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Article ; Online: Patterns and Predictors of Sustained Training and Technical Assistance Engagement Among Addiction Treatment and Affiliated Providers.

Shafer, Michael S / Oh, Hyunsung / Sturtevant, Hanna / Freese, Thomas / Rutkowski, Beth

The journal of behavioral health services & research

2023 Volume 51, Issue 2, Page(s) 264–274

Abstract: The current study draws upon data collected over a 4-year period by a regional addiction technology transfer center (ATTC) to better understand the learning patterns and methods of learning engagement among behavioral health professionals. Training ... ...

Abstract	The current study draws upon data collected over a 4-year period by a regional addiction technology transfer center (ATTC) to better understand the learning patterns and methods of learning engagement among behavioral health professionals. Training participants were found to be predominately female and ethnically diverse, evenly split on attaining a graduate degree, with a third of the participants possessing less than a 4-year college degree. More than one-half reported working in non-health/non-behavioral healthcare settings. Individuals who attended more ATTC events were found to possess less than a master's degree, work in non-behavioral health settings, and identify as Hispanic or other races. In addition, individuals who initially accessed training through an ATTC conference or online asynchronous learning events were found to become engaged learners.
MeSH term(s)	Humans ; Female ; Health Personnel ; Educational Status ; Psychiatry
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1419909-9
ISSN	1556-3308 ; 1094-3412
ISSN (online)	1556-3308
ISSN	1094-3412
DOI	10.1007/s11414-023-09854-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A molecular motor from lignocellulose

Freese, Thomas / Fridrich, Bálint / Crespi, Stefano / Lubbe, Anouk S. / Barta, Katalin / Feringa, Ben L.

Green chemistry. 2022 May 9, v. 24, no. 9

2022

Abstract: Lignin is the largest natural source of functionalized aromatics on the planet, therefore exploiting its inherent structural features for the synthesis of aromatic products is a timely and ambitious goal. While the recently developed lignin ... ...

Abstract	Lignin is the largest natural source of functionalized aromatics on the planet, therefore exploiting its inherent structural features for the synthesis of aromatic products is a timely and ambitious goal. While the recently developed lignin depolymerization strategies gave rise to well-defined aromatic platform chemicals, the diversification of these structures, especially toward high-end applications is still poorly addressed. Molecular motors and switches have found widespread application in many important areas such as targeted drug delivery systems, responsive coatings for self-healing surfaces, paints and resins or muscles for soft robotics. They typically comprise a functionalized aromatic backbone, yet their synthesis from lignin has not been considered before. In this contribution, we showcase the synthesis of a novel light-driven unidirectional molecular motor from the specific aromatic platform chemical 4-(3-hydroxypropyl)-2,6-dimethoxyphenol (dihydrosynapyl alcohol) that can be directly obtained from lignocellulose via a reductive catalytic fractionation strategy. The synthetic path takes into account the principles of green chemistry and aims to maintain the intrinsic functionality of the lignin-derived platform molecule.
Keywords	alcohols ; aromatic compounds ; depolymerization ; drugs ; fractionation ; green chemistry ; lignin ; lignocellulose
Language	English
Dates of publication	2022-0509
Size	p. 3689-3696.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d2gc00291d
Database	NAL-Catalogue (AGRICOLA)

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Article: A molecular motor from lignocellulose.

Freese, Thomas / Fridrich, Bálint / Crespi, Stefano / Lubbe, Anouk S / Barta, Katalin / Feringa, Ben L

Green chemistry : an international journal and green chemistry resource : GC

2022 Volume 24, Issue 9, Page(s) 3689–3696

Abstract	Lignin is the largest natural source of functionalized aromatics on the planet, therefore exploiting its inherent structural features for the synthesis of aromatic products is a timely and ambitious goal. While the recently developed lignin depolymerization strategies gave rise to well-defined aromatic platform chemicals, the diversification of these structures, especially toward high-end applications is still poorly addressed. Molecular motors and switches have found widespread application in many important areas such as targeted drug delivery systems, responsive coatings for self-healing surfaces, paints and resins or muscles for soft robotics. They typically comprise a functionalized aromatic backbone, yet their synthesis from lignin has not been considered before. In this contribution, we showcase the synthesis of a novel light-driven unidirectional molecular motor from the specific aromatic platform chemical 4-(3-hydroxypropyl)-2,6-dimethoxyphenol (dihydrosynapyl alcohol) that can be directly obtained from lignocellulose
Language	English
Publishing date	2022-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d2gc00291d
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Article ; Online: Recovery incentives program: California's contingency management benefit.

