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  1. Article: Mind body medicine: a modern bio-psycho-social model forty-five years after Engel.

    Fricchione, Gregory

    BioPsychoSocial medicine

    2023  Volume 17, Issue 1, Page(s) 12

    Language English
    Publishing date 2023-03-30
    Publishing country England
    Document type Editorial
    ZDB-ID 2265705-8
    ISSN 1751-0759
    ISSN 1751-0759
    DOI 10.1186/s13030-023-00268-3
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  2. Article ; Online: Brain evolution and the meaning of catatonia - An update.

    Fricchione, Gregory

    Schizophrenia research

    2023  Volume 263, Page(s) 139–150

    Abstract: Back in 2004, in a chapter titled "Brain Evolution and the Meaning of Catatonia", a case was made that the syndrome's core meaning is embedded in millions of years of vertebrate brain evolution. (Fricchione, 2004) In this update, advances over the last ... ...

    Abstract Back in 2004, in a chapter titled "Brain Evolution and the Meaning of Catatonia", a case was made that the syndrome's core meaning is embedded in millions of years of vertebrate brain evolution. (Fricchione, 2004) In this update, advances over the last almost 20 years, in catatonia theory and research in particular, and pertinent neuropsychiatry in general, will be applied to this question of meaning. The approach will rely heavily on a number of thought leaders, including Nicos Tinbergen, Paul MacLean, John Bowlby, M. Marsel Mesulam, Bruce McEwen and Karl Friston. Their guidance will be supplemented with a selected survey of 21
    MeSH term(s) Humans ; Catatonia/diagnosis ; Population Health ; Brain/diagnostic imaging ; Syndrome ; Fear
    Language English
    Publishing date 2023-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2023.01.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2351: Show issues Location:
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  3. Book: Compassion and healing in medicine and society

    Fricchione, Gregory

    on the nature and use of attachment solutions to separation challenges

    2012  

    Author's details Gregory L. Fricchione
    Keywords Object Attachment ; Anxiety, Separation ; Empathy ; Mental Healing ; Social Medicine ; Biological Evolution
    Language English
    Size XV, 534 S.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; The medical mission and evolution -- Two realms of knowledge-or one? -- Knowledge, meaning, and healing -- Evolution of the protocell -- Cellular evolution -- Animal evolution -- Evolution of the brain -- Structuring the brain to know and act -- Memory and motivation -- Meaning, healing, and the brain -- Separation, attachment, and human development -- Separation, attachment, and the life cycle -- The social neuroscience of separation and attachment -- Consciousness, language, and their origins -- Evolutionary consciousness -- Implications for society, culture, and ethics -- An evolutionary true cause? -- Investigating the separation challenge-attachment solution hypothesis -- A testable hypothesis -- Analogies and analysis -- Implications for the mission of modern medicine -- Implications for medicine at the end of life -- Postscript : a commentary on human evolution
    HBZ-ID HT017211811
    ISBN 978-1-4214-0220-8 ; 1-4214-0220-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 2001 order for loan Magazin

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  4. Article ; Online: Clinical Implications of Illness Denial.

    Fricchione, Gregory L

    Psychotherapy and psychosomatics

    2023  Volume 92, Issue 4, Page(s) 208–210

    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 209490-3
    ISSN 1423-0348 ; 0033-3190
    ISSN (online) 1423-0348
    ISSN 0033-3190
    DOI 10.1159/000533124
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  5. Article ; Online: Stress-induced failure of embodied cognition: A general model.

    Wallace, Rodrick / Fricchione, Gregory

    Bio Systems

    2024  Volume 239, Page(s) 105193

    Abstract: We derive the classic, ubiquitous, but enigmatic Yerkes-Dodson effect of applied stress on real-world performance in a highly natural manner from fundamental assumptions on cognition and its dynamics, as constrained by the asymptotic limit theorems of ... ...

