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Article ; Online: Letter to the Editor Regarding "Case Series and Systematic Review of Electronic Scooter Crashes and Severe Traumatic Brain Injury".

Armocida, Daniele / Santoro, Antonio / Frati, Alessandro

2023 Volume 173, Page(s) 301–302

MeSH term(s)	Humans ; Accidents, Traffic ; Brain Injuries, Traumatic/epidemiology ; Retrospective Studies
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.02.130
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Article ; Online: Letter to editor regarding: "Vertebral bone quality score independently predicts cage subsidence following transforaminal lumbar interbody fusion" by Soliman et al.

Armocida, Daniele / Proietti, Luca / Frati, Alessandro

The spine journal : official journal of the North American Spine Society

2023 Volume 23, Issue 8, Page(s) 1237–1238

MeSH term(s)	Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion/adverse effects ; Retrospective Studies
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2037072-6
ISSN	1878-1632 ; 1529-9430
ISSN (online)	1878-1632
ISSN	1529-9430
DOI	10.1016/j.spinee.2023.04.019
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Article ; Online: Combined Anterior Odontoid Screw Fixation and C1-C2 Jefferson Fracture Anterior Fixation: A Step-by-Step Technical Note.

Frati, Alessandro / Cimatti, Marco / Ileyassoff, Hernán / Capobianco, Mattia / Santoro, Antonio / Armocida, Daniele

World neurosurgery

2024 Volume 184, Page(s) 112–118

Abstract: Background: Combined triple atlas (C1)-axis (C2) fixation has been described in previous literature as a safe, effective, and minimally invasive procedure for complex atlas and odontoid fractures that allows for a greater range of motion compared with ... ...

Abstract	Background: Combined triple atlas (C1)-axis (C2) fixation has been described in previous literature as a safe, effective, and minimally invasive procedure for complex atlas and odontoid fractures that allows for a greater range of motion compared with posterior approaches and atlanto-occipital fusion. However, it is rarely performed due to the occipital-cervical diastasis resulting from often-fractured C1 joint masses. No evidence-based consensus has been reached regarding the treatment of complex atlantoaxial fractures, and the choice of surgical strategy is based only on clinical experience. Methods: We report the combined triple C1-C2 fixation technique with manual reduction of the joint masses during patient positioning on the operating table, which allowed for effective stabilization during a single surgical session. We describe our experience in the management of a 75-year-old patient presenting with an acute complex type II fracture of C1, which also involved 1 lateral mass, combined with a type II odontoid fracture and occipital-cervical diastasis. Results: We provide a step-by-step guide for combined triple C1-C2 anterior fixation with manual fracture reduction and describe the clinical case of an acute complex type II fracture of C1, which also involved 1 lateral mass, combined with a type II odontoid fracture and occipital-cervical diastasis. Conclusions: Combined triple C1-C2 fixation represents a safe and efficient minimally invasive anterior approach for complex type II fractures of C1 with type II odontoid fractures. Manual reduction of the joint masses during patient positioning allows for effective stabilization in a single surgical session.
MeSH term(s)	Humans ; Aged ; Odontoid Process/diagnostic imaging ; Odontoid Process/surgery ; Odontoid Process/injuries ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery ; Bone Screws ; Fractures, Bone ; Fracture Fixation ; Neck Injuries ; Fracture Fixation, Internal/methods
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.01.094
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Article ; Online: Radiological and surgical aspects of polymorphous low-grade neuroepithelial tumor of the young (PLNTY).

Armocida, Daniele / Berra, Luigi Valentino / Frati, Alessandro / Santoro, Antonio

Acta neurologica Belgica

2023 Volume 123, Issue 2, Page(s) 327–340

Abstract: Background: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a low-grade epilepsy-associated tumor recently introduced in WHO 2021 classification. Since it has been recognized as an independent nosological entity, PLNTY has been ... ...

