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  1. Article ; Online: Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer.

    Stevens, Kristen N / Wang, Xianshu / Fredericksen, Zachary / Pankratz, V Shane / Cerhan, James / Vachon, Celine M / Olson, Janet E / Couch, Fergus J

    Breast cancer research and treatment

    2011  Volume 129, Issue 2, Page(s) 617–622

    Abstract: Mitotic regulatory pathways insure proper timing of mitotic entry, sister chromatid cohesion and separation, and cytokinesis. Disruption of this process results in inappropriate chromosome segregation and aneuploidy, and appears to contribute to cancer. ... ...

    Abstract Mitotic regulatory pathways insure proper timing of mitotic entry, sister chromatid cohesion and separation, and cytokinesis. Disruption of this process results in inappropriate chromosome segregation and aneuploidy, and appears to contribute to cancer. Specifically, disregulation and somatic mutation of mitotic regulators has been observed in human cancers, and overexpression of mitotic regulators is common in aggressive and late stage tumors. However, the role of germline variation in mitotic pathways and risk of cancer is not well understood. We tested 1,084 haplotype-tagging and functional variants from 164 genes in mitotic regulatory pathways in 791 Caucasian women with breast cancer and 843 healthy controls for association with risk of overall and high grade breast cancer. Sixty-one single nucleotide polymorphisms (SNPs) from 40 genes were associated (P < 0.05) with risk of breast cancer in a log-additive model. In addition, 60 SNPs were associated (P < 0.05) with risk of high grade breast cancer. However, none of these associations were significant after Bonferroni correction for multiple testing. In gene-level analyses, CDC25C, SCC1/RAD21, TLK2, and SMC6L1 were associated (P < 0.05) with overall breast cancer risk, CDC6, CDC27, SUMO3, RASSF1, KIF2, and CDC14A were associated with high grade breast cancer risk, and EIF3S10 and CDC25A were associated with both. Further investigation in breast and other cancers are needed to understand the influence of inherited variation in mitotic genes on tumor grade and cancer risk.
    MeSH term(s) Breast Neoplasms/ethnology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Case-Control Studies ; European Continental Ancestry Group/genetics ; Female ; Genes, cdc ; Genetic Predisposition to Disease ; Heredity ; Humans ; Logistic Models ; Minnesota ; Mitosis/genetics ; Neoplasm Grading ; Odds Ratio ; Pedigree ; Phenotype ; Polymorphism, Single Nucleotide ; Principal Component Analysis ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2011-05-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-011-1587-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1655: Show issues Location:
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  2. Article ; Online: Trans fatty acid intake is associated with increased risk and n3 fatty acid intake with reduced risk of non-hodgkin lymphoma.

    Charbonneau, Bridget / O'Connor, Helen M / Wang, Alice H / Liebow, Mark / Thompson, Carrie A / Fredericksen, Zachary S / Macon, William R / Slager, Susan L / Call, Timothy G / Habermann, Thomas M / Cerhan, James R

    The Journal of nutrition

    2013  Volume 143, Issue 5, Page(s) 672–681

    Abstract: We evaluated the association of dietary fat and protein intake with risk of non-Hodgkin lymphoma (NHL) in a clinic-based study in 603 cases (including 218 chronic lymphocytic leukemia/small lymphocytic lymphoma, 146 follicular lymphoma, and 105 diffuse ... ...

