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  1. Article ; Online: Modern treatment of a Klippel-Trenaunay syndrome patient with Palma procedure.

    Tatakis, Ana / Bowder, Alexis / Fraser, Simon / Hohenwalter, Eric / Malinowski, Michael

    Vascular

    2023  , Page(s) 17085381231161852

    Abstract: Klippel-Trenaunay syndrome is a rare congenital anomaly that is associated with abnormalities in the deep venous system. Operative intervention is often used only when patients fail conservative management for chronic venous insufficiency. We present a ... ...

    Abstract Klippel-Trenaunay syndrome is a rare congenital anomaly that is associated with abnormalities in the deep venous system. Operative intervention is often used only when patients fail conservative management for chronic venous insufficiency. We present a case of a deep venous abnormality requiring a saphenous vein crossover Palma procedure, in combination with a left femoral arteriovenous PTFE fistula to manage a non-healing wound from chronic venous insufficiency in a 22-year-old man. This case highlights updates for modern treatment tips for technical and medical management decisions to avoid early graft thrombosis.
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2137151-9
    ISSN 1708-539X ; 1708-5381
    ISSN (online) 1708-539X
    ISSN 1708-5381
    DOI 10.1177/17085381231161852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4277: Show issues Location:
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  2. Article ; Online: Influence of health-system change on treatment burden: a systematic review.

    Matthews, Kate Sh / Rennoldson, Susannah C / Fraser, Simon Ds

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2022  Volume 73, Issue 726, Page(s) e59–e66

    Abstract: Background: Treatment burden is a patient-centred concept describing the effort required of people to look after their health and the impact this has on their functioning and wellbeing. High treatment burden is more likely for people with multiple long- ... ...

    Abstract Background: Treatment burden is a patient-centred concept describing the effort required of people to look after their health and the impact this has on their functioning and wellbeing. High treatment burden is more likely for people with multiple long-term conditions (LTCs). Validated treatment burden measures exist, but have not been widely used in practice or as research outcomes.
    Aim: To establish whether changes in organisation and delivery of health systems and services improve aspects contributing to treatment burden for people with multiple LTCs.
    Design and setting: Systematic review of randomised controlled trials (RCTs) investigating the impact of system-level interventions on at least one outcome relevant to previously defined treatment burden domains among adults with ≥2 LTCs.
    Method: The Embase, Ovid MEDLINE, and Web of Science electronic databases were searched for terms related to multimorbidity, system-level change, and treatment burden published between January 2010 and July 2021. Treatment burden domains were derived from validated measures and qualitative literature. Synthesis without meta-analysis (SWiM) methodology was used to synthesise results and study quality was assessed using the Cochrane risk-of-bias (version 2) tool.
    Results: The searches identified 1881 articles, 18 of which met the review inclusion criteria. Outcomes were grouped into seven domains. There was some evidence for the effect of system-level interventions on some domains, but the studies exhibited substantial heterogeneity, limiting the synthesis of results. Some concern over bias gave low confidence in study results.
    Conclusion: System-level interventions may affect some treatment burden domains. However, adoption of a standardised outcome set, incorporating validated treatment burden measures, and the development of standard definitions for care processes in future research would aid study comparability.
    MeSH term(s) Adult ; Humans ; Treatment Outcome ; Bias ; Swimming
    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/BJGP.2022.0066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 576: Show issues Location:
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  3. Article: Helping people to live well with chronic kidney disease.

    Fraser, Simon / Taal, Maarten

    British journal of hospital medicine (London, England : 2005)

    2020  Volume 81, Issue 6, Page(s) 1–10

    Abstract: Reduced glomerular filtration rate and presence of albuminuria are both associated with increased risk of several poor outcomes. People with chronic kidney disease also commonly suffer from lower quality of life than their age-matched peers. The ... ...

