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  1. Book ; Thesis: Der Quilty-Effekt

    Freytag, Dorothee

    Untersuchungen zum Vorkommen und zu möglichen Abhängigkeiten in 4.398 Endomyokardbiopsien verstorbener herztransplantierter Patienten

    (Berichte aus der Medizin)

    2001  

    Author's details Dorothee Freytag
    Series title Berichte aus der Medizin
    Keywords Herztransplantation ; Transplantatabstoßung ; Biopsie ; Histopathologie
    Subject Gewebepathologie ; Histologische Diagnose ; Histologische Pathologie ; Pathohistologie ; Pathologische Histologie ; Abstoßungsreaktion ; Transplantat ; Herzverpflanzung ; Herz
    Language German
    Size VI, 71 S., graph. Darst., 21 cm
    Publisher Shaker
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2001
    HBZ-ID HT013222320
    ISBN 3-8265-9489-4 ; 978-3-8265-9489-2
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Uterine Fibroids and Infertility.

    Freytag, Damaris / Günther, Veronika / Maass, Nicolai / Alkatout, Ibrahim

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 8

    Abstract: Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Uterine fibroids are the most common tumor in women, and their prevalence is ... ...

    Abstract Infertility is a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Uterine fibroids are the most common tumor in women, and their prevalence is high in patients with infertility. Fibroids may be the sole cause of infertility in 2-3% of women. Depending on their location in the uterus, fibroids have been implicated in recurrent pregnancy loss as well as infertility. Pregnancy and live birth rates appear to be low in women with submucosal fibroids; their resection has been shown to improve pregnancy rates. In contrast, subserosal fibroids do not affect fertility outcomes and their removal does not confer any benefit. Intramural fibroids appear to reduce fertility, but recommendations concerning their treatment remain unclear. Myomectomy should be discussed individually with the patient; other potential symptoms such as dysmenorrhea or bleeding disorders should be included in the indication for surgery.
    Language English
    Publishing date 2021-08-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11081455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: PRIMAERE AUSLOCKERUNGEN VON TOTALENDOPROTHESEN DES HUEFTGELENKS

    Freytag, Dirk

    1980  

    Size 118 BL. : ILL.
    Document type Book
    Note HEIDELBERG, UNIV., MED. GESAMTFAK., DISS., 1980 (NICHT F.D. AUSTAUSCH.)
    HBZ-ID HT000127123
    Database Catalogue ZB MED Medicine, Health

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  4. Article: Critical Role of 3D ultrasound in the diagnosis and management of Robert's uterus: a single-centre case series and a review.

    Deenadayal, M / Günther, V / Alkatout, I / Freytag, D / Deenadayal-Mettler, A / Deenadayal Tolani, A / Sinha, R / Mettler, L

    Facts, views & vision in ObGyn

    2021  Volume 13, Issue 1, Page(s) 41–49

    Abstract: A septate uterus with a non-communicating hemicavity was first described by Robert in 1969/70 as a specific malformation of the uterus. The condition is commonly associated with a blind uterine hemicavity, unilateral haematometra, a contralateral ... ...

    Abstract A septate uterus with a non-communicating hemicavity was first described by Robert in 1969/70 as a specific malformation of the uterus. The condition is commonly associated with a blind uterine hemicavity, unilateral haematometra, a contralateral unicornuate uterine cavity and a normal external uterine fundus. The main symptoms are repetitive attacks of pain at four-weekly intervals around menarche, repeated dysmenorrhea, recurrent pregnancy loss and infertility. In this report, we review the disease, its diagnosis and treatment, and describe five cases of Robert's uterus. Three dimensional (3D) ultrasound (US) imaging was performed by the transvaginal route in four cases. In the fifth case of a 13-year-old girl, we avoided the vaginal route and magnetic resonance imaging (MRI) and 3D transrectal US yielded the correct diagnosis. The following treatment procedures were undertaken: laparoscopic endometrectomy, hysteroscopic septum resection, laparoscopic uterine hemicavity resection and total laparoscopic hysterectomy (TLH). The diagnosis and optimum treatment of Robert's uterus remains difficult for clinicians because of its rarity. A detailed and careful assessment by 3D US should be performed, followed by hysteroscopy in combination with laparoscopy, to confirm the diagnosis.
    Language English
    Publishing date 2021-03-31
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 2701574-9
    ISSN 2032-0418 ; 2684-4230
    ISSN 2032-0418 ; 2684-4230
    DOI 10.52054/FVVO.13.1.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Das Neue kommunale Finanzmanagement in Nordrhein-Westfalen

    Freytag, Dieter

    Verwaltung & Management : VM ; Zeitschrift für moderne Verwaltung Vol. 20, No. 3 , p. 142-147

    2014  Volume 20, Issue 3, Page(s) 142–147

    Author's details Dieter Freytag
    Keywords Kommunales Rechnungswesen ; Nordrhein-Westfalen
    Language German
    Size Ill., graph. Darst.
    Publisher Nomos-Verl.-Ges
    Publishing place Baden-Baden
    Document type Article
    ZDB-ID 1235149-0
    ISSN 0947-9856
    Database ECONomics Information System

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  6. Article: Ovariopexy-Before and after Endometriosis Surgery.