    Abstract We evaluated the association of dietary fat and protein intake with risk of non-Hodgkin lymphoma (NHL) in a clinic-based study in 603 cases (including 218 chronic lymphocytic leukemia/small lymphocytic lymphoma, 146 follicular lymphoma, and 105 diffuse large B-cell lymphoma) and 1007 frequency-matched controls. Usual diet was assessed with a 128-item food-frequency questionnaire. Unconditional logistic regression was used to estimate ORs and 95% CIs, and polytomous logistic regression was used to assess subtype-specific risks. trans Fatty acid (TFA) intake was positively associated with NHL risk [OR = 1.60 for highest vs. lowest quartile (95% CI = 1.18, 2.15); P-trend = 0.0014], n3 (ω3) fatty acid intake was inversely associated with risk [OR = 0.48 (95% CI = 0.35, 0.65); P-trend < 0.0001], and there was no association with total, animal, plant-based, or saturated fat intake. When examining intake of specific foods, processed meat [OR = 1.37 (95% CI = 1.02, 1.83); P-trend = 0.03], milk containing any fat [OR = 1.47 (95% CI = 1.16, 1.88); P-trend = 0.0025], and high-fat ice cream [OR = 4.03 (95% CI = 2.80, 5.80); P-trend < 0.0001], intakes were positively associated with risk, whereas intakes of fresh fish and total seafood [OR = 0.61 (95% CI = 0.46, 0.80); P-trend = 0.0025] were inversely associated with risk. Overall, there was little evidence for NHL subtype-specific heterogeneity. In conclusion, diets high in TFAs, processed meats, and higher fat dairy products were positively associated with NHL risk, whereas diets high in n3 fatty acids and total seafood were inversely associated with risk.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Confidence Intervals ; Diet/adverse effects ; Diet Surveys ; Dietary Fats/adverse effects ; Dietary Fats/therapeutic use ; Fatty Acids, Omega-3/therapeutic use ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/etiology ; Leukemia, Lymphocytic, Chronic, B-Cell/prevention & control ; Leukemia, Lymphoid/etiology ; Leukemia, Lymphoid/prevention & control ; Logistic Models ; Lymphoma, B-Cell/etiology ; Lymphoma, B-Cell/prevention & control ; Lymphoma, Follicular/etiology ; Lymphoma, Follicular/prevention & control ; Lymphoma, Non-Hodgkin/etiology ; Lymphoma, Non-Hodgkin/prevention & control ; Male ; Middle Aged ; Odds Ratio ; Risk Factors ; Surveys and Questionnaires ; Trans Fatty Acids/adverse effects
    Chemical Substances Dietary Fats ; Fatty Acids, Omega-3 ; Trans Fatty Acids
    Language English
    Publishing date 2013-03-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.3945/jn.112.168658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: A clinic-based case-control study

    Charbonneau, Bridget / Maurer, Matthew J / Ansell, Stephen M / Slager, Susan L / Fredericksen, Zachary S / Ziesmer, Steven C / Macon, William R / Habermann, Thomas M / Witzig, Thomas E / Link, Brian K / Cerhan, James R / Novak, Anne J

    Cytokine. 2012 Dec., v. 60, no. 3

    2012  

    Abstract: BACKGROUND: Abnormal immune function is a key factor in predisposition to non-Hodgkin lymphoma (NHL). We evaluated the association of 30 cytokines individually and as a profile with diffuse large B-cell (DLBCL) and follicular (FL) lymphomas. METHODS: We ... ...

