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  1. Article ; Online: Caveat Emptor: Commercialized Manganese Oxide Nanoparticles Exhibit Unintended Properties.

    Martinez de la Torre, Celia / Freshwater, Kasey A / Looney-Sanders, Mara A / Wang, Qiang / Bennewitz, Margaret F

    ACS omega

    2023  Volume 8, Issue 21, Page(s) 18799–18810

    Abstract: Nano-encapsulated manganese oxide (NEMO) particles are noteworthy contrast agents for magnetic resonance imaging (MRI) due to their bright, pH-switchable signal ("OFF" to "ON" at low pH), high metal loading, and targeting capability for increased ... ...

    Abstract Nano-encapsulated manganese oxide (NEMO) particles are noteworthy contrast agents for magnetic resonance imaging (MRI) due to their bright, pH-switchable signal ("OFF" to "ON" at low pH), high metal loading, and targeting capability for increased specificity. For the first time, we performed a head-to-head comparison of NEMO particles from In-house and commercialized sources (US Nano vs Nanoshel) to assess their potential as bright T
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PEGylation of Alternative MRI Contrast Agents Modulate Neutrophil Extracellular Trap Formation.

    Snoderly, Hunter T / Freshwater, Kasey A / de la Torre, Celia Martinez / Panchal, Dhruvi M / Vito, Jenna N / Redigolo, Marcela L / Bennewitz, Margaret F

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 1142–1143

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: PEGylation of Metal Oxide Nanoparticles Modulates Neutrophil Extracellular Trap Formation.

    Snoderly, Hunter T / Freshwater, Kasey A / Martinez de la Torre, Celia / Panchal, Dhruvi M / Vito, Jenna N / Bennewitz, Margaret F

    Biosensors

    2022  Volume 12, Issue 2

    Abstract: Novel metal oxide nanoparticle (NP) contrast agents may offer safety and functionality advantages over conventional gadolinium-based contrast agents (GBCAs) for cancer diagnosis by magnetic resonance imaging. However, little is known about the behavior ... ...

    Abstract Novel metal oxide nanoparticle (NP) contrast agents may offer safety and functionality advantages over conventional gadolinium-based contrast agents (GBCAs) for cancer diagnosis by magnetic resonance imaging. However, little is known about the behavior of metal oxide NPs, or of their effect, upon coming into contact with the innate immune system. As neutrophils are the body's first line of defense, we sought to understand how manganese oxide and iron oxide NPs impact leukocyte functionality. Specifically, we evaluated whether contrast agents caused neutrophils to release web-like fibers of DNA known as neutrophil extracellular traps (NETs), which are known to enhance metastasis and thrombosis in cancer patients. Murine neutrophils were treated with GBCA, bare manganese oxide or iron oxide NPs, or poly(lactic-co-glycolic acid) (PLGA)-coated metal oxide NPs with different incorporated levels of poly(ethylene glycol) (PEG). Manganese oxide NPs elicited the highest NETosis rates and had enhanced neutrophil uptake properties compared to iron oxide NPs. Interestingly, NPs with low levels of PEGylation produced more NETs than those with higher PEGylation. Despite generating a low rate of NETosis, GBCA altered neutrophil cytokine expression more than NP treatments. This study is the first to investigate whether manganese oxide NPs and GBCAs modulate NETosis and reveals that contrast agents may have unintended off-target effects which warrant further investigation.
    MeSH term(s) Animals ; Contrast Media ; Extracellular Traps ; Humans ; Metal Nanoparticles ; Mice ; Nanoparticles ; Neutrophils/metabolism ; Oxides
    Chemical Substances Contrast Media ; Oxides
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12020123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Short-term exposure of female BALB/cJ mice to e-cigarette aerosol promotes neutrophil recruitment and enhances neutrophil-platelet aggregation in pulmonary microvasculature.

    Snoderly, Hunter T / Alkhadrawi, Hassan / Panchal, Dhruvi M / Weaver, Kelly L / Vito, Jenna N / Freshwater, Kasey A / Santiago, Stell P / Olfert, I Mark / Nurkiewicz, Timothy R / Bennewitz, Margaret F

    Journal of toxicology and environmental health. Part A

    2023  Volume 86, Issue 8, Page(s) 246–262

    Abstract: Despite the perception that e-cigarettes are safer than conventional cigarettes, numerous findings demonstrated that e-cigarette aerosol (EC) exposure induced compromised immune functionality, vascular changes even after acute exposure, and lung injury. ... ...

    Abstract Despite the perception that e-cigarettes are safer than conventional cigarettes, numerous findings demonstrated that e-cigarette aerosol (EC) exposure induced compromised immune functionality, vascular changes even after acute exposure, and lung injury. Notably, altered neutrophil functionality and platelet hemodynamics have been observed post-EC exposure. It was hypothesized that EC exposure initiates an inflammatory response resulting in altered neutrophil behavior and increased neutrophil-platelet interaction in the pulmonary microvasculature. Neutrophil and platelet responses were examined up to 48 hrs following whole-body, short-term EC exposure without flavorants or nicotine in a murine model, which most closely modeled secondhand exposure. This study is the first to investigate the impact of EC exposure through lung intravital imaging. Compared to room air-exposed mice, EC-exposed mice displayed significantly increased 1.7‒1.9-fold number of neutrophils in the pulmonary microvasculature associated with no marked change in neutrophils within whole blood or bronchoalveolar lavage fluid (BALF). Neutrophil-platelet interactions were also significantly elevated 1.9‒2.5-fold in exposed mice. Plasma concentration of myeloperoxidase was markedly reduced 1.5-fold 48 hr following exposure cessation, suggesting suppressed neutrophil antimicrobial activity. Cytokine expression exhibited changes indicating vascular damage. Effects persisted for 48 hr post-EC exposure. Data demonstrated that EC exposure repeated for 3 consecutive days in 2.5 hr intervals in the absence of flavorants or nicotine resulted in modified pulmonary vasculature hemodynamics, altered immune functionality, and a pro-inflammatory state in female BALB/cJ mice.
    MeSH term(s) Female ; Mice ; Animals ; Neutrophils/metabolism ; Electronic Nicotine Delivery Systems ; Platelet Aggregation ; Nicotine/metabolism ; Neutrophil Infiltration ; Respiratory Aerosols and Droplets ; Lung/metabolism ; Microvessels
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1413345-3
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    DOI 10.1080/15287394.2023.2184738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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