Freese, Thomas E / Rutkowski, Beth A / Peck, James A / Urada, Darren / Clark, H Westley / Bland, Anton Nigusse / Friedman, Joseph / Rawson, Richard A

Preventive medicine

2023 Volume 176, Page(s) 107703

Abstract: Objective: The role of methamphetamine and cocaine use in California's drug poisoning (overdose) crisis has dramatically increased in the past five (5) years and has disproportionately affected American Indian, Alaska Native, and Black Californians. No ... ...

Abstract	Objective: The role of methamphetamine and cocaine use in California's drug poisoning (overdose) crisis has dramatically increased in the past five (5) years and has disproportionately affected American Indian, Alaska Native, and Black Californians. No FDA-approved medications currently exist for the treatment of individuals with stimulant use disorder (StimUD). Outside the Veteran's Administration, the Recovery Incentives Program: California's Contingency Management Benefit is the first large scale implementation of contingency management (CM). CM is the behavioral treatment with the most evidence and largest effect sizes for StimUD. Methods: The Program uses a CM protocol where participants can receive a maximum of $599 over a six-month period, contingent upon 36 stimulant-negative urine test results. Urine tests are conducted using a set of approved, CLIA-waived, point-of-care urine drug tests (UDTs). To ensure fidelity to the CM protocol and to prevent fraud, waste, and abuse, all aspects of incentive accounting and distribution are managed electronically via a custom-developed software system. Incentive distribution utilizes electronic gift cards. A significant innovation of the project is the conceptualization of the CM Coordinator, a designated and highly trained and supervised individual responsible for all aspects of CM operation in a specific site. Results and conclusions: The California Department of Health Care Services contracted with UCLA to develop and implement a robust evaluation of the Program; goals include evaluating the effectiveness of real-world implementation and facilitating quality improvement. The project will likely significantly impact the use of CM for StimUD nationally and may well reduce stimulant-related drug poisoning deaths.
MeSH term(s)	Humans ; Motivation ; Behavior Therapy ; Methamphetamine/urine ; Drug Overdose ; California
Chemical Substances	Methamphetamine (44RAL3456C)
Language	English
Publishing date	2023-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2023.107703
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Article ; Online: Stimulant use among patients in opioid treatment settings: Provider perspectives.

Breland, Haley / Larkins, Sherry / Antonini, Valerie / Freese, Thomas / McGovern, Mark / Dunn, Julia / Rawson, Richard

Journal of substance use and addiction treatment

2023 Volume 151, Page(s) 209012

Abstract: Introduction: Methadone maintenance therapy (MMT) has been a pillar of opioid addiction treatment. Opioid treatment programs (OTPs) have been faced with an escalating threat of stimulant use and related overdose deaths among patients. We know little ... ...