Abstract	Background: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a low-grade epilepsy-associated tumor recently introduced in WHO 2021 classification. Since it has been recognized as an independent nosological entity, PLNTY has been mainly studied from a genetic and molecular perspective, not recognizing unique characteristic clinical and radiological features. Methods: A systematic literature research has been conducted aiming to identify all relevant studies about the radiological, clinical and surgical features of PLNTY. We described a representative case of a 45-year-old man treated with awake-surgery with confirmed diagnosis of PLNTY, reporting the radiological and surgical characteristics through imaging and intra-operative video. We performed a statistical meta-analysis attempting to assess the presence of relationships between surgical and radiologic tumor characteristics and clinical outcome and type of surgery. Results: A total of 16 studies were included in the systematic review. The final cohort was composed of 51 patients. Extent of resection (EOR) and outcome are not significantly associated with the different genetic profiling (p = 1), the presence of cystic intralesional component, calcification (p = 0.85), contrast-enhancing and lesion boundaries (p = 0.82). No significant correlation there is between EOR and remission or better control of epilepsy-related symptoms (p = 0.38). The contrast enhancement in the tumor is significantly associated with recurrence or poor control of epileptic symptoms (p = 0.07). Conclusions: In PLNTYs, contrast enhancement seems to impact prognosis, recurrence, and seizure control much more than radiological features, genetic features and type of resection of the tumor.
MeSH term(s)	Male ; Humans ; Middle Aged ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Brain Neoplasms/pathology ; Neoplasms, Neuroepithelial/diagnostic imaging ; Neoplasms, Neuroepithelial/genetics ; Neoplasms, Neuroepithelial/surgery ; Radiography ; Epilepsy/genetics ; Seizures/complications
Language	English
Publishing date	2023-03-10
Publishing country	Italy
Document type	Meta-Analysis ; Case Reports ; Journal Article ; Review
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-023-02231-z
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Article ; Online: The Role of Cellular Prion Protein in Glioma Tumorigenesis Could Be through the Autophagic Mechanisms: A Narrative Review.

Armocida, Daniele / Busceti, Carla Letizia / Biagioni, Francesca / Fornai, Francesco / Frati, Alessandro

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: The carcinogenesis of glial tumors appears complex because of the many genetic and epigenetic phenomena involved. Among these, cellular prion protein (PrPC) is considered a key factor in cell-death resistance and important aspect implicated in ... ...

Abstract	The carcinogenesis of glial tumors appears complex because of the many genetic and epigenetic phenomena involved. Among these, cellular prion protein (PrPC) is considered a key factor in cell-death resistance and important aspect implicated in tumorigenesis. Autophagy also plays an important role in cell death in various pathological conditions. These two cellular phenomena are related and share the same activation by specific alterations in the cellular microenvironment. Furthermore, there is an interdependence between autophagy and prion activity in glioma tumorigenesis. Glioma is one of the most aggressive known cancers, and the fact that such poorly studied processes as autophagy and PrPC activity are so strongly involved in its carcinogenesis suggests that by better understanding their interaction, more can be understood about its origin and treatment. Few studies in the literature relate these two cellular phenomena, much less try to explain their combined activity and role in glioma carcinogenesis. In this study, we explored the recent findings on the molecular mechanism and regulation pathways of autophagy, examining the role of PrPC in autophagy processes and how they may play a central role in glioma tumorigenesis. Among the many molecular interactions that PrP physiologically performs, it appears that processes shared with autophagy activity are those most implicated in glial tumor carcinogeneses such as activity on MAP kinases, PI3K, and mTOR. This work can be supportive and valuable as a basis for further future studies on this topic.
MeSH term(s)	Humans ; Prion Proteins ; Prions/metabolism ; Glioma/genetics ; Autophagy ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic/genetics ; PrPC Proteins/metabolism ; Tumor Microenvironment
Chemical Substances	Prion Proteins ; Prions ; PrPC Proteins
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021405
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Article: Editorial: Novel techniques and technologies in spine surgery: New approaches for the traumatic, oncologic, and aging spine.

Palmieri, Mauro / Frati, Alessandro / D'Andrea, Giancarlo / Santoro, Antonio / Salvati, Maurizio / Pesce, Alessandro

Frontiers in surgery

2023 Volume 10, Page(s) 1155636

Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1155636
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Article ; Online: An understimated maneuver for oculomotor nerve palsy due to posterior communicating artery aneurysm: the opening of the anterior petroclinoid ligament. A technical note.

