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  1. Article ; Online: Pulse oximetry signal loss during hypoxic episodes in preterm infants receiving automated oxygen control.

    Langanky, Lukas O / Kreutzer, Karen B / Poets, Christian F / Franz, Axel R / Schwarz, Christoph E

    European journal of pediatrics

    2024  

    Abstract: The aim of this study was to analyze signal loss (SL) resulting from low signal quality of pulse oximetry-derived hemoglobin oxygen saturation (SpO: Clinicaltrials: gov under the registration no. NCT03785899.: What is known: • Previous studies ... ...

    Abstract The aim of this study was to analyze signal loss (SL) resulting from low signal quality of pulse oximetry-derived hemoglobin oxygen saturation (SpO
    Clinicaltrials: gov under the registration no. NCT03785899.
    What is known: • Previous studies examined SpO2 signal loss (SL) during routine manual oxygen control being rare, but pronounced in lower SpO2 states. • Oxygen titration during SL is unlikely to be beneficial as SpO2 may recover to a normoxic range.
    What is new: • Periods of low signal quality of SpO2 are common during pHEs and while supported with automated oxygen control (SPOC), FiO2 is set to a back-up value reflecting FiO2 requirements during normoxemia in response to SL, although SpO2 remained below target until signal recovery. • FiO2 overshoots following pHEs were rare during AOC and occurred with a delayed onset; therefore, increased FiO2 during SL does not necessarily lead to overshoots.
    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-024-05549-9
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  2. Article ; Conference proceedings: Analgosedierung zur wenig invasiven Surfactant Applikation (LISA) – Eine narrative Literaturübersicht zur Entwicklung einer lokalen Leitlinie

    Maiwald, Christian A. / Poets, Christian / Franz, Axel R.

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769197
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  3. Article ; Online: Choline supplementation for preterm infants: metabolism of four Deuterium-labeled choline compounds

    Böckmann, Katrin A. / Bernhard, Wolfgang / Minarski, Michaela / Shunova, Anna / Wiechers, Cornelia / Poets, Christian F. / Franz, Axel R.

    Eur J Nutr. 2023 Apr., v. 62, no. 3 p.1195-1205

    2023  

    Abstract: BACKGROUND: Supply of choline is not guaranteed in current preterm infant nutrition. Choline serves in parenchyma formation by membrane phosphatidylcholine (PC), plasma transport of poly-unsaturated fatty acids (PUFA) via PC, and methylation processes ... ...

