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Article: Current intraoperative storage and handling practices of autologous bypass conduit: A survey of the royal australasian college of surgeons.

Haymet, A B / Pinto, N / Peden, S / Cohen, T / Vallely, M P / McGiffin, D / Naidoo, R / Jenkins, J / Suen, J Y / Fraser, J F

Frontiers in surgery

2022 Volume 9, Page(s) 956177

Abstract: During bypass surgery for peripheral arterial occlusive disease and ischaemic heart disease, autologous graft conduit including great saphenous veins and radial arteries are frequently stored in solution. Endothelial damage adversely affects the ... ...

Abstract	During bypass surgery for peripheral arterial occlusive disease and ischaemic heart disease, autologous graft conduit including great saphenous veins and radial arteries are frequently stored in solution. Endothelial damage adversely affects the performance and patency of autologous bypass grafts, and intraoperative graft storage solutions have been shown to influence this process. The distribution of storage solutions currently used amongst Cardiothoracic and Vascular Surgeons from Australia and New Zealand is not well defined in the literature. The aim of this study was to determine current practices regarding autologous graft storage and handling amongst this cohort of surgeons, and discuss their potential relevance in the context of early graft failure. From this survey, the most frequently used storage solutions were heparinized saline for great saphenous veins, and pH-buffered solutions for radial arteries. Duration of storage was 30-45 min for almost half of respondents, although responses to this question were limited. Further research is required to investigate whether ischaemic endothelial injury generates a prothrombotic state, whether different storage media can alter this state, and whether this is directly associated with clinical outcomes of interest such as early graft failure.
Language	English
Publishing date	2022-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.956177
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Article ; Online: Mesenchymal stromal cells and the acute respiratory distress syndrome (ARDS): challenges for clinical application.

Millar, J E / Fraser, J F / McAuley, D F

Thorax

2015 Volume 70, Issue 7, Page(s) 611–612

MeSH term(s)	Acute Lung Injury/prevention & control ; Animals ; Escherichia coli Infections/prevention & control ; Humans ; Male ; Mesenchymal Stem Cell Transplantation/methods ; Pneumonia, Bacterial/prevention & control
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	204353-1
ISSN	1468-3296 ; 0040-6376
ISSN (online)	1468-3296
ISSN	0040-6376
DOI	10.1136/thoraxjnl-2015-207121
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Article ; Online: Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem.

Hayes, R A / Shekar, K / Fraser, J F

Perfusion

2013 Volume 28, Issue 3, Page(s) 184–193

Abstract: Extracorporeal membrane oxygenation (ECMO) facilitates organ support in patients with refractory cardiorespiratory failure whilst disease-modifying treatments can be administered. Improvements to the ECMO process have resulted in its increased ... ...

Abstract	Extracorporeal membrane oxygenation (ECMO) facilitates organ support in patients with refractory cardiorespiratory failure whilst disease-modifying treatments can be administered. Improvements to the ECMO process have resulted in its increased utilisation. However, iatrogenic injuries remain, with bleeding and thrombosis the most significant concerns. Many factors contribute to the formation of thrombi, with the hyperoxaemia experienced during ECMO a potential contributor. Outside of ECMO, emerging evidence associates hyperoxaemia with increased mortality. Currently, no universal definition of hyperoxaemia exists, a gap in clinical standards that may impact patient outcomes. Hyperoxaemia has the potential to induce platelet activation, aggregation and, subsequently, thrombosis through markedly increasing the production of reactive oxygen species. There are minimal data in the current literature that explore the relationship between ECMO-induced hyperoxaemia and the production of reactive oxygen species - a putative link towards pathology. Furthermore, there is limited research directly linking hyperoxaemia and platelet activation. These are areas that warrant investigation as definitive data regarding the nascence of these pathological processes may delineate and define the relative risk of supranormal oxygen tension. These data could then assist in defining optimal oxygenation practice, reducing the risks associated with extracorporeal support.
MeSH term(s)	Extracorporeal Membrane Oxygenation/adverse effects ; Hemorrhage/etiology ; Hemorrhage/metabolism ; Hemorrhage/mortality ; Humans ; Hyperoxia/etiology ; Hyperoxia/metabolism ; Hyperoxia/mortality ; Platelet Aggregation ; Reactive Oxygen Species/metabolism ; Risk Factors ; Thrombosis/etiology ; Thrombosis/metabolism ; Thrombosis/mortality
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2013-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/0267659112473172
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Article: The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery.