LA Pira, Biagia / Picotti, Veronica / Frati, Alessandro / Pesce, Alessandro / D'Andrea, Giancarlo

Journal of neurosurgical sciences

2023

Abstract: Posterior communicating artery aneurysms (PcomAs) present with oculomotor nerve (OMN) palsy in 20-30% of cases, and the sudden onset of OMN palsy has to raise the suspicion of rupture, until proven otherwise. The surgical technique is described in a ... ...

Abstract	Posterior communicating artery aneurysms (PcomAs) present with oculomotor nerve (OMN) palsy in 20-30% of cases, and the sudden onset of OMN palsy has to raise the suspicion of rupture, until proven otherwise. The surgical technique is described in a stepwise fashion. An illustrative case is reported: a 57-year-old female was admitted to our department with the diagnosis of a right sided-PcomA. Three months before the admission, when she harbored with the acute onset of complete ptosis, diplopia, orbital pain, impairment of the medial, upward, and downward gaze, with no pupil dysfunction. The origin of the Pcom and the neck of the aneurysm were easily identified and the aneurysm was clipped. Then, we followed the OMN and cut for less than 4 mm the above-lying anterior petroclinoid ligament (APL) to obtain nerve release. Although few cases are described in the literature, and ours represents a single case, we support that this maneuver should be introduced in the clinical practice of expert neurosurgeons dealing with vascular pathologies, such as the opening of the falciform ligament occurs for the decompression of the optical nerve.
Language	English
Publishing date	2023-05-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	193139-8
ISSN	1827-1855 ; 0390-5616 ; 0026-4881
ISSN (online)	1827-1855
ISSN	0390-5616 ; 0026-4881
DOI	10.23736/S0390-5616.23.06020-4
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Article ; Online: Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration.

Biagioni, Francesca / Ferrucci, Michela / Lazzeri, Gloria / Scioli, Mariarosaria / Frati, Alessandro / Puglisi-Allegra, Stefano / Fornai, Francesco

International journal of molecular sciences

2024 Volume 25, Issue 6

Abstract: The present investigation was designed based on the evidence that, in neurodegenerative disorders, such as Alzheimer's dementia (AD) and Parkinson's disease (PD), damage to the locus coeruleus (LC) arising norepinephrine (NE) axons (LC-NE) is documented ... ...

Abstract	The present investigation was designed based on the evidence that, in neurodegenerative disorders, such as Alzheimer's dementia (AD) and Parkinson's disease (PD), damage to the locus coeruleus (LC) arising norepinephrine (NE) axons (LC-NE) is documented and hypothesized to foster the onset and progression of neurodegeneration within target regions. Specifically, the present experiments were designed to assess whether selective damage to LC-NE axons may alter key proteins involved in neurodegeneration within specific limbic regions, such as the hippocampus and piriform cortex, compared with the dorsal striatum. To achieve this, a loss of LC-NE axons was induced by the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) in C57 Black mice, as assessed by a loss of NE and dopamine-beta-hydroxylase within target regions. In these experimental conditions, the amount of alpha-synuclein (alpha-syn) protein levels were increased along with alpha-syn expressing neurons within the hippocampus and piriform cortex. Similar findings were obtained concerning phospho-Tau immunoblotting. In contrast, a decrease in inducible HSP70-expressing neurons and a loss of sequestosome (p62)-expressing cells, along with a loss of these proteins at immunoblotting, were reported. The present data provide further evidence to understand why a loss of LC-NE axons may foster limbic neurodegeneration in AD and limbic engagement during PD.
MeSH term(s)	Mice ; Animals ; Locus Coeruleus/metabolism ; Norepinephrine/metabolism ; Neurons/metabolism ; Neurotoxins/pharmacology ; Axons/metabolism ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Parkinson Disease/metabolism
Chemical Substances	Norepinephrine (X4W3ENH1CV) ; Neurotoxins
Language	English
Publishing date	2024-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25063159
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Article ; Online: Combined light and electron microscopy (CLEM) to quantify methamphetamine-induced alpha-synuclein-related pathology.

