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  1. Article: Activation of Cryptochrome 4 from Atlantic Herring.

    Frederiksen, Anders / Aldag, Mandus / Solov'yov, Ilia A / Gerhards, Luca

    Biology

    2024  Volume 13, Issue 4

    Abstract: Marine fish migrate long distances up to hundreds or even thousands of kilometers for various reasons that include seasonal dependencies, feeding, or reproduction. The ability to perceive the geomagnetic field, called magnetoreception, is one of the many ...

    Abstract Marine fish migrate long distances up to hundreds or even thousands of kilometers for various reasons that include seasonal dependencies, feeding, or reproduction. The ability to perceive the geomagnetic field, called magnetoreception, is one of the many mechanisms allowing some fish to navigate reliably in the aquatic realm. While it is believed that the photoreceptor protein cryptochrome 4 (Cry4) is the key component for the radical pair-based magnetoreception mechanism in night migratory songbirds, the Cry4 mechanism in fish is still largely unexplored. The present study aims to investigate properties of the fish Cry4 protein in order to understand the potential involvement in a radical pair-based magnetoreception. Specifically, a computationally reconstructed atomistic model of Cry4 from the Atlantic herring (
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13040262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of in vitro irradiation setup: Designed for the horizontal beamline at the Danish Centre for Particle Therapy.

    Frederiksen, Anders Tobias / Jensen, Morten Bjørn / Poulsen, Per Rugaard / Bassler, Niels / Sørensen, Brita Singers / Sitarz, Mateusz

    Acta oncologica (Stockholm, Sweden)

    2024  Volume 63, Page(s) 23–27

    Abstract: Background: Radiobiological experimental setups are challenged by precise sample positioning along depth dose profile, scattering conditions, and practical difficulties that must be addressed in individual designs. The aim of this study was to produce ... ...

    Abstract Background: Radiobiological experimental setups are challenged by precise sample positioning along depth dose profile, scattering conditions, and practical difficulties that must be addressed in individual designs. The aim of this study was to produce cell survival curves with several irradiation modalities, by using a setup designed at the Danish Centre for Particle Therapy (DCPT) for in vitro proton irradiations using a horizontal beam line and thereby evaluating the setups use for in vitro irradiations experiments.
    Materials and methods: The setup is a water phantom suitable for in vitro research with multiple irradiation modalities, in particular the pencil scanning proton beam available from a horizontal experimental beamline. The phantom included a water tank of 39.0 × 17.0 × 20.5 cm. Cell survival-curves were produced using the cell line V79 Chinese hamster lung fibroblast cells (V79s) in biological triplicates of clonogenic assays. Cell survival curves were produced with both a 18 MeV electron beam, 6 MV photon beam, and a Spread-Out Bragg Peak (SOBP) proton beam formed by pristine energies of 85-111 MeV where three positions were examined.
    Results: Survival curves with uncertainty areas were made for all modalities. Dosimetric uncertainty amounted to, respectively, 4%, 3% and 3% for proton, electron, and high energy photon irradiations. Cell survival fraction uncertainty was depicted as the standard deviation between replications of the experiment.
    Conclusion: Cell survival curves could be produced with acceptable uncertainties using this novel water phantom and cellular laboratory workflow. The setup is useful for future in vitro irradiation experiments.
    MeSH term(s) Animals ; Cricetinae ; Humans ; Protons ; Photons ; Cell Survival ; Water ; Denmark
    Chemical Substances Protons ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.2340/1651-226X.2024.19657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Job satisfaction and employee turnover

    Frederiksen, Anders

    a firm-level perspective

    (Discussion paper series / Forschungsinstitut zur Zukunft der Arbeit ; 9296)

    2015  

    Abstract: In this paper, I study an employment situation where the employer and the employees cooperate about the implementation of a job satisfaction survey. Cooperation is valuable because it improves the firm's ability to predict employee quits, but it is only ... ...

    Author's details Anders Frederiksen
    Series title Discussion paper series / Forschungsinstitut zur Zukunft der Arbeit ; 9296
    Abstract In this paper, I study an employment situation where the employer and the employees cooperate about the implementation of a job satisfaction survey. Cooperation is valuable because it improves the firm's ability to predict employee quits, but it is only an equilibrium outcome because the employer-employee relation is repeated and long-term. Using a unique combination of firm-level data and information from job satisfaction surveys, the empirical analysis reveals that the cooperation reduces the firm's employee turnover costs significantly by improving its ability to predict quits. This cost reduction may easily exceed the cost of conducting the survey. The analysis also reveals that the firm is willing to sacrifice profits in a given year to be able to sustain the cooperative relationship with the employees.
    Keywords Arbeitszufriedenheit ; Arbeitsplatzwechsel ; Mitarbeiterbefragung ; Mitbestimmung ; Deutschland ; quits ; job satisfaction ; cooperation ; retention
    Language Undetermined
    Size Online-Ressource (25 S.), graph. Darst.
    Publisher IZA
    Publishing place Bonn
    Document type Book ; Online
    Database ECONomics Information System

