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  1. Book: Advances in nuclear architecture

    Adams, Niall M. / Freemont, Paul S.

    2011  

    Author's details Niall M. Adams ; Paul S. Freemont ed
    Language English
    Size VII, 210 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016636576
    ISBN 978-90-481-9898-6 ; 9789048198993 ; 90-481-9898-4 ; 9048198992
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 6372 order for loan Magazin

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  2. Article: Synthetic biology industry: data-driven design is creating new opportunities in biotechnology.

    Freemont, Paul S

    Emerging topics in life sciences

    2021  Volume 3, Issue 5, Page(s) 651–657

    Abstract: Synthetic biology is a rapidly emerging interdisciplinary research field that is primarily built upon foundational advances in molecular biology combined with engineering design. The field considers living systems as programmable at the genetic level and ...

    Abstract Synthetic biology is a rapidly emerging interdisciplinary research field that is primarily built upon foundational advances in molecular biology combined with engineering design. The field considers living systems as programmable at the genetic level and has been defined by the development of new platform technologies. This has spurned a rapid growth in start-up companies and the new synthetic biology industry is growing rapidly, with start-up companies receiving ∼$6.1B investment since 2015 and a global synthetic biology market value estimated to be $14B by 2026. Many of the new start-ups can be grouped within a multi-layer 'technology stack'. The 'stack' comprises a number of technology layers which together can be applied to a diversity of new biotechnology applications like consumer biotechnology products and living therapies. The 'stack' also enables new commercial opportunities and value chains similar to the software design and manufacturing revolution of the 20th century. However, the synthetic biology industry is at a crucial point, as it now requires recognisable commercial successes in order for the industry to expand and scale, in terms of investment and companies. However, such expansion may directly challenge the ethos of synthetic biology, in terms of open technology sharing and democratisation, which could unintentionally lead to multi-national corporations and technology monopolies similar to the existing biotechnology/biopharma industry.
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20190040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pandemic preparedness: synthetic biology and publicly funded biofoundries can rapidly accelerate response time.

    Vickers, Claudia E / Freemont, Paul S

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 453

    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28103-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Biofoundries are a nucleating hub for industrial translation.

    Farzaneh, Tabasum / Freemont, Paul S

    Synthetic biology (Oxford, England)

    2021  Volume 6, Issue 1, Page(s) ysab013

    Abstract: Contemporary synthetic biology embraces the entire innovation pipeline; it is a transformative technology platform impacting new applications and improving existing industrial products and processes. However, challenges still emerge at the interface of ... ...

    Abstract Contemporary synthetic biology embraces the entire innovation pipeline; it is a transformative technology platform impacting new applications and improving existing industrial products and processes. However, challenges still emerge at the interface of upstream and downstream processes, integral to the value chain. It is now clear that biofoundries have a key role to play in addressing this; they provide unique and accessible infrastructure to drive the standardization necessary to deliver systematic design and engineering of biological systems and workflows. As for other biofoundries, the success of the London Biofoundry has been in part due to its expertise in establishing channels for industrial translation through its extensive strategic collaborations. It has also become cemented as a key component of various consortia and partnerships that serve the broader bioeconomy and industrial strategies. Adopting a networked approach enables links to be made between infrastructure, researchers, industrialists and policy makers to de-risk the economic challenges of scale-up, as well as contribute to the growing bioeconomy.
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-7000
    ISSN (online) 2397-7000
    DOI 10.1093/synbio/ysab013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Streptomyces

    Moore, Simon J / Lai, Hung-En / Li, Jian / Freemont, Paul S

    Natural product reports

    2023  Volume 40, Issue 2, Page(s) 228–236

    Abstract: ... ...

    Abstract Streptomyces
    MeSH term(s) Streptomyces/genetics ; Cell-Free System/metabolism ; Biological Products/metabolism ; Multigene Family
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/d2np00057a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A global forum on synthetic biology: the need for international engagement.

