LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 46

Search options

  1. Article: An unusual pigmented tonsil neoplasm presenting to Head & Neck Clinic: a case report and literature review of primary tonsillar malignant mucosal melanoma.

    Rae, Pete J / Bates, James E H M / Fraser, Lisa R

    Journal of surgical case reports

    2022  Volume 2022, Issue 2, Page(s) rjac022

    Abstract: Primary mucosal melanoma of the tonsil is rare, with 27 reported cases. Careful diagnosis is necessary, as the tonsil is more often a site of metastatic melanoma from a cutaneous primary tumour. In this report, we present a case of primary right ... ...

    Abstract Primary mucosal melanoma of the tonsil is rare, with 27 reported cases. Careful diagnosis is necessary, as the tonsil is more often a site of metastatic melanoma from a cutaneous primary tumour. In this report, we present a case of primary right tonsillar mucosal melanoma with widespread metastasis in a 31-year-old man who presented with a 3-month history of enlarging neck lumps. On examination, he had cervical lymphadenopathy and a pigmented, vascular lesion of his right tonsil, which was diagnosed as melanoma following investigation. He had widespread metastases upon presentation, and is currently undergoing palliative immunotherapy. Owing to the aggressive behaviour, late presentations and lack of effective treatment to cure mucosal melanomas, they have a poor prognosis. Treatment involves wide local excision in local disease, and immunotherapy as the first-line for metastatic disease.
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjac022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Functional Outcomes Following Total Laryngectomy and Pharyngolaryngectomy: A 20-Year Single Center Study.

    Layton, Thomas / Thomas, Rachel / Harris, Carol / Holmes, Sam / Fraser, Lisa / Silva, Priy / Winter, Stuart C

    The Annals of otology, rhinology, and laryngology

    2022  Volume 131, Issue 12, Page(s) 1301–1309

    Abstract: Background: Laryngeal cancer accounts for 1% of all cancers in men and 0.3% of all cancers in women. Pharyngolaryngectomy (TPL) and total laryngectomy (TL) are central surgical techniques in the management of advanced laryngeal malignancies but are ... ...

    Abstract Background: Laryngeal cancer accounts for 1% of all cancers in men and 0.3% of all cancers in women. Pharyngolaryngectomy (TPL) and total laryngectomy (TL) are central surgical techniques in the management of advanced laryngeal malignancies but are associated with significant morbidity. In addition, optimal reconstruction following TPL remains an area of active research.
    Methods: Here, we compared speech and swallowing outcomes following circumferential and partial pharyngeal resection alongside total laryngectomy in patients with laryngeal and hypolaryngeal tumors. We performed a systemic analysis of patient demographics, tumor characteristics, treatment modality, and pharyngeal reconstruction technique following TPL and TL, leveraging data collected over a 20-year period at a large tertiary referral center.
    Results: Analyzing 155 patients the results show circumferential pharyngeal defects and prior radiotherapy have a significant impact on surgical complications.
    Conclusion: Pharyngeal resection carries a substantial risk of incurring impaired speech and swallowing in patients. Moreover, our results support poorer functional outcomes with more radical pharyngeal resections and show a clear trend toward worse swallowing outcomes in salvage surgery.
    MeSH term(s) Female ; Humans ; Laryngeal Neoplasms/pathology ; Laryngectomy/methods ; Male ; Pharyngectomy ; Retrospective Studies ; Salvage Therapy
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/00034894211072987
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Type 1 diabetes and osteoporosis: from molecular pathways to bone phenotype.

    Khan, Tayyab S / Fraser, Lisa-Ann

    Journal of osteoporosis

    2015  Volume 2015, Page(s) 174186

    Abstract: The link between type 1 diabetes mellitus (DM1) and osteoporosis, identified decades ago, has gained attention in recent years. While a number of cellular mechanisms have been postulated to mediate this association, it is now established that defects in ... ...

