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  1. Article: AN OVERVIEW AND OUR APPROACH IN THE TREATMENT OF MALIGNANT CUTANEOUS TUMOURS OF THE HAND.

    Tripoli, M / Franza, M / Cordova, A

    Acta chirurgiae plasticae

    2020  Volume 62, Issue 1-2, Page(s) 4–9

    Abstract: Introduction: Diagnosis of malignant cutaneous tumours of the hand is often difficult because of the different anatomic structures present in this region and yet clinicians must be able to distinguish typical benign entities from life-threatening or ... ...

    Title translation PŘEHLED A NÁŠ PŘÍSTUP K LÉČBĚ MALIGNÍCH KOŽNÍCH NÁDORŮ RUKY.
    Abstract Introduction: Diagnosis of malignant cutaneous tumours of the hand is often difficult because of the different anatomic structures present in this region and yet clinicians must be able to distinguish typical benign entities from life-threatening or limb-threatening malignant diseases. Due to the hand's complex structures located in a small area, surgeons must evaluate constantly the balance of inadequate surgery against functional and cosmetic aspects. Thus, a multidisciplinary approach is recommended for a correct diagnosis and treatment design.
    Materials and methods: Between 2006 and 2017, 354 consecutive patients with basal and squamous cell carcinomas, and melanoma of the hand were retrospectively analysed at the Department of Plastic and Reconstructive Surgery at the University of Palermo, treatment was surgical for all of them; also radio- and chemotherapy were necessary based on the histological diagnosis.
    Results: The most common tumour was basal cell carcinoma (BCCs), followed by squamous cell carcinoma (SCCs). Melanoma was the most frequent lesion diagnosed in the digits. Radical excision was the main treatment of choice. In 29 cases (11 with SCC, 18 with melanoma) axillary lymphadenectomy was performed, because of lymph nodes metastases. In the follow up, the spread of cancer to distant organs caused the death in three cases. Recurrence rate was higher in case of infiltrative SCCs and BCCs.
    Conclusions: The major references provide only limited information on malignant soft-tissue tumours of the hand. Our retrospective study aims to present the most commonly observed malignant soft-tissue tumours of the hand, analysing their causes, their objective and instrumental evaluation, and their treatments.
    MeSH term(s) Carcinoma, Basal Cell ; Humans ; Melanoma/diagnosis ; Melanoma/therapy ; Neoplasm Recurrence, Local ; Retrospective Studies ; Skin Neoplasms/diagnosis ; Skin Neoplasms/therapy
    Keywords covid19
    Language English
    Publishing date 2020-09-10
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 428718-6
    ISSN 1805-4404 ; 0001-5423 ; 0323-0414
    ISSN (online) 1805-4404
    ISSN 0001-5423 ; 0323-0414
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  2. Article: PŘEHLED A NÁŠ PŘÍSTUP K LÉČBĚ MALIGNÍCH KOŽNÍCH NÁDORŮ RUKY./ AN OVERVIEW AND OUR APPROACH IN THE TREATMENT OF MALIGNANT CUTANEOUS TUMOURS OF THE HAND

    Tripoli, M / Franza, M / Cordova, A

    Acta Chir Plast

    Abstract: INTRODUCTION: Diagnosis of malignant cutaneous tumours of the hand is often difficult because of the different anatomic structures present in this region and yet clinicians must be able to distinguish typical benign entities from life-threatening or limb- ...