    Dhanawat, Juhi / Pape, Julian / Freytag, Damaris / Maass, Nicolai / Alkatout, Ibrahim

    Biomedicines

    2020  Volume 8, Issue 12

    Abstract: Endometriosis surgery is often very challenging. Key to complete resection of endometriosis is access to the retroperitoneum. Endometriosis can involve the ureter and uterine vessels, and ovary on the lateral pelvic wall makes retroperitoneal access ... ...

    Abstract Endometriosis surgery is often very challenging. Key to complete resection of endometriosis is access to the retroperitoneum. Endometriosis can involve the ureter and uterine vessels, and ovary on the lateral pelvic wall makes retroperitoneal access difficult. Primary and post-surgical adhesions prevalence in endometriosis is very high. Ovariopexy, transposition of ovaries temporarily, is done for better surgical access and to reduce postoperative adhesions. We concluded that although limited evidence, ovariopexy is an excellent tool to aid endometriosis surgery and prevent postoperative adhesions. It is cost effective, simple and complication rate almost nil. More robust trials are required to substantiate evidence for its impact on preventing postoperative adhesions and its effect on fertility. In this review, we describe our technique of ovariopexy supplemented with a video, with the aim to put light on this useful and important technique, which is beneficial both for surgeons and patients.
    Language English
    Publishing date 2020-11-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines8120533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Perioperative considerations in the treatment of endometriosis

    Freytag, Damaris / Peters, Göntje / Mettler, Liselotte / Gitas, Georgios / Maass, Nicolai / Alkatout, Ibrahim

    Journal of the Turkish German Gynecological Association

    2021  Volume 22, Issue 4, Page(s) 319–325

    Abstract: Endometriosis is one of the most common benign diseases in women of reproductive age. Nearly all gynecological offices and clinics will contain patients with endometriosis; the frequency and severity of the disease will vary from one setting to another. ... ...

    Abstract Endometriosis is one of the most common benign diseases in women of reproductive age. Nearly all gynecological offices and clinics will contain patients with endometriosis; the frequency and severity of the disease will vary from one setting to another. Adjoining specialties, such as internal medicine, general medicine, surgery, urology, orthopedics, neurology and psychosomatic medicine, will be challenged directly or indirectly by various forms of endometriosis and its sequelae. The disease is characterized by pelvic pain, dysmenorrhea, dyspareunia and sterility. Even now, several years may elapse between the onset of the disease and its diagnosis. The diagnosis of endometriosis is complicated by the diversity of the symptoms. A precise documentation of the patient’s medical history and thorough diagnostic procedures are essential to establish a robust diagnosis. This article will discuss the perioperative considerations, diagnosis and treatment of endometriosis.
    Language English
    Publishing date 2021-06-10
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.galenos.2021.2021.0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Recurrent implantation failure - an overview of current research.

    Günther, Veronika / Otte, Sören V / Freytag, Damaris / Maass, Nicolai / Alkatout, Ibrahim

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2021  Volume 37, Issue 7, Page(s) 584–590

    Abstract: Background: Recurrent implantation failure (RIF) can be defined as a failure to achieve a clinical pregnancy after transfer of at least four embryos of good quality in a minimum of three fresh or frozen cycles in women under the age of 40. RIF is often ... ...

    Abstract Background: Recurrent implantation failure (RIF) can be defined as a failure to achieve a clinical pregnancy after transfer of at least four embryos of good quality in a minimum of three fresh or frozen cycles in women under the age of 40. RIF is often a complex problem with a wide variety of etiologies and mechanisms as well as treatment options.
    Summary: Anatomical conditions of the uterus, thrombophilia, genetic abnormalities, or immunological factors are only a few examples which could be responsible for RIF. The recommendations for women with RIF vary depending on the source of their problem. There is not just one treatment option, but many depending on the etiology and the severity of the problem.
    Key message: However, it would help to establish a set of standardized examinations and tests to use, in order to do a preliminary evaluation on each patient, which would then hopefully direct the approach of treatment for each individual couple.
    MeSH term(s) Chromosome Aberrations ; Chronic Disease ; Embryo Implantation ; Embryo Transfer ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/surgery ; Endometritis/complications ; Endometritis/diagnosis ; Endometritis/drug therapy ; Female ; Humans ; Infertility, Female/etiology ; Infertility, Female/immunology ; Infertility, Female/therapy ; Leiomyoma/complications ; Leiomyoma/diagnosis ; Leiomyoma/surgery ; Maternal Age ; Pregnancy ; Preimplantation Diagnosis ; Recurrence ; Semen Analysis ; Th1-Th2 Balance ; Thrombophilia/complications ; Thrombophilia/diagnosis ; Thrombophilia/therapy ; Treatment Failure ; Uterine Neoplasms/complications ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/surgery ; Uterus/abnormalities
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2021.1878136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A risk factor analysis of complications after surgery for vulvar cancer.