    Abstract Reduced glomerular filtration rate and presence of albuminuria are both associated with increased risk of several poor outcomes. People with chronic kidney disease also commonly suffer from lower quality of life than their age-matched peers. The experiences reported by patients with chronic kidney disease include being shocked by the diagnosis, being uncertain about the cause and worrying about progression and future treatment. Issues such as depression, pain and fatigue are common in people with chronic kidney disease. Helping people to live well with a long-term condition like chronic kidney disease should include efforts to reduce the risk of adverse events occurring in the future, and consider what can be done to enhance quality of life now. Clinicians can help by being aware of the patient perspective, communicating clearly and recommending interventions that reduce future risk as well as recognising and treating symptoms. Assessing overall treatment burden is an important component of management and non-pharmacological interventions that may improve mobility, strength and pain should be considered.
    MeSH term(s) Acute Kidney Injury/physiopathology ; Acute Kidney Injury/psychology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/mortality ; Comorbidity ; Depression/psychology ; Disease Progression ; Fatigue/physiopathology ; Fatigue/psychology ; Frailty/epidemiology ; Frailty/physiopathology ; Frailty/psychology ; Functional Status ; Glomerular Filtration Rate ; Hospitalization ; Humans ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/psychology ; Pain/physiopathology ; Pain/psychology ; Proportional Hazards Models ; Quality of Life ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/physiopathology ; Renal Insufficiency, Chronic/psychology
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2020.0069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What are the modifiable factors of treatment burden and capacity among people with Parkinson's disease and their caregivers: A qualitative study.

    Tan, Qian Yue / Roberts, Helen C / Fraser, Simon D S / Amar, Khaled / Ibrahim, Kinda

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0283713

    Abstract: Background: People with long-term conditions must complete many healthcare tasks such as take medications, attend appointments, and change their lifestyle. This treatment burden and ability to manage it (capacity) is not well-researched in Parkinson's ... ...

    Abstract Background: People with long-term conditions must complete many healthcare tasks such as take medications, attend appointments, and change their lifestyle. This treatment burden and ability to manage it (capacity) is not well-researched in Parkinson's disease.
    Objective: To explore and identify potentially modifiable factors contributing to treatment burden and capacity in people with Parkinson's disease and caregivers.
    Methods: Semi-structured interviews with nine people with Parkinson's disease and eight caregivers recruited from Parkinson's disease clinics in England (ages 59-84 years, duration of Parkinson's disease diagnosis 1-17 years, Hoehn and Yahr (severity of Parkinson's disease) stages 1-4) were conducted. Interviews were recorded and analyzed thematically.
    Results: Four themes of treatment burden with modifiable factors were identified: 1) Challenges with appointments and healthcare access: organizing appointments, seeking help and advice, interactions with healthcare professionals, and caregiver role during appointments; 2) Issues obtaining satisfactory information: sourcing and understanding information, and satisfaction with information provision; 3) Managing medications: getting prescriptions right, organizing polypharmacy, and autonomy to adjust treatments; and 4) Lifestyle changes: exercise, dietary changes, and financial expenses. Aspects of capacity included access to car and technology, health literacy, financial capacity, physical and mental ability, personal attributes and life circumstances, and support from social networks.
    Conclusions: There are potentially modifiable factors of treatment burden including addressing the frequency of appointments, improving healthcare interactions and continuity of care, improving health literacy and information provision, and reducing polypharmacy. Some changes could be implemented at individual and system levels to reduce treatment burden for people with Parkinson's and their caregivers. Recognition of these by healthcare professionals and adopting a patient-centered approach may improve health outcomes in Parkinson's disease.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Caregivers ; Parkinson Disease/therapy ; Health Personnel ; Qualitative Research ; Health Services Accessibility ; Quality of Life
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283713
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  5. Article ; Online: Monocytes and macrophages in chronic sarcoidosis pathology.

    Fraser, Simon D / Hart, Simon P

    The European respiratory journal

    2019  Volume 54, Issue 5

    MeSH term(s) Autoimmune Diseases ; Humans ; Macrophages ; Monocytes ; Sarcoidosis ; Sarcoidosis, Pulmonary
    Language English
    Publishing date 2019-11-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01626-2019
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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  6. Article ; Online: Risk factors for ill health: How do we specify what is 'modifiable'?

    Alwan, Nisreen A / Stannard, Seb / Berrington, Ann / Paranjothy, Shantini / Hoyle, Rebecca B / Owen, Rhiannon K / Fraser, Simon D S

    PLOS global public health

    2024  Volume 4, Issue 3, Page(s) e0002887

    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0002887
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  7. Article ; Online: Associations With Baseline Blood Pressure Control in NURTuRE-CKD.

    Lucas, Bethany J / Cockwell, Paul / Fraser, Simon D S / Kalra, Philip A / Wheeler, David C / Taal, Maarten W

    Kidney international reports

    2024  Volume 9, Issue 5, Page(s) 1508–1512

    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2024.02.013
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  8. Article ; Online: Public Health and Nephrology: Contributions of Epidemiology to the Study, Understanding, Prevention and Treatment of Kidney Disease.