Abstract	Introduction: Methadone maintenance therapy (MMT) has been a pillar of opioid addiction treatment. Opioid treatment programs (OTPs) have been faced with an escalating threat of stimulant use and related overdose deaths among patients. We know little about how providers currently address stimulant use while maintaining treatment for opioid use disorder. Methods: We conducted 5 focus groups with 36 providers (n = 11 prescribers; 25 behavioral health staff), and collected an additional 46 surveys (n = 7 prescribers; 12 administrators; 27 behavioral health staff). Questions focused on perceptions of patient stimulant use and interventions. We applied inductive analysis to identify themes relevant to identification of stimulant use, use trends, intervention approaches, and perceived needs to improve care. Results: Providers indicated a trend of rising stimulant use among patients, especially those experiencing homelessness or comorbid health conditions. They reported a range of approaches to patient screening and intervention, including medication and harm reduction, improving treatment engagement, increasing level of care, and providing incentives. Providers expressed less agreement as to which of these interventions were effective, and though providers saw stimulant use as a common and severe problem, they reported little problem recognition and interest in treatment from their patients. A particular concern of providers was the prevalence and danger of synthetic opioids, such as fentanyl. They sought more research and resources to identify effective interventions and medications to address these issues. Also notable was an interest in contingency management (CM) and use of reinforcements/rewards to encourage stimulant use reduction. Conclusion: Providers face challenges in treating patients who use both opioids and stimulants. Although methadone is available to treat opioid use, no such "silver bullet" exists for stimulant use disorder. The rise in stimulant and synthetic opioid (e.g., fentanyl) combination products is presenting an extraordinary challenge for providers whose patients are at unprecedented risk for overdose. Providing OTPs with more resources to address polysubstance use is critical. Existing research indicates strong support for CM in OTPs, but providers reported regulatory and financial barriers to implementation. Further research should develop effective interventions that are accessible to providers in OTPs.
MeSH term(s)	Humans ; Analgesics, Opioid/adverse effects ; Methadone/therapeutic use ; Opioid-Related Disorders/epidemiology ; Opiate Substitution Treatment ; Fentanyl/therapeutic use ; Drug Overdose/drug therapy
Chemical Substances	Analgesics, Opioid ; Methadone (UC6VBE7V1Z) ; Fentanyl (UF599785JZ)
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ISSN	2949-8759
ISSN (online)	2949-8759
DOI	10.1016/j.josat.2023.209012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Secrets of Question-Based Selling

Freese, Thomas

How the Most Powerful Tool in Business Can Double Your Sales Results

2013

Abstract: After I sent my team to the Question Based Selling program, not only was the feedback from the training outstanding, but we experienced an immediate positive impact in results.""-Jim Cusick, vice president of sales, SAP America, Inc. "" ... ...

Abstract	""After I sent my team to the Question Based Selling program, not only was the feedback from the training outstanding, but we experienced an immediate positive impact in results.""-Jim Cusick, vice president of sales, SAP America, Inc. ""Following the program, even our most experienced salespeople raved, saying QBS was the best sales training they have ever experienced!""-Alan D. Rohrer, director of sales, Hewlett Packard For nearly fifteen years, The Secrets of Question Based Selling has been helping great salespeople live you deliver big</em<br />
Language	English
Size	Online-Ressource (352 p)
Edition	2nd ed
Publisher	Sourcebooks
Publishing place	Naperville
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781402287527 ; 1402287526
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Iron oxide-promoted photochemical oxygen reduction to hydrogen peroxide (H

Freese, Thomas / Meijer, Jelmer T / Brands, Maria B / Alachouzos, Georgios / Stuart, Marc C A / Tarozo, Rafael / Gerlach, Dominic / Smits, Joost / Rudolf, Petra / Reek, Joost N H / Feringa, Ben L

EES catalysis

2023 Volume 2, Issue 1, Page(s) 262–275

Abstract: Hydrogen peroxide ( ... ...

Abstract	Hydrogen peroxide (H
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article
ISSN	2753-801X
ISSN (online)	2753-801X
DOI	10.1039/d3ey00256j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Contingency Management for Stimulant Use Disorder: Progress, Challenges, and Recommendations.

Rawson, Richard A / Erath, Tyler G / Chalk, Mady / Clark, H Westley / McDaid, Carol / Wattenberg, Sarah A / Roll, John M / McDonell, Michael G / Parent, Sara / Freese, Thomas E

The Journal of ambulatory care management

2023 Volume 46, Issue 2, Page(s) 152–159

Abstract: The United States is currently in the fourth wave of the overdose crisis wherein stimulants together with fentanyl are the major drivers of overdose deaths. To date, there has been limited effort outside the US Veterans Administration Health System ... ...

