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  1. Article ; Online: HIV and Cardiovascular Disease - An Ounce of Prevention.

    Freiberg, Matthew S

    The New England journal of medicine

    2023  Volume 389, Issue 8, Page(s) 760–761

    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; HIV Infections/prevention & control
    Language English
    Publishing date 2023-07-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2306782
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  2. Article ; Online: Beyond Smoking Cessation: Investigating Medicinal Nicotine to Prevent and Treat COVID-19.

    Tindle, Hilary A / Newhouse, Paul A / Freiberg, Matthew S

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2020  Volume 22, Issue 9, Page(s) 1669–1670

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Nicotine ; Nicotinic Agonists ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Smoking Cessation
    Chemical Substances Nicotinic Agonists ; Nicotine (6M3C89ZY6R)
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntaa077
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    Zs.A 5789: Show issues Location:
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  3. Article ; Online: Cardiometabolic Risk Factors Associated With Right Ventricular Function and Compensation in Patients Referred for Echocardiography.

    Morrison, Amanda M / Huang, Shi / Annis, Jeffrey S / Garry, Jonah D / Hemnes, Anna R / Freiberg, Matthew S / Brittain, Evan L

    Journal of the American Heart Association

    2023  Volume 12, Issue 12, Page(s) e028936

    Abstract: Background Pulmonary hypertension and right ventricular (RV) dysfunction are drivers of adverse outcomes; however, modifiable risk factors for RV dysfunction are not well described. We investigated the association between clinical markers of metabolic ... ...

    Abstract Background Pulmonary hypertension and right ventricular (RV) dysfunction are drivers of adverse outcomes; however, modifiable risk factors for RV dysfunction are not well described. We investigated the association between clinical markers of metabolic syndrome and echocardiographic RV function in a large referral population. Methods and Results Using electronic health record data, we performed a retrospective cohort study of patients aged ≥18 years referred for transthoracic echocardiography between 2010 and 2020 with RV systolic pressure (RVSP) or tricuspid annular plane systolic excursion (TAPSE) values. Pulmonary hypertension was defined by RVSP >33 mm Hg and RV dysfunction by TAPSE ≤1.8 cm. Our sample included 37 203 patients of whom 19 495 (52%) were women, 29 752 (83%) were White, with a median age of 63 years (interquartile range, 51-73). Median (interquartile range) RVSP was 30.0 mm Hg (24.0-38.7), and median TAPSE was 2.1 cm (1.7-2.4). Within our sample, 40% had recorded RVSP >33 mm Hg, and 32% with TAPSE <1.8 cm. Increase in RVSP from normal (<33 mm Hg) to mildly elevated (33-39 mm Hg) or elevated (>39 mm Hg) was associated with lower low-density lipoprotein and high-density lipoprotein, and higher hemoglobin A1c and body mass index (
    MeSH term(s) Humans ; Female ; Adolescent ; Adult ; Middle Aged ; Male ; Hypertension, Pulmonary ; Retrospective Studies ; Ventricular Function, Right ; Cardiometabolic Risk Factors ; Glycated Hemoglobin ; Echocardiography ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/epidemiology ; Ventricular Dysfunction, Right/etiology
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2023-06-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.122.028936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetics of Pulmonary Pressure and Right Ventricle Stress Identify Diabetes as a Causal Risk Factor.

    Bagheri, Minoo / Agrawal, Vineet / Annis, Jeffrey / Shi, Mingjian / Ferguson, Jane F / Freiberg, Matthew S / Mosley, Jonathan D / Brittain, Evan L

    Journal of the American Heart Association

    2023  Volume 12, Issue 15, Page(s) e029190

    Abstract: Background Epidemiologic studies have identified risk factors associated with pulmonary hypertension and right heart failure, but causative drivers of pulmonary hypertension and right heart adaptation are not well known. We sought to leverage unbiased ... ...