    Abstract The link between type 1 diabetes mellitus (DM1) and osteoporosis, identified decades ago, has gained attention in recent years. While a number of cellular mechanisms have been postulated to mediate this association, it is now established that defects in osteoblast differentiation and activity are the main culprits underlying bone fragility in DM1. Other contributing factors include an accumulation of advanced glycation end products (AGEs) and the development of diabetes complications (such as neuropathy and hypoglycemia), which cause further decline in bone mineral density (BMD), worsening geometric properties within bone, and increased fall risk. As a result, patients with DM1 have a 6.9-fold increased incidence of hip fracture compared to controls. Despite this increased fracture risk, bone fragility remains an underappreciated complication of DM1 and is not addressed in most diabetes guidelines. There is also a lack of data regarding the efficacy of therapeutic strategies to treat osteoporosis in this patient population. Together, our current understanding of bone fragility in DM1 calls for an update of diabetes guidelines, better screening tools, and further research into the use of therapeutic strategies in this patient population.
    Language English
    Publishing date 2015-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2090-8059
    ISSN 2090-8059
    DOI 10.1155/2015/174186
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Composite poorly differentiated mucoepidermoid carcinoma of the thyroid and follicular variant of papillary thyroid carcinoma. Report of a case and review of the literature.

    Jayakody, Nimeshi S / Faoury, Morad / Fraser, Lisa R / Jogai, Sanjay / Patel, Nimesh N

    Journal of surgical case reports

    2019  Volume 2019, Issue 4, Page(s) rjz092

    Abstract: Mucoepidermoid variant of thyroid carcinoma is a rare and complex disease. Securing a diagnosis and formulating an evidence-based treatment plan is challenging. A case report of a patient with the dual pathology of a composite mucoepidermoid carcinoma of ...

    Abstract Mucoepidermoid variant of thyroid carcinoma is a rare and complex disease. Securing a diagnosis and formulating an evidence-based treatment plan is challenging. A case report of a patient with the dual pathology of a composite mucoepidermoid carcinoma of the thyroid and a follicular variant of papillary thyroid carcinoma with malignant metastasis is presented in this article. We discuss the challenges in diagnosis, prognostic factors and management of this rare presentation by reviewing current literature.
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Case Reports
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjz092
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Glucocorticoid-induced osteoporosis: treatment update and review.

    Fraser, Lisa-Ann / Adachi, Jonathan D

    Therapeutic advances in musculoskeletal disease

    2012  Volume 1, Issue 2, Page(s) 71–85

    Abstract: Glucocorticoid-induced osteoporosis (GIO) is a serious consequence of glucocorticoid therapy leading to fractures in 30-50% of patients. A wide range of protective medications have been studied in this condition including calcium, vitamin D, vitamin D ... ...

    Abstract Glucocorticoid-induced osteoporosis (GIO) is a serious consequence of glucocorticoid therapy leading to fractures in 30-50% of patients. A wide range of protective medications have been studied in this condition including calcium, vitamin D, vitamin D analogs, oral and intravenous bisphosphonates, sex hormones, anabolic agents and calcitonin. The mechanism of action, and evidence for these therapies, are reviewed - focusing on important trials and new evidence. Recently published guidelines are also reviewed and compared. Bisphosphonates are currently the recommended first-line therapy for the prevention and treatment of GIO. They have been shown to increase bone mineral density (BMD) at the spine and hip and to decrease the incidence of vertebral fractures (especially in postmenopausal women). Testosterone therapy and female hormone replacement therapy (HRT) have been found to increase lumbar spine BMD in hypogonadal patients on glucocorticoid therapy, but effects on hip BMD have not been consistent and there is no fracture data in the GIO population. Similarly, calcitonin increases lumbar spine BMD but has no proven fracture efficacy. The effect of selective estrogen receptor modulators, the oral contraceptive pill and strontium on GIO is relatively unknown. Parathyroid hormone (PTH 1-34) and zoledronic acid have emerged as exciting new options for the treatment of GIO. Both therapies have been found to result in gains in BMD at the spine and hip that are either noninferior or superior to those seen with oral bisphosphonate therapy. PTH 1-34 has also been found to decrease the incidence of new vertebral fractures and may be an option in high-risk patients established on long-term glucocorticoid therapy.
    Language English
    Publishing date 2012-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X09343729
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Contracting Strategies for Arthroplasty-Bundles to Population Health.

