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  1. Article ; Online: Mandatory medication content in the curricula of six health care personnel types with patient contact in Denmark.

    Druedahl, Louise C / Mølby Hansen, Johanne / Freese, Ellen Linnea / Almarsdóttir, Anna Birna / Traulsen, Janine M

    Basic & clinical pharmacology & toxicology

    2018  Volume 124, Issue 4, Page(s) 431–438

    Abstract: Medication use is a complex process involving different types of health care personnel. This study investigated and compared mandatory medication content in the curricula of six types of health care personnel with patient contact. Using content analysis, ...

    Abstract Medication use is a complex process involving different types of health care personnel. This study investigated and compared mandatory medication content in the curricula of six types of health care personnel with patient contact. Using content analysis, three independent raters analysed the mandatory medication content for physicians, pharmacists, pharmaconomists, nurses, health care assistants and support workers in the Capital Region of Denmark. Three dimensions were analysed as follows: communication with patients about medication, medication use or pharmacology and medication formulation and production. ECTS credits were totalled for courses analysed to have high or medium content, and inter-rater reliability was tested with Fleiss' kappa. The total mandatory medication content for pharmacists was 197.0 ECTS, physicians 136.0 ECTS, pharmaconomists 123.3 ECTS, nurses 52.0 ECTS, health care assistants 17.8 ECTS and support workers 0.0 ECTS. Communication with patients about medication was included to the greatest extent in the educations of pharmaconomists (112.0 ECTS), pharmacists (37.5 ECTS) and physicians (25.0 ECTS). Knowledge about medication use and pharmacology was taught primarily to pharmacists (146.5 ECTS), physicians (123.6 ECTS) and pharmaconomists (89.8 ECTS) and to a lesser extent nurses (52.0 ECTS), health care assistants (17.8 ECTS) and support workers (0.0 ECTS). Medication formulation and production were taught only to pharmacists (93.0 ECTS) and pharmaconomists (25.1 ECTS). Mapping the basic competencies about medication taught to each of the six health care personnel types can lead to a better understanding of how they can complement each other in patient care. The study points to weaknesses in medication curriculum content for health care personnel with the most patient contact.
    MeSH term(s) Competency-Based Education/statistics & numerical data ; Curriculum/statistics & numerical data ; Denmark ; Drug Therapy ; Educational Measurement ; Health Personnel/education ; Humans ; Observer Variation ; Pharmaceutical Preparations/administration & dosage ; Pharmacology/education
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2018-11-07
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Apolipoprotein M in patients with chronic kidney disease.

    Sørensen, Ida Mh / Bertelsen, Marianne / Freese, Ellen / Lindhard, Kristine / Ullum, Henrik / Feldt-Rasmussen, Bo / Nielsen, Lars Bo / Christoffersen, Christina / Bro, Susanne

    Atherosclerosis

    2018  Volume 275, Page(s) 304–311

    Abstract: Background and aims: Plasma apolipoprotein M (APOM) is bound to HDL-particles and has anti-atherogenic effects. The present study explored whether plasma APOM is reduced in patients with chronic kidney disease (CKD), and associated with cardiovascular ... ...

    Abstract Background and aims: Plasma apolipoprotein M (APOM) is bound to HDL-particles and has anti-atherogenic effects. The present study explored whether plasma APOM is reduced in patients with chronic kidney disease (CKD), and associated with cardiovascular disease (CVD). In addition, we tested the hypothesis that the excretion of APOM into the urine is increased in patients with kidney disease.
    Methods: Plasma samples were collected from a cohort of patients with CKD stages 1 to 5D (N = 409) and controls (N = 35). Urine was collected from 47 subjects. Plasma APOM was measured with sandwich ELISA and urine APOM with competitive ELISA.
    Results: Plasma APOM levels were reduced in patients with CKD stages 3-5D as compared to patients with CKD stages 1 + 2 and controls (p < 0.01). CKD patients with known CVD displayed even further reduction in plasma APOM levels than CKD patients without known CVD (p < 0.001). Fast-phase liquid chromatography showed that plasma APOM was primarily associated with HDL-cholesterol (HDL-C) across CKD stages. Accordingly, when plasma APOM values were corrected for HDL-C, a significant difference only persisted between patients with CKD stage 3 and stages 1 + 2 (p < 0.05), and the difference between CKD patients with and without known CVD disappeared. Urine APOM/creatinine ratio was not significantly increased in patients with kidney disease.
    Conclusions: The results show that the difference in plasma APOM levels observed between patients with mild and advanced CKD may mainly be due to differences in plasma HDL-C. Whether APOM plays a role in human uremic atherogenesis warrants further experimental studies.
    MeSH term(s) Adult ; Aged ; Apolipoproteins M/blood ; Apolipoproteins M/urine ; Biomarkers/blood ; Biomarkers/urine ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/urine ; Case-Control Studies ; Cholesterol, HDL/blood ; Chromatography, High Pressure Liquid ; Denmark/epidemiology ; Down-Regulation ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/urine ; Risk Assessment ; Risk Factors ; Urinalysis
    Chemical Substances APOM protein, human ; Apolipoproteins M ; Biomarkers ; Cholesterol, HDL
    Language English
    Publishing date 2018-06-15
    Publishing country Ireland
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2018.06.815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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