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  1. Article ; Online: Current treatment options for pneumonia caused by carbapenem-resistant Acinetobacter baumannii.

    Franzone, John P / Mackow, Natalie A / van Duin, David

    Current opinion in infectious diseases

    2024  Volume 37, Issue 2, Page(s) 137–143

    Abstract: Purpose of review: The purpose of this review is to briefly summarize the challenges associated with the treatment of pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB), discuss its carbapenem-resistance, and review the literature ... ...

    Abstract Purpose of review: The purpose of this review is to briefly summarize the challenges associated with the treatment of pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB), discuss its carbapenem-resistance, and review the literature supporting the current treatment paradigm and therapeutic options.
    Recent findings: In a multicenter, randomized, and controlled trial the novel β-lactam-β-lactamase inhibitor sulbactam-durlobactam was compared to colistin, both in addition to imipenem-cilastatin. The drug met the prespecified criteria for noninferiority for 28-day all-cause mortality while demonstrating higher clinical cure rates in the treatment of CRAB pneumonia. In an international, randomized, double-blind, placebo controlled trial colistin monotherapy was compared to colistin combined with meropenem. In this trial, combination therapy was not superior to monotherapy in the treatment of drug-resistant gram-negative organisms including CRAB pneumonia.
    Summary: CRAB pneumonia is a preeminent public health threat without an agreed upon first line treatment strategy. Historically, there have been drawbacks to available treatment modalities without a clear consensus on the first-line treatment regimen. CRAB pneumonia is a top priority for the continued development of antimicrobials, adjuvant therapies and refinement of current treatment strategies.
    MeSH term(s) Humans ; Anti-Bacterial Agents ; Colistin/therapeutic use ; Acinetobacter baumannii ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Acinetobacter Infections/drug therapy ; beta-Lactamase Inhibitors/therapeutic use ; Pneumonia/drug therapy ; Microbial Sensitivity Tests ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
    Chemical Substances Anti-Bacterial Agents ; Colistin (Z67X93HJG1) ; Carbapenems ; beta-Lactamase Inhibitors
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000001001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2462: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Microbial Cell-Free DNA Identifies the Causative Pathogen in Infective Endocarditis and Remains Detectable Longer Than Conventional Blood Culture in Patients with Prior Antibiotic Therapy.

    Eichenberger, Emily M / Degner, Nicholas / Scott, Erick R / Ruffin, Felicia / Franzone, John / Sharma-Kuinkel, Batu / Shah, Pratik / Hong, David / Dalai, Sudeb C / Blair, Lily / Hollemon, Desiree / Chang, Eliza / Ho, Carine / Wanda, Lisa / de Vries, Christiaan R / Fowler, Vance G / Ahmed, Asim A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 76, Issue 3, Page(s) e1492–e1500

    Abstract: Background: The diagnosis of infective endocarditis (IE) can be difficult, particularly if blood cultures fail to yield a pathogen. This study evaluates the potential utility of microbial cell-free DNA (mcfDNA) as a tool to identify the microbial ... ...

    Abstract Background: The diagnosis of infective endocarditis (IE) can be difficult, particularly if blood cultures fail to yield a pathogen. This study evaluates the potential utility of microbial cell-free DNA (mcfDNA) as a tool to identify the microbial etiology of IE.
    Methods: Blood samples from patients with suspected IE were serially collected. mcfDNA was extracted from plasma and underwent next-generation sequencing. Reads were aligned against a library containing DNA sequences belonging to >1400 different pathogens. mcfDNA from organisms present above a statistical threshold were reported and quantified in molecules per milliliter (MPM). Additional mcfDNA was collected on each subject every 2-3 days for a total of 7 collections or until discharge.
    Results: Of 30 enrolled patients with suspected IE, 23 had definite IE, 2 had possible IE, and IE was rejected in 5 patients by modified Duke Criteria. Only the 23 patients with definite IE were included for analysis. Both mcfDNA and blood cultures achieved a sensitivity of 87%. The median duration of positivity from antibiotic treatment initiation was estimated to be approximately 38.1 days for mcfDNA versus 3.7 days for blood culture (proportional odds, 2.952; P = .02771), using a semiparametric survival analysis. mcfDNA (log10) levels significantly declined (-0.3 MPM log10 units, 95% credible interval -0.45 to -0.14) after surgical source control was performed (pre- vs postprocedure, posterior probability >0.99).
    Conclusion: mcfDNA accurately identifies the microbial etiology of IE. Sequential mcfDNA levels may ultimately help to individualize therapy by estimating a patient's burden of infection and response to treatment.
    MeSH term(s) Humans ; Blood Culture ; Anti-Bacterial Agents/therapeutic use ; Cell-Free Nucleic Acids ; Endocarditis, Bacterial/diagnosis ; Endocarditis/diagnosis ; Endocarditis/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Cell-Free Nucleic Acids
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  3. Article: Dermpath quiz.

    Kazlousakaya, Viktoryia / Lal, Karan / Franzone, John / Elston, Dirk

    Indian dermatology online journal

    2013  Volume 4, Issue 2, Page(s) 128–130

    Language English
    Publishing date 2013-05-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 2585814-2
    ISSN 2249-5673 ; 2229-5178
    ISSN (online) 2249-5673
    ISSN 2229-5178
    DOI 10.4103/2229-5178.110581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The "PRONE" Study.

    Friedman, Eugene / Franzone, John / Ko, Emily R / Corey, Kristin / Mock, Jason / Alavian, Naseem / Schwartz, Adam / Drummond, M Bradley / Suber, Tomeka / Linstrum, Kelsey / Bain, William / Castiblanco, Saramaria Afanador / Zak, Martin / Zaeh, Sandra / Gupta, Ishaan / Damarla, Mahendra / Punjabi, Naresh M

    Contemporary clinical trials

    2021  Volume 109, Page(s) 106541

    Abstract: While benefits of prone position in mechanically-ventilated patients have been well-described, a randomized-control trial to determine the effects of prone positioning in awake, spontaneously-breathing patients with an acute pneumonia has not been ... ...

    Abstract While benefits of prone position in mechanically-ventilated patients have been well-described, a randomized-control trial to determine the effects of prone positioning in awake, spontaneously-breathing patients with an acute pneumonia has not been previously conducted. Prone Position and Respiratory Outcomes in Non-Intubated COVID-19 PatiEnts: the "PRONE" Study (PRONE) was conducted in non-intubated hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia as defined by respiratory rate ≥ 20/min or an oxyhemoglobin saturation (SpO
    MeSH term(s) COVID-19 ; Humans ; Patient Positioning ; Prone Position ; Respiration, Artificial ; SARS-CoV-2
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2021.106541
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    Zs.A 1581: Show issues Location:
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