    Abstract We derive the classic, ubiquitous, but enigmatic Yerkes-Dodson effect of applied stress on real-world performance in a highly natural manner from fundamental assumptions on cognition and its dynamics, as constrained by the asymptotic limit theorems of information and control theories. We greatly extend the basic approach by showing how differences in an underlying probability model can affect the dynamics of decision across a broad range of cognitive enterprise. Most particularly, however, this development may help inform our understanding of the different expressions of human psychopathology. A 'thin tailed' underlying distribution appears to characterize expression of 'ordinary' situational depression/anxiety symptoms of conditions like burnout induced by toxic stress. A 'fat tailed' underlying distribution appears to be associated with brain structure and function abnormalities leading to serious mental illness and poor decision making where symptoms are not only emerging in the setting of severe stress but may also appear in a highly punctuated manner at relatively lower levels of stress. A simple hierarchical optimization shows how environmental 'shadow price' constraints can buffer or aggravate the effects of stress and arousal. Extension of the underlying theory to other patterns of pathology, like immune disorders and premature aging, seems apt. Applications to the punctuated dynamics of institutional cognition under stress also appear possible. Ultimately, the probability models studied here can be converted to new statistical tools for the analysis of observational and experimental data.
    MeSH term(s) Humans ; Cognition/physiology ; Stress, Psychological/physiopathology ; Decision Making/physiology ; Models, Psychological
    Language English
    Publishing date 2024-03-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 186234-0
    ISSN 1872-8324 ; 0303-2647
    ISSN (online) 1872-8324
    ISSN 0303-2647
    DOI 10.1016/j.biosystems.2024.105193
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  6. Book: The challenges of Mental health caregiving

    Talley, Ronda C. / Fricchione, Gregory / Druss, Benjamin G.

    research, practice, policy

    (Caregiving: research. practice, policy)

    2014  

    Author's details Ronda C. Talley ; Gregory L. Fricchione ; Benjamin G. Druss ed
    Series title Caregiving: research. practice, policy
    Language English
    Size XXVI, 234 S.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018093969
    ISBN 978-1-4614-8790-6 ; 978-1-4614-8791-3 ; 1-4614-8790-0 ; 1-4614-8791-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 3894 available for loan (reading room) Lesesaal EG

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  7. Article ; Online: Generalized Periodic Discharges Associated With Catatonia and Delirium: A Case Series.

    Luccarelli, James / Smith, Joshua R / Fricchione, Gregory / Westover, M Brandon

    The Journal of neuropsychiatry and clinical neurosciences

    2024  , Page(s) appineuropsych20230174

    Abstract: Objective: Generalized periodic discharges are a repeated and generalized electroencephalography (EEG) pattern that can be seen in the context of altered mental status. This article describes a series of five individuals with generalized periodic ... ...

    Abstract Objective: Generalized periodic discharges are a repeated and generalized electroencephalography (EEG) pattern that can be seen in the context of altered mental status. This article describes a series of five individuals with generalized periodic discharges who demonstrated signs and symptoms of catatonia, a treatable neuropsychiatric condition.
    Methods: Inpatients with a clinical diagnosis of catatonia, determined with the Bush-Francis Catatonia Rating Scale (BFCRS), and EEG recordings with generalized periodic discharges were analyzed in a retrospective case series.
    Results: Five patients with catatonia and generalized periodic discharges on EEG were evaluated from among 106 patients with catatonia and contemporaneous EEG measurements. Four of these patients showed an improvement in catatonia severity when treated with benzodiazepines, with an average reduction of 6.75 points on the BFCRS.
    Conclusions: Among patients with generalized periodic discharges, catatonia should be considered, in the appropriate clinical context. Patients with generalized periodic discharges and catatonia may benefit from treatment with empiric trials of benzodiazepines.
    Language English
    Publishing date 2024-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1036340-3
    ISSN 1545-7222 ; 0895-0172
    ISSN (online) 1545-7222
    ISSN 0895-0172
    DOI 10.1176/appi.neuropsych.20230174
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  8. Article: A Link Between Inflammatory Mechanisms and Fibromyalgia.

    Bains, Ashika / Kohrman, Samuel / Punko, Diana / Fricchione, Gregory

    Advances in experimental medicine and biology

    2023  Volume 1411, Page(s) 357–378

    Abstract: Fibromyalgia (FM) is a condition characterized by chronic widespread pain, which has traditionally been considered psychogenic in nature due to lack of known underlying organic pathophysiology. In more recent years, inflammation of the nervous system has ...

