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  1. Article ; Online: Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats.

    Bezerra, Lorena Soares / Magnani, Marciane / Pimentel, Tatiana Colombo / de Oliveira, Júlio César Pinheiro Lúcio / Freire, Francisca Manuela de Souza / de Almeida, Arthur José Pontes Oliveira / Rezende, Mathania Silva de Almeida / Gonçalves, Islânia Giselia Albuquerque / de Medeiros, Isac Almeida / Veras, Robson Cavalcante

    Food & function

    2022  Volume 13, Issue 9, Page(s) 5406–5415

    Abstract: Carboxymethyl-glucan is a semi-synthetic derivative of β-D-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. ...

    Abstract Carboxymethyl-glucan is a semi-synthetic derivative of β-D-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. However, studies exploring carboxymethyl-glucan bioactivity in cardiovascular health remain lacking, mainly in hypertension. Thus, this study sought to expand understanding of the effects of carboxymethyl-glucan on vascular and platelet functions in a hypertensive animal model. Spontaneously hypertensive rats and their normotensive Wistar-Kyoto controls were assigned to five groups: control, carboxymethyl-glucan (60 mg kg
    MeSH term(s) Animals ; Glucans ; Hypertension/drug therapy ; Platelet Aggregation ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reactive Oxygen Species ; Saccharomyces cerevisiae
    Chemical Substances Glucans ; Reactive Oxygen Species
    Language English
    Publishing date 2022-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo03492h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  2. Article ; Online: Carboxymethyl-glucan from

    Bezerra, Lorena Soares / Magnani, Marciane / Pimentel, Tatiana Colombo / Freire, Francisca Manuela de Souza / da Silva, Tays Amanda Felisberto / Ramalho, Ricardo Cartaxo / Alves, Adriano Francisco / de Brito Alves, José Luiz / de Medeiros, Isac Almeida / Veras, Robson Cavalcante

    Food & function

    2021  Volume 12, Issue 18, Page(s) 8552–8560

    Abstract: Carboxymethyl-glucan (CMG) is a derivative of β-D-glucan extracted ... ...

    Abstract Carboxymethyl-glucan (CMG) is a derivative of β-D-glucan extracted from
    MeSH term(s) Animals ; Antihypertensive Agents/pharmacology ; Baroreflex/drug effects ; Blood Pressure/drug effects ; Cardiomegaly/pathology ; Heart Rate/drug effects ; Hypertension/drug therapy ; Hypertension/physiopathology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Saccharomyces cerevisiae/chemistry ; Weight Gain/drug effects ; beta-Glucans/pharmacology
    Chemical Substances Antihypertensive Agents ; beta-Glucans ; carboxymethyl-beta-1,3-glucan (61163-25-5)
    Language English
    Publishing date 2021-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo01079d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Carboxymethyl-glucan from Saccharomyces cerevisiae reduces blood pressure and improves baroreflex sensitivity in spontaneously hypertensive rats

    Bezerra, Lorena Soares / Magnani, Marciane / Pimentel, Tatiana Colombo / Freire, Francisca Manuela de Souza / da Silva, Tays Amanda Felisberto / Ramalho, Ricardo Cartaxo / Alves, Adriano Francisco / de Brito Alves, José Luiz / de Medeiros, Isac Almeida / Veras, Robson Cavalcante

    Food & function. 2021 Sept. 20, v. 12, no. 18

    2021  

    Abstract: Carboxymethyl-glucan (CMG) is a derivative of β-d-glucan extracted from Sacharomyces cerevisae. This polymer presents improved physicochemical properties and shows health benefits, such as immunomodulation, antioxidant, anti-inflammatory, anti-tumor, and ...

    Abstract Carboxymethyl-glucan (CMG) is a derivative of β-d-glucan extracted from Sacharomyces cerevisae. This polymer presents improved physicochemical properties and shows health benefits, such as immunomodulation, antioxidant, anti-inflammatory, anti-tumor, and antiplatelet activities, and improved vascular function. However, studies concerning the effect of administration of CMG on the cardiovascular parameters, mainly in the field of hypertension, are scarce. This study aimed to investigate the effect of administration of CMG in spontaneously hypertensive rats (SHR) and normotensive rats (WKY) models. Normotensive and hypertensive animals received CMG at doses of 20 mg kg⁻¹ and 60 mg kg⁻¹ for four weeks. Then, weight gain, lipid profile, renal function, blood pressure, cardiac hypertrophy, baroreflex sensitivity, and sympathetic tone were evaluated. Oral administration of CMG influenced weight gain and cholesterol levels, and significantly reduced urea in the hypertensive animals. It decreased blood pressure levels and cardiac hypertrophy, improved baroreflex response, and reduced the influence of sympathetic tone. The results demonstrate the antihypertensive effect of CMG through improvement in baroreflex sensitivity via sympathetic tone modulation.
    Keywords Saccharomyces cerevisiae ; antihypertensive effect ; antioxidants ; blood pressure ; cholesterol ; hypertension ; hypertrophy ; immunomodulation ; lipid composition ; oral administration ; polymers ; renal function ; urea ; weight gain
    Language English
    Dates of publication 2021-0920
    Size p. 8552-8560.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo01079d
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats

    Bezerra, Lorena Soares / Magnani, Marciane / Pimentel, Tatiana Colombo / de Oliveira, Júlio César Pinheiro Lúcio / Freire, Francisca Manuela de Souza / de Almeida, Arthur José Pontes Oliveira / Rezende, Mathania Silva de Almeida / Gonçalves, Islânia Giselia Albuquerque / de Medeiros, Isac Almeida / Veras, Robson Cavalcante

    Food & function. 2022 May 10, v. 13, no. 9

    2022  

    Abstract: Carboxymethyl-glucan is a semi-synthetic derivative of β-d-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. ...

    Abstract Carboxymethyl-glucan is a semi-synthetic derivative of β-d-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. However, studies exploring carboxymethyl-glucan bioactivity in cardiovascular health remain lacking, mainly in hypertension. Thus, this study sought to expand understanding of the effects of carboxymethyl-glucan on vascular and platelet functions in a hypertensive animal model. Spontaneously hypertensive rats and their normotensive Wistar-Kyoto controls were assigned to five groups: control, carboxymethyl-glucan (60 mg kg⁻¹), control spontaneously hypertensive rats, spontaneously hypertensive rats carboxymethyl-glucan (20 mg kg⁻¹), and spontaneously hypertensive rats carboxymethyl-glucan (60 mg kg⁻¹). Animals were treated for four weeks with carboxymethyl-glucan at doses of 20 and 60 mg kg⁻¹ orally, and control rats received saline as a placebo. Vascular reactivity, platelet aggregation, and reactive oxygen species production were evaluated at the end of treatment. The results showed that carboxymethyl-glucan improved vascular function and reduced platelet aggregation, mainly at a 60 mg kg⁻¹ dose. However, despite these effects, there was no reduction in levels of reactive oxygen species. These findings suggested that carboxymethyl-glucan modulates endothelial function. It also acts as a platelet antiaggregant, which is an interesting resource for managing hypertension and its thrombotic complications.
    Keywords bioactive properties ; hypertension ; immunomodulators ; placebos ; platelet aggregation ; reactive oxygen species ; yeasts
    Language English
    Dates of publication 2022-0510
    Size p. 5406-5415.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo03492h
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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