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  4. Book ; Online: Job satisfaction and employee turnover

    Frederiksen, Anders

    a firm-level perspective

    (Working paper series / Center for Economic Institutions, Institute for Economic Research, Hitotsubashi University ; 2015,04)

    2015  

    Author's details Anders Frederiksen
    Series title Working paper series / Center for Economic Institutions, Institute for Economic Research, Hitotsubashi University ; 2015,04
    Keywords Arbeitszufriedenheit ; Arbeitsplatzwechsel ; Mitarbeiterbefragung ; Mitbestimmung ; Deutschland ; quits ; job satisfaction ; cooperation ; retention
    Language Undetermined
    Size Online-Ressource (41 S.)
    Publisher Center for Economic Inst., Inst. for Economic Research, Hitotsubashi Univ
    Publishing place Tokyo
    Document type Book ; Online
    Database ECONomics Information System

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  5. Book ; Article ; Online: Does Group-Based Incentive Pay Lead To Higher Productivity? Evidence from a Complex and Interdependent Industrial Production Process

    Frederiksen, Anders / Hansen, Daniel Baltzer Schjødt / Flaherty Manchester, Colleen

    2022  

    Abstract: Group-based incentive pay is attractive in contexts where production is complex and interdependent, yet freeriding is a paramount concern. We assess the introduction of group-based performance pay in a modern industrial production setting using ... ...

    Abstract Group-based incentive pay is attractive in contexts where production is complex and interdependent, yet freeriding is a paramount concern. We assess the introduction of group-based performance pay in a modern industrial production setting using difference-in-difference estimation. Performance increased by 19 percent, with three quarters coming from increased performance of existing workers and the remaining from selection; workers became more efficient and were absent less often. We find little evidence of freeriding; quantile regressions show increased performance throughout the distribution of workers. Features of the design and implementation process created trust, a common goal, and a shared identity, which limited freeriding.
    Keywords ddc:330 ; M5 ; J33 ; L23 ; difference-in-differences ; performance pay ; group-based incentive ; freeriding ; incentive effects ; selection effects ; absenteeism ; efficiency ; performance ; productivity ; trust
    Subject code 338
    Language English
    Publisher Bonn: Institute of Labor Economics (IZA)
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Electrodiagnostic Testing of Large Fiber Polyneuropathies: A Review of Existing Guidelines.

    Tankisi, Hatice / Pugdahl, Kirsten / Fuglsang-Frederiksen, Anders

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2020  Volume 37, Issue 4, Page(s) 277–287

    Abstract: Electrodiagnostic testing for polyneuropathies is a large part of the diagnostic workup in all electrodiagnostic laboratories. Guidelines on examination and diagnostic strategies and classification of polyneuropathies are crucial for standardization of ... ...

    Abstract Electrodiagnostic testing for polyneuropathies is a large part of the diagnostic workup in all electrodiagnostic laboratories. Guidelines on examination and diagnostic strategies and classification of polyneuropathies are crucial for standardization of electrodiagnostic testing and best clinical practice. Several guidelines have been suggested on pathophysiological classification, particularly for the definition of inflammatory neuropathies, whereas for axonal polyneuropathies, the literature is sparse. Similarly, there are a few recommendations on examination and diagnostic strategies. This review will cover the existing guidelines on electrodiagnostic testing of large fiber polyneuropathies including examination and diagnostic strategies and pathophysiological classification. In addition, the diagnostic criteria for Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, and hereditary neuropathies are summarized.
    MeSH term(s) Electrodiagnosis/methods ; Humans ; Neurophysiology/methods ; Polyneuropathies/diagnosis ; Practice Guidelines as Topic
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000674
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    Zs.A 1921: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Electrodiagnostic Testing of Entrapment Neuropathies: A Review of Existing Guidelines.

    Pugdahl, Kirsten / Tankisi, Hatice / Fuglsang-Frederiksen, Anders

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2020  Volume 37, Issue 4, Page(s) 299–305

    Abstract: Entrapment neuropathies cover a wide range of isolated nerve injuries along the course of the upper and lower extremity nerves. Electrodiagnostic (EDX) testing is usually an essential part of the evaluation of entrapment neuropathies, and examinations ... ...

    Abstract Entrapment neuropathies cover a wide range of isolated nerve injuries along the course of the upper and lower extremity nerves. Electrodiagnostic (EDX) testing is usually an essential part of the evaluation of entrapment neuropathies, and examinations for the most common entrapment neuropathies, carpal tunnel syndrome and ulnar neuropathy at the elbow, constitute a significant part of the daily work in EDX laboratories. Despite this, guidelines for EDX testing are generally sparse or do not exist for entrapment neuropathies, whereas a wide variety of different techniques are available to the clinical neurophysiologist. This study reviews the existing, more or less, detailed EDX criteria or practice parameters that are suggested by consensus groups in peer-reviewed journals for the most common entrapment neuropathies: carpal tunnel syndrome, ulnar neuropathy at the elbow, common peroneal (fibular) neuropathy at the fibular head, and tibial neuropathy at the tarsal tunnel. It is concluded that future research is needed to develop and refine EDX guidelines in entrapment neuropathies.
    MeSH term(s) Electrodiagnosis/methods ; Humans ; Nerve Compression Syndromes/diagnosis ; Neurophysiology/methods ; Practice Guidelines as Topic
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000668
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  8. Article ; Online: Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation.