    Fraser, Simon D S / Roderick, Paul J

    Contributions to nephrology

    2021  Volume 199, Page(s) 1–14

    Abstract: Kidney disease is frequently described as a public health problem. This chapter will unpack what we mean by "public health" and by "taking a public health approach." We will consider the global burden of kidney diseases and their determinants, with a ... ...

    Abstract Kidney disease is frequently described as a public health problem. This chapter will unpack what we mean by "public health" and by "taking a public health approach." We will consider the global burden of kidney diseases and their determinants, with a focus on chronic kidney disease. We will explore the aetiology of chronic kidney disease across the life course and the way in which kidney health frequently reflects inequities in societal health, therefore requiring a public health response. We will describe some of the public health endeavours that help address these problems and then introduce epidemiology as the core science of public health. We will describe the common epidemiological study designs with a focus on observational studies and explore the role of the various study designs in addressing different types of research question, and thereby contributing to distinct aspects of disease understanding. We will introduce concepts of primary and secondary prevention and explore the ways in which the application of different epidemiological study designs has contributed to the knowledge and understanding of kidney diseases. We will discuss the strengths and weaknesses of different study designs and explain how epidemiological methods allow for the quantification of public health problems.
    MeSH term(s) Humans ; Kidney ; Nephrology ; Public Health ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/prevention & control ; Research Design
    Language English
    Publishing date 2021-07-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000517671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endovascular Repair of Incidentally Found Subclavian Artery Aneurysm: A Case Report From an Urban Level 1 Trauma Center.

    Franz, Randall W / Fraser, Simon R

    Vascular and endovascular surgery

    2018  Volume 52, Issue 5, Page(s) 382–385

    Abstract: Subclavian artery aneurysms (SAAs) are historically rare peripheral aneurysm. However, it can be associated with serious life-threatening complications including rupture, thrombosis, and embolism. The majority of such aneurysms are found incidentally. ... ...

    Abstract Subclavian artery aneurysms (SAAs) are historically rare peripheral aneurysm. However, it can be associated with serious life-threatening complications including rupture, thrombosis, and embolism. The majority of such aneurysms are found incidentally. Historically, SAA have been repaired via an open approach. Increasing case reports demonstrate successful management of SAAs with endovascular repair. The present report describes a case of incidentally discovered large proximal saccular subclavian aneurysm with suspected remote traumatic etiology with a successful endovascular repair.
    MeSH term(s) Aneurysm/diagnostic imaging ; Aneurysm/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/instrumentation ; Computed Tomography Angiography ; Endovascular Procedures ; Hospitals, Urban ; Humans ; Incidental Findings ; Male ; Middle Aged ; Stents ; Subclavian Artery/diagnostic imaging ; Subclavian Artery/surgery ; Trauma Centers ; Treatment Outcome
    Language English
    Publishing date 2018-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2076272-0
    ISSN 1938-9116 ; 1538-5744
    ISSN (online) 1938-9116
    ISSN 1538-5744
    DOI 10.1177/1538574418763208
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    Zs.A 622: Show issues Location:
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  10. Article: Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis.

    Fraser, Simon D / Crooks, Michael G / Kaye, Paul M / Hart, Simon P

    ERJ open research

    2021  Volume 7, Issue 1

    Abstract: Background: In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 and ... ...

    Abstract Background: In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 and CD16. Regulatory receptors serve to dampen monocyte and macrophage inflammatory responses. We investigated the relationship between monocyte subsets and regulatory receptor expression in sarcoidosis.
    Methods: Multiparameter flow cytometry was used to perform detailed analyses of cell surface regulatory molecules on freshly isolated blood immune cells from patients with chronic pulmonary sarcoidosis and age-matched healthy controls.
    Results: 25 patients with chronic pulmonary sarcoidosis (median duration of disease 22 months) who were not taking oral corticosteroids or other immunomodulators were recruited. Nonclassical monocytes were expanded in sarcoidosis and exhibited significantly lower expression of regulatory receptors CD200R, signal regulatory protein-α and CD47 than classical or intermediate monocytes. In sarcoidosis, all three monocyte subsets had significantly reduced CD200R and CD47 expression compared with healthy controls. A dichotomous distribution of CD200R was seen on classical and intermediate monocytes in the sarcoidosis population, with 14 out of 25 (56%) sarcoidosis patients having a CD200R
    Conclusions: Nonclassical monocytes, which are expanded in sarcoidosis, express very low levels of regulatory receptors. Two distinct and persistent phenotypes of CD200R expression in classical and intermediate monocytes could be evaluated as sarcoidosis biomarkers.
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00804-2020
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