    Abstract Background Epidemiologic studies have identified risk factors associated with pulmonary hypertension and right heart failure, but causative drivers of pulmonary hypertension and right heart adaptation are not well known. We sought to leverage unbiased genetic approaches to determine clinical conditions that share genetic architecture with pulmonary pressure and right ventricular dysfunction. Methods and Results We leveraged Vanderbilt University's deidentified electronic health records and DNA biobank to identify 14 861 subjects of European ancestry who underwent at least 1 echocardiogram with available estimates of pulmonary pressure and right ventricular function. Analyses of the study were performed between 2020 and 2022. The final analytical sample included 14 861 participants (mean [SD] age, 63 [15] years and mean [SD] body mass index, 29 [7] kg/m
    MeSH term(s) Humans ; Middle Aged ; Diabetes Mellitus, Type 2 ; Genome-Wide Association Study/methods ; Heart Ventricles ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/genetics ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/genetics ; Risk Factors ; Aged
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.122.029190
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  5. Article: Clinical features do not identify risk of progression from isolated postcapillary pulmonary hypertension to combined pre- and postcapillary pulmonary hypertension.

    Babu, Gautam / Annis, Jeffrey S / Garry, Jonah D / Freiberg, Matthew S / Hemnes, Anna R / Brittain, Evan L

    Pulmonary circulation

    2023  Volume 13, Issue 2, Page(s) e12249

    Abstract: Pulmonary hypertension is a common sequelae of left heart failure and may present as isolated postcapillary pulmonary hypertension (Ipc-PH) or combined pre- and postcapillary pulmonary hypertension (Cpc-PH). Clinical features associated with progression ... ...

    Abstract Pulmonary hypertension is a common sequelae of left heart failure and may present as isolated postcapillary pulmonary hypertension (Ipc-PH) or combined pre- and postcapillary pulmonary hypertension (Cpc-PH). Clinical features associated with progression from Ipc-PH to Cpc-PH have not yet been described. We extracted clinical data from patients who underwent right heart catheterizations (RHC) on two separate occasions. Ipc-PH was defined as mean pulmonary pressure >20 mmHg, pulmonary capillary wedge pressure >15 mmHg, and pulmonary vascular resistance (PVR) < 3 WU. Progression to Cpc-PH required an increase in PVR to ≥3 WU. We performed a retrospective cohort study with repeated assessments comparing subjects that progressed to Cpc-PH to subjects that remained with Ipc-PH. Of 153 patients with Ipc-PH at baseline who underwent a repeat RHC after a median of 0.7 years (IQR 0.2, 2.1), 33% (50/153) had developed Cpc-PH. In univariate analysis comparing the two groups at baseline, body mass index (BMI) and right atrial pressure were lower, while the prevalence of moderate or worse mitral regurgitation (MR) was higher among those who progressed. In age- and sex-adjusted multivariable analysis, only BMI (OR 0.94, 95% CI 0.90-0.99,
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2638089-4
    ISSN 2045-8940 ; 2045-8932
    ISSN (online) 2045-8940
    ISSN 2045-8932
    DOI 10.1002/pul2.12249
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  6. Article ; Online: Interaction between Continuous Pack-Years Smoked and Polygenic Risk Score on Lung Cancer Risk: Prospective Results from the Framingham Heart Study.

    Duncan, Meredith S / Diaz-Zabala, Hector / Jaworski, James / Tindle, Hilary A / Greevy, Robert A / Lipworth, Loren / Hung, Rayjean J / Freiberg, Matthew S / Aldrich, Melinda C

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2024  Volume 33, Issue 4, Page(s) 500–508

    Abstract: Background: Lung cancer risk attributable to smoking is dose dependent, yet few studies examining a polygenic risk score (PRS) by smoking interaction have included comprehensive lifetime pack-years smoked.: Methods: We analyzed data from participants ...

    Abstract Background: Lung cancer risk attributable to smoking is dose dependent, yet few studies examining a polygenic risk score (PRS) by smoking interaction have included comprehensive lifetime pack-years smoked.
    Methods: We analyzed data from participants of European ancestry in the Framingham Heart Study Original (n = 454) and Offspring (n = 2,470) cohorts enrolled in 1954 and 1971, respectively, and followed through 2018. We built a PRS for lung cancer using participant genotyping data and genome-wide association study summary statistics from a recent study in the OncoArray Consortium. We used Cox proportional hazards regression models to assess risk and the interaction between pack-years smoked and genetic risk for lung cancer adjusting for European ancestry, age, sex, and education.
    Results: We observed a significant submultiplicative interaction between pack-years and PRS on lung cancer risk (P = 0.09). Thus, the relative risk associated with each additional 10 pack-years smoked decreased with increasing genetic risk (HR = 1.56 at one SD below mean PRS, HR = 1.48 at mean PRS, and HR = 1.40 at one SD above mean PRS). Similarly, lung cancer risk per SD increase in the PRS was highest among those who had never smoked (HR = 1.55) and decreased with heavier smoking (HR = 1.32 at 30 pack-years).
    Conclusions: These results suggest the presence of a submultiplicative interaction between pack-years and genetics on lung cancer risk, consistent with recent findings. Both smoking and genetics were significantly associated with lung cancer risk.
    Impact: These results underscore the contributions of genetics and smoking on lung cancer risk and highlight the negative impact of continued smoking regardless of genetic risk.
    MeSH term(s) Humans ; Lung Neoplasms/etiology ; Lung Neoplasms/genetics ; Smoke ; Genetic Risk Score ; Prospective Studies ; Genome-Wide Association Study ; Risk Factors ; Longitudinal Studies
    Chemical Substances Smoke
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-23-0571
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    Zs.A 3693: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Is Abstinence from Alcohol and Smoking Associated with Less Anxiety and Depressive Symptoms Among People with HIV?

