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Article: Big anal skin tags? What is this?

Guttadauro, Angelo / Frassani, Silvia / Maternini, Matteo / Gabrielli, Francesco

2015 Volume 3, Issue 6, Page(s) 515

Abstract: A hard and bleeding anal and perianal mass stenotized the anus and required left-sided colostomy. Incisional biopsy showed a moderately differentiated spiniocellular carcinoma. Chemoradiotherapy treatment alone reduced significantly the mass. ...

Abstract	A hard and bleeding anal and perianal mass stenotized the anus and required left-sided colostomy. Incisional biopsy showed a moderately differentiated spiniocellular carcinoma. Chemoradiotherapy treatment alone reduced significantly the mass.
Language	English
Publishing date	2015-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.236
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Article ; Online: Pneumoretroperitoneum and pneumomediastinum after Stapled Anopexy Is conservative treatment possible?

Macchini, Daniele / Guttadauro, Angelo / Frassani, Silvia / Maternini, Matteo / Gabrielli, Francesco

Annali italiani di chirurgia

2016 Volume 87, Page(s) 456–460

Abstract: Introduction: Stapled anopexy is considered the gold standard in treating haemorroidal disease associated to mucosal prolapse, but severe complications have been described. Among these, a minimal anastomotic leakage may lead to gas spreading into ... ...

Abstract	Introduction: Stapled anopexy is considered the gold standard in treating haemorroidal disease associated to mucosal prolapse, but severe complications have been described. Among these, a minimal anastomotic leakage may lead to gas spreading into surrounding soft tissues. Case report: We report the case of a 61 year old male who developed pneumoretroperitoneum and pneumomediastinun two days after a Stapled Anopexy. CT scans showed a minimal leakage with no abscess. The patient was successfully treated by bowel rest, antibiotics and total parenteral nutrition, avoiding surgical approach. Conclusion: A minimal anastomotic leakage following Stapled Anopexy, when leading to air diffusion into soft tissues and not associated to abscess or peritonitis may be treated conservatively avoiding ileostomy or colostomy. Key words: Anastomotic leakage, Pneumoretroperitoneum, Stapled Anopexy.
MeSH term(s)	Anastomotic Leak/etiology ; Anastomotic Leak/therapy ; Anti-Bacterial Agents/therapeutic use ; Combined Modality Therapy ; Conservative Treatment ; Hemorrhoids/surgery ; Humans ; Male ; Mediastinal Emphysema/etiology ; Mediastinal Emphysema/therapy ; Metronidazole/therapeutic use ; Middle Aged ; Parenteral Nutrition, Total ; Penicillanic Acid/analogs & derivatives ; Penicillanic Acid/therapeutic use ; Piperacillin/therapeutic use ; Piperacillin, Tazobactam Drug Combination ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Retropneumoperitoneum/etiology ; Retropneumoperitoneum/therapy ; Surgical Stapling/adverse effects ; Tomography, X-Ray Computed
Chemical Substances	Anti-Bacterial Agents ; Metronidazole (140QMO216E) ; Piperacillin, Tazobactam Drug Combination (157044-21-8) ; Penicillanic Acid (87-53-6) ; Piperacillin (X00B0D5O0E)
Language	English
Publishing date	2016-11-12
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article ; Online: Desmoid tumor of the abdominal wall A case report and literature review.

Guttadauro, Angelo / Maternini, Matteo / Frassani, Silvia / Guanziroli, Elena / Lo Bianco, Giulia / Gabrielli, Francesco

Annali italiani di chirurgia

2017 Volume 6

Abstract: Background: Desmoid tumor is a rare soft tissues neoplasia characterized by local invasiveness and by a tendency towards local recurrence although not towards metastasization.: Discussion: Etiology is not clear. Desmoid tumors originate from the ... ...