    Abstract BACKGROUND: Abnormal immune function is a key factor in predisposition to non-Hodgkin lymphoma (NHL). We evaluated the association of 30 cytokines individually and as a profile with diffuse large B-cell (DLBCL) and follicular (FL) lymphomas. METHODS: We used a multiplexed assay to measure 30 cytokine concentrations in pre-treatment serum in a case-control study of 234 FL, 188 DLBCL, and 400 control participants. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age and sex, and polytomous regression was used to evaluate heterogeneity between FL and DLBCL. Principal components analysis (PCA) was used to assess cytokine profiles associated with FL and DLBCL. RESULTS: In single cytokine modeling, we found that 12 of the 30 circulating serum cytokines were significantly (P<0.05) associated with FL and/or DLBCL after accounting for multiple testing (q<0.05). Soluble IL-2R (sIL-2R) had the strongest association with both FL (OR=6.0 for highest versus lowest tertile, 95% CI 3.8–9.5; p-trend=1.8×10⁻²¹) and DLBCL (OR=7.6, 95% CI 4.5–13.1; p-trend=7.2×10⁻²⁰). IL1RA and IL-12p40 also showed similar associations for DLBCL and FL. In contrast, HGF, MIG, and MIP-1α had a stronger association with DLBCL compared to FL, and IL-6, IL-8, IL-10, IFN-γ, IP-10, and VEGF were only statistically significantly associated with DLBCL after accounting for multiple testing. However, in PCA modeling, a cytokine profile based on sIL-2R, IL-1RA, MIG, IP-10, IL-8, and IL-12p40 explained most of the variability between controls and both FL and DLBCL. CONCLUSIONS: We identified some cytokines unique to DLBCL, but overall cytokine associations were more similar than distinct for DLBCL and FL. While these data are limited by concerns of reverse causality, they do suggest cytokines and cytokine profiles that can be prioritized in future studies.
    Keywords B-lymphocytes ; blood serum ; case-control studies ; confidence interval ; interleukin-10 ; interleukin-6 ; interleukin-8 ; models ; non-Hodgkin lymphoma ; odds ratio ; pretreatment ; principal component analysis ; regression analysis
    Language English
    Dates of publication 2012-12
    Size p. 882-889.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2012.08.028
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: A two-stage evaluation of genetic variation in immune and inflammation genes with risk of non-Hodgkin lymphoma identifies new susceptibility locus in 6p21.3 region.

    Cerhan, James R / Fredericksen, Zachary S / Novak, Anne J / Ansell, Stephen M / Kay, Neil E / Liebow, Mark / Dogan, Ahmet / Cunningham, Julie M / Wang, Alice H / Witzig, Thomas E / Habermann, Thomas M / Asmann, Yan W / Slager, Susan L

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2012  Volume 21, Issue 10, Page(s) 1799–1806

    Abstract: Background: Non-Hodgkin lymphoma (NHL) is a malignancy of lymphocytes, and there is growing evidence for a role of germline genetic variation in immune genes in NHL etiology.: Methods: To identify susceptibility immune genes, we conducted a 2-stage ... ...

    Abstract Background: Non-Hodgkin lymphoma (NHL) is a malignancy of lymphocytes, and there is growing evidence for a role of germline genetic variation in immune genes in NHL etiology.
    Methods: To identify susceptibility immune genes, we conducted a 2-stage analysis of single-nucleotide polymorphisms (SNP) from 1,253 genes using the Immune and Inflammation Panel. In Stage 1, we genotyped 7,670 SNPs in 425 NHL cases and 465 controls, and in Stage 2 we genotyped the top 768 SNPs on an additional 584 cases and 768 controls. The association of individual SNPs with NHL risk from a log-additive model was assessed using the OR and 95% confidence intervals (CI).
    Results: In the pooled analysis, only the TAP2 coding SNP rs241447 (minor allele frequency = 0.26; Thr655Ala) at 6p21.3 (OR = 1.34, 95% CI 1.17-1.53) achieved statistical significance after accounting for multiple testing (P = 3.1 × 10(-5)). The TAP2 SNP was strongly associated with follicular lymphoma (FL, OR = 1.82, 95%CI 1.46-2.26; p = 6.9 × 10(-8)), and was independent of other known loci (rs10484561 and rs2647012) from this region. The TAP2 SNP was also associated with diffuse large B-cell lymphoma (DLBCL, OR = 1.38, 95% CI 1.08-1.77; P = 0.011), but not chronic lymphocytic leukemia (OR = 1.08; 95% CI 0.88-1.32). Higher TAP2 expression was associated with the risk allele in both FL and DLBCL tumors.
    Conclusion: Genetic variation in TAP2 was associated with NHL risk overall, and FL risk in particular, and this was independent of other established loci from 6p21.3.
    Impact: Genetic variation in antigen presentation of HLA class I molecules may play a role in lymphomagenesis.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 3 ; ATP-Binding Cassette Transporters/genetics ; Adult ; Aged ; Case-Control Studies ; Chromosome Mapping ; Chromosomes, Human, Pair 6 ; Female ; Genetic Loci ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Linkage Disequilibrium ; Lymphoma, Non-Hodgkin/etiology ; Lymphoma, Non-Hodgkin/genetics ; Lymphoma, Non-Hodgkin/immunology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 3 ; ATP-Binding Cassette Transporters ; TAP2 protein, human (145892-13-3)
    Language English
    Publishing date 2012-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-12-0696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3693: Show issues Location:
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  5. Article ; Online: The association between early life and adult body mass index and physical activity with risk of non-Hodgkin lymphoma: impact of gender.