    Abstract BACKGROUND: Supply of choline is not guaranteed in current preterm infant nutrition. Choline serves in parenchyma formation by membrane phosphatidylcholine (PC), plasma transport of poly-unsaturated fatty acids (PUFA) via PC, and methylation processes via betaine. PUFA-PC concentrations are high in brain, liver and lung, and deficiency may result in developmental disorders. We compared different deuterated (D9-) choline components for kinetics of D9-choline, D9-betaine and D9-PC. METHODS: Prospective study (1/2021–12/2021) in 32 enterally fed preterm infants (28 0/7–32 0/7 weeks gestation). Patients were randomized to receive enterally a single dose of 2.7 mg/kg D9-choline-equivalent as D9-choline chloride, D9-phosphoryl-choline, D9-glycerophosphorylcholine (D9-GPC) or D9-1-palmitoyl-2-oleoyl-PC(D9-POPC), followed by blood sampling at 1 + 24 h or 12 + 60 h after administration. Plasma concentrations were analyzed by tandem mass spectrometry. Results are expressed as median (25th/75th percentile). RESULTS: At 1 h, plasma D9-choline was 1.8 (0.9/2.2) µmol/L, 1.3 (0.9/1.5) µmol/L and 1.2 (0.7/1.4) µmol/L for D9-choline chloride, D9-GPC and D9-phosphoryl-choline, respectively. D9-POPC did not result in plasma D9-choline. Plasma D9-betaine was maximal at 12 h, with lowest concentrations after D9-POPC. Maximum plasma D9-PC values at 12 h were the highest after D9-POPC (14.4 (9.1/18.9) µmol/L), compared to the other components (D9-choline chloride: 8.1 [5.6/9.9] µmol/L; D9-GPC: 8.4 (6.2/10.3) µmol/L; D9-phosphoryl-choline: 9.8 (8.6/14.5) µmol/L). Predominance of D9-PC comprising linoleic, rather than oleic acid, indicated fatty-acyl remodeling of administered D9-POPC prior to systemic delivery. CONCLUSION: D9-Choline chloride, D9-GPC and D9-phosphoryl-choline equally increased plasma D9-choline and D9-betaine. D9-POPC shifted metabolism from D9-betaine to D9-PC. Combined supplementation of GPC and (PO) PC may be best suited to optimize choline supply in preterm infants. Due to fatty acid remodeling of (PO) PC during its assimilation, PUFA co-supplementation with (PO) PC may increase PUFA-delivery to critical organs. This study was registered (22.01.2020) at the Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020502. STUDY REGISTRATION: This study was registered at the Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020502.
    Keywords betaine ; blood ; brain ; chlorides ; choline ; infant nutrition ; liver ; lungs ; metabolism ; methylation ; oleic acid ; phosphatidylcholines ; pregnancy ; premature birth ; prospective studies ; tandem mass spectrometry
    Language English
    Dates of publication 2023-04
    Size p. 1195-1205.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-022-03059-8
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  4. Article: [No title information]

    Bernhard, Wolfgang / Poets, Christian F. / Franz, Axel R.

    Ernährung & Medizin

    2022  Volume 37, Issue 04, Page(s) 180–186

    Abstract: Cholin ist ein essenzieller Nährstoff mit wachstumsproportionalem Bedarf. Eine zu geringe Zufuhr, eine gestörte Wiederaufnahme bzw. fäkale Verluste durch Darmerkrankungen und bakterieller Abbau kann bei Kindern zu ... ...

    Abstract Cholin ist ein essenzieller Nährstoff mit wachstumsproportionalem Bedarf. Eine zu geringe Zufuhr, eine gestörte Wiederaufnahme bzw. fäkale Verluste durch Darmerkrankungen und bakterieller Abbau kann bei Kindern zu einem Cholinmangel führen, ebenso wie ein erhöhter Fettgehalt der Leber (Steatose). Bei Säuglingen liegt die Cholinzufuhr durch Formula häufig unter der durch Muttermilch und hat eine unphysiologische Zusammensetzung.:
    Language German
    Publishing date 2022-12-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2133391-9
    ISSN 1438-9002 ; 1439-1635
    ISSN (online) 1438-9002
    ISSN 1439-1635
    DOI 10.1055/a-1961-9703
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  5. Article: Anämien und Erythrozytentransfusionen in der Neugeborenenperiode

    Maier, Rolf F. / Franz, Axel R.

    Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie

    2020  Volume 10, Issue 01, Page(s) 35–49

    Abstract: In kaum einer anderen Periode des Lebens gibt es so viele verschiedene Ursachen für eine Anämie wie in der Perinatalzeit. Neugeborene und insbesondere Frühgeborene mit ihrem geringen Blutvolumen zählen zu den Patientengruppen mit den meisten ... ...

    Abstract In kaum einer anderen Periode des Lebens gibt es so viele verschiedene Ursachen für eine Anämie wie in der Perinatalzeit. Neugeborene und insbesondere Frühgeborene mit ihrem geringen Blutvolumen zählen zu den Patientengruppen mit den meisten Erythrozytentransfusionen. Dieser Beitrag informiert über Besonderheiten bei der Indikation für und der Durchführung von Erythrozytentransfusionen in der Neonatalperiode sowie über Maßnahmen zu deren Vermeidung.
    Keywords Neugeborenes ; Frühgeborenes ; Neonatologie ; Transfusionsmedizin ; Anämie ; newborn ; premature born ; neonatology ; transfusion medicine ; anemia
    Language German
    Publishing date 2020-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2599278-8
    ISSN 2191-8813 ; 2191-8805
    ISSN (online) 2191-8813
    ISSN 2191-8805
    DOI 10.1055/a-0896-7869
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  6. Article ; Online: Achieving Stability in Oxygenation: Servo-Controlled Oxygen Environment as a First Step to Fully Automated Oxygen Control?