    Abstract INTRODUCTION: Diagnosis of malignant cutaneous tumours of the hand is often difficult because of the different anatomic structures present in this region and yet clinicians must be able to distinguish typical benign entities from life-threatening or limb-threatening malignant diseases. Due to the hand's complex structures located in a small area, surgeons must evaluate constantly the balance of inadequate surgery against functional and cosmetic aspects. Thus, a multidisciplinary approach is recommended for a correct diagnosis and treatment design. MATERIALS AND METHODS: Between 2006 and 2017, 354 consecutive patients with basal and squamous cell carcinomas, and melanoma of the hand were retrospectively analysed at the Department of Plastic and Reconstructive Surgery at the University of Palermo, treatment was surgical for all of them; also radio- and chemotherapy were necessary based on the histological diagnosis. RESULTS: The most common tumour was basal cell carcinoma (BCCs), followed by squamous cell carcinoma (SCCs). Melanoma was the most frequent lesion diagnosed in the digits. Radical excision was the main treatment of choice. In 29 cases (11 with SCC, 18 with melanoma) axillary lymphadenectomy was performed, because of lymph nodes metastases. In the follow up, the spread of cancer to distant organs caused the death in three cases. Recurrence rate was higher in case of infiltrative SCCs and BCCs. CONCLUSIONS: The major references provide only limited information on malignant soft-tissue tumours of the hand. Our retrospective study aims to present the most commonly observed malignant soft-tissue tumours of the hand, analysing their causes, their objective and instrumental evaluation, and their treatments.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32911936
    Database COVID19

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  3. Article: "Functional trapezius muscle reconstruction after resection of a desmoid tumor using an innervated gracilis free flap".

    De Michele, Federico / Massarelli, Olindo / Franza, Mara / Gebbia, Vittorio / D'Arpa, Salvatore

    Case reports in plastic surgery & hand surgery

    2022  Volume 9, Issue 1, Page(s) 115–118

    Abstract: Desmoid tumors are characterized by indolent growth, progressive invasion of surrounding tissues and a high rate of relapse. We present the case of a desmoid tumor rising from the trapezius of a young woman. Following resection, we performed a functional ...

    Abstract Desmoid tumors are characterized by indolent growth, progressive invasion of surrounding tissues and a high rate of relapse. We present the case of a desmoid tumor rising from the trapezius of a young woman. Following resection, we performed a functional reconstruction using an innervated gracilis free flap.
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Case Reports
    ISSN 2332-0885
    ISSN 2332-0885
    DOI 10.1080/23320885.2022.2062363
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  4. Article ; Online: Analysis of MSCs' secretome and EVs cargo: Evaluation of functions and applications.

    Urrata, Valentina / Trapani, Marco / Franza, Mara / Moschella, Francesco / Di Stefano, Anna Barbara / Toia, Francesca

    Life sciences

    2022  Volume 308, Page(s) 120990

    MeSH term(s) Extracellular Vesicles/metabolism ; Mesenchymal Stem Cell Transplantation ; Secretome
    Language English
    Publishing date 2022-09-22
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2022.120990
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  5. Article ; Online: The clinically relevant CHK1 inhibitor MK-8776 induces the degradation of the oncogenic protein PML-RARα and overcomes ATRA resistance in acute promyelocytic leukemia cells.

    Franza, Maria / Albanesi, Jacopo / Mancini, Benedetta / Pennisi, Rosa / Leone, Stefano / Acconcia, Filippo / Bianchi, Fabrizio / di Masi, Alessandra

    Biochemical pharmacology

    2023  Volume 214, Page(s) 115675

    Abstract: Acute promyelocytic leukemia (APL) is a hematological disease characterized by the expression of the oncogenic fusion protein PML-RARα. The current treatment approach for APL involves differentiation therapy using all-trans retinoic acid (ATRA) and ... ...