    Kelly, Jennifer L / Fredericksen, Zachary S / Liebow, Mark / Shanafelt, Tait D / Thompson, Carrie A / Call, Timothy G / Habermann, Thomas M / Macon, William R / Wang, Alice H / Slager, Susan L / Cerhan, James R

    Annals of epidemiology

    2012  Volume 22, Issue 12, Page(s) 855–862

    Abstract: Purpose: To evaluate the association of body mass index (BMI) and physical activity (PA) during adulthood and at the age of 18 years with risk of non-Hodgkin lymphoma (NHL).: Methods: We enrolled 950 newly diagnosed NHL patients and 1146 frequency- ... ...

    Abstract Purpose: To evaluate the association of body mass index (BMI) and physical activity (PA) during adulthood and at the age of 18 years with risk of non-Hodgkin lymphoma (NHL).
    Methods: We enrolled 950 newly diagnosed NHL patients and 1146 frequency-matched clinic-based controls. Height, weight, and PA (recent adult and at the age of 18 years) were self-reported. Odds ratios (ORs), 95% confidence intervals, and tests for trend were estimated using unconditional logistic regression adjusted for age, gender, and residence.
    Results: BMI at the age of 18 years was associated with an increased NHL risk (OR, 1.38 for highest vs. lowest quartile; p-trend = .0012), which on stratified analysis was specific to females (OR, 1.90; p-trend = .00025). There was no association of adult BMI with NHL risk. Higher PA in adulthood (OR, 1.03; p-trend = .85) or at the age of 18 years (OR, 0.88; 95% confidence interval, 0.72-1.07) was not associated with risk, but there was an inverse association for adult PA that was specific to females (OR, 0.71; p-trend = .039). Only BMI at the age of 18 years remained significantly associated with NHL risk when modeled together with PA in adulthood or at the age of 18 years. There was little evidence for heterogeneity in these results for the common NHL subtypes.
    Conclusions: Early adult BMI may be of greatest relevance to NHL risk, particularly in females.
    MeSH term(s) Adolescent ; Adult ; Aged ; Body Mass Index ; Case-Control Studies ; Confidence Intervals ; Female ; Humans ; Logistic Models ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/epidemiology ; Lymphoma, Non-Hodgkin/etiology ; Male ; Middle Aged ; Motor Activity ; Obesity/complications ; Odds Ratio ; Residence Characteristics ; Risk Factors ; Sex Characteristics ; Sex Factors ; Socioeconomic Factors ; Surveys and Questionnaires ; Time Factors ; Young Adult
    Language English
    Publishing date 2012-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1074355-8
    ISSN 1873-2585 ; 1047-2797
    ISSN (online) 1873-2585
    ISSN 1047-2797
    DOI 10.1016/j.annepidem.2012.10.002
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    Zs.A 3225: Show issues Location:
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  6. Article ; Online: Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: a clinic-based case-control study.

    Charbonneau, Bridget / Maurer, Matthew J / Ansell, Stephen M / Slager, Susan L / Fredericksen, Zachary S / Ziesmer, Steven C / Macon, William R / Habermann, Thomas M / Witzig, Thomas E / Link, Brian K / Cerhan, James R / Novak, Anne J

    Cytokine

    2012  Volume 60, Issue 3, Page(s) 882–889

    Abstract: Background: Abnormal immune function is a key factor in predisposition to non-Hodgkin lymphoma (NHL). We evaluated the association of 30 cytokines individually and as a profile with diffuse large B-cell (DLBCL) and follicular (FL) lymphomas.: Methods!# ...