    Jacofsky, David J / Jawin, Paul / Walton, Geoff / Fraser, Lisa

    The journal of knee surgery

    2017  Volume 30, Issue 1, Page(s) 19–27

    Abstract: Orthopedics, and especially total joint replacement (TJR), is growing in payer prominence due to large projected increases in volume. The unsustainability of the fee-for-service payment system has lead Centers for Medicare and Medicaid Services to employ ...

    Abstract Orthopedics, and especially total joint replacement (TJR), is growing in payer prominence due to large projected increases in volume. The unsustainability of the fee-for-service payment system has lead Centers for Medicare and Medicaid Services to employ new value and risk-based contracting strategies on a population health basis and on an episode of care basis, with programs such as the Bundled Payment for Care Improvement program and the Comprehensive Care for Joint Replacement program. These trends are forcing hospitals and physicians to align to improve quality and reduce costs through new structures such as Accountable Care Organizations, comanagement programs, and gainsharing. Bundled payment programs are typically used to align specialists such as orthopedic surgeons and TJR has been on the forefront of bundled payment contracting strategies. Bundled payment programs with commercial insurers can create additional opportunities, as do commercial bundled payment contracts for TJR performed on an outpatient basis. As these programs are now becoming mandatory, surgeons must understand the structural aspects of these arrangements and the levers available to optimize the likelihood of success.
    MeSH term(s) Arthroplasty, Replacement/economics ; Contract Services ; Humans ; Medicare ; Patient Care Bundles ; United States
    Language English
    Publishing date 2017-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2075354-8
    ISSN 1938-2480 ; 1538-8506 ; 0899-7403
    ISSN (online) 1938-2480
    ISSN 1538-8506 ; 0899-7403
    DOI 10.1055/s-0036-1593613
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology.

    Khatun, Achia / Wu, Xiaopeng / Qi, Fu / Gai, Kexin / Kharel, Arjun / Kudek, Matthew R / Fraser, Lisa / Ceicko, Ashley / Kasmani, Moujtaba Y / Majnik, Amber / Burns, Robert / Chen, Yi-Guang / Salzman, Nita / Taparowsky, Elizabeth J / Fang, Dayu / Williams, Calvin B / Cui, Weiguo

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 28, Page(s) e2206692

    Abstract: Regulatory T (Treg) cells are inevitable to prevent deleterious immune responses to self and commensal microorganisms. Treg function requires continuous expression of the transcription factor (TF) FOXP3 and is divided into two major subsets: resting ( ... ...

    Abstract Regulatory T (Treg) cells are inevitable to prevent deleterious immune responses to self and commensal microorganisms. Treg function requires continuous expression of the transcription factor (TF) FOXP3 and is divided into two major subsets: resting (rTregs) and activated (aTregs). Continuous T cell receptor (TCR) signaling plays a vital role in the differentiation of aTregs from their resting state, and in their immune homeostasis. The process by which Tregs differentiate, adapt tissue specificity, and maintain stable phenotypic expression at the transcriptional level is still inconclusivei. In this work, the role of BATF is investigated, which is induced in response to TCR stimulation in naïve T cells and during aTreg differentiation. Mice lacking BATF in Tregs developed multiorgan autoimmune pathology. As a transcriptional regulator, BATF is required for Treg differentiation, homeostasis, and stabilization of FOXP3 expression in different lymphoid and non-lymphoid tissues. Epigenetically, BATF showed direct regulation of Treg-specific genes involved in differentiation, maturation, and tissue accumulation. Most importantly, FOXP3 expression and Treg stability require continuous BATF expression in Tregs, as it regulates demethylation and accessibility of the CNS2 region of the Foxp3 locus. Considering its role in Treg stability, BATF should be considered an important therapeutic target in autoimmune disease.
    MeSH term(s) Mice ; Animals ; T-Lymphocytes, Regulatory ; Autoimmune Diseases ; Cell Differentiation ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Receptors, Antigen, T-Cell/metabolism
    Chemical Substances Forkhead Transcription Factors ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206692
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape.

    Fung, Connie / Fraser, Lisa M / Barrón, Gabriel M / Gologorsky, Matthew B / Atkinson, Samantha N / Gerrick, Elias R / Hayward, Michael / Ziegelbauer, Jennifer / Li, Jessica A / Nico, Katherine F / Tyner, Miles D W / DeSchepper, Leila B / Pan, Amy / Salzman, Nita H / Howitt, Michael R

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 23, Page(s) e2216908120

    Abstract: Succinate produced by the commensal ... ...

