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  1. Article ; Online: Toxicity due to steroid treatment in ITP remains a concern.

    Frederiksen, Henrik

    British journal of haematology

    2024  Volume 204, Issue 5, Page(s) 1600–1601

    Abstract: Corticosteroids are the preferred first-line treatment in ITP in guidelines. The analyses by Wang et al. shows that hospital-registered steroid-related toxicity occurs frequently and emphasizes that exposure should be for a limited duration of time. ... ...

    Abstract Corticosteroids are the preferred first-line treatment in ITP in guidelines. The analyses by Wang et al. shows that hospital-registered steroid-related toxicity occurs frequently and emphasizes that exposure should be for a limited duration of time. Commentary on: Wang et al. Longitudinal evaluation of adverse events due to steroid use in primary immune thrombocytopenia: a population-based study. Br J Haematol 2024;204:1986-1993.
    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Adrenal Cortex Hormones/adverse effects ; Female
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A leap in recognizing drug-induced immune hemolytic anemia.

    Hansen, Dennis Lund / Frederiksen, Henrik

    Blood advances

    2024  Volume 8, Issue 3, Page(s) 815–816

    MeSH term(s) Humans ; Cohort Studies ; Risk Assessment
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Experimental bladder reconstruction

    Frederiksen, Hans

    (Doctoral dissertation series ; 2007,125)

    2007  

    Author's details Hans Frederiksen
    Series title Doctoral dissertation series ; 2007,125
    Collection
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 2007
    HBZ-ID HT015367138
    ISBN 978-91-85897-03-2 ; 91-85897-03-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2007 E 2479 order for loan Magazin

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  4. Article ; Online: The incidence and mortality of neutropenic fever in hematologic patients did not change during the SARS-CoV2 pandemic.

    Brabrand, M / Bogh, S B / Fløjstrup, M / Frederiksen, H

    Acute medicine

    2024  Volume 22, Issue 4, Page(s) 201–203

    Abstract: During the current SARS-CoV2 pandemic, fear of nosocomial infection could keep neutropenic patients from contacting the healthcare system with infection. We analyzed nationwide hospital contacts for neutropenic fever during the first seven weeks of the ... ...

    Abstract During the current SARS-CoV2 pandemic, fear of nosocomial infection could keep neutropenic patients from contacting the healthcare system with infection. We analyzed nationwide hospital contacts for neutropenic fever during the first seven weeks of the Danish shelter at home order. Using national registers, we extracted data on all unplanned hospital contacts due to neutropenic fever. We included 311 admissions, 13-30 per week, and found no difference between 2017-2019 and 2020. The incidence rate ratio varied between 0.68 and 1.11 with no effect on mortality. Thus, our data indicate that Danish neutropenic patients are admitted with fever, even during a pandemic.
    MeSH term(s) Humans ; Incidence ; RNA, Viral ; Pandemics ; Neutropenia/epidemiology ; Neutropenia/etiology ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2024-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213243-0
    ISSN 1747-4892 ; 1747-4884 ; 1476-5063
    ISSN (online) 1747-4892
    ISSN 1747-4884 ; 1476-5063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Disseminated Melanoma: A Disappearing Left Ventricular Mass.

    Frederiksen, Hunter / Ashwath, Mahi L

    CASE (Philadelphia, Pa.)

    2023  Volume 7, Issue 11, Page(s) 456–460

    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Case Reports
    ISSN 2468-6441
    ISSN (online) 2468-6441
    DOI 10.1016/j.case.2023.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Dehydrated hereditary stomatocytosis: clinical perspectives.

    Frederiksen, Henrik

    Journal of blood medicine

    2019  Volume 10, Page(s) 183–191

    Abstract: Dehydrated hereditary stomatocytosis (DHSt) is a nonimmune congenital hemolytic disorder characterized by red blood cell (RBC) dehydration and lysis. It has been a recognized diagnostic entity for almost 50 years, and autosomal dominant inheritance has ... ...