Ferrucci, Michela / Lenzi, Paola / Lazzeri, Gloria / Busceti, Carla L / Frati, Alessandro / Puglisi-Allegra, Stefano / Fornai, Francesco

Journal of neural transmission (Vienna, Austria : 1996)

2024 Volume 131, Issue 4, Page(s) 335–358

Abstract: Methamphetamine (METH) produces a cytopathology, which is rather specific within catecholamine neurons both in vitro and ex vivo, in animal models and chronic METH abusers. This led some authors to postulate a sort of parallelism between METH ... ...

Abstract	Methamphetamine (METH) produces a cytopathology, which is rather specific within catecholamine neurons both in vitro and ex vivo, in animal models and chronic METH abusers. This led some authors to postulate a sort of parallelism between METH cytopathology and cell damage in Parkinson's disease (PD). In fact, METH increases and aggregates alpha-syn proto-fibrils along with producing spreading of alpha-syn. Although alpha-syn is considered to be the major component of aggregates and inclusions developing within diseased catecholamine neurons including classic Lewy body (LB), at present, no study provided a quantitative assessment of this protein in situ, neither following METH nor in LB occurring in PD. Similarly, no study addressed the quantitative comparison between occurrence of alpha-syn and other key proteins and no investigation measured the protein compared with non-protein structure within catecholamine cytopathology. Therefore, the present study addresses these issues using an oversimplified model consisting of a catecholamine cell line where the novel approach of combined light and electron microscopy (CLEM) was used measuring the amount of alpha-syn, which is lower compared with p62 or poly-ubiquitin within pathological cell domains. The scenario provided by electron microscopy reveals unexpected findings, which are similar to those recently described in the pathology of PD featuring packing of autophagosome-like vesicles and key proteins shuttling autophagy substrates. Remarkably, small seed-like areas, densely packed with p62 molecules attached to poly-ubiquitin within wide vesicular domains occurred. The present data shed new light about quantitative morphometry of catecholamine cell damage in PD and within the addicted brain.
MeSH term(s)	Animals ; Methamphetamine/pharmacology ; alpha-Synuclein/metabolism ; Parkinson Disease/metabolism ; Microscopy, Electron ; Catecholamines ; Ubiquitins
Chemical Substances	Methamphetamine (44RAL3456C) ; alpha-Synuclein ; Catecholamines ; Ubiquitins
Language	English
Publishing date	2024-02-17
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	184163-4
ISSN	1435-1463 ; 0300-9564
ISSN (online)	1435-1463
ISSN	0300-9564
DOI	10.1007/s00702-024-02741-x
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Article ; Online: Is There a Place for Lewy Bodies before and beyond Alpha-Synuclein Accumulation? Provocative Issues in Need of Solid Explanations.

Lenzi, Paola / Lazzeri, Gloria / Ferrucci, Michela / Scotto, Marco / Frati, Alessandro / Puglisi-Allegra, Stefano / Busceti, Carla Letizia / Fornai, Francesco

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: In the last two decades, alpha-synuclein (alpha-syn) assumed a prominent role as a major component and seeding structure of Lewy bodies (LBs). This concept is driving ongoing research on the pathophysiology of Parkinson's disease (PD). In line with this, ...

Abstract	In the last two decades, alpha-synuclein (alpha-syn) assumed a prominent role as a major component and seeding structure of Lewy bodies (LBs). This concept is driving ongoing research on the pathophysiology of Parkinson's disease (PD). In line with this, alpha-syn is considered to be the guilty protein in the disease process, and it may be targeted through precision medicine to modify disease progression. Therefore, designing specific tools to block the aggregation and spreading of alpha-syn represents a major effort in the development of disease-modifying therapies in PD. The present article analyzes concrete evidence about the significance of alpha-syn within LBs. In this effort, some dogmas are challenged. This concerns the question of whether alpha-syn is more abundant compared with other proteins within LBs. Again, the occurrence of alpha-syn compared with non-protein constituents is scrutinized. Finally, the prominent role of alpha-syn in seeding LBs as the guilty structure causing PD is questioned. These revisited concepts may be helpful in the process of validating which proteins, organelles, and pathways are likely to be involved in the damage to meso-striatal dopamine neurons and other brain regions involved in PD.
MeSH term(s)	Humans ; alpha-Synuclein ; Lewy Bodies ; Parkinson Disease ; Corpus Striatum ; Disease Progression
Chemical Substances	alpha-Synuclein
Language	English
Publishing date	2024-04-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073929
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