral artery aneurysms and the different bleeding patterns – influence of the sylvian fissure anatomy and geometric vascular parameters

Siblini, Ali / Neyazi, Belal / Frantsev, Roman / Özkan, Neriman / Sandalcioglu, I. Erol / Sure, Ulrich / Maslehaty, Homajoun

2019 , Page(s) P132

Title translation	Rupturierte Aneurysmen der A. cerebri media und die unterschiedlichen Blutungsmuster – Einfluss der anatomischen Varaitionen der Sylvischen Fissur und geometrische vaskuläre Parameter
Event/congress	70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie; Würzburg; Deutsche Gesellschaft für Neurochirurgie; 2019
Keywords	Medizin, Gesundheit
Publishing date	2019-05-08
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/19dgnc468
Database	German Medical Science

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Article ; Online: TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors.

Hantel, Constanze / Ozimek, Alexandra / Lira, Regia / Ragazzon, Bruno / Jäckel, Carsten / Frantsev, Roman / Reincke, Martin / Bertherat, Jérôme / Mussack, Thomas / Beuschlein, Felix

Molecular and cellular endocrinology

2016 Volume 423, Page(s) 87–95

Abstract: ASA404 (Vadimezan) belongs to a class of agents with disrupting properties against tumor vasculature, which is partly mediated by TNFα-signaling. Preclinical and early clinical studies have indicated promising results for ASA404, while extended clinical ... ...

Abstract	ASA404 (Vadimezan) belongs to a class of agents with disrupting properties against tumor vasculature, which is partly mediated by TNFα-signaling. Preclinical and early clinical studies have indicated promising results for ASA404, while extended clinical trials performed poorly. Our aim was to investigate the potential therapeutic applicability of ASA404 against endocrine tumors. Moreover, as the reason for the unpredictable clinical anti-tumor activity of ASA 404 remained uncertain in previous studies, we compared two tumor models of endocrine origin with different responses to ASA404 treatment. Specifically, we determined anti-tumoral effects in preclinical models of neuroendocrine tumors of the gastroenteropancreatic system (BON) and adrenocortical cancer (NCI-H295R) in vitro and in xenograft models in vivo. Upon treatment of tumor bearing mice significant anti-tumoral effects, an increase in TNFα as well as activation of TNFα-specific downstream signaling were evident in the BON tumor model while no comparable effects were detectable for NCI-H295R. We identified TNFAIP3/A20, a key molecule of an inhibitory feedback-loop downstream of TNF-receptor 1, CD40, Toll-like receptors, NOD-like receptors and the interleukin-1 receptor signaling cascades, as overexpressed in the adrenocortical carcinoma tumor model. Subsequent analyses of clinical patient samples confirmed a correlation between tumor TNFAIP3 expression levels and overall survival in patients with ACC. Taken together our findings provide evidence that modulation of TNFα-signaling could be of relevance both for the clinical course of ACC patients and as a marker of treatment response.
MeSH term(s)	Adrenal Cortex Neoplasms/drug therapy ; Adrenal Cortex Neoplasms/metabolism ; Adrenal Cortex Neoplasms/mortality ; Adrenocortical Carcinoma/drug therapy ; Adrenocortical Carcinoma/metabolism ; Adrenocortical Carcinoma/mortality ; Angiogenesis Inhibitors/pharmacology ; Animals ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Interleukin-1 Receptor-Associated Kinases/genetics ; Interleukin-1 Receptor-Associated Kinases/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Kaplan-Meier Estimate ; Mice, Nude ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Paclitaxel/pharmacology ; Proportional Hazards Models ; Signal Transduction ; Transcriptional Activation ; Tumor Necrosis Factor alpha-Induced Protein 3 ; Tumor Necrosis Factor-alpha/physiology ; Xanthones/pharmacology ; Xenograft Model Antitumor Assays
Chemical Substances	Angiogenesis Inhibitors ; DNA-Binding Proteins ; Intracellular Signaling Peptides and Proteins ; Nuclear Proteins ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Xanthones ; vadimezan (0829J8133H) ; Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1) ; TNFAIP3 protein, human (EC 3.4.19.12) ; Tumor Necrosis Factor alpha-Induced Protein 3 (EC 3.4.19.12) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2016-03-05
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2015.12.009
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Article ; Online: Intraventricular Hemorrhage Caused by Subarachnoid Hemorrhage: Does the Severity Matter?