    Abstract Acute promyelocytic leukemia (APL) is a hematological disease characterized by the expression of the oncogenic fusion protein PML-RARα. The current treatment approach for APL involves differentiation therapy using all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, the development of resistance to therapy, occurrence of differentiation syndrome, and relapses necessitate the exploration of new treatment options that induce differentiation of leukemic blasts with low toxicity. In this study, we investigated the cellular and molecular effects of MK-8776, a specific inhibitor of CHK1, in ATRA-resistant APL cells. Treatment of APL cells with MK-8776 resulted in a decrease in PML-RARα levels, increased expression of CD11b, and increased granulocytic activity consistent with differentiation. Interestingly, we showed that the MK-8776-induced differentiating effect resulted synergic with ATO. We found that the reduction of PML-RARα by MK-8776 was dependent on both proteasome and caspases. Specifically, both caspase-1 and caspase-3 were activated by CHK1 inhibition, with caspase-3 acting upstream of caspase-1. Activation of caspase-3 was necessary to activate caspase-1 and promote PML-RARα degradation. Transcriptomic analysis revealed significant modulation of pathways and upstream regulators involved in the inflammatory response and cell cycle control upon MK-8776 treatment. Overall, the ability of MK-8776 to induce PML-RARα degradation and stimulate differentiation of immature APL cancer cells into more mature forms recapitulates the concept of differentiation therapy. Considering the in vivo tolerability of MK-8776, it will be relevant to evaluate its potential clinical benefit in APL patients resistant to standard ATRA/ATO therapy, as well as in patients with other forms of acute leukemias.
    MeSH term(s) Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/metabolism ; Caspase 3 ; Tretinoin/pharmacology ; Arsenic Trioxide/pharmacology ; Arsenic Trioxide/therapeutic use ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Cell Differentiation ; Caspases
    Chemical Substances promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein ; Caspase 3 (EC 3.4.22.-) ; MK-8776 ; Tretinoin (5688UTC01R) ; Arsenic Trioxide (S7V92P67HO) ; Oncogene Proteins, Fusion ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2023.115675
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  6. Article ; Online: Oculomotor prismatic training is effective in ameliorating spatial neglect: a pilot study.

    Ronga, I / Franza, M / Sarasso, P / Neppi-Modona, M

    Experimental brain research

    2017  Volume 235, Issue 6, Page(s) 1771–1780

    Abstract: Visuomotor prismatic training has been demonstrated to be among the most effective rehabilitative techniques of spatial neglect, a neurological syndrome manifested by a number of right brain-damaged patients characterized by unawareness of the egocentric ...

    Abstract Visuomotor prismatic training has been demonstrated to be among the most effective rehabilitative techniques of spatial neglect, a neurological syndrome manifested by a number of right brain-damaged patients characterized by unawareness of the egocentric left half of the world. In the present study, we demonstrate that a novel oculomotor prismatic training procedure only consisting in a sequence of gaze shifts to visual targets, can reduce spatial neglect symptoms. Following oculomotor prismatic training, patients show a significant decrease in neglect severity in straight ahead and paper and pencil tasks. We propose that during oculomotor prismatic training, the inconsistency between the prisms-biased visual/oculomotor input and the unbiased head-on-trunk proprioceptive information relative to the straight-ahead position determines the observed aftereffects and the amelioration of spatial neglect symptoms.
    Language English
    Publishing date 2017-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-017-4923-6
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  7. Article ; Online: Effect of tool-use observation on metric body representation and peripersonal space.

    Galigani, M / Castellani, N / Donno, B / Franza, M / Zuber, C / Allet, L / Garbarini, F / Bassolino, M

    Neuropsychologia

    2020  Volume 148, Page(s) 107622

    Abstract: In everyday life, we constantly act and interact with objects and with others' people through our body. To properly perform actions, the representations of the dimension of body-parts (metric body representation, BR) and of the space surrounding the body ...