O'Connor, E / Fraser, J F

Anaesthesia and intensive care

2012 Volume 40, Issue 4, Page(s) 598–603

Abstract: Hyperlactataemia and lactic acidosis are commonly encountered during and after cardiac surgery. Perioperative lactate production increases in the myocardium, skeletal muscle, lungs and in the splanchnic circulation during cardiopulmonary bypass. ... ...

Abstract	Hyperlactataemia and lactic acidosis are commonly encountered during and after cardiac surgery. Perioperative lactate production increases in the myocardium, skeletal muscle, lungs and in the splanchnic circulation during cardiopulmonary bypass. Hyperlactataemia has a bimodal distribution in the perioperative period. An early increase in lactate levels, arising intraoperatively or soon after intensive care unit admission, is a familiar and concerning finding for most clinicians. It is highly suggestive of tissue ischaemia and is associated with a prolonged intensive care unit stay, a prolonged requirement for respiratory and cardiovascular support and increased postoperative mortality. Its presence should prompt a thorough search for potential causes of tissue hypoxia. In contrast, late-onset hyperlactataemia, a less well recognised complication, occurs 4 to 24 hours after completion of surgery and is typically associated with preserved cardiac output and oxygen delivery. Risk factors for late-onset hyperlactataemia include hyperglycaemia, long cardiopulmonary bypass time and elevated endogenous catecholamines. Although patients with this complication may have a longer duration of ventilation and intensive care unit length of stay than those with normolactataemia, an association with increased mortality has not been demonstrated. The discovery of late-onset hyperlactataemia should not delay the postoperative progress of an otherwise stable patient following cardiac surgery.
MeSH term(s)	Acidosis, Lactic/etiology ; Cardiac Surgical Procedures ; Cardiopulmonary Bypass ; Humans ; Lactic Acid/metabolism ; Myocardium/metabolism ; Perioperative Period
Chemical Substances	Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2012-07-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	187524-3
ISSN	1448-0271 ; 0310-057X
ISSN (online)	1448-0271
ISSN	0310-057X
DOI	10.1177/0310057X1204000404
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Article: The dRTA-rhabdomyolysis connection.

Dhanani, J A / McCarthy, J / Fraser, J F

Anaesthesia and intensive care

2012 Volume 40, Issue 4, Page(s) 728–730

MeSH term(s)	Acidosis, Renal Tubular/complications ; Female ; Humans ; Hypokalemia/complications ; Middle Aged ; Rhabdomyolysis/etiology
Language	English
Publishing date	2012-07-04
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	187524-3
ISSN	1448-0271 ; 0310-057X
ISSN (online)	1448-0271
ISSN	0310-057X
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Article ; Online: Efficacy and safety of fibrinogen concentrate in trauma patients--a systematic review.

Aubron, C / Reade, M C / Fraser, J F / Cooper, D J

Journal of critical care

2014 Volume 29, Issue 3, Page(s) 471.e11–7

Abstract: Purpose: Uncontrolled bleeding is the main preventable cause of death in severe trauma patients. Fibrinogen is the first coagulation factor to decrease during trauma-induced coagulopathy, suggesting that pharmacological replacement might assist early ... ...

Abstract	Purpose: Uncontrolled bleeding is the main preventable cause of death in severe trauma patients. Fibrinogen is the first coagulation factor to decrease during trauma-induced coagulopathy, suggesting that pharmacological replacement might assist early hemorrhage control. Several sources of fibrinogen are available; however, fibrinogen concentrate (FC) is not routinely used in trauma settings in most countries. The aim of this review is to summarize the available literature evaluating the use of FC in the management of severe trauma. Methods: Studies reporting the administration of FC in trauma patients published between January 2000 and April 2013 were identified from MEDLINE and from the Cochrane Library. Results: The systematic review identified 12 articles reporting FC usage in trauma patients: 4 case reports, 7 retrospective studies, and 1 prospective observational study. Three of these were not restricted to trauma patients. Conclusions: Despite methodological flaws, some of the available studies suggested that FC administration may be associated with a reduced blood product requirement. Randomized trials are warranted to determine whether FC improves outcomes in prehospital management of trauma patients or whether FC is superior to another source of fibrinogen in early hospital management of trauma patients.
MeSH term(s)	Fibrinogen/adverse effects ; Fibrinogen/therapeutic use ; Hemorrhage/etiology ; Hemorrhage/therapy ; Hemostatics/adverse effects ; Hemostatics/therapeutic use ; Humans ; Observational Studies as Topic ; Prospective Studies ; Retrospective Studies ; Safety ; Wounds and Injuries/complications
Chemical Substances	Hemostatics ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632818-0
ISSN	1557-8615 ; 0883-9441
ISSN (online)	1557-8615
ISSN	0883-9441
DOI	10.1016/j.jcrc.2013.12.011
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Article ; Online: Cardiac surgery in indigenous Australians: early onset cardiac disease with follow-up challenges.