    Høie, Magnus Haraldson / Cagiada, Matteo / Beck Frederiksen, Anders Haagen / Stein, Amelie / Lindorff-Larsen, Kresten

    Cell reports

    2022  Volume 38, Issue 2, Page(s) 110207

    Abstract: Understanding and predicting the functional consequences of single amino acid changes is central in many areas of protein science. Here, we collect and analyze experimental measurements of effects of >150,000 variants in 29 proteins. We use biophysical ... ...

    Abstract Understanding and predicting the functional consequences of single amino acid changes is central in many areas of protein science. Here, we collect and analyze experimental measurements of effects of >150,000 variants in 29 proteins. We use biophysical calculations to predict changes in stability for each variant and assess them in light of sequence conservation. We find that the sequence analyses give more accurate prediction of variant effects than predictions of stability and that about half of the variants that show loss of function do so due to stability effects. We construct a machine learning model to predict variant effects from protein structure and sequence alignments and show how the two sources of information support one another and enable mechanistic interpretations. Together, our results show how one can leverage large-scale experimental assessments of variant effects to gain deeper and general insights into the mechanisms that cause loss of function.
    MeSH term(s) Amino Acid Substitution ; Animals ; Computational Biology/methods ; Forecasting/methods ; Humans ; Machine Learning ; Mutation/genetics ; Mutation/physiology ; Protein Stability ; Proteins/metabolism ; Sequence Alignment/methods ; Sequence Analysis, DNA/methods
    Chemical Substances Proteins
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.110207
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  9. Article ; Online: Mutational Study of the Tryptophan Tetrad Important for Electron Transfer in European Robin Cryptochrome 4a.

    Frederiksen, Anders / Langebrake, Corinna / Hanić, Maja / Manthey, Georg / Mouritsen, Henrik / Liedvogel, Miriam / Solov'yov, Ilia A

    ACS omega

    2023  Volume 8, Issue 29, Page(s) 26425–26436

    Abstract: The ability of migratory birds to sense magnetic fields has been known for decades, although the understanding of the underlying mechanism is still elusive. Currently, the strongest magnetoreceptor candidate in birds is a protein called cryptochrome 4a. ... ...

    Abstract The ability of migratory birds to sense magnetic fields has been known for decades, although the understanding of the underlying mechanism is still elusive. Currently, the strongest magnetoreceptor candidate in birds is a protein called cryptochrome 4a. The cryptochrome 4a protein has changed through evolution, apparently endowing some birds with a more pronounced magnetic sensitivity than others. Using phylogenetic tools, we show that a specific tryptophan tetrad and a tyrosine residue predicted to be essential for cryptochrome activation are highly conserved in the avian clade. Through state-of-the-art molecular dynamics simulations and associated analyses, we also studied the role of these specific residues and the associated mutants on the overall dynamics of the protein. The analyses of the single residue mutations were used to judge how far a local change in the protein structure can impact specific dynamics of European robin cryptochrome 4a. We conclude that the replacements of each of the tryptophans one by one with a phenylalanine do not compromise the overall stability of the protein.
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02963
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  10. Article ; Online: Adaptive evolution and loss of a putative magnetoreceptor in passerines.

    Langebrake, Corinna / Manthey, Georg / Frederiksen, Anders / Lugo Ramos, Juan S / Dutheil, Julien Y / Chetverikova, Raisa / Solov'yov, Ilia A / Mouritsen, Henrik / Liedvogel, Miriam

    Proceedings. Biological sciences

    2024  Volume 291, Issue 2016, Page(s) 20232308

    Abstract: Migratory birds possess remarkable accuracy in orientation and navigation, which involves various compass systems including the magnetic compass. Identifying the primary magnetosensor remains a fundamental open question. Cryptochromes (Cry) have been ... ...

    Abstract Migratory birds possess remarkable accuracy in orientation and navigation, which involves various compass systems including the magnetic compass. Identifying the primary magnetosensor remains a fundamental open question. Cryptochromes (Cry) have been shown to be magnetically sensitive, and Cry4a from a migratory songbird seems to show enhanced magnetic sensitivity
    MeSH term(s) Animals ; Phylogeny ; Songbirds/physiology ; Cryptochromes/metabolism ; Magnetic Fields ; Animal Migration/physiology
    Chemical Substances Cryptochromes
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2023.2308
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    Zs.A 1364: Show issues Location:
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