    Abstract In everyday life, we constantly act and interact with objects and with others' people through our body. To properly perform actions, the representations of the dimension of body-parts (metric body representation, BR) and of the space surrounding the body (peripersonal space, PPS) need to be constantly updated. Previous evidence has shown that BR and PPS representation are highly flexible, being modulated by sensorimotor experiences, such as the active use of tools to reach objects in the far space. In this study, we investigate whether the observation of another person using a tool to interact with objects located in the far space is sufficient to influence the plasticity of BR and PPS representation in a similar way to active tool-use. With this aim, two groups of young healthy participants were asked to perform 20 min trainings based on the active use of a tool to retrieve far cubes (active tool-use) and on the first-person observation of an experimenter doing the same tool-use training (observational tool-use). Behavioural tasks adapted from literature were used to evaluate the effects of the active and observational tool-use on BR (body-landmarks localization task-group 1), and PPS (audio-tactile interaction task - group 2). Results show that after active tool-use, participants perceived the length of their arm as longer than at baseline, while no significant differences appear after observation. Similarly, significant modifications in PPS representation, with comparable multisensory facilitation on tactile responses due to near and far sounds, were seen only after active tool-use, while this did not occur after observation. Together these results suggest that a mere observational training could not be sufficient to significantly modulate BR or PPS. The dissociation found in the active and observational tool-use points out differences between action execution and action observation, by suggesting a fundamental role of the motor planning, the motor intention, and the related sensorimotor feedback in driving BR and PPS plasticity.
    MeSH term(s) Body Image ; Humans ; Personal Space ; Space Perception ; Tool Use Behavior ; Touch
    Language English
    Publishing date 2020-09-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207151-4
    ISSN 1873-3514 ; 0028-3932
    ISSN (online) 1873-3514
    ISSN 0028-3932
    DOI 10.1016/j.neuropsychologia.2020.107622
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  8. Article ; Online: Tactile spatial discrimination on the torso using vibrotactile and force stimulation.

    Jouybari, Atena Fadaei / Franza, Matteo / Kannape, Oliver Alan / Hara, Masayuki / Blanke, Olaf

    Experimental brain research

    2021  Volume 239, Issue 11, Page(s) 3175–3188

    Abstract: There is a steadily growing number of mobile communication systems that provide spatially encoded tactile information to the humans' torso. However, the increased use of such hands-off displays is currently not matched with or supported by systematic ... ...

    Abstract There is a steadily growing number of mobile communication systems that provide spatially encoded tactile information to the humans' torso. However, the increased use of such hands-off displays is currently not matched with or supported by systematic perceptual characterization of tactile spatial discrimination on the torso. Furthermore, there are currently no data testing spatial discrimination for dynamic force stimuli applied to the torso. In the present study, we measured tactile point localization (LOC) and tactile direction discrimination (DIR) on the thoracic spine using two unisex torso-worn tactile vests realized with arrays of 3 × 3 vibrotactile or force feedback actuators. We aimed to, first, evaluate and compare the spatial discrimination of vibrotactile and force stimulations on the thoracic spine and, second, to investigate the relationship between the LOC and DIR results across stimulations. Thirty-four healthy participants performed both tasks with both vests. Tactile accuracies for vibrotactile and force stimulations were 60.7% and 54.6% for the LOC task; 71.0% and 67.7% for the DIR task, respectively. Performance correlated positively with both stimulations, although accuracies were higher for the vibrotactile than for the force stimulation across tasks, arguably due to specific properties of vibrotactile stimulations. We observed comparable directional anisotropies in the LOC results for both stimulations; however, anisotropies in the DIR task were only observed with vibrotactile stimulations. We discuss our findings with respect to tactile perception research as well as their implications for the design of high-resolution torso-mounted tactile displays for spatial cueing.
    MeSH term(s) Humans ; Spine ; Torso ; Touch ; Touch Perception ; Vibration
    Language English
    Publishing date 2021-08-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-021-06181-x
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  9. Article ; Online: How ageing shapes body and space representations: A comparison study between healthy young and older adults.

    Sorrentino, Giuliana / Franza, Matteo / Zuber, Charlène / Blanke, Olaf / Serino, Andrea / Bassolino, Michela

    Cortex; a journal devoted to the study of the nervous system and behavior

    2020  Volume 136, Page(s) 56–76

    Abstract: To efficiently interact with the external world, the brain needs to represent the size of the involved body parts - body representations (BR) - and the space around the body in which the interactions with the environment take place - peripersonal space ... ...