    Abstract Fibromyalgia (FM) is a condition characterized by chronic widespread pain, which has traditionally been considered psychogenic in nature due to lack of known underlying organic pathophysiology. In more recent years, inflammation of the nervous system has become increasingly recognized as a sign of neuropsychiatric conditions, and this association may enhance our knowledge of conditions such as FM. Emerging evidence has suggested inflammation, particularly neuroinflammation, as a potential contributor underlying the etiology of FM. Studies have searched for linked biomarkers with mixed results, though the literature is beginning to point to increased systemic levels of pro-inflammatory cytokines such as IL-6 and IL-8 in patients with FM relative to healthy controls. A multicenter imaging study has also reported results suggestive of microglial activation related to the presence of FM. Given the consistency in neuroinflammatory effects implicated in "sickness behavior" characteristic of chronic systemic inflammatory conditions such as cancer or rheumatic diseases, therein springs the hypothesis for a connection between FM and neuroinflammation as discussed in this chapter.
    MeSH term(s) Humans ; Fibromyalgia/diagnosis ; Fibromyalgia/psychology ; Neuroinflammatory Diseases ; Chronic Pain ; Cytokines ; Inflammation
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-19-7376-5_16
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  9. Article ; Online: Evolving a new neuropsychiatry.

    Fricchione, Gregory L

    Dialogues in clinical neuroscience

    2018  Volume 20, Issue 2, Page(s) 141–145

    Abstract: Clinical neuroscience struggles with poor scientific validity of neuropsychiatric diagnosis and its negative impact on management. Sydenham's ancient conformity of type approach to nosology with its assumption that the symptom cluster and course of a ... ...

    Abstract Clinical neuroscience struggles with poor scientific validity of neuropsychiatric diagnosis and its negative impact on management. Sydenham's ancient conformity of type approach to nosology with its assumption that the symptom cluster and course of a disorder are due to a common etiology, has proven no match for the complicated comorbidities faced in neuropsychiatry. In the absence of accurate pathological biomarkers there is a challenge in finding a solid foundation for modern neuropsychiatry. We find standard psychiatric nosology to be of limited benefit at the general hospital bedside in evaluating and treating neuropsychiatric disorders. Consequently, we have developed over the years a neuro-circuitry-based training for our psychosomatic medicine fellows. In this commentary, we will introduce a strategy for understanding patients with neuropsychiatric disorders that may advance our ability to diagnose and treat them in accordance with neuroscientific evidence anchored in evolutionary neurocircuitry and attachment neurobehavior.
    MeSH term(s) Animals ; Comorbidity ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/physiopathology ; Neurology/methods ; Neuropsychiatry ; Neurosciences ; Psychiatry
    Language English
    Publishing date 2018-09-24
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2188781-0
    ISSN 1958-5969 ; 1294-8322
    ISSN (online) 1958-5969
    ISSN 1294-8322
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  10. Article ; Online: The Challenge of Stress-Related Non-Communicable Diseases.

    Fricchione, Gregory L

    Medical science monitor basic research

    2018  Volume 24, Page(s) 93–95

    Abstract: The greatest challenge facing medicine today involves the so-called non-communicable diseases (NCDs). This is true regardless of whether one's location is considered high-income, middle-income, or low-income. Basic research at all "OMICs" system levels ... ...

    Abstract The greatest challenge facing medicine today involves the so-called non-communicable diseases (NCDs). This is true regardless of whether one's location is considered high-income, middle-income, or low-income. Basic research at all "OMICs" system levels will be significant in uncovering causal links that create NCD vulnerabilities in mind, brain, body, and society. Therefore, meeting this 21st century challenge by improving NCD management and prevention around the world will rely on advancement in this type of basic research.
    MeSH term(s) Humans ; Noncommunicable Diseases/epidemiology ; Noncommunicable Diseases/psychology
    Language English
    Publishing date 2018-06-15
    Publishing country United States
    Document type Editorial
    ISSN 2325-4416
    ISSN (online) 2325-4416
    DOI 10.12659/MSMBR.911473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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