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Book: NF-κB transcription factors

Franzoso, Guido / Zazzeroni, Francesca

methods and protocols

(Methods in molecular biology ; 2366 ; Springer protocols)

2021

Author's details	edited by Guido Franzoso, Francesca Zazzeroni
Series title	Methods in molecular biology ; 2366 Springer protocols
Collection
Language	English
Size	xvi, 359 Seiten, Illustrationen
Publisher	Humana Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book
HBZ-ID	HT020995485
ISBN	978-1-0716-1668-0 ; 9781071616697 ; 1-0716-1668-4 ; 1071616692
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 7042 -2366-	verfügbar in Königswinter	Königswinter

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Article: Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma.

Capece, Daria / Franzoso, Guido

Molecular & cellular oncology

2022 Volume 9, Issue 1, Page(s) 2024051

Abstract: Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via ... ...

Abstract	Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC.
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article
ISSN	2372-3556
ISSN	2372-3556
DOI	10.1080/23723556.2021.2024051
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Article ; Online: NF-κB: Governing Macrophages in Cancer.

Cornice, Jessica / Verzella, Daniela / Arboretto, Paola / Vecchiotti, Davide / Capece, Daria / Zazzeroni, Francesca / Franzoso, Guido

Genes

2024 Volume 15, Issue 2

Abstract: Tumor-associated macrophages (TAMs) are the major component of the tumor microenvironment (TME), where they sustain tumor progression and or-tumor immunity. Due to their plasticity, macrophages can exhibit anti- or pro-tumor functions through the ... ...

Abstract	Tumor-associated macrophages (TAMs) are the major component of the tumor microenvironment (TME), where they sustain tumor progression and or-tumor immunity. Due to their plasticity, macrophages can exhibit anti- or pro-tumor functions through the expression of different gene sets leading to distinct macrophage phenotypes: M1-like or pro-inflammatory and M2-like or anti-inflammatory. NF-κB transcription factors are central regulators of TAMs in cancers, where they often drive macrophage polarization toward an M2-like phenotype. Therefore, the NF-κB pathway is an attractive therapeutic target for cancer immunotherapy in a wide range of human tumors. Hence, targeting NF-κB pathway in the myeloid compartment is a potential clinical strategy to overcome microenvironment-induced immunosuppression and increase anti-tumor immunity. In this review, we discuss the role of NF-κB as a key driver of macrophage functions in tumors as well as the principal strategies to overcome tumor immunosuppression by targeting the NF-κB pathway.
MeSH term(s)	Humans ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Macrophages/metabolism ; Neoplasms/genetics ; Neoplasms/therapy ; Neoplasms/metabolism ; NF-kappa B p50 Subunit ; Phenotype ; Tumor Microenvironment/genetics
Chemical Substances	NF-kappa B ; NF-kappa B p50 Subunit
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes15020197
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NF-κB: blending metabolism, immunity, and inflammation.

Capece, Daria / Verzella, Daniela / Flati, Irene / Arboretto, Paola / Cornice, Jessica / Franzoso, Guido

Trends in immunology

2022 Volume 43, Issue 9, Page(s) 757–775

Abstract: The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the need ... ...

Abstract	The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the need to maintain metabolic homeostasis. NF-κB transcription factors are central regulators of immunity and inflammation. Over the last two decades, these factors have emerged as a pivotal node coordinating the immune and metabolic systems in physiology and the etiopathogenesis of major threats to human health, including cancer, autoimmunity, chronic inflammation, and others. In this review, we discuss recent advances in understanding how NF-κB-dependent metabolic programs control inflammation, metabolism, and immunity and how improved knowledge of them may lead to better diagnostics and therapeutics for widespread human diseases.
MeSH term(s)	Autoimmunity ; Homeostasis ; Humans ; Inflammation ; NF-kappa B ; Neoplasms
Chemical Substances	NF-kappa B
Language	English
Publishing date	2022-08-11
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2022.07.004
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Article: The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target.

Verzella, Daniela / Cornice, Jessica / Arboretto, Paola / Vecchiotti, Davide / Di Vito Nolfi, Mauro / Capece, Daria / Zazzeroni, Francesca / Franzoso, Guido

Biomedicines

2022 Volume 10, Issue 9

Abstract: NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB signaling is constitutively activated by genetic alterations or environmental signals in many human cancers, where it contributes to almost all hallmarks of ... ...