    Abstract To efficiently interact with the external world, the brain needs to represent the size of the involved body parts - body representations (BR) - and the space around the body in which the interactions with the environment take place - peripersonal space representation (PPS). BR and PPS are both highly flexible, being updated by the continuous flow of sensorimotor signals between the brain and the body, as observed for example after tool-use or immobilization. The progressive decline of sensorimotor abilities typically described in ageing could thus influence BR and PPS representations in the older adults. To explore this hypothesis, we compared BR and PPS in healthy young and older participants. By focusing on the upper limb, we adapted tasks previously used to evaluate BR and PPS plasticity, i.e., the body-landmarks localization task and audio-tactile interaction task, together with a new task targeting explicit BR (avatar adjustment task, AAT). Results show significantly higher distortions in the older rather than young participants in the perceived metric characteristic of the upper limbs. We found significant modifications in the implicit BR of the global shape (length and width) of both upper limbs, together with an underestimation in the arm length. Similar effects were also observed in the AAT task. Finally, both young and older adults showed equivalent multisensory facilitation in the space close to the hand, suggesting an intact PPS representation. Together, these findings demonstrated significant alterations of implicit and explicit BR in the older participants, probably associated with a less efficient contribution of bodily information typically subjected to age-related decline, whereas the comparable PPS representation in both groups could be supported by preserved multisensory abilities in older participants. These results provide novel empirical insight on how multiple representations of the body in space, subserving actions and perception, are shaped by the normal course of life.
    MeSH term(s) Aged ; Aging ; Humans ; Personal Space ; Physical Stimulation ; Space Perception ; Touch Perception
    Language English
    Publishing date 2020-12-17
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280622-8
    ISSN 1973-8102 ; 0010-9452
    ISSN (online) 1973-8102
    ISSN 0010-9452
    DOI 10.1016/j.cortex.2020.11.021
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  10. Article ; Online: Non-invasive brain stimulation of motor cortex induces embodiment when integrated with virtual reality feedback.

    Bassolino, M / Franza, M / Bello Ruiz, J / Pinardi, M / Schmidlin, T / Stephan, M A / Solcà, M / Serino, A / Blanke, O

    The European journal of neuroscience

    2018  Volume 47, Issue 7, Page(s) 790–799

    Abstract: Previous evidence highlighted the multisensory-motor origin of embodiment - that is, the experience of having a body and of being in control of it - and the possibility of experimentally manipulating it. For instance, an illusory feeling of embodiment ... ...

    Abstract Previous evidence highlighted the multisensory-motor origin of embodiment - that is, the experience of having a body and of being in control of it - and the possibility of experimentally manipulating it. For instance, an illusory feeling of embodiment towards a fake hand can be triggered by providing synchronous visuo-tactile stimulation to the hand of participants and to a fake hand or by asking participants to move their hand and observe a fake hand moving accordingly (rubber hand illusion). Here, we tested whether it is possible to manipulate embodiment not through stimulation of the participant's hand, but by directly tapping into the brain's hand representation via non-invasive brain stimulation. To this aim, we combined transcranial magnetic stimulation (TMS), to activate the hand corticospinal representation, with virtual reality (VR), to provide matching (as contrasted to non-matching) visual feedback, mimicking involuntary hand movements evoked by TMS. We show that the illusory embodiment occurred when TMS pulses were temporally matched with VR feedback, but not when TMS was administered outside primary motor cortex, (over the vertex) or when stimulating motor cortex at a lower intensity (that did not activate peripheral muscles). Behavioural (questionnaires) and neurophysiological (motor-evoked-potentials, TMS-evoked-movements) measures further indicated that embodiment was not explained by stimulation per se, but depended on the temporal coherence between TMS-induced activation of hand corticospinal representation and the virtual bodily feedback. This reveals that non-invasive brain stimulation may replace the application of external tactile hand cues and motor components related to volition, planning and anticipation.
    MeSH term(s) Adult ; Evoked Potentials, Motor/physiology ; Feedback, Sensory/physiology ; Female ; Hand/physiology ; Humans ; Illusions/physiology ; Male ; Motor Cortex/physiology ; Pyramidal Tracts/physiology ; Transcranial Magnetic Stimulation ; Virtual Reality ; Young Adult
    Language English
    Publishing date 2018-03-09
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.13871
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