    Abstract Succinate produced by the commensal protist
    MeSH term(s) Mice ; Animals ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism ; Intestines ; Succinic Acid/metabolism ; Anti-Infective Agents/metabolism
    Chemical Substances Succinic Acid (AB6MNQ6J6L) ; Anti-Infective Agents
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2216908120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Use of the self-retaining Alexis ring retractor in transoral robotic surgery.

    Perenyei, Miklos / Dobbs, Thomas D / Fraser, Lisa R / Winter, Stuart C

    Head & neck

    2017  Volume 39, Issue 10, Page(s) 2132–2134

    Abstract: Background: Ring retractors, such as the Alexis® wound retractor, are simple devices used in a wide range of surgical settings to provide atraumatic exposure while protecting wound edges.: Methods: Here, we describe the application of the Alexis® to ... ...

    Abstract Background: Ring retractors, such as the Alexis® wound retractor, are simple devices used in a wide range of surgical settings to provide atraumatic exposure while protecting wound edges.
    Methods: Here, we describe the application of the Alexis® to provide access during transoral robotic surgery (TORS).
    Conclusion: Its ease of application and many benefits, including maximization of intraoral space and protection of perioral soft tissues, make this device an excellent adjunct for TORS procedures.
    MeSH term(s) Humans ; Mouth/surgery ; Natural Orifice Endoscopic Surgery/instrumentation ; Natural Orifice Endoscopic Surgery/methods ; Robotic Surgical Procedures/instrumentation ; Robotic Surgical Procedures/methods ; Surgical Instruments
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Technical Report
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.24882
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Enzyme-inducing antiepileptic drugs and fractures in people with epilepsy: A systematic review.

    Fraser, Lisa-Ann / Burneo, Jorge G / Fraser, J Alexander

    Epilepsy research

    2015  Volume 116, Page(s) 59–66

    Abstract: Objective: People with epilepsy (PWE) have an increased fracture risk, independent of seizures. Antiepileptic drugs are thought to increase this risk, particularly those that induce the hepatic cytochrome P450 enzyme system. We aimed to determine ... ...

    Abstract Objective: People with epilepsy (PWE) have an increased fracture risk, independent of seizures. Antiepileptic drugs are thought to increase this risk, particularly those that induce the hepatic cytochrome P450 enzyme system. We aimed to determine whether PWE treated with enzyme-inducing antiepileptic drugs (EIAEDs) have decreased bone mineral density (BMD), or increased fracture incidence, versus those treated with non-EIAEDs.
    Methods: We searched MedLine, EMBase, CENTRAL, and CINAHL prior to November 2014 for all studies comparing fracture risk, or BMD change, in PWE treated for ≥ 1 year with EIAEDs versus non-EIAEDs.
    Results: Thirteen observational studies met eligibility criteria. These studies, representing 68,973 adult PWE, were significantly heterogeneous, making meta-analysis impossible. Study results were split, with 5 studies showing decreased BMD in EIAED users, 5 studies showing no effect of EIAED on BMD, 2 studies showing increased fracture incidence in EIAED users, and 1 study showing no difference in fracture risk. The largest study (n = 63,259), which was also the most methodologically rigorous, showed an increased hazard ratio of 9-22% for any fracture, and 49-53% for hip fracture, in EIAED users.
    Significance: The literature is divided regarding the bone effects of EIAEDs; however, current best evidence supports an increased fracture risk in PWE treated with an EIAED compared to those treated with non-EIAEDs. A single article dominated our review, and other large methodologically rigorous studies are needed to confirm or refute its results. Further small studies, with limited power to control for multiple potentially confounding variables, are not likely to help.
    MeSH term(s) Anticonvulsants/therapeutic use ; Cytochrome P-450 Enzyme System/metabolism ; Databases, Factual/statistics & numerical data ; Epilepsy/complications ; Epilepsy/drug therapy ; Female ; Fractures, Bone/etiology ; Humans ; Male
    Chemical Substances Anticonvulsants ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2015-10
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2015.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top