Abstract	Background: Desmoid tumor is a rare soft tissues neoplasia characterized by local invasiveness and by a tendency towards local recurrence although not towards metastasization. Discussion: Etiology is not clear. Desmoid tumors originate from the monoclonal proliferation of one mesenchymal cell and develop in the context of fascial, muscular and aponeurotic tissue. They are free of capsule and do not usually metastatize, although they do present a high risk of local recurrence CONCLUSION: In the absence of a systematic data collection and of a clear distinction, in the existing databases, between primitive and recurrent lesions and between lesions of different sites, there are no standard guidelines for a correct management of desmoids. Key words: Aggressive fibromatos Desmoid tumor, Soft tissue neoplasia.
MeSH term(s)	Abdominal Neoplasms/diagnosis ; Abdominal Neoplasms/pathology ; Abdominal Neoplasms/surgery ; Abdominal Wall/pathology ; Abdominal Wall/surgery ; Adult ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antineoplastic Agents/therapeutic use ; Disease Management ; Estrogen Receptor Modulators/therapeutic use ; Female ; Fibromatosis, Aggressive/diagnosis ; Fibromatosis, Aggressive/pathology ; Fibromatosis, Aggressive/surgery ; Fibromatosis, Aggressive/therapy ; Humans ; Radiotherapy, Adjuvant
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Antineoplastic Agents ; Estrogen Receptor Modulators
Language	English
Publishing date	2017-11-20
Publishing country	Italy
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
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Article: What is this very big skin lesion?

Guttadauro, Angelo / Frassani, Silvia / Maternini, Matteo / Rubino, Barbara / Guanziroli, Elena / Gabrielli, Francesco

Clinical case reports

2017 Volume 5, Issue 9, Page(s) 1550–1551

Abstract: This clinical image shows the importance of the early diagnosis and treatment of any suspicious skin lesion. ...

Abstract	This clinical image shows the importance of the early diagnosis and treatment of any suspicious skin lesion.
Language	English
Publishing date	2017-08-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.1031
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Article ; Online: Circumferential anal giant condyloma acuminatum: a new surgical approach.

Guttadauro, Angelo / Chiarelli, Marco / Macchini, Daniele / Frassani, Silvia / Maternini, Matteo / Bertolini, Aimone / Gabrielli, Francesco

Diseases of the colon and rectum

2015 Volume 58, Issue 4, Page(s) e49–52

Abstract: Introduction: Perianal giant condyloma acuminatum is a rare clinical condition related to human papillomavirus infection and characterized by a circumferential, exophytic, cauliflower-like mass with an irregular warty surface localized in the anal ... ...

Abstract	Introduction: Perianal giant condyloma acuminatum is a rare clinical condition related to human papillomavirus infection and characterized by a circumferential, exophytic, cauliflower-like mass with an irregular warty surface localized in the anal region. Technique: A circular incision with a diathermocoagulator was performed on macroscopically healthy skin, 1 cm from the margin of the lesion. The dermis was divided from the subcutaneous tissue. This way, a mucocutaneous cylinder including the whole lesion was obtained. A median radial incision was carried out to open the cylinder at its front. A progressive circumferential section on healthy mucosa (≈1 cm above the margin of the lesion) by means of a radiofrequency dissector allowed for the complete removal of the mass. The healthy mucosa of the anal canal was pulled out by Allis forceps and was sutured to the external margin of the internal sphincter with single layer of Vicryl (polyglactin 910) 2-0 sutures. Results: Two months after surgery, no findings of anal stenosis or mucosal ectropion were reported. At the 1-year follow-up there was no recurrence of condylomatosis in any of the 3 cases. Conclusions: Our procedure seems simpler to perform when compared with other techniques and reduces hospital stay and complications such as anal stenosis and mucosal ectropion.
MeSH term(s)	Anal Canal/surgery ; Buschke-Lowenstein Tumor/pathology ; Buschke-Lowenstein Tumor/surgery ; Female ; Humans ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Journal Article ; Technical Report
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000000339
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Article ; Online: Persistent perianal dermatitis associated with mucosal hemorrhoidal prolapse.

Guanziroli, Elena / Veraldi, Stefano / Guttadauro, Angelo / Rizzitelli, Gaetano / Frassani, Silvia

Dermatitis : contact, atopic, occupational, drug

2011 Volume 22, Issue 4, Page(s) 227–229

MeSH term(s)	Adult ; Aged ; Chronic Disease ; Dermatitis/drug therapy ; Dermatitis/etiology ; Dermatitis/microbiology ; Female ; Hemorrhoids/complications ; Humans ; Male ; Middle Aged ; Mucous Membrane/drug effects ; Potassium Permanganate/therapeutic use ; Staphylococcal Skin Infections/complications ; Staphylococcal Skin Infections/drug therapy ; Treatment Outcome ; Young Adult
Chemical Substances	Potassium Permanganate (00OT1QX5U4)
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Letter
ZDB-ID	2144723-8
ISSN	2162-5220 ; 1532-8163 ; 1710-3568
ISSN (online)	2162-5220 ; 1532-8163
ISSN	1710-3568
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Article ; Online: Psyllium fiber vs. placebo in early treatment after STARR for obstructed defecation: a randomized double-blind clinical trial.