    Abstract Dehydrated hereditary stomatocytosis (DHSt) is a nonimmune congenital hemolytic disorder characterized by red blood cell (RBC) dehydration and lysis. It has been a recognized diagnostic entity for almost 50 years, and autosomal dominant inheritance has long been suspected, but it was not until 2011 that the first genetic alterations were identified. The current study reviews 73 articles published during 1971-2019 and focuses on clinical perspectives of the disease. All but one of the published clinical data in DHSt were either single case reports or case series. From these, it can be seen that patients with DHSt often have fully or partially compensated hemolysis with few symptoms. Despite this, iron overload is an almost universal finding even in patients without or with only sporadic blood transfusions, and this may lead to organ dysfunction. Other severe complications, such as thrombosis and perinatal fluid effusions unrelated to fetal hemoglobin concentration, may also occur. No specific treatment for symptomatic hemolysis exists, and splenectomy should be avoided as it seems to aggravate the risk of thrombosis. Recently, treatment with senicapoc has shown activity against RBC dehydration in vitro; however, it is not known if this translates into relevant clinical effects. In conclusion, despite recent advances in the understanding of pathophysiology in DHSt, options for clinical management have not improved. Entering data into international registries has the potential to fill gaps in knowledge and eventually care of these rare patients.
    Language English
    Publishing date 2019-07-04
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2587464-0
    ISSN 1179-2736
    ISSN 1179-2736
    DOI 10.2147/JBM.S179764
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  7. Article: Early Mortality in Paroxysmal Nocturnal Hemoglobinuria.

    Sørensen, Anne Lykke / Lund Hansen, Dennis / Frederiksen, Henrik

    Cureus

    2023  Volume 15, Issue 10, Page(s) e47225

    Abstract: Objectives:  The elevated mortality risk among patients with paroxysmal nocturnal hemoglobinuria (PNH) has been suggested to derive from a high risk of thromboembolism (TE); however, the risks of coexisting cardiovascular risk factors are not well ... ...

    Abstract Objectives:  The elevated mortality risk among patients with paroxysmal nocturnal hemoglobinuria (PNH) has been suggested to derive from a high risk of thromboembolism (TE); however, the risks of coexisting cardiovascular risk factors are not well described. We studied mortality associated with PNH taking comorbidity and treatment into account.
    Methods: Patients with PNH (n=115) were identified in the 1977-2016 Danish National Patient Register (DNPR). For each patient with PNH, we identified 50 age- and sex-matched general population comparators. Using the Kaplan-Meier estimator and Cox regression, we compared the overall survival of patients with comparators. Cumulative incidences were used to analyze the effects of comorbidity and the causes of death.
    Results: One-year survival among patients and comparators was 92.2% and 99.4%, and after 10 years, it was 68.4% and 85.8%, respectively. Early mortality was associated with older age, higher levels of comorbidity, and solid malignancies prior to PNH diagnosis. The leading causes of death were infections and associated hematological diseases. Patients with early mortality were less likely to have received treatment with eculizumab and/or warfarin. Cardiovascular risk factors were evenly distributed between patients and comparators at diagnosis.
    Conclusion: We conclude that early mortality in PNH is associated with older age, cardiovascular comorbidity, and hematological malignancies.
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47225
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  8. Article ; Online: Balance on slack line; diagnostic intensity and patient safety during the SARS-CoV-2 pandemic.

    Jensen, Henry / Frederiksen, Henrik

    Acta oncologica (Stockholm, Sweden)

    2021  Volume 60, Issue 1, Page(s) 1–3

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Delivery of Health Care ; Humans ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy ; Patient Safety ; Periodicals as Topic ; Risk ; SARS-CoV-2
    Language English
    Publishing date 2021-01-08
    Publishing country England
    Document type Editorial
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2020.1867766
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    Zs.A 6348: Show issues Location:
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  9. Article ; Online: Mental health and use of psychotropic prescription drugs in adult patients with primary immune thrombocytopenia: a nationwide population-based cohort study.

    Mannering, Nikolaj / Hansen, Dennis Lund / Pottegård, Anton / Andersen, Kjeld / Frederiksen, Henrik

    Haematologica

    2024  

    Abstract: Patients with primary immune thrombocytopenia (ITP) suffer from reduced survival and quality of life, but the underlying reasons for this are largely undescribed. Mental health and the use of psychotropic drugs in ITP is unknown. We investigated the risk ...

