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Article ; Online: Comment on "Safety of systemic hormone replacement therapy in breast cancer survivors: a systematic review and meta‑analysis".

Poggio, Francesca / Ceppi, Marcello / Fregatti, Piero / Lambertini, Matteo / Tagliamento, Marco

2022 Volume 194, Issue 3, Page(s) 709–710

MeSH term(s)	Breast ; Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Cancer Survivors ; Female ; Hormone Replacement Therapy/adverse effects ; Humans ; Survivors
Language	English
Publishing date	2022-06-24
Publishing country	Netherlands
Document type	Letter ; Meta-Analysis ; Systematic Review ; Comment
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-022-06590-8
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Zs.A 1655: Show issues

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Article ; Online: Re: "Guidelines for cadaver dissection in education and research of clinical medicine (The Japan Surgical Society and The Japanese Association of Anatomists)".

Diaz, Raquel / Leonardi, Rosario / Fregatti, Piero / Murelli, Federica / Terrone, Carlo / Mantica, Guglielmo

Surgery today

2022 Volume 53, Issue 3, Page(s) 396–397

MeSH term(s)	Humans ; Anatomists/education ; Cadaver ; Clinical Medicine ; Japan ; Guidelines as Topic
Language	English
Publishing date	2022-08-18
Publishing country	Japan
Document type	Letter
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-022-02577-6
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Zs.B 1077: Show issues

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Article ; Online: The evolving scenario of cancer care provision across the COVID-19 pandemic in Europe.

Tagliamento, Marco / Poggio, Francesca / Perachino, Marta / Pirrone, Chiara / Fregatti, Piero / Lambertini, Matteo

Current opinion in supportive and palliative care

2022 Volume 16, Issue 3, Page(s) 110–116

Abstract: Purpose of review: Over the past 2 years, the COVID-19 pandemic has had short-term and long-term effects on the delivery of cancer care. Some European countries faced an unprecedented widespread crisis during the first year of the SARS-CoV-2 pandemic, ... ...

Abstract	Purpose of review: Over the past 2 years, the COVID-19 pandemic has had short-term and long-term effects on the delivery of cancer care. Some European countries faced an unprecedented widespread crisis during the first year of the SARS-CoV-2 pandemic, only being able afterwards to gradually recover, thanks to the improvement in preventive measures, changes in public health and reactive processes in cancer care and a better understanding of the ongoing heath emergency. Recent findings: The development of SARS-CoV-2 vaccines and COVID-19 specific treatments, the growing testing and tracking capability to limit virus diffusion, and research efforts to better define areas of action have all greatly limited the negative impact of the health emergency on routine cancer care.The need to protect those more vulnerable and to ensure continuity of care for oncology patients has been balanced across the pandemic, with the aim to guarantee an optimal standard of care. Summary: This article aims to provide an overview on the evolving scenario of cancer care throughout the COVID-19 pandemic in Europe, focusing on the particular features that characterized the pandemic course as well as the main differences that were observed across it.
MeSH term(s)	COVID-19/epidemiology ; COVID-19 Vaccines ; Europe/epidemiology ; Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; Pandemics/prevention & control ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2633726-5
ISSN	1751-4266 ; 1751-4258
ISSN (online)	1751-4266
ISSN	1751-4258
DOI	10.1097/SPC.0000000000000601
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Zs.A 6946: Show issues

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Article ; Online: Breast Edema after Conservative Surgery for Early-Stage Breast Cancer: A Retrospective Single-Center Assessment of Risk Factors.

Cornacchia, C / Dessalvi, S / Santori, G / Canobbio, F / Atzori, G / De Paoli, F / Diaz, R / Franchelli, S / Gipponi, M / Murelli, F / Sparavigna, M / Pitto, F / Fozza, A / Boccardo, F / Friedman, D / Fregatti, P

Lymphology

2023 Volume 55, Issue 4, Page(s) 167–177

Abstract: Breast-conserving surgery (BCS) is the standard of care for early-stage breast cancer. We retrospectively enrolled 530 patients (mean age: 62.96 ± 12.69 years) undergoing BCS between January 1, 2018, and December 31, 2019. During the COVID-19 pandemic, ... ...