Matebele, M P / Rohde, S / Clarke, A / Fraser, J F

Heart, lung & circulation

2014 Volume 23, Issue 6, Page(s) 566–571

Abstract: Objective: To review the risk factors, complications and follow-up of Indigenous patients post cardiac surgery.: Methods: This was a retrospective study of Indigenous patients who underwent cardiac surgery at an Australian tertiary hospital between ... ...

Abstract	Objective: To review the risk factors, complications and follow-up of Indigenous patients post cardiac surgery. Methods: This was a retrospective study of Indigenous patients who underwent cardiac surgery at an Australian tertiary hospital between 2002 and 2009. Patients' medical notes were reviewed and data collected and analysed. Results: There were 220 Indigenous patients who had cardiac surgery. Non-elective surgery was performed in 45.0% (99/220). A history of smoking was reported by 76.8% (169/220). The most common operation was coronary artery bypass grafting with a mean age of 55 years. Of the 71 valve operations, 31.0% had rheumatic heart disease. Mechanical valves were given to 56.3% (40/71) of patients with a mean age of 45 years. The rate of peri-operative bleeding requiring blood transfusion or reoperation was 8.6% (19/220) and 28-day mortality was 0.45% (1/220). Of the patients with mechanical valves, 10.0% (4/40) did not present for outpatient review. Late anticoagulation related complications were haemorrhagic stroke 7.5% (3/40) and ischaemic bowel 2.5% (1/40). Late mortality was 9.5% (21/220). Late anticoagulation related deaths were in 1.8% (4/220), of whom 0.9% (2/220) had mechanical valves. Conclusions: The mean age of 52 years at which Indigenous patients have cardiac surgery is significantly low compared to non-Indigenous patients. Indigenous patients have multiple risk factors for cardiac disease and with a large number requiring emergency surgery. Although surgical outcome in the short term is favourable, a large number of patients are lost to follow-up. The use of mechanical valve and warfarin should be individualised. Strategic post-operative follow-up mechanisms are needed to address these issues.
MeSH term(s)	Age Factors ; Australia/epidemiology ; Cardiac Surgical Procedures ; Female ; Follow-Up Studies ; Heart Diseases/mortality ; Heart Diseases/surgery ; Humans ; Male ; Middle Aged ; Oceanic Ancestry Group ; Retrospective Studies
Language	English
Publishing date	2014-06
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2014.01.004
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Article ; Online: Nursing team leader handover in the intensive care unit contains diverse and inconsistent content: An observational study.

Spooner, A J / Aitken, L M / Corley, A / Fraser, J F / Chaboyer, W

International journal of nursing studies

2016 Volume 61, Page(s) 165–172

Abstract: Background: Despite a proliferation of evidence and the development of standardised tools to improve communication at handover, evidence to guide the handover of critical patient information between nursing team leaders in the intensive care unit is ... ...