    Abstract Patients with primary immune thrombocytopenia (ITP) suffer from reduced survival and quality of life, but the underlying reasons for this are largely undescribed. Mental health and the use of psychotropic drugs in ITP is unknown. We investigated the risk of hospital registered mental health events including fatigue and the use of psychotropic drugs in adult patients with ITP compared with the general population, using nationwide registry-data. We identified 3,749 patients with ITP and 149,849 age-sex matched general population comparators in the Danish Health Registries in the period 1997-2016. The median age was 60 years (IQR 40-73) and 53% were women. We followed the individuals for incident mental health events and estimated the use of psychotropic drugs over calendar-years and in temporal relation to diagnosis of ITP. The first year cumulative incidence of any mental health event was 2.3% (95% confidence interval, 1.9-2.9) in patients and 0.7% (0.6-0.7) in comparators, yielding an adjusted cause-specific hazard ratio (csHR) of 3.57 (2.84-4.50). The corresponding estimates for depression were 1.2% (0.9-1.6) and 0.3% (0.3-0.4) respectively, with an adjusted csHR of 3.53 (2.56-4.85). We found similar findings for anxiety and fatigue, but risks generally diminished after 1-5 years. The use of opioids, antidepressants, and benzodiazepines increased in temporal relation to diagnosis of ITP. The risk of mental health events and the use of psychotropic drugs is higher in adult patients with ITP compared with the general population, and has a temporal relation to diagnosis of ITP emphasizing that mental health in ITP is a concern.
    Language English
    Publishing date 2024-05-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2024.285364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Risk of fractures and use of bisphosphonates in adult patients with immune thrombocytopenia-A nationwide population-based study.

    Mannering, Nikolaj / Hansen, Dennis Lund / Moulis, Guillaume / Ghanima, Waleed / Pottegård, Anton / Frederiksen, Henrik

    British journal of haematology

    2024  Volume 204, Issue 4, Page(s) 1464–1475

    Abstract: Corticosteroids remain the first-line treatment of immune thrombocytopenia (ITP), but increase the risk of osteoporosis and fractures. Bisphosphonates are used for the treatment of osteoporosis, but their usage among patients with ITP has not been ... ...

    Abstract Corticosteroids remain the first-line treatment of immune thrombocytopenia (ITP), but increase the risk of osteoporosis and fractures. Bisphosphonates are used for the treatment of osteoporosis, but their usage among patients with ITP has not been systemically described. We investigated the risk of fractures and the use of bisphosphonates in adult patients with primary (pITP) and secondary ITP (sITP) compared with matched comparators in a nationwide registry-based cohort study. We identified 4030 patients with pITP (median age 60 years [IQR, 40-74]), 550 with sITP (median age 59 years [IQR, 43-74]) and 182 939 age-sex-matched general population comparators. All individuals were followed for incident fractures. Bisphosphonate use was estimated for calendar-years and in temporal relation to the ITP diagnosis. Adjusted cause-specific hazard ratio (csHR) for any fracture was 1.37 (95% confidence interval [CI] 1.23; 1.54) for pITP and 1.54 (1.17; 2.03) for sITP. The first-year csHR was 1.82 (1.39; 2.40) for pITP and 2.78 (1.58; 4.91) for sITP. Bisphosphonate use over calendar-years and in the early years following ITP diagnosis was higher among patients with ITP diagnosis compared with the general population. In conclusion, the risk of fractures and the use of bisphosphonates are higher in patients with ITP compared with the general population.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Diphosphonates/adverse effects ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Purpura, Thrombocytopenic, Idiopathic/chemically induced ; Cohort Studies ; Fractures, Bone/epidemiology ; Fractures, Bone/etiology ; Osteoporosis/drug therapy ; Osteoporosis/epidemiology ; Osteoporosis/chemically induced ; Bone Density Conservation Agents/adverse effects
    Chemical Substances Diphosphonates ; Bone Density Conservation Agents
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19301
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