Abstract	Breast-conserving surgery (BCS) is the standard of care for early-stage breast cancer. We retrospectively enrolled 530 patients (mean age: 62.96 ± 12.69 years) undergoing BCS between January 1, 2018, and December 31, 2019. During the COVID-19 pandemic, all patients with at least 1 year of follow-up were telephonically asked after surgery to provide clinical signs and symptoms attributable to postoperative breast cancer-related lymphedema of the breast (BCRL-B). Thirty-one (5.8%) patients reported breast edema and were visited to measure the tissue dielectric constant (TDC) and to assess the induration of the skin. There was a difference seen in treatment with lumpectomy + ALND performed more frequently in patients with (29%) than without (12%) BCRL-B. In the subgroup of patients with BCRL-B (n=31), significantly higher values of local total water were calculated in the nine patients who underwent Lump + ALND procedure (1.86 ± 0.48 vs. 1.48 ± 0.38; p = 0.046). Among patients with BCRL-B (n=31), in eight patients (25.8%) tissue induration measured with SkinFibroMeter was >0.100 N, thus suggesting tissue fibrosis. Cumulative survival probability at 1-year after surgery was 0.992. No statistical differences in 1-year survival after surgery were found for type of surgery (p = 0.890) or absence/presence of BCRL-B (p = 0.480). In univariate logistic regression, only lumpectomy + ALND surgery (p = 0.009) and any subsequent axillary lymph node removal surgery (p = 0.003) were associated with BCRL-B. Both of these variables were also found to be statistically significant in the multivariate regression model. Further prospective research is warranted to analyze potentential predictors of BCRL-B and to reduce/ prevent this complication.
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80181-1
ISSN	2522-7963 ; 0024-7766
ISSN (online)	2522-7963
ISSN	0024-7766
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Zs.A 656: Show issues

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Article ; Online: Integrated Treatment With Stapled Haemorrhoidopexy and Proctonorm® of Haemorrhoidal Disease.

Reboa, Giuliano / Gipponi, Marco / Fregatti, Piero / Depaoli, Francesca

In vivo (Athens, Greece)

2019 Volume 33, Issue 5, Page(s) 1671–1675

Abstract: Background/aim: This retrospective study was performed in patients undergoing Stapled Haemorrhoidopexy (SH) who were post-operatively treated with Proctonorm® with the aim of assessing its effect on early and late haemorrhoidal-related symptoms.: ... ...

Abstract	Background/aim: This retrospective study was performed in patients undergoing Stapled Haemorrhoidopexy (SH) who were post-operatively treated with Proctonorm® with the aim of assessing its effect on early and late haemorrhoidal-related symptoms. Patients and methods: Forty-six males and 54 females received Proctonorm® (one tablet twice daily for 14 days) and Ketoprofene R (200 mg, one tablet twice daily, as requested). Results: "Early Complication Score" (0-12) two days after surgery was 2.02±1.03; pain VAS (Visual Analogue Scale) (0-10) was 1.21±0.89, and the number of anti-inflammatory tablets was 4.24±1.06. At 40-day post-operative assessment, seven patients had post-operative complications with "Late Complication Score" (0-20) of 0.34±0.68. At six-month follow-up, a high index of patient satisfaction (VAS=9.39±0.24) was self-reported with 75% reduction in CSS (Constipation Scoring System) (1.95±2.58) compared to preoperative scores; "Late Complication Score" was 0. Conclusion: The specific target activity of Proctonorm® at the microcircular level may be effective in patients undergoing SH in order to reduce the inflammatory response of residual haemorrhoids while waiting for stable resolution of symptoms within one or two weeks.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Hemorrhoidectomy/adverse effects ; Hemorrhoidectomy/methods ; Hemorrhoids/surgery ; Humans ; Male ; Middle Aged ; Postoperative Complications ; Surgical Stapling ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2019-08-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.11654
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Zs.A 2288: Show issues

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Article ; Online: Ovarian Suppression: Early Menopause and Late Effects.

Molinelli, Chiara / Jacobs, Flavia / Nader-Marta, Guilherme / Borea, Roberto / Scavone, Graziana / Ottonello, Silvia / Fregatti, Piero / Villarreal-Garza, Cynthia / Bajpai, Jyoti / Kim, Hee Jeong / Puglisi, Silvia / de Azambuja, Evandro / Lambertini, Matteo

Current treatment options in oncology

2024 Volume 25, Issue 4, Page(s) 523–542

Abstract: Opinion statement: Around 90% of breast tumours are diagnosed in the early stage, with approximately 70% being hormone receptor-positive. The cornerstone of adjuvant therapy for early-stage hormone receptor-positive breast cancer is endocrine therapy, ... ...

