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  1. Article: Editorial: Applications of metabolomics to the discovery of biomolecules from natural products.

    Choi, Young Hae / Jang, Young Pyo / Frédérich, Michel

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1190730

    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1190730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Overview of Natural Antiplasmodials from the Last Decade to Inspire Medicinal Chemistry.

    Degotte, Gilles / Pirotte, Bernard / Francotte, Pierre / Frédérich, Michel

    Current medicinal chemistry

    2021  Volume 28, Issue 30, Page(s) 6199–6233

    Abstract: Background: Despite major advances in the fight against this parasitic disease, malaria remained a major cause of concern in 2021. This infection, mainly due to Plasmodium falciparum, causes more than 200 million cases every year and hundreds of ... ...

    Abstract Background: Despite major advances in the fight against this parasitic disease, malaria remained a major cause of concern in 2021. This infection, mainly due to Plasmodium falciparum, causes more than 200 million cases every year and hundreds of thousands deaths in the developing regions, mostly in Africa. The last statistics show an increase in the cases for the third consecutive year; from 211 million in 2015, it has reached 229 million in 2019. This trend could be partially explained by the appearance of resistance to all the used antimalarials, including artemisinin. Thus, the design of new anti- Plasmodium compounds is an urgent need. For thousands of years, nature has offered humans medicines to cure their diseases or the inspiration for the development of new active principles. It then seems logical to explore the natural sources to find new molecules to treat this parasitosis.
    Methods: Therefore, this review reports and analyzes the extracts (plants, bacteria, sponges, fungi) and the corresponding isolated compounds, showing antiplasmodial properties between 2013 and 2019.
    Results and conclusion: Nature remains a major source of active compounds. Indeed, 648 molecules from various origins, mostly plants, have been reported for their inhibitory effect on Plasmodium falciparum. Among them, 188 scaffolds were defined as highly active with IC
    MeSH term(s) Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Chemistry, Pharmaceutical ; Humans ; Malaria/drug therapy ; Plant Extracts/therapeutic use ; Plasmodium ; Plasmodium falciparum
    Chemical Substances Antimalarials ; Plant Extracts
    Language English
    Publishing date 2021-03-26
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867328666210329112354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
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  3. Article ; Online: Polyhydroxybenzoic acid derivatives as potential new antimalarial agents.

    Degotte, Gilles / Pirotte, Bernard / Frédérich, Michel / Francotte, Pierre

    Archiv der Pharmazie

    2021  Volume 354, Issue 11, Page(s) e2100190

    Abstract: With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria ... ...

    Abstract With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria since 2015 (from 211 million in 2015 to 229 million in 2019). This trend could partially be due to the development of resistance to all the current drugs. Therefore, there is an urgent need for new alternatives. We have, thus, selected common natural scaffolds, polyhydroxybenzoic acids, and synthesized a library of derivatives to better understand the structure-activity relationships explaining their antiplasmodial effect. Only gallic acid derivatives showed a noticeable potential for further developments. Indeed, they showed a selective inhibitory effect on Plasmodium (IC
    Language English
    Publishing date 2021-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202100190
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  4. Article ; Online: Comparison of Three Widely Employed Extraction Methods for Metabolomic Analysis of Trypanosoma brucei.

    Fall, Fanta / Desmet, Lieven / Mamede, Lúcia / Schioppa, Laura / de Tullio, Pascal / Frédérich, Michel / Govaerts, Bernadette / Quetin-Leclercq, Joëlle

    Current protocols

    2024  Volume 4, Issue 5, Page(s) e1043

    Abstract: Trypanosoma brucei (Tb) is the causative agent of human African trypanosomiasis (HAT), also known as sleeping sickness, which can be fatal if left untreated. An understanding of the parasite's cellular metabolism is vital for the discovery of new ... ...

    Abstract Trypanosoma brucei (Tb) is the causative agent of human African trypanosomiasis (HAT), also known as sleeping sickness, which can be fatal if left untreated. An understanding of the parasite's cellular metabolism is vital for the discovery of new antitrypanosomal drugs and for disease eradication. Metabolomics can be used to analyze numerous metabolic pathways described as essential to Tb. brucei but has some limitations linked to the metabolites' physicochemical properties and the extraction process. To develop an optimized method for extracting and analyzing Tb. brucei metabolites, we tested the three most commonly used extraction methods, analyzed the extracts by hydrophilic interaction liquid chromatography high-resolution mass spectrometry (HILIC LC-HRMS), and further evaluated the results using quantitative criteria including the number, intensity, reproducibility, and variability of features, as well as qualitative criteria such as the specific coverage of relevant metabolites. Here, we present the resulting protocols for untargeted metabolomic analysis of Tb. brucei using (HILIC LC-HRMS). © 2024 Wiley Periodicals LLC. Basic Protocol 1: Culture of Trypanosoma brucei brucei parasites Basic Protocol 2: Preparation of samples for metabolomic analysis of Trypanosoma brucei brucei Basic Protocol 3: LC-HRMS-based metabolomic data analysis of Trypanosoma brucei brucei.
    MeSH term(s) Trypanosoma brucei brucei/metabolism ; Metabolomics/methods ; Chromatography, Liquid/methods ; Mass Spectrometry/methods ; Trypanosomiasis, African/parasitology
    Language English
    Publishing date 2024-05-06
    Publishing country United States
    Document type Journal Article ; Comparative Study ; Research Support, Non-U.S. Gov't
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.1043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparison of extraction methods in vitro Plasmodium falciparum: A

    Mamede, Lúcia / Fall, Fanta / Schoumacher, Matthieu / Ledoux, Allison / Bugli, Céline / De Tullio, Pascal / Quetin-Leclercq, Joëlle / Govaerts, Bernadette / Frédérich, Michel

    Biochemical and biophysical research communications

    2024  Volume 703, Page(s) 149684

    Abstract: Malaria is a parasitic disease that remains a global concern and the subject of many studies. Metabolomics has emerged as an approach to better comprehend complex pathogens and discover possible drug targets, thus giving new insights that can aid in the ... ...