    Poets, Christian F / Franz, Axel R

    The Journal of pediatrics

    2018  Volume 200, Page(s) 8–9

    MeSH term(s) Cannula ; Cross-Over Studies ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Lung ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2018-04-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2018.04.028
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  7. Article ; Online: Choline and Betaine Levels in Plasma Mirror Choline Intake in Very Preterm Infants.

    Minarski, Michaela / Maas, Christoph / Heinrich, Christine / Böckmann, Katrin A / Bernhard, Wolfgang / Shunova, Anna / Poets, Christian F / Franz, Axel R

    Nutrients

    2023  Volume 15, Issue 22

    Abstract: Choline is essential for cell membrane formation and methyl transfer reactions, impacting parenchymal and neurological development. It is therefore enriched via placental transfer, and fetal plasma concentrations are high. In spite of the greater needs ... ...

    Abstract Choline is essential for cell membrane formation and methyl transfer reactions, impacting parenchymal and neurological development. It is therefore enriched via placental transfer, and fetal plasma concentrations are high. In spite of the greater needs of very low birth weight infants (VLBWI), choline content of breast milk after preterm delivery is lower (median (p25-75): 158 mg/L (61-360 mg/L) compared to term delivery (258 mg/L (142-343 mg/L)). Even preterm formula or fortified breast milk currently provide insufficient choline to achieve physiological plasma concentrations. This secondary analysis of a randomized controlled trial comparing growth of VLBWI with different levels of enteral protein supply aimed to investigate whether increased enteral choline intake results in increased plasma choline, betaine and phosphatidylcholine concentrations. We measured total choline content of breast milk from 33 mothers of 34 VLBWI. Enteral choline intake from administered breast milk, formula and fortifier was related to the respective plasma choline, betaine and phosphatidylcholine concentrations. Plasma choline and betaine levels in VLBWI correlated directly with enteral choline intake, but administered choline was insufficient to achieve physiological (fetus-like) concentrations. Hence, optimizing maternal choline status, and the choline content of milk and fortifiers, is suggested to increase plasma concentrations of choline, ameliorate the choline deficit and improve growth and long-term development of VLBWI.
    MeSH term(s) Infant ; Infant, Newborn ; Humans ; Female ; Pregnancy ; Betaine ; Infant, Premature ; Choline ; Placenta ; Infant, Very Low Birth Weight ; Milk, Human ; Lecithins ; Infant, Premature, Diseases
    Chemical Substances Betaine (3SCV180C9W) ; Choline (N91BDP6H0X) ; Lecithins
    Language English
    Publishing date 2023-11-12
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15224758
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  8. Article ; Online: Automated FiO2 control: nice to have, or an essential addition to neonatal intensive care?

    Poets, Christian F / Franz, Axel R

    Archives of disease in childhood. Fetal and neonatal edition

    2017  Volume 102, Issue 1, Page(s) F5–F6

    MeSH term(s) Automation ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature, Diseases/blood ; Infant, Premature, Diseases/diagnosis ; Intensive Care, Neonatal/methods ; Oximetry/methods ; Oxygen/blood
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2016-311647
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  9. Article ; Online: Different choline supplement metabolism in adults using deuterium labelling.