Abstract	Opinion statement: Around 90% of breast tumours are diagnosed in the early stage, with approximately 70% being hormone receptor-positive. The cornerstone of adjuvant therapy for early-stage hormone receptor-positive breast cancer is endocrine therapy, tailored according to disease stage, biological characteristics of the tumour, patient's comorbidities, preferences and age. In premenopausal patients with hormone receptor-positive breast cancer, ovarian function suppression is a key component of the adjuvant endocrine treatment in combination with an aromatase inhibitor or tamoxifen. Moreover, it can be used during chemotherapy as a standard strategy for ovarian function preservation in all breast cancer subtypes. In the metastatic setting, ovarian function suppression should be used in all premenopausal patients with hormone receptor-positive breast cancer to achieve a post-menopausal status. Despite its efficacy, ovarian function suppression may lead to several side effects that can have a major negative impact on patients' quality of life if not properly managed (e.g. hot flashes, depression, cognitive impairment, osteoporosis, sexual dysfunction, weight gain). A deep knowledge of the side effects of ovarian function suppression is necessary for clinicians. A correct counselling in this regard and proactive management should be considered a fundamental part of survivorship care to improve treatment adherence and patients' quality of life.
MeSH term(s)	Female ; Humans ; Quality of Life ; Ovary/pathology ; Tamoxifen/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/etiology ; Breast Neoplasms/pathology ; Premenopause ; Chemotherapy, Adjuvant/adverse effects ; Antineoplastic Agents, Hormonal/therapeutic use
Chemical Substances	Tamoxifen (094ZI81Y45) ; Antineoplastic Agents, Hormonal
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057351-0
ISSN	1534-6277 ; 1527-2729
ISSN (online)	1534-6277
ISSN	1527-2729
DOI	10.1007/s11864-024-01190-8
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Zs.A 5523: Show issues

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Article ; Online: Moving trastuzumab emtansine (T-DM1) to the early setting of breast cancer treatment.

Arecco, Luca / Blondeaux, Eva / Damassi, Alessandra / Fregatti, Piero / Lambertini, Matteo

Annals of palliative medicine

2020 Volume 9, Issue 2, Page(s) 512–516

MeSH term(s)	Ado-Trastuzumab Emtansine/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Humans ; Randomized Controlled Trials as Topic ; Receptor, ErbB-2/metabolism
Chemical Substances	Antibodies, Monoclonal, Humanized ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Ado-Trastuzumab Emtansine (SE2KH7T06F)
Language	English
Publishing date	2020-03-18
Publishing country	China
Document type	Editorial
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5820
ISSN (online)	2224-5839
ISSN	2224-5820
DOI	10.21037/apm.2020.01.09
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Article: Assessment of Circulating Nucleic Acids in Cancer: From Current Status to Future Perspectives and Potential Clinical Applications.

Cirmena, Gabriella / Dameri, Martina / Ravera, Francesco / Fregatti, Piero / Ballestrero, Alberto / Zoppoli, Gabriele

Cancers

2021 Volume 13, Issue 14

Abstract: Current approaches for cancer detection and characterization are based on radiological procedures coupled with tissue biopsies, despite relevant limitations in terms of overall accuracy and feasibility, including relevant patients' discomfort. Liquid ... ...

Abstract	Current approaches for cancer detection and characterization are based on radiological procedures coupled with tissue biopsies, despite relevant limitations in terms of overall accuracy and feasibility, including relevant patients' discomfort. Liquid biopsies enable the minimally invasive collection and analysis of circulating biomarkers released from cancer cells and stroma, representing therefore a promising candidate for the substitution or integration in the current standard of care. Despite the potential, the current clinical applications of liquid biopsies are limited to a few specific purposes. The lack of standardized procedures for the pre-analytical management of body fluids samples and the detection of circulating biomarkers is one of the main factors impacting the effective advancement in the applicability of liquid biopsies to clinical practice. The aim of this work, besides depicting current methods for samples collection, storage, quality check and biomarker extraction, is to review the current techniques aimed at analyzing one of the main circulating biomarkers assessed through liquid biopsy, namely cell-free nucleic acids, with particular regard to circulating tumor DNA (ctDNA). ctDNA current and potential applications are reviewed as well.
Language	English
Publishing date	2021-07-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13143460
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Article: Inferior Pedicle Reduction Mammoplasty as Corrective Surgery after Breast Conserving Surgery and Radiation Therapy.