Abstract	NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB signaling is constitutively activated by genetic alterations or environmental signals in many human cancers, where it contributes to almost all hallmarks of malignancy, including sustained proliferation, cell death resistance, tumor-promoting inflammation, metabolic reprogramming, tissue invasion, angiogenesis, and metastasis. As such, the NF-κB pathway is an attractive therapeutic target in a broad range of human cancers, as well as in numerous non-malignant diseases. Currently, however, there is no clinically useful NF-κB inhibitor to treat oncological patients, owing to the preclusive, on-target toxicities of systemic NF-κB blockade. In this review, we discuss the principal and most promising strategies being developed to circumvent the inherent limitations of conventional IκB kinase (IKK)/NF-κB-targeting drugs, focusing on new molecules that target upstream regulators or downstream effectors of oncogenic NF-κB signaling, as well as agents targeting individual NF-κB subunits.
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10092233
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Article ; Online: Apoptosis in mesenchymal stromal cells activates an immunosuppressive secretome predicting clinical response in Crohn's disease.

Cheung, Tik Shing / Giacomini, Chiara / Cereda, Matteo / Avivar-Valderas, Alvaro / Capece, Daria / Bertolino, Giuliana Minani / delaRosa, Olga / Hicks, Ryan / Ciccocioppo, Rachele / Franzoso, Guido / Galleu, Antonio / Ciccarelli, Francesca D / Dazzi, Francesco

Molecular therapy : the journal of the American Society of Gene Therapy

2023 Volume 31, Issue 12, Page(s) 3531–3544

Abstract: In vivo apoptosis of human mesenchymal stromal cells (MSCs) plays a critical role in delivering immunomodulation. Yet, caspase activity not only mediates the dying process but also death-independent functions that may shape the immunogenicity of ... ...

Abstract	In vivo apoptosis of human mesenchymal stromal cells (MSCs) plays a critical role in delivering immunomodulation. Yet, caspase activity not only mediates the dying process but also death-independent functions that may shape the immunogenicity of apoptotic cells. Therefore, a better characterization of the immunological profile of apoptotic MSCs (ApoMSCs) could shed light on their mechanistic action and therapeutic applications. We analyzed the transcriptomes of MSCs undergoing apoptosis and identified several immunomodulatory factors and chemokines dependent on caspase activation following Fas stimulation. The ApoMSC secretome inhibited human T cell proliferation and activation, and chemoattracted monocytes in vitro. Both immunomodulatory activities were dependent on the cyclooxygenase2 (COX2)/prostaglandin E2 (PGE2) axis. To assess the clinical relevance of ApoMSC signature, we used the peripheral blood mononuclear cells (PBMCs) from a cohort of fistulizing Crohn's disease (CD) patients who had undergone MSC treatment (ADMIRE-CD). Compared with healthy donors, MSCs exposed to patients' PBMCs underwent apoptosis and released PGE2 in a caspase-dependent manner. Both PGE2 and apoptosis were significantly associated with clinical responses to MSCs. Our findings identify a new mechanism whereby caspase activation delivers ApoMSC immunosuppression. Remarkably, such molecular signatures could implicate translational tools for predicting patients' clinical responses to MSC therapy in CD.
MeSH term(s)	Humans ; Crohn Disease/genetics ; Crohn Disease/therapy ; Dinoprostone/metabolism ; Leukocytes, Mononuclear/metabolism ; Secretome ; Mesenchymal Stem Cells/metabolism ; Immunomodulation ; Apoptosis ; Caspases
Chemical Substances	Dinoprostone (K7Q1JQR04M) ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2023-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2023.10.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5640: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Extracellular Flux Analysis to Investigate the Impact of NF-κB on Mitochondrial Respiration in Colorectal Carcinoma (CRC).

Capece, Daria / Verzella, Daniela / Begalli, Federica / Bennett, Jason / D'Andrea, Daniel / Vecchiotti, Davide / Zazzeroni, Francesca / Franzoso, Guido

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2366, Page(s) 293–303

Abstract: The reprogramming of cell metabolism is a hallmark of cancer. NF-κB transcription factors coordinate the host defense responses to stress, injury, and infection. They also play a central role in oncogenesis, at least in part by regulating cell metabolism ...

Abstract	The reprogramming of cell metabolism is a hallmark of cancer. NF-κB transcription factors coordinate the host defense responses to stress, injury, and infection. They also play a central role in oncogenesis, at least in part by regulating cell metabolism and the adaptation to energy stress conditions in various types of cancer, such as colorectal carcinoma (CRC). Here, we describe the XF Cell Mito Stress Test methodology aimed at characterizing the metabolic and bioenergetic profile of CRC cells following the silencing of the essential NF-κB subunit, RelA. This methodology may also be applied to other cancers to reveal novel core vulnerabilities of malignant cells.
MeSH term(s)	Colorectal Neoplasms/metabolism ; Energy Metabolism ; Humans ; Mitochondria/metabolism ; NF-kappa B/metabolism ; Respiration ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism
Chemical Substances	NF-kappa B ; Transcription Factor RelA
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1669-7_18
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Screening of Combinatorial Peptide Libraries for Targeting Key Molecules or Protein-Protein Interactions in the NF-κB Pathway.

