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  1. Book ; Thesis: Corticale Oberflächenmorphometrie von Resilienz bei Major Depression

    Frey, Alexandra

    2022  

    Institution Philipps-Universität Marburg
    Author's details vorgelegt von Alexandra Frey
    Language German
    Size V, 130 Seiten, Illustrationen, Diagramme
    Publishing place Marburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Philipps-Universität Marburg, 2023
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT030668286
    Database Catalogue ZB MED Medicine, Health

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    2024 D 102 order for loan Magazin

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  2. Book ; Online: Erbgut von Primaten als Schlüssel zur menschlichen Gesundheit

    Frey, Alexandra

    Primaten-Genome mittels KI auf klinische Relevanz von individuellen Genvarianten analysiert

    2023  

    Abstract: Neue Genomdaten einer großen Zahl verschiedener Affenarten, die von einem internationalen Forschungsteam generiert wurden, bringen neue Erkenntnisse über die genetischen Ursachen menschlicher Krankheiten. Mit Entwicklung eines auf Deep-Learning ... ...

    Abstract Neue Genomdaten einer großen Zahl verschiedener Affenarten, die von einem internationalen Forschungsteam generiert wurden, bringen neue Erkenntnisse über die genetischen Ursachen menschlicher Krankheiten. Mit Entwicklung eines auf Deep-Learning basierenden Algorithmus könnten sie in Zukunft als eine Grundlage für personalisierte medizinische Behandlungskonzepte beim Menschen dienen. Martin Kuhlwilm, Wissenschafter am Department für Evolutionäre Anthropologie der Universität Wien, hat an dieser und weiteren Studien zum Genom verschiedener Primaten mitgewirkt, deren gesammelten Ergebnisse aktuell in der neuesten Ausgabe des renommierten Fachjournals Science publiziert wurden. Die erzielten Resultate sind vielversprechend und ermöglichen weitere Einblicke in die Evolution der Primaten, in manche (vermeintliche) Alleinstellungsmerkmale des Menschen sowie in genetische Ursachen menschlicher Erkrankungen.
    Keywords Text ; ddc:610 ; Pressespiegel -- Friedrich-Loeffler-Institut -- Forschung -- Publikation -- Science
    Language German
    Publishing date 2023-06-01
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Thesis: Die Herzfrequenz an der individuellen anaeroben Schwelle beim Triathleten

    Frey, Alexandra

    Laufband- und Fahrradergometrie im Vergleich

    2001  

    Author's details vorgelegt von Alexandra Frey
    Language German
    Size IV, 91 S.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2001
    HBZ-ID HT013180042
    Database Catalogue ZB MED Medicine, Health

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  4. Article: Real-World Administration of Once-Daily MeltDose

    Willuweit, Katharina / Frey, Alexandra / Hörster, Anne / Saner, Fuat / Herzer, Kerstin

    Journal of clinical medicine

    2020  Volume 10, Issue 1

    Abstract: The calcineurin inhibitor tacrolimus is included in most immunosuppressive protocols after liver transplantation. This retrospective, observational 24-month study investigated the tolerability of once-daily ... ...

    Abstract The calcineurin inhibitor tacrolimus is included in most immunosuppressive protocols after liver transplantation. This retrospective, observational 24-month study investigated the tolerability of once-daily MeltDose
    Language English
    Publishing date 2020-12-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10010124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Safe for Mother, Baby, and Graft? Pregnancy After Liver Transplant: A Single-Center Experience.

    Rashidi-Alavijeh, Jassin / Frey, Alexandra / Hörster, Anne / Nguyen, Buu-Phuc / Iannaccone, Antonella / Saner, Fuat / Lange, Christian M / Willuweit, Katharina

    Transplantation proceedings

    2022  Volume 54, Issue 3, Page(s) 744–748

    Abstract: Background: Although fertility is reduced in patients with liver cirrhosis, recovery of menstrual cycle is acquired after liver transplantation (LT) in most patients, and pregnancy in LT recipients is not unusual. The aim of this study was to evaluate ... ...