    Gitas, Georgios / Proppe, L / Baum, S / Kruggel, M / Rody, A / Tsolakidis, D / Zouzoulas, D / Laganà, A S / Guenther, V / Freytag, D / Alkatout, I

    Archives of gynecology and obstetrics

    2021  Volume 304, Issue 2, Page(s) 511–519

    Abstract: Introduction: Despite the less frequent use of surgery in patients with vulvar cancer, the high rates of postoperative complications are still a matter of concern. The aim of the present study was to identify risk factors that influence postoperative ... ...

    Abstract Introduction: Despite the less frequent use of surgery in patients with vulvar cancer, the high rates of postoperative complications are still a matter of concern. The aim of the present study was to identify risk factors that influence postoperative complications rates in vulvar cancer and identify specific clinical parameters that may influence their incidence.
    Materials: Patients who underwent curative-intent surgery for squamous cell carcinoma of the vulva from 2003 to 2018 were selected. All patient characteristics were analyzed as risk factors for the development of postoperative lymphocele, lymphedema, and wound dehiscence. The patients were followed up for 2 years postoperatively.
    Results: The investigation comprised 121 patients, of whom 18.1% developed wound dehiscence, 17.7% a lymphocele, and 20.4% lymphedema. We found no significant evidence of an association between patient's characteristics and postoperative complications. The depth of tumor invasion and the appearance of lymph-node metastasis were significantly associated with postoperative complications. Free resection margins of 5 mm or more were associated with a reduced risk of postoperative complications compared to resection margins less than 5 mm. No complications were encountered after sentinel node biopsy (SNB). Complication rates were associated with inguinofemoral lymphadenectomy, but not with the extent of lymphadenectomy. The development of a lymphocele or wound dehiscence may be correlated with the development of long-term lymphedema.
    Conclusion: FIGO stage at diagnosis influences the risk of postoperative complications. The use of SNB minimized postoperative complications. Correlations between the free microscopic resection margin distance and the risk of postoperative wound dehiscence must be investigated further.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Factor Analysis, Statistical ; Female ; Humans ; Lymph Node Excision/adverse effects ; Lymphocele ; Middle Aged ; Neoplasm Staging ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Risk Factors ; Vulvar Neoplasms/pathology ; Vulvar Neoplasms/surgery
    Language English
    Publishing date 2021-01-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-020-05949-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Uterine anomalies and endometriosis.

    Freytag, Damaris / Mettler, Liselotte / Maass, Nicolai / Günther, Veronika / Alkatout, Ibrahim

    Minerva medica

    2019  Volume 111, Issue 1, Page(s) 33–49

    Abstract: Introduction: Endometriosis is a common disease in women of reproductive age. In addition to causing pain, it may also reduce fertility. The coexistence of endometriosis and congenital uterine anomalies (CUA) has been frequently reported in the ... ...

    Abstract Introduction: Endometriosis is a common disease in women of reproductive age. In addition to causing pain, it may also reduce fertility. The coexistence of endometriosis and congenital uterine anomalies (CUA) has been frequently reported in the published literature. The present report is a review of existing studies on the subject and our own hitherto unpublished data.
    Evidence acquisition: The electronic search was conducted using the Pubmed database with specific keyword combinations including endometriosis, adenomyosis, infertility, Müllerian malformations/anomalies, and septate uterus. The principal aspects addressed in the present study were: diagnosis, management, and classification of CUA, their impact on fertility and coexistence with endometriosis.
    Evidence synthesis: Endometriosis and CUA are frequently detected in the exploration of infertility, because both of these are liable to impair fertility. Endometriosis is associated with obstructive anomalies and nonobstructive malformations, especially those concerning the septate uterus. The diagnosis and management of CUA have been discussed for several years. Various classification systems have been proposed.
    Conclusions: The analysis of the existing literature has revealed the absence of any consensus about the management, diagnosis, and classification of CUA, especially with regard to the septate uterus. We need to find and speak a common language in order to avoid inappropriate or unnecessary surgery and optimize the individual patient's treatment. The combined presence of endometriosis or adenomyosis and CUA is a reason to perform precise diagnostic imaging investigations and early surgery for the purpose of enhancing the chances of pregnancy in infertile patients. Further research is needed on the subject.
    MeSH term(s) Adenomyosis/complications ; Adenomyosis/pathology ; Endometriosis/complications ; Endometriosis/pathology ; Female ; Humans ; Infertility, Female/etiology ; Ultrasonography ; Urogenital Abnormalities/classification ; Urogenital Abnormalities/complications ; Urogenital Abnormalities/diagnosis ; Urogenital Abnormalities/therapy ; Uterus/abnormalities
    Language English
    Publishing date 2019-11-12
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.19.06341-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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