    Abstract Background: Abnormal immune function is a key factor in predisposition to non-Hodgkin lymphoma (NHL). We evaluated the association of 30 cytokines individually and as a profile with diffuse large B-cell (DLBCL) and follicular (FL) lymphomas.
    Methods: We used a multiplexed assay to measure 30 cytokine concentrations in pre-treatment serum in a case-control study of 234 FL, 188 DLBCL, and 400 control participants. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age and sex, and polytomous regression was used to evaluate heterogeneity between FL and DLBCL. Principal components analysis (PCA) was used to assess cytokine profiles associated with FL and DLBCL.
    Results: In single cytokine modeling, we found that 12 of the 30 circulating serum cytokines were significantly (P<0.05) associated with FL and/or DLBCL after accounting for multiple testing (q<0.05). Soluble IL-2R (sIL-2R) had the strongest association with both FL (OR=6.0 for highest versus lowest tertile, 95% CI 3.8-9.5; p-trend=1.8 × 10(-21)) and DLBCL (OR=7.6, 95% CI 4.5-13.1; p-trend=7.2 × 10(-20)). IL1RA and IL-12p40 also showed similar associations for DLBCL and FL. In contrast, HGF, MIG, and MIP-1α had a stronger association with DLBCL compared to FL, and IL-6, IL-8, IL-10, IFN-γ, IP-10, and VEGF were only statistically significantly associated with DLBCL after accounting for multiple testing. However, in PCA modeling, a cytokine profile based on sIL-2R, IL-1RA, MIG, IP-10, IL-8, and IL-12p40 explained most of the variability between controls and both FL and DLBCL.
    Conclusions: We identified some cytokines unique to DLBCL, but overall cytokine associations were more similar than distinct for DLBCL and FL. While these data are limited by concerns of reverse causality, they do suggest cytokines and cytokine profiles that can be prioritized in future studies.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cytokines/blood ; Female ; Humans ; Lymphocytes/immunology ; Lymphoma, Follicular/blood ; Lymphoma, Follicular/immunology ; Lymphoma, Large B-Cell, Diffuse/blood ; Lymphoma, Large B-Cell, Diffuse/immunology ; Male ; Middle Aged ; Odds Ratio ; Young Adult
    Chemical Substances Cytokines
    Language English
    Publishing date 2012-09-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2012.08.028
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  7. Article ; Online: Risk factors for intrahepatic cholangiocarcinoma: association between metformin use and reduced cancer risk.

    Chaiteerakij, Roongruedee / Yang, Ju Dong / Harmsen, William S / Slettedahl, Seth W / Mettler, Teresa A / Fredericksen, Zachary S / Kim, W Ray / Gores, Gregory J / Roberts, Rosebud O / Olson, Janet E / Therneau, Terry M / Roberts, Lewis R

    Hepatology (Baltimore, Md.)

    2012  Volume 57, Issue 2, Page(s) 648–655

    Abstract: Unlabelled: The associations between diabetes, smoking, obesity, and intrahepatic cholangiocarcinoma (ICC) risk remain inconclusive. Metformin is purportedly associated with a reduced risk for various cancers. This case-control study evaluated risk ... ...