    Abstract Background: Although fertility is reduced in patients with liver cirrhosis, recovery of menstrual cycle is acquired after liver transplantation (LT) in most patients, and pregnancy in LT recipients is not unusual. The aim of this study was to evaluate the outcomes of pregnancies in LT recipients in our center.
    Methods: Data of 24 pregnancies in 14 LT recipients were collected and statistically analyzed. Demographic and clinical data were documented in each trimester of pregnancy and thereafter. The analysis was conducted in accordance with the 1975 Declaration of Helsinki and was approved by the ethics committee of the University Hospital Essen.
    Results: Median patient age was 21.5 years (range, 2-32 years) at LT and 31 years (range, 19-41 years) at conception. Median time between LT and conception was 126 months (range, 38-332 months), and median gestation time of completed pregnancies was 38 weeks (range, 29-40 weeks). Seven pregnancies terminated in abortions (29%). Of all deliveries, 6 resulted in preterm births (35%) with median gestation time of 34.5 weeks (range, 29-37 weeks). Gestational diabetes mellitus was the most common maternal complication, occurring in 4 patients (17%). One patient suffered from preeclampsia (4%). Pregnancy-induced hypertension or acute cellular rejection was not reported in our cohort. None of the children had serious complications.
    Conclusions: Our data show favorable outcome for pregnancy in LT recipients for mother and offspring. However, these patients are still at risk, particularly regarding high rates of preterm delivery, and preconception counseling and multidisciplinary monitoring are crucial to manage possible complications.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Graft Rejection ; Humans ; Infant ; Infant, Newborn ; Liver Transplantation/adverse effects ; Mothers ; Pregnancy ; Pregnancy Complications/etiology ; Pregnancy Outcome ; Premature Birth ; Young Adult
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 835: Show issues Location:
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  6. Book ; Online ; Thesis: Der Einfluss verschiedener Immunsuppressiva auf die HCV-Replikation

    Frey, Alexandra [Verfasser] / Herzer, Kerstin [Akademischer Betreuer]

    2020  

    Author's details Alexandra Frey ; Betreuer: Kerstin Herzer
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  7. Article: Durability of Immune Response after Application of a Third Dose of SARS-CoV-2 Vaccination in Liver Transplant Recipients.

    Passenberg, Moritz / Authorsen-Grudmann, Roxane / Frey, Alexandra / Korth, Johannes / Zmudzinski, Jaqueline / Anastasiou, Olympia E / Möhlendick, Birte / Schmidt, Hartmut / Rashidi-Alavijeh, Jassin / Willuweit, Katharina

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Immunogenicity after SARS-CoV-2 vaccination is known to be impaired in liver transplant (LT) recipients, but the results after the application of a third dose show significant improvement in seroconversion rates. In the general population, the antibody ... ...

    Abstract Immunogenicity after SARS-CoV-2 vaccination is known to be impaired in liver transplant (LT) recipients, but the results after the application of a third dose show significant improvement in seroconversion rates. In the general population, the antibody response wanes over the course of time after two doses of the vaccination, but seems to be more robust after the application of three doses. Still, the durability of the antibody response in LT recipients who receive a third dose of SARS-CoV-2 vaccination has not been analyzed yet. We therefore assessed antibody responses in a total of 300 LT recipients and observed antibody titers for six months each after patients had received the second and the third doses of the vaccination, explicitly excluding all patients who had suffered from SARS-CoV-2 infection. The initial antibody response was compared to a control group of 122 healthcare workers. After the application of two doses of the vaccination, 74% of LT recipients (158 out of 213) developed antibodies against SARS-CoV-2; this result depended significantly on whether the patients were taking the medication mycophenolate mofetil, and on the age of the patients. Antibody titers declined significantly within six months from 407 BAU/mL (IQR: 0-1865) to 105 BAU/mL (IQR: 0-145) (
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Implications of anaemia and response to anaemia treatment on outcomes in patients with cirrhosis.

    Rashidi-Alavijeh, Jassin / Nuruzade, Nargiz / Frey, Alexandra / Huessler, Eva-Maria / Hörster, Anne / Zeller, Amos Cornelius / Schütte, Andreas / Schmidt, Hartmut / Willuweit, Katharina / Lange, Christian Markus

    JHEP reports : innovation in hepatology

    2023  Volume 5, Issue 4, Page(s) 100688

    Abstract: Background & aims: Anaemia is frequently observed in patients with cirrhosis and was identified as a predictor of adverse outcomes, such as increased mortality and occurrence of acute-on-chronic liver failure. To date, the possible effects of iron ... ...