Abstract	The United States is currently in the fourth wave of the overdose crisis wherein stimulants together with fentanyl are the major drivers of overdose deaths. To date, there has been limited effort outside the US Veterans Administration Health System health system to disseminate evidence-based treatment for people with stimulant use disorder. Contingency management, a behavioral intervention in which positive reinforcement is provided for a target behavior indicating treatment progress, has decades of empirical support but limited implementation in real-world, non-US Veterans Administration Health System settings. The purpose of the report is to provide an overview of contingency management, the barriers to adoption, and recommendations for overcoming these barriers.
MeSH term(s)	Humans ; Behavior Therapy ; Central Nervous System Stimulants ; Substance-Related Disorders/therapy ; United States
Chemical Substances	Central Nervous System Stimulants
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	198845-1
ISSN	1550-3267 ; 0148-9917
ISSN (online)	1550-3267
ISSN	0148-9917
DOI	10.1097/JAC.0000000000000450
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Article ; Online: The urgent need for contingency management among Tribal communities in the United States: Considerations for implementation, policy, and sovereignty.

Hirchak, Katherine A / Echo-Hawk, Holly / Parent, Sara / Peavy, K Michelle / Webb, Kellie / Bajet, Kelsey / Richardson, Meenakshi / Granbois, Alexandria / Herron, Jalene L / Catron, Krista / King, Keli / Parsells, Ed / Freese, Thomas E / Thomas, Lisa Rey / Rawson, Richard / Clark, H Westley / Roll, John / McDonell, Michael G

Preventive medicine

2023 Volume 176, Page(s) 107662

Abstract: In two randomized controlled trials, culturally adapted contingency management (i.e., incentives provided for substance-negative urine samples) was associated with reduced alcohol and drug use among geographically diverse American Indian and Alaska ... ...

Abstract	In two randomized controlled trials, culturally adapted contingency management (i.e., incentives provided for substance-negative urine samples) was associated with reduced alcohol and drug use among geographically diverse American Indian and Alaska Native (AI/AN) adults. In response to interest in contingency management from other Tribal and AI/AN communities, our research team in collaboration with AI/AN behavioral health experts, translated the research into practice with new AI/AN community partners. Tenets of community-based participatory research were applied to develop, pilot, and refine contingency management training and implementation tools, and identify implementation challenges. In partnership with the AI/AN communities, four members of the university team developed tools and identified implementation and policy strategies to increase the successful uptake of contingency management in each location. Through our collaborative work, we identified policy barriers including inadequate federal funding of contingency management incentives and a need for further clarity regarding federal anti-kickback regulations. Adoption of contingency management is feasible and can strengthen Tribal communities' capacity to deliver evidence-based substance use disorder treatments to AI/AN people. Unfortunately, non-evidence-based limits to the use of federal funding for contingency management incentives discriminate against AI/AN communities. We recommend specific federal policy reforms, as well as other practical solutions for Tribal communities interested in contingency management.
MeSH term(s)	Adult ; Humans ; Behavior Therapy ; Policy ; United States ; American Indian or Alaska Native ; Culturally Competent Care ; Alcoholism/prevention & control ; Substance-Related Disorders/prevention & control
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2023.107662
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Article ; Online: A coating from nature.

Hermens, Johannes G H / Freese, Thomas / van den Berg, Keimpe J / van Gemert, Rogier / Feringa, Ben L

Science advances

2020 Volume 6, Issue 51

Abstract: For almost a century, petrochemical-based monomers like acrylates have been widely used as the basis for coatings, resins, and paints. The development of sustainable alternatives, integrating the principles of green chemistry in starting material, ... ...

Abstract	For almost a century, petrochemical-based monomers like acrylates have been widely used as the basis for coatings, resins, and paints. The development of sustainable alternatives, integrating the principles of green chemistry in starting material, synthesis process, and product function, offers tremendous challenges for science and society. Here, we report on alkoxybutenolides as a bio-based alternative for acrylates and the formation of high-performance coatings. Starting from biomass-derived furfural and an environmentally benign photochemical conversion using visible light and oxygen in a flow reactor provides the alkoxybutenolide monomers. This is followed by radical (co)polymerization, which results in coatings with tunable properties for applications on distinct surfaces like glass or plastic. The performance is comparable to current petrochemical-derived industrial coatings.
Language	English
Publishing date	2020-12-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abe0026
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