Gabrielli, Francesco / Macchini, Daniele / Guttadauro, Angelo / Frassani, Silvia / Bertolini, Aimone / Giussani, Cristina / DE Simone, Matilde / Cioffi, Ugo

Minerva chirurgica

2016 Volume 71, Issue 2, Page(s) 98–105

Abstract: Background: Previous Literature has never evaluated the effectiveness of fiber intake after surgery for obstructed defecation in improving residual constipation and defecation urgency.: Methods: From May 2010 to June 2011, 65 patients were randomly ... ...

Abstract	Background: Previous Literature has never evaluated the effectiveness of fiber intake after surgery for obstructed defecation in improving residual constipation and defecation urgency. Methods: From May 2010 to June 2011, 65 patients were randomly assigned to either the active group (N.=32) or placebo group (N.=33) receiving 3.5 g/day of pure Psyllium fiber or inert compound respectively. During the 6-month follow-up score systems were evaluated: Longo's Obstructed Defecation Syndrome Score, Cleveland Constipation Score; Wexner incontinence Score and Visual Analogic Scale. We also recorded the incidence of postoperative defecation urgency. Results: Active group reported less constipation at 1 week (ODS: 6.25±3.55 vs. 11.94±4.99, P<0.01-CCS: 6.59±2.65 vs. 15.10±3.33, P<0.01) and 6 months (ODS: 3.40±5.26 vs. 4.97±4.21, P<0.05-CCS: 5.00±3.82 vs. 6.63±3.68; P<0.01). Wexner Score was better at t-test in the treatment group (difference from baseline: 0.5 vs. 2.70, P<0.01 after 1 week and -0.17 vs. 1.33, P<0.01 after 6 months). Defecation urgency was less frequent in the treatment group (15.62% vs. 42.42%, P<0.05 at the χ2 Test). Conclusions: Early treatment with Psyllium fiber improves early and 6 month results after stapled transanal rectal resection, both in terms of residual constipation and fecal incontinence. It also reduces postoperative defecation urgency.
MeSH term(s)	Adult ; Aged ; Body Mass Index ; Cathartics/administration & dosage ; Constipation/diagnostic imaging ; Constipation/drug therapy ; Constipation/etiology ; Constipation/surgery ; Defecography/methods ; Double-Blind Method ; Female ; Humans ; Middle Aged ; Psyllium/administration & dosage ; Quality of Life ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Cathartics ; Psyllium (8063-16-9)
Language	English
Publishing date	2016-04
Publishing country	Italy
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	123603-9
ISSN	1827-1626 ; 0026-4733
ISSN (online)	1827-1626
ISSN	0026-4733
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Article ; Online: "All-in-one mesh" hernioplasty: A new procedure for primary inguinal hernia open repair.

Guttadauro, Angelo / Maternini, Matteo / Frassani, Silvia / De Simone, Matilde / Chiarelli, Marco / Macchini, Daniele / Pecora, Nicoletta / Bertolini, Aimone / Cioffi, Ugo / Gabrielli, Francesco

Asian journal of surgery

2017 Volume 41, Issue 5, Page(s) 473–479

Abstract: Background: We propose a new open mesh hernia repair procedure for the treatment of inguinal hernias in adults aiming to improve patients' comfort and to reduce the incidence of chronic neuralgia.: Methods: From September 2012 to August 2015, 250 ... ...