Atzori, Giulia / Franchelli, Simonetta / Gipponi, Marco / Cornacchia, Chiara / Diaz, Raquel / Depaoli, Francesca / Murelli, Federica / Sparavigna, Marco / Fregatti, Piero / Friedman, Daniele

Journal of personalized medicine

2022 Volume 12, Issue 10

Abstract: Background/Aim-Twenty patients had corrective reconstruction surgery by means of a reduction mammaplasty or mastopexy after a previous BCS (Breast Conserving Surgery) and RT (Radiation Therapy); the risk factors and post-operative complications were ... ...

Abstract	Background/Aim-Twenty patients had corrective reconstruction surgery by means of a reduction mammaplasty or mastopexy after a previous BCS (Breast Conserving Surgery) and RT (Radiation Therapy); the risk factors and post-operative complications were reported in order to define a safe and effective technique for reduction mammaplasty in previously irradiated breast cancer patients. Materials and Methods-From June 2011 to December 2019, 20 pts. were operated on at the Breast Surgery Clinic of San Martino Policlinic Hospital, Genoa, Italy. Pre- and post-operative parameters included clinic-pathological features of the primary tumor; a lapse of time from primary radio-surgery; the extent of follow-up; the rate of post-operative wound infections; the persistence of breast asymmetry, and a post-operative patient satisfaction index by means of a BREAST-Q questionnaire. Results-Three patients (15%) developed minor complications in the irradiated breast, but no complication was observed into the non-irradiated breast. No statistically significant correlation was found between the post-operative complications and the risk factors. The statistical analysis of BREAST-Q questionnaire responses gave an average patient's satisfaction index that was equal to 90.8/100 (range: 44 to 100). Conclusions-Inferior pedicle reduction mammoplasty is an effective reduction mammoplasty technique in regard to the extent of breast tissues that are to be removed both in irradiated and contralateral breast; moreover, the incidence of post-operative complications is clearly limited when a careful technique is adopted, and it can be reasonably applied also in patients with co-morbidity factors.
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12101569
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Article ; Online: Intraoperative digital breast tomosynthesis using a dedicated device is more accurate than standard intraoperative mammography for identifying positive margins.

Garlaschi, A / Fregatti, P / Oddone, C / Friedman, D / Houssami, N / Calabrese, M / Tagliafico, A S

Clinical radiology

2019 Volume 74, Issue 12, Page(s) 974.e1–974.e6

Abstract: Aim: To compare a standard intra-operative mammography (IM) device with digital breast tomosynthesis using a dedicated device (Mozart system) in the evaluation of surgical margins at first excision.: Materials and methods: The study received ... ...

Abstract	Aim: To compare a standard intra-operative mammography (IM) device with digital breast tomosynthesis using a dedicated device (Mozart system) in the evaluation of surgical margins at first excision. Materials and methods: The study received institutional review board approval and written informed consent was obtained from participants. From January 2018 to December 2018, a prospective analysis of the images of IM device and intra-operative digital breast tomosynthesis with a dedicated device (Mozart system) in n=89 breast cancer patients (average patients age: 58 years, age range: 35-76 years) was undertaken. Images were evaluated by two expert breast radiologists independently of each other and blinded to each other's interpretation, who indicated the positive cases requiring surgical re-excision intra-operatively. Results: Mean cancer size was 12.5±4.5 mm. Radiological signs of the lesions were microcalcifications (n=71), nodules (n=10), and architectural distortions (n=8). A total of 20/89 (17%) patients underwent intra-operative re-excision for positive margins. Intra-operative digital breast tomosynthesis with a dedicated device and IM showed discrepancies in 15/89 cases (17%). Mozart system results informed the necessity to perform a re-excision (n=15). Overall, receiver operating characteristic (ROC) curve analysis showed and area under the ROC curve (AUC) of 0.82 for the Mozart system versus 0.65 for IM. ROC analysis of radiological findings with microcalcifications showed an AUC of 0.92 for the Mozart system versus 0.74 for IM, whereas AUC in cases with no microcalcifications were 0.87 and 0.75, respectively. Conclusion: Intra-operative digital breast tomosynthesis with a dedicated device provides more information (better accuracy) than IM and facilitated a reduction in re-excision rates.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Calcinosis/diagnostic imaging ; Female ; Humans ; Intraoperative Period ; Mammography/methods ; Margins of Excision ; Mastectomy, Segmental/methods ; Middle Aged
Language	English
Publishing date	2019-09-11
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2019.08.004
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