    Abstract Unlabelled: The associations between diabetes, smoking, obesity, and intrahepatic cholangiocarcinoma (ICC) risk remain inconclusive. Metformin is purportedly associated with a reduced risk for various cancers. This case-control study evaluated risk factors for ICC and explored the effects of metformin on ICC risk in a clinic/hospital-based cohort. ICC patients observed at the Mayo Clinic (Rochester, MN) between January 2000 and May 2010 were identified. Age, sex, ethnicity, and residential area-matched controls were selected from among Mayo Clinic Biobank participants. The associations between potential factors and ICC risk were determined. Six hundred and twelve cases and 594 controls were identified. Factors associated with increased ICC risk included biliary tract diseases (adjusted odds ratio [AOR]: 81.8; 95% confidence interval [CI]: 11.2-598.8; P < 0.001), cirrhosis (AOR, 8.0; 95% CI: 1.8-36.5; P = 0.007), diabetes (AOR, 3.6; 95% CI: 2.3-5.5; P < 0.001), and smoking (AOR, 1.6; 95% CI: 1.3-2.1; P < 0.001). Compared to diabetic patients not treated with metformin, the odds ratio (OR) for ICC for diabetic patients treated with metformin was significantly decreased (OR, 0.4; 95% CI: 0.2-0.9; P = 0.04). Obesity and metabolic syndrome were not associated with ICC.
    Conclusion: This study confirmed diabetes and smoking as independent risk factors for ICC. A novel finding was that treatment with metformin was significantly associated with a 60% reduction in ICC risk in diabetic patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms/etiology ; Bile Ducts, Intrahepatic ; Case-Control Studies ; Cholangiocarcinoma/etiology ; Cholangiocarcinoma/prevention & control ; Diabetes Complications/prevention & control ; Diabetes Mellitus/drug therapy ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hyperlipidemias/drug therapy ; Liver Neoplasms/etiology ; Liver Neoplasms/prevention & control ; Male ; Metformin/therapeutic use ; Middle Aged ; Obesity/complications ; Regression Analysis ; Risk Factors ; Smoking/adverse effects
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Metformin (9100L32L2N)
    Language English
    Publishing date 2012-12-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.26092
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  8. Article ; Online: No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer

    White Kristin L / Collins Francis S / Fredericksen Zachary S / Vierkant Robert A / Prokunina-Olsson Ludmila / Szabo Csilla / Goode Ellen L / Schmidt Michele / Fridley Brooke L / Couch Fergus J

    BMC Cancer, Vol 9, Iss 1, p

    2009  Volume 312

    Abstract: Abstract Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No ... ...

    Abstract Abstract Background TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Methods Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori -defined subsets. Results No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Conclusion Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed.
    Keywords Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 616
    Language English
    Publishing date 2009-09-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Design and validity of a clinic-based case-control study on the molecular epidemiology of lymphoma.

    Cerhan, James R / Fredericksen, Zachary S / Wang, Alice H / Habermann, Thomas M / Kay, Neil E / Macon, William R / Cunningham, Julie M / Shanafelt, Tait D / Ansell, Stephen M / Call, Timothy G / Witzig, Thomas E / Slager, Susan L / Liebow, Mark

    International journal of molecular epidemiology and genetics

    2011  Volume 2, Issue 2, Page(s) 95–113

    Abstract: We present the design features and implementation of a clinic-based case-control study on the molecular epidemiology of lymphoma conducted at the Mayo Clinic (Rochester, Minnesota, USA), and then assess the internal and external validity of the study. ... ...

    Abstract We present the design features and implementation of a clinic-based case-control study on the molecular epidemiology of lymphoma conducted at the Mayo Clinic (Rochester, Minnesota, USA), and then assess the internal and external validity of the study. Cases were newly diagnosed lymphoma patients from Minnesota, Iowa and Wisconsin seen at Mayo and controls were patients from the same region without lymphoma who had a pre-scheduled general medical examination, frequency matched on age, sex and residence. Overall response rates were 67% for cases and 70% for controls; response rates were lower for cases and controls over age 70 years, cases with more aggressive disease, and controls from the local area, although absolute differences were modest. Cases and controls were well-balanced on age, sex, and residence characteristics. Demographic and disease characteristics of NHL cases were similar to population-based cancer registry data. Control distributions were similar to population-based data on lifestyle factors and minor allele frequencies of over 500 SNPs, although smoking rates were slightly lower. Associations with NHL in the Mayo study for smoking, alcohol use, family history of lymphoma, autoimmune disease, asthma, eczema, body mass index, and single nucleotide polymorphisms in TNF (rs1800629), LTA (rs909253), and IL10 (rs1800896) were at a magnitude consistent with estimates from pooled studies in InterLymph, with history of any allergy the only directly discordant result in the Mayo study. These data suggest that this study should have strong internal and external validity. This framework may be useful to others who are designing a similar study.
    Language English
    Publishing date 2011-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2553441-5
    ISSN 1948-1756 ; 1948-1756
    ISSN (online) 1948-1756
    ISSN 1948-1756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma.