    Freibott, Christina E / Biondi, Breanne E / Rao, Sowmya R / Blokhina, Elena / Dugas, Julianne N / Patts, Gregory / Bendiks, Sally / Krupitsky, Evgeny / Chichetto, Natalie E / Samet, Jeffrey H / Freiberg, Matthew S / Stein, Michael D / Tindle, Hilary A

    AIDS and behavior

    2024  Volume 28, Issue 4, Page(s) 1447–1455

    Abstract: Achieving abstinence from alcohol, tobacco, or both may improve mental health, but is understudied in people with HIV (PWH). The St PETER HIV randomized clinical trial compared varenicline, cytisine, and nicotine replacement therapy on alcohol and ... ...

    Abstract Achieving abstinence from alcohol, tobacco, or both may improve mental health, but is understudied in people with HIV (PWH). The St PETER HIV randomized clinical trial compared varenicline, cytisine, and nicotine replacement therapy on alcohol and smoking behavior among 400 PWH in Russia. The primary exposure was thirty-day point prevalence abstinence (PPA) from (1) alcohol, (2) smoking, (3) both, or (4) neither and was assessed at 1, 3, 6 and 12-months as were the study outcomes of anxiety (GAD-7) and depressive (CES-D) symptoms. The primary aim was to examine the association between smoking and/or alcohol abstinence and subsequent symptoms of depression and anxiety. Primary analysis used repeated measures generalized linear modeling to relate PPA with mental health scores across time. In secondary analyses, Kruskal-Wallis tests related PPA with mental health scores at each timepoint. Primary analyses did not identify significant differences in anxiety or depressive symptoms between exposure groups over time. Secondary analyses found CES-D scores across PPA categories were similar at 1-month (11, 10, 11, 11) and 6-months (10, 10, 11, 11) but differed at 3-months (9, 11, 10, 12; p = 0.035) and 12-months (10, 6, 11, 10; p = 0.019). GAD-7 scores did not vary across PPA categories at any time point. While abstinence was associated with fewer depressive symptoms at times, findings were not consistent during follow-up, perhaps reflecting intermittent relapse. PWH with polysubstance use and mental health comorbidity are complex, and larger samples with sustained abstinence would further elucidate effects of abstinence on mental health.
    MeSH term(s) Humans ; Smoking Cessation/psychology ; Depression/epidemiology ; Tobacco Use Cessation Devices ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/drug therapy ; Smoking/epidemiology ; Smoking/therapy ; Varenicline/therapeutic use ; Ethanol ; Anxiety/epidemiology
    Chemical Substances Varenicline (W6HS99O8ZO) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-023-04231-9
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  8. Article ; Online: Editorial Commentary: Nicotine in electronic cigarettes: Cardiovascular harm reduction, not elimination.

    Tindle, Hilary Aurora / Freiberg, Matthew S

    Trends in cardiovascular medicine

    2016  Volume 26, Issue 6, Page(s) 524–525

    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2016.03.013
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  10. Article ; Online: Beyond Smoking Cessation

    Tindle, Hilary A / Newhouse, Paul A / Freiberg, Matthew S

    Nicotine & Tobacco Research

    Investigating Medicinal Nicotine to Prevent and Treat COVID-19

    2020  Volume 22, Issue 9, Page(s) 1669–1670

    Keywords Public Health, Environmental and Occupational Health ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntaa077
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