Abstract	Background: We propose a new open mesh hernia repair procedure for the treatment of inguinal hernias in adults aiming to improve patients' comfort and to reduce the incidence of chronic neuralgia. Methods: From September 2012 to August 2015, 250 consecutive patients were treated with "all in-one" mesh hernioplasty procedure in our Institution. According to the devised technique, a new smaller prosthesis was placed on the floor of the inguinal canal in order to strengthen all areas of weakness from which hernias may originate. The mesh was enveloped by a fibro-cremasteric sheath avoiding contact with neural structures. Follow-up was carried out at 3, 6, 12, 18 and 24 months for evaluation of postoperative pain using Visual Analogue Scale score, need of medication, patients' comfort and short or long-term complications. Results: All patients were discharged within 24 h from surgery. Slight pain was reported by the majority of patients and 47.6% of them did not require pain medication at home. After the 1st postoperative week 96.8% reported no pain and no other symptoms. No relevant limitation of normal activities was reported. There has been no postoperative neuralgia. One recurrence was observed. Conclusions: This new hernioplasty technique respects the anatomy of the inguinal canal, uses a smaller mesh, and seems to avoid neuralgia with maximum comfort for the patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Chronic Disease ; Female ; Follow-Up Studies ; Hernia, Inguinal/surgery ; Herniorrhaphy/methods ; Humans ; Male ; Middle Aged ; Neuralgia/prevention & control ; Postoperative Complications/prevention & control ; Surgical Mesh ; Time Factors ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2017-08-26
Publishing country	China
Document type	Journal Article
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2017.07.003
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Article ; Online: Curative versus palliative treatments for recurrent hepatocellular carcinoma: a multicentric weighted comparison.

Famularo, Simone / Donadon, Matteo / Cipriani, Federica / Bernasconi, Davide P / LaBarba, Giuliano / Dominioni, Tommaso / Iaria, Maurizio / Molfino, Sarah / Conci, Simone / Ferrari, Cecilia / Garatti, Marco / Delvecchio, Antonella / Troci, Albert / Patauner, Stefan / Frassani, Silvia / Cosimelli, Maurizio / Zanus, Giacomo / Giuliante, Felice / Jovine, Elio /

Valsecchi, Maria G / Grazi, GianLuca / Antonucci, Adelmo / Frena, Antonio / Crespi, Michele / Memeo, Riccardo / Zimmitti, Giuseppe / Griseri, Guido / Ruzzenente, Andrea / Baiocchi, Gianluca / DallaValle, Raffaele / Maestri, Marcello / Ercolani, Giorgio / Aldrighetti, Luca / Torzilli, Guido / Romano, Fabrizio

HPB : the official journal of the International Hepato Pancreato Biliary Association

2020 Volume 23, Issue 6, Page(s) 889–898

Abstract: Background: Management of recurrence after surgery for hepatocellular carcinoma (rHCC) is still a debate. The aim was to compare the Survival after Recurrence (SAR) of curative (surgery or thermoablation) versus palliative (TACE or Sorafenib) treatments ...

Abstract	Background: Management of recurrence after surgery for hepatocellular carcinoma (rHCC) is still a debate. The aim was to compare the Survival after Recurrence (SAR) of curative (surgery or thermoablation) versus palliative (TACE or Sorafenib) treatments for patients with rHCC. Methods: This is a multicentric Italian study, which collected data between 2007 and 2018 from 16 centers. Selected patients were then divided according to treatment allocation in Curative (CUR) or Palliative (PAL) Group. Inverse Probability Weighting (IPW) was used to weight the groups. Results: 1,560 patients were evaluated, of which 421 experienced recurrence and were then eligible: 156 in CUR group and 256 in PAL group. Tumor burden and liver function were weighted by IPW, and two pseudo-population were obtained (CUR = 397.5 and PAL = 415.38). SAR rates at 1, 3 and 5 years were respectively 98.3%, 76.7%, 63.8% for CUR and 91.7%, 64.2% and 48.9% for PAL (p = 0.007). Median DFS was 43 months (95%CI = 32-74) for CUR group, while it was 23 months (95%CI = 18-27) for PAL (p = 0.017). Being treated by palliative approach (HR = 1.75; 95%CI = 1.14-2.67; p = 0.01) and having a median size of the recurrent nodule>5 cm (HR = 1.875; 95%CI = 1.22-2.86; p = 0.004) were the only predictors of mortality after recurrence, while time to recurrence was the only protective factor (HR = 0.616; 95%CI = 0.54-0.69; p<0.001). Conclusion: Curative approaches may guarantee long-term survival in case of recurrence.
MeSH term(s)	Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic ; Humans ; Liver Neoplasms/therapy ; Neoplasm Recurrence, Local/therapy ; Palliative Care ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2020.10.007
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