Abstract	Background: Despite a proliferation of evidence and the development of standardised tools to improve communication at handover, evidence to guide the handover of critical patient information between nursing team leaders in the intensive care unit is limited. Objective: The study aim was to determine the content of information handed over during intensive care nursing team leader shift-to-shift handover. Design: A prospective observational study. Setting: A 21-bed medical/surgical adult intensive care unit specialising in cardiothoracic surgery at a tertiary referral hospital in Queensland, Australia. Participants: Senior nurses (Grade 5 and 6 Registered nurses) working in team leader roles, employed in the intensive care unit were sampled. Method: After obtaining consent from nursing staff, team leader handovers were audiotaped over 20 days. Audio recordings were transcribed and analysed using deductive and inductive content analysis. The frequency of content discussed at handover that fell within the a priori categories of the ISBAR schema (Identify-Situation-Background-Assessment-Recommendation) was calculated. Results: Forty nursing team leader handovers were recorded resulting in 277 patient handovers and a median of 7 (IQR 2) patients discussed at each handover. The majority of nurses discussed the Identity (99%), Situation (96%) and Background (88%) of the patient, however Assessment (69%) content was varied and patient Recommendations (60%) were discussed less frequently. A diverse range of additional information was discussed that did not fit into the ISBAR schema. Conclusions: Despite universal acknowledgement of the importance of nursing team leader handover, there are no previous studies assessing its content. Study findings indicate that nursing team leader handovers contain diverse and inconsistent content, which could lead to inadequate handovers that compromise patient safety. Further work is required to develop structured handover processes for nursing team leader handovers.
MeSH term(s)	Humans ; Intensive Care Units ; Leadership ; Patient Handoff ; Prospective Studies
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	80148-3
ISSN	1873-491X ; 0020-7489
ISSN (online)	1873-491X
ISSN	0020-7489
DOI	10.1016/j.ijnurstu.2016.05.006
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Article ; Online: Neutrophil antibody diagnostics and screening: review of the classical versus the emerging.

Fung, Y L / Minchinton, R M / Fraser, J F

Vox sanguinis

2011 Volume 101, Issue 4, Page(s) 282–290

Abstract: BACKGROUND AND OBJECTIVES Severe transfusion-related acute lung injury (TRALI) events have been linked to donor-derived neutrophil antibodies. The journey to developing mass donor neutrophil antibody screening platforms is challenged by the fragility of ...

Abstract	BACKGROUND AND OBJECTIVES Severe transfusion-related acute lung injury (TRALI) events have been linked to donor-derived neutrophil antibodies. The journey to developing mass donor neutrophil antibody screening platforms is challenged by the fragility of neutrophils and their unique-specific antigenic characteristics. MATERIAL AND METHODS This article critically evaluates the capabilities and potential of five emerging antibody screening platforms designed to detect neutrophil reactive antibodies relevant to TRALI. They are compared with established neutrophil serological methods. RESULTS Data from two recombinant antigen platforms and a method using human neutrophil antigens-expressing KY cells indicated high specificity. Two mixed cellular flow cytometric assays have the advantage of presenting native conformation of the human polymorphonuclear neutrophil antigenic epitopes. CONCLUSIONS To date, the number and specificity of test sera applied to each platform is small. This needs to be substantially increased and further rigorous serological evaluation is yet needed to compare the sensitivity and specificity limits of each new platform with classical methods. With a limited world supply of TRALI-relevant test sera, a collaborative effort of laboratories with neutrophil and TRALI investigation expertise is required.
MeSH term(s)	Acute Lung Injury/diagnosis ; Acute Lung Injury/etiology ; Acute Lung Injury/immunology ; Animals ; Antigen-Antibody Reactions ; Antigens/immunology ; Enzyme-Linked Immunosorbent Assay ; Epitopes ; Humans ; Isoantibodies/immunology ; Neutrophils/immunology ; Transfusion Reaction
Chemical Substances	Antigens ; Epitopes ; Isoantibodies
Language	English
Publishing date	2011-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/j.1423-0410.2011.01511.x
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Article ; Online: Uroscopic rainbow: modern matula medicine.

Foot, C L / Fraser, J F

Postgraduate medical journal

2006 Volume 82, Issue 964, Page(s) 126–129

Abstract: Visual inspection of a patient's urine has long been used by physicians, with colour recognised as having important clinical implications. In this review the authors will revisit this ancient pastime with relevance to contemporary medical practice. ...

Abstract	Visual inspection of a patient's urine has long been used by physicians, with colour recognised as having important clinical implications. In this review the authors will revisit this ancient pastime with relevance to contemporary medical practice.
MeSH term(s)	Color ; Diagnosis ; Humans ; Urinalysis/methods
Language	English
Publishing date	2006-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80325-x
ISSN	1469-0756 ; 0032-5473
ISSN (online)	1469-0756
ISSN	0032-5473
DOI	10.1136/pgmj.2005.037598
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