    Dixon, Thomas A / Freemont, Paul S / Johnson, Richard A / Pretorius, Isak S

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3516

    MeSH term(s) Global Health ; Synthetic Biology
    Language English
    Publishing date 2022-06-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31265-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Publisher Correction: DNA synthesis technologies to close the gene writing gap.

    Hoose, Alex / Vellacott, Richard / Storch, Marko / Freemont, Paul S / Ryadnov, Maxim G

    Nature reviews. Chemistry

    2023  Volume 7, Issue 8, Page(s) 590

    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Published Erratum
    ISSN 2397-3358
    ISSN (online) 2397-3358
    DOI 10.1038/s41570-023-00521-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: DNA synthesis technologies to close the gene writing gap.

    Hoose, Alex / Vellacott, Richard / Storch, Marko / Freemont, Paul S / Ryadnov, Maxim G

    Nature reviews. Chemistry

    2023  Volume 7, Issue 3, Page(s) 144–161

    Abstract: Synthetic DNA is of increasing demand across many sectors of research and commercial activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid developments if DNA can be provided at scale and low cost. Stimulated by ... ...

    Abstract Synthetic DNA is of increasing demand across many sectors of research and commercial activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid developments if DNA can be provided at scale and low cost. Stimulated by successes in next generation sequencing and gene editing technologies, DNA synthesis is already a burgeoning industry. However, the synthesis of >200 bp sequences remains unaffordable. To overcome these limitations and start writing DNA as effectively as it is read, alternative technologies have been developed including molecular assembly and cloning methods, template-independent enzymatic synthesis, microarray and rolling circle amplification techniques. Here, we review the progress in developing and commercializing these technologies, which are exemplified by innovations from leading companies. We discuss pros and cons of each technology, the need for oversight and regulatory policies for DNA synthesis as a whole and give an overview of DNA synthesis business models.
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-3358
    ISSN 2397-3358
    DOI 10.1038/s41570-022-00456-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Biological Materials: The Next Frontier for Cell-Free Synthetic Biology.

    Kelwick, Richard J R / Webb, Alexander J / Freemont, Paul S

    Frontiers in bioengineering and biotechnology

    2020  Volume 8, Page(s) 399

    Abstract: Advancements in cell-free synthetic biology are enabling innovations in sustainable biomanufacturing, that may ultimately shift the global manufacturing paradigm toward localized and ecologically harmonized production processes. Cell-free synthetic ... ...

    Abstract Advancements in cell-free synthetic biology are enabling innovations in sustainable biomanufacturing, that may ultimately shift the global manufacturing paradigm toward localized and ecologically harmonized production processes. Cell-free synthetic biology strategies have been developed for the bioproduction of fine chemicals, biofuels and biological materials. Cell-free workflows typically utilize combinations of purified enzymes, cell extracts for biotransformation or cell-free protein synthesis reactions, to assemble and characterize biosynthetic pathways. Importantly, cell-free reactions can combine the advantages of chemical engineering with metabolic engineering, through the direct addition of co-factors, substrates and chemicals -including those that are cytotoxic. Cell-free synthetic biology is also amenable to automatable design cycles through which an array of biological materials and their underpinning biosynthetic pathways can be tested and optimized in parallel. Whilst challenges still remain, recent convergences between the materials sciences and these advancements in cell-free synthetic biology enable new frontiers for materials research.
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2020.00399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A curcumin direct protein biosensor for cell-free prototyping.

    Kennedy, Agata / Griffin, Guy / Freemont, Paul S / Polizzi, Karen M / Moore, Simon J

    Engineering biology

    2022  Volume 6, Issue 2-3, Page(s) 62–68

    Abstract: In synthetic biology, biosensors are routinely coupled with a gene expression system for detecting small molecules and physical signals. We reveal a fluorescent complex, based on the interaction of ... ...

    Abstract In synthetic biology, biosensors are routinely coupled with a gene expression system for detecting small molecules and physical signals. We reveal a fluorescent complex, based on the interaction of an
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article
    ISSN 2398-6182
    ISSN (online) 2398-6182
    DOI 10.1049/enb2.12024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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