    Böckmann, Katrin A / Franz, Axel R / Shunova, Anna / Minarski, Michaela / Wiechers, Cornelia / Poets, Christian F / Bernhard, Wolfgang

    European journal of nutrition

    2023  Volume 62, Issue 4, Page(s) 1795–1807

    Abstract: Background: Choline deficiency leads to pathologies particularly of the liver, brain and lung. Adequate supply is important for preterm infants and patients with cystic fibrosis. We analysed the assimilation of four different enterally administered ... ...

    Abstract Background: Choline deficiency leads to pathologies particularly of the liver, brain and lung. Adequate supply is important for preterm infants and patients with cystic fibrosis. We analysed the assimilation of four different enterally administered deuterium-labelled (D9-) choline supplements in adults.
    Methods: Prospective randomised cross-over study (11/2020-1/2022) in six healthy men, receiving four single doses of 2.7 mg/kg D9-choline equivalent each in the form of D9-choline chloride, D9-phosphorylcholine, D9-alpha-glycerophosphocholine (D9-GPC) or D9-1-palmitoyl-2-oleoyl-glycero-3-phosphoryl-choline (D9-POPC), in randomised order 6 weeks apart. Plasma was obtained at baseline (t = - 0.1 h) and at 0.5 h to 7d after intake. Concentrations of D9-choline and its D9-labelled metabolites were analysed by tandem mass spectrometry. Results are shown as median and interquartile range.
    Results: Maximum D9-choline and D9-betaine concentrations were reached latest after D9-POPC administration versus other components. D9-POPC and D9-phosphorylcholine resulted in lower D9-trimethylamine (D9-TMAO) formation. The AUCs (0-7d) of plasma D9-PC concentration showed highest values after administration of D9-POPC. D9-POPC appeared in plasma after fatty acid remodelling, predominantly as D9-1-palmitoyl-2-linoleyl-PC (D9-PLPC), confirming cleavage to 1-palmitoyl-lyso-D9-PC and re-acylation with linoleic acid as the most prominent alimentary unsaturated fatty acid.
    Conclusion: There was a delayed increase in plasma D9-choline and D9-betaine after D9-POPC administration, with no differences in AUC over time. D9-POPC resulted in a higher AUC of D9-PC and virtually absent D9-TMAO levels. D9-POPC is remodelled according to enterocytic fatty acid availability. D9-POPC seems best suited as choline supplement to increase plasma PC concentrations, with PC as a carrier of choline and targeted fatty acid supply as required by organs. This study was registered at Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020498, 22.01.2020.
    Study registration: This study was registered at Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020498.
    MeSH term(s) Adult ; Humans ; Infant ; Infant, Newborn ; Male ; Betaine ; Choline ; Cross-Over Studies ; Deuterium ; Fatty Acids ; Infant, Premature ; Phosphatidylcholines ; Phosphorylcholine ; Prospective Studies
    Chemical Substances Betaine (3SCV180C9W) ; Choline (N91BDP6H0X) ; Deuterium (AR09D82C7G) ; Fatty Acids ; Phosphatidylcholines ; Phosphorylcholine (107-73-3) ; trimethyloxamine (FLD0K1SJ1A)
    Language English
    Publishing date 2023-02-25
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-023-03121-z
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  10. Article: Letter to the Editor Re: Billeaud et al. <i>Nutrients</i> 2018, <i>10</i>, 690

    Bernhard, Wolfgang / Franz, Axel R / Poets, Christian F

    Nutrients. 2019 Jan. 06, v. 11, no. 1

    2019  

    Abstract: Billeaud and co-authors recently described the effects of a new middle-chain fatty acid and docosahexaenoic acid enriched breast milk fortifier to improve preterm infants’ lipid nutrition [1] [ ... ] ...

    Abstract Billeaud and co-authors recently described the effects of a new middle-chain fatty acid and docosahexaenoic acid enriched breast milk fortifier to improve preterm infants’ lipid nutrition [1] [...]
    Keywords breast milk ; docosahexaenoic acid ; nutrients ; nutrition
    Language English
    Dates of publication 2019-0106
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11010103
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