    Abstract Background & aims: Anaemia is frequently observed in patients with cirrhosis and was identified as a predictor of adverse outcomes, such as increased mortality and occurrence of acute-on-chronic liver failure. To date, the possible effects of iron supplementation on these adverse outcomes are not well described. We therefore aimed to assess the role of iron supplementation in patients with cirrhosis and its capability to improve prognosis.
    Methods: Laboratory diagnostics were performed in consecutive outpatients with cirrhosis admitted between July 2018 and December 2019 to the University Hospital Essen. Associations with transplant-free survival were assessed in regression models.
    Results: A total of 317 outpatients with cirrhosis were included, of whom 61 received a liver transplant (n = 19) or died (n = 42). In multivariate Cox regression analysis, male sex (hazard ratio [HR] = 3.33, 95% CI [1.59, 6.99],
    Conclusions: An increase of haemoglobin levels is associated with improvement of transplant-free survival in patients with cirrhosis. Because the prediction of haemoglobin increase significantly depends on rifaximin and iron supplementation, application of these two medications can have an important impact on the outcome of these patients.
    Impact and implications: Anaemia is very common in patients with cirrhosis and is known to be a predictor of negative outcomes, but little is known about the effect of iron substitution in these individuals. In our cohort, increase of haemoglobin levels improved transplant-free survival of patients with cirrhosis. The increase of haemoglobin levels was mainly induced by iron supplementation and was even stronger in the case of concomitant use of iron and rifaximin.
    Clinical trial registration: UME-ID-10042.
    Language English
    Publishing date 2023-01-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2023.100688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Transplantation for Primary Sclerosing Cholangitis: Outcomes and Recurrence.

    Saner, Fuat H / Frey, Alexandra / Stüben, Björn-Ole / Hoyer, Dieter P / Willuweit, Katharina / Daniel, Martina / Rashidi-Alavieh, Jassin / Treckmann, Jurgen W / Schmidt, Hartmut H

    Journal of clinical medicine

    2023  Volume 12, Issue 10

    Abstract: Primary sclerosing cholangitis (PSC) is characterized by inflammation of the whole bile duct system. Liver transplantation is only approved as a curative treatment when it comes to end-stage liver disease. The aim of our study was to assess morbidity, ... ...

    Abstract Primary sclerosing cholangitis (PSC) is characterized by inflammation of the whole bile duct system. Liver transplantation is only approved as a curative treatment when it comes to end-stage liver disease. The aim of our study was to assess morbidity, survival rates and PSC recurrence and the impact of donor characteristics in long-term follow-up. This was an IRB-approved retrospective study. A total of 82 patients were identified who were transplanted between January 2010 and December 2021 for PSC. Among these patients, 76 adult liver transplant PSC patients and their corresponding donors were analyzed. Three pediatric cases and three adult patients with a follow-up within <1 year were excluded from further analysis. Median (range) age was 47 years (18-70) with a median (range) lab-MELD of 16 (7-40). Median (range) ICU and hospital stays were 4.6 days (0-147) and 21 days (1-176), respectively. The majority of patients suffered from Crohn's disease or ulcerative colitis as a concomitant comorbidity (65.8%). The ten-year survival rate was 74.6%. A significantly lower lab-MELD score was identified in patients surviving for > 10 years (15 vs. 22,
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12103405
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  10. Article ; Conference proceedings: Safety of coronary angiography in patients with cirrhosis as part of an evaluation for liver transplantation

    Passenberg, Moritz / Bogazliyan, Aycan / Frey, Alexandra / Konstantis, Georgios / Huessler, Eva-Maria / Al-Rashid, Fadi / Rassaf, Tienush / Lange, Christian Markus / Schmidt, Hartmut H. / Willuweit, Katharina / Rashidi-Alavijeh, Jassin

    Zeitschrift für Gastroenterologie

    2024  Volume 62, Issue 01

    Event/congress 40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26
    Language German
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1777548
    Database Thieme publisher's database

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