    Abstract Malaria is a parasitic disease that remains a global concern and the subject of many studies. Metabolomics has emerged as an approach to better comprehend complex pathogens and discover possible drug targets, thus giving new insights that can aid in the development of antimalarial therapies. However, there is no standardized method to extract metabolites from in vitro Plasmodium falciparum intraerythrocytic parasites, the stage that causes malaria. Additionally, most methods are developed with either LC-MS or NMR analysis in mind, and have rarely been evaluated with both tools. In this work, three extraction methods frequently found in the literature were reproduced and samples were analyzed through both LC-MS and
    MeSH term(s) Humans ; Plasmodium falciparum/metabolism ; Liquid Chromatography-Mass Spectrometry ; Chromatography, Liquid/methods ; Proton Magnetic Resonance Spectroscopy ; Methanol/metabolism ; Tandem Mass Spectrometry/methods ; Metabolomics/methods ; Malaria ; Antimalarials
    Chemical Substances Methanol (Y4S76JWI15) ; Antimalarials
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149684
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    Zs.A 116: Show issues Location:
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  6. Article ; Conference proceedings: Identification and profiling of flavonoids in ten samples of Alliaria petiolata aerial parts collected from Belgium.

    Marotte, Alison / Nouet, Cécile / Bonnet, Olivier / Hanikenne, Marc / Frederich, Michel

    Planta Medica

    2023  Volume 89, Issue 14

    Event/congress 71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
    Language English
    Publishing date 2023-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0043-1773945
    Database Thieme publisher's database

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  7. Article ; Online: Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents.

    Mamede, Lucia / Ledoux, Allison / Jansen, Olivia / Frédérich, Michel

    Planta medica

    2020  Volume 86, Issue 9, Page(s) 585–618

    Abstract: Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, ... ...

    Abstract Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the
    MeSH term(s) Antimalarials ; Coumarins ; Humans ; Malaria ; Plants ; Plasmodium falciparum ; Structure-Activity Relationship
    Chemical Substances Antimalarials ; Coumarins
    Language English
    Publishing date 2020-04-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-1148-9000
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  8. Article ; Online: In vitro antiviral activity against SARS-CoV-2 of common herbal medicinal extracts and their bioactive compounds.

    Leka, Kristi / Hamann, Carla / Desdemoustier, Pauline / Frédérich, Michel / Garigliany, Mutien-Marie / Ledoux, Allison

    Phytotherapy research : PTR

    2022  Volume 36, Issue 8, Page(s) 3013–3015

    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Plant Extracts/pharmacology ; Plants, Medicinal ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Plant Extracts
    Language English
    Publishing date 2022-04-09
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.7463
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    Zs.B 3092: Show issues Location:
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  9. Article ; Online: Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues.

    Degotte, Gilles / Frederich, Michel / Francotte, Pierre / Franck, Thierry / Colson, Thomas / Serteyn, Didier / Mouithys-Mickalad, Ange

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 11

    Abstract: Malaria is an infectious disease caused by ... ...

    Abstract Malaria is an infectious disease caused by a
    MeSH term(s) Humans ; Antioxidants/chemistry ; Antimalarials/pharmacology ; Reactive Oxygen Species/pharmacology ; Neutrophils ; Ellagic Acid/pharmacology ; Peroxidase/metabolism ; Oxidation-Reduction ; Malaria ; Plasmodium/metabolism
    Chemical Substances Antioxidants ; Antimalarials ; Reactive Oxygen Species ; Ellagic Acid (19YRN3ZS9P) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28114516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: OSMAC Method to Assess Impact of Culture Parameters on Metabolomic Diversity and Biological Activity of Marine-Derived Actinobacteria.

    Le Loarer, Alexandre / Dufossé, Laurent / Bignon, Jérôme / Frédérich, Michel / Ledoux, Allison / Fouillaud, Mireille / Gauvin-Bialecki, Anne

    Marine drugs

    2023  Volume 22, Issue 1

    Abstract: Actinobacteria are known for their production of bioactive specialized metabolites, but they are still under-exploited. This study uses the "One Strain Many Compounds" (OSMAC) method to explore the potential of three preselected marine-derived ... ...

    Abstract Actinobacteria are known for their production of bioactive specialized metabolites, but they are still under-exploited. This study uses the "One Strain Many Compounds" (OSMAC) method to explore the potential of three preselected marine-derived actinobacteria:
    MeSH term(s) Actinobacteria ; Antimalarials/pharmacology ; Metabolomics ; Micromonosporaceae ; Bacteria ; Micromonospora
    Chemical Substances Antimalarials
    Language English
    Publishing date 2023-12-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22010023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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