    Holtan, Shernan G / O'Connor, Helen M / Fredericksen, Zachary S / Liebow, Mark / Thompson, Carrie A / Macon, William R / Micallef, Ivana N / Wang, Alice H / Slager, Susan L / Habermann, Thomas M / Call, Timothy G / Cerhan, James R

    International journal of cancer

    2011  Volume 131, Issue 5, Page(s) 1158–1168

    Abstract: Antioxidants, primarily from fruits and vegetables, have been hypothesized to protect against non-Hodgkin lymphoma (NHL). The oxygen radical absorbance capacity (ORAC) assay, which measures total antioxidant capacity of individual foods and accounts for ... ...

    Abstract Antioxidants, primarily from fruits and vegetables, have been hypothesized to protect against non-Hodgkin lymphoma (NHL). The oxygen radical absorbance capacity (ORAC) assay, which measures total antioxidant capacity of individual foods and accounts for synergism, can be estimated using a food-frequency questionnaire (FFQ). We tested the hypothesis that higher intake of antioxidant nutrients from foods, supplements and FFQ-based ORAC values are associated with a lower risk of NHL in a clinic-based study of 603 incident cases and 1,007 frequency-matched controls. Diet was assessed with a 128-item FFQ. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals adjusted for age, sex, residence and total energy. Dietary intake of α-tocopherol (OR=0.50; p-trend=0.0002), β-carotene (OR=0.58; p-trend=0.0005), lutein/zeaxanthin (OR=0.62; p-trend=0.005), zinc (OR=0.54; p-trend=0.003) and chromium (OR=0.68; p-trend=0.032) was inversely associated with NHL risk. Inclusion of supplement use had little impact on these associations. Total vegetables (OR=0.52; p-trend<0.0001), particularly green leafy (OR=0.52; p-trend<0.0001) and cruciferous (OR=0.68; p-trend=0.045) vegetables, were inversely associated with NHL risk. NHL risk was inversely associated with both hydrophilic ORAC (OR=0.61, p-trend=0.003) and lipophilic ORAC (OR=0.48, p-trend=0.0002), although after simultaneous adjustment for other antioxidants or total vegetables, only the association for lipophilic ORAC remained significant. There was no striking heterogeneity in results across the common NHL subtypes. Higher antioxidant intake as estimated by the FFQ-ORAC, particularly the lipophilic component, was associated with a lower NHL risk after accounting for other antioxidant nutrients and vegetable intake, supporting this as potentially useful summary measure of total antioxidant intake.
    MeSH term(s) Adult ; Aged ; Antioxidants/therapeutic use ; Case-Control Studies ; Diet ; Female ; Free Radical Scavengers/chemistry ; Fruit ; Humans ; Lymphoma, Non-Hodgkin/classification ; Lymphoma, Non-Hodgkin/epidemiology ; Lymphoma, Non-Hodgkin/prevention & control ; Male ; Middle Aged ; Minnesota/epidemiology ; Prognosis ; Reactive Oxygen Species/chemistry ; Risk Factors ; Surveys and Questionnaires ; Vegetables ; alpha-Tocopherol/administration & dosage ; beta Carotene/administration & dosage
    Chemical Substances Antioxidants ; Free Radical Scavengers ; Reactive Oxygen Species ; beta Carotene (01YAE03M7J) ; alpha-Tocopherol (H4N855PNZ1)
    Language English
    Publishing date 2011-11-30
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.26491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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