Tornatore, Laura / Capece, Daria / Sandomenico, Annamaria / Verzella, Daniela / Vecchiotti, Davide / Zazzeroni, Francesca / Ruvo, Menotti / Franzoso, Guido

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2366, Page(s) 343–356

Abstract: Peptides are emerging as an increasingly dependable class of therapeutics in the treatment of cancer and metabolic and cardiovascular diseases, which are all areas of high interest to the pharmaceutical industry. The global market for peptide ... ...

Abstract	Peptides are emerging as an increasingly dependable class of therapeutics in the treatment of cancer and metabolic and cardiovascular diseases, which are all areas of high interest to the pharmaceutical industry. The global market for peptide therapeutics was valued at about 25 billion USD in 2018 and is estimated to reach 57.2 billion USD by the end of 2027. Here, we describe a method for the screening and deconvolution of combinatorial peptide libraries to discover compounds that target discrete signaling components of the NF-κB pathway. Recently, we used this approach to specifically disrupt the interaction between the JNK-activating kinase, MKK7, and the NF-κB-regulated antiapoptotic factor, GADD45β, in multiple myeloma (MM). We showed that the GADD45β/MKK7 complex is a functionally critical survival module downstream of NF-κB in MM cells and as such provides an attractive therapeutic target to selectively inhibit NF-κB antiapoptotic signaling in cancer cells. By integrating the library screening and deconvolution methods described here with a rational chemical optimization strategy, we developed the first-in-class GADD45β/MKK7 inhibitor, DTP3 (a D-tripeptide), which is now being trialed in MM and diffuse large B-cell lymphoma (DLBCL) patients. The same drug discovery approach may be generally applied to therapeutically target other key components of the NF-κB pathway in cancers beyond MM and DLBCL, as well as in non-malignant NF-κB-driven diseases.
MeSH term(s)	Apoptosis ; Humans ; Lymphoma, Large B-Cell, Diffuse ; Multiple Myeloma/drug therapy ; NF-kappa B/metabolism ; Peptide Library ; Peptides ; Protein Interaction Mapping ; Signal Transduction
Chemical Substances	NF-kappa B ; Peptide Library ; Peptides
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1669-7_21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunohistochemical Analysis of Expression, Phosphorylation, and Nuclear Translocation of NF-κB Proteins in Human Tissues.

Vecchiotti, Davide / Verzella, Daniela / Capece, Daria / Cornice, Jessica / Nolfi, Mauro Di Vito / Di Francesco, Barbara / Franzoso, Guido / Alesse, Edoardo / Zazzeroni, Francesca

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2366, Page(s) 27–42

Abstract: Immunohistochemistry (IHC) is a technique aimed at detecting specific antigens on tissue sections by the use of targeting reagents labeled with reporter molecules. This technique allows a snapshot of the structure of tissue and determines the cellular ... ...

Abstract	Immunohistochemistry (IHC) is a technique aimed at detecting specific antigens on tissue sections by the use of targeting reagents labeled with reporter molecules. This technique allows a snapshot of the structure of tissue and determines the cellular and subcellular localization of a target antigen. This chapter describes how to identify and localize NF-κB proteins in human tissue using immunohistochemical staining on formalin-fixed paraffin-embedded and frozen tissue.
MeSH term(s)	Antigens ; Formaldehyde ; Humans ; Immunohistochemistry ; NF-kappa B/metabolism ; Paraffin Embedding ; Phosphorylation ; Tissue Fixation
Chemical Substances	Antigens ; NF-kappa B ; Formaldehyde (1HG84L3525)
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1669-7_3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biochemical Methods to Analyze the Subcellular Localization of NF-κB Proteins Using Cell Fractionation.

Vecchiotti, Davide / Verzella, Daniela / Capece, Daria / Nolfi, Mauro Di Vito / Di Francesco, Barbara / Cornice, Jessica / Franzoso, Guido / Alesse, Edoardo / Zazzeroni, Francesca

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2366, Page(s) 19–25

Abstract: Cell fractionation is a method used to study different cellular events like protein translocation and sequestration by disrupting cells and fractionating their contents, thus allowing an enrichment of the protein of interest. Using different ... ...

Abstract	Cell fractionation is a method used to study different cellular events like protein translocation and sequestration by disrupting cells and fractionating their contents, thus allowing an enrichment of the protein of interest. Using different concentrations of sucrose or detergent buffer formulations in combination with centrifugations, the cell fractions are separated based on their density and size.
MeSH term(s)	Cell Fractionation ; NF-kappa B ; Subcellular Fractions
Chemical Substances	NF-kappa B
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1669-7_2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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