Darkwah Oppong, Marvin / Gembruch, Oliver / Herten, Annika / Frantsev, Roman / Chihi, Mehdi / Dammann, Philipp / El Hindy, Nicolai / Forsting, Michael / Sure, Ulrich / Jabbarli, Ramazan

World neurosurgery

2018 Volume 111, Page(s) e693–e702

Abstract: Objective: Aneurysm rupture might be accompanied by intraventricular hemorrhage (IVH), which is associated with poor outcome of subarachnoid hemorrhage (SAH). The aim of this study was to analyze risk factors and clinical impact of IVH severity.: ... ...

Abstract	Objective: Aneurysm rupture might be accompanied by intraventricular hemorrhage (IVH), which is associated with poor outcome of subarachnoid hemorrhage (SAH). The aim of this study was to analyze risk factors and clinical impact of IVH severity. Methods: A total of 995 consecutive patients with SAH treated at our institution between January 2003 and June 2016 were eligible for this study. Clinical and radiologic findings were correlated with the presence and severity of IVH assessed with the original Graeb score. Results: A total of 487 patients with SAH (48.9%) presented with IVH (mean IVH severity, 5.48 points [±3.5]). IVH severity correlated with poorer initial clinical condition (World Federation of Neurosurgical Societies grade >3; P < 0.001), acute hydrocephalus (P = 0.001), and poor outcome at 6 months (modified Rankin Scale score >2; P < 0.001). The location of the ruptured aneurysm in the anterior cerebral artery independently predicted the occurrence (P = 0.007) and severity of IVH (P < 0.001). In turn, aneurysm size affected only the severity of IVH (P = 0.001) but not its occurrence (P = 0.153). Early complications of SAH occurring within 72 hours after the bleeding event (cerebral infarction [P = 0.043], early mortality [P = 0.001], and primary craniectomy [P = 0.043]) were independently associated with the severity of IVH. Conclusions: Severity of aneurysmal IVH is a strong contributor to initial severity and early complications of SAH. Patients with larger aneurysms, especially located in the anterior cerebral artery, are at particular risk of severe IVH in cases of aneurysm rupture.
MeSH term(s)	Adult ; Aged ; Aneurysm, Ruptured/complications ; Anterior Cerebral Artery ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/etiology ; Cerebral Ventricles/diagnostic imaging ; Decompressive Craniectomy ; Female ; Humans ; Hydrocephalus/complications ; Male ; Middle Aged ; Prognosis ; Risk Factors ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnostic imaging ; Treatment Outcome
Language	English
Publishing date	2018-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2017.12.148
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Conference proceedings: Management of invasive intracranial aspergillosis in immunocompetent patients – report of two cases

Frantsev, Roman / Maslehaty, Homajoun / Sure, Ulrich / El Hindy, Nicolai / Müller, Oliver

2016 , Page(s) P 053

Event/congress	67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS); Frankfurt am Main; Deutsche Gesellschaft für Neurochirurgie; 2016
Keywords	Medizin, Gesundheit ; Aspergillosis ; intracranial ; surgery
Publishing date	2016-06-08
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/16dgnc428
Database	German Medical Science

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Article ; Online: Predictive anatomical factors for rupture in middle cerebral artery mirror bifurcation aneurysms.

Maslehaty, Homajoun / Capone, Crescenzo / Frantsev, Roman / Fischer, Igor / Jabbarli, Ramazan / Cornelius, Jan F / Kamp, Marcel A / Cappabianca, Paolo / Sure, Ulrich / Steiger, Hans-Jakob / Petridis, Athanasios K

Journal of neurosurgery

2017 Volume 128, Issue 6, Page(s) 1799–1807

Abstract: OBJECTIVE The aim of this study was to define predictive factors for rupture of middle cerebral artery (MCA) mirror bifurcation aneurysms. METHODS The authors retrospectively analyzed the data in patients with ruptured MCA bifurcation aneurysms with ... ...

Abstract	OBJECTIVE The aim of this study was to define predictive factors for rupture of middle cerebral artery (MCA) mirror bifurcation aneurysms. METHODS The authors retrospectively analyzed the data in patients with ruptured MCA bifurcation aneurysms with simultaneous presence of an unruptured MCA bifurcation mirror aneurysm treated in two neurosurgical centers. The following parameters were measured and analyzed with the statistical software R: neck, dome, and width of both MCA aneurysms-including neck/dome and width/neck ratios, shape of the aneurysms (regular vs irregular), inflow angle of both MCA aneurysms, and the diameters of the bilateral A
MeSH term(s)	Adult ; Aged ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/surgery ; Angiography, Digital Subtraction ; Cerebral Angiography ; Computed Tomography Angiography ; Female ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Male ; Middle Aged ; Middle Cerebral Artery/diagnostic imaging ; Middle Cerebral Artery/surgery ; Predictive Value of Tests ; Retrospective Studies
Language	English
Publishing date	2017-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2017.2.JNS162705
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