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  1. Article: Diagnosing Oncocytoma by Core Needle Biopsy: A Single-Center Experience.

    Mayer, Chen / Abu-Ghanem, Yasmin / Dotan, Zohar A / Barshack, Iris / Fridman, Eddie

    Advances in urology

    2022  Volume 2022, Page(s) 1589040

    Abstract: Background: Oncocytoma is one of the most common benign kidney tumors, accounting for 3-7% of all solid renal masses. Diagnosing oncocytomas using renal biopsy remains a controversy in the uro-pathologic community. With the increasing use of biopsies ... ...

    Abstract Background: Oncocytoma is one of the most common benign kidney tumors, accounting for 3-7% of all solid renal masses. Diagnosing oncocytomas using renal biopsy remains a controversy in the uro-pathologic community. With the increasing use of biopsies for assessment of renal lesions, reaching this pathologically benign diagnosis may prevent further surgical measures and have significant clinical benefit.
    Objective: To demonstrate our center's results using renal biopsy to diagnose oncocytomas and to suggest that this diagnosis can be made with high success rates.
    Design: ,
    Conclusions: Our study demonstrates that with good patient selection and proficient cooperation between urologists, radiologists and dedicated uro-pathologists, correctly diagnosing oncocytomas using RCB is a viable task.
    Language English
    Publishing date 2022-08-29
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2397564-7
    ISSN 1687-6377 ; 1687-6369
    ISSN (online) 1687-6377
    ISSN 1687-6369
    DOI 10.1155/2022/1589040
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  2. Article ; Online: Penile secondary lesions: a rare entity detected by PET/CT.

    Davidson, Tima / Domachevsky, Liran / Giladi, Yogev / Fridman, Eddie / Dotan, Zohar / Rosenzweig, Barak / Leibowitz, Raya / Ben Shimol, Jennifer

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 5912

    Abstract: While penile metastases are rare, PET/CT has facilitated their detection. We aimed to describe penile secondary lesions (PSL) identified by PET/CT. We reviewed 18F-FDG and Ga68-PSMA PET/CT records performed in a single center during May 2012-March 2020, ... ...

    Abstract While penile metastases are rare, PET/CT has facilitated their detection. We aimed to describe penile secondary lesions (PSL) identified by PET/CT. We reviewed 18F-FDG and Ga68-PSMA PET/CT records performed in a single center during May 2012-March 2020, for PSL. Of 16,774 18F-FDG and 1,963 Ga68-PSMA-PET scans, PSL were found in 24(0.13%) men with a mean age of 74. PSMA detected PSL in 12 with prostate cancer; FDG identified PSL in 4 with lymphoma, 3 with colorectal cancer, 2 with lung cancer, and one each with bladder cancer, pelvic sarcoma, and leukemia. Mean SUVmax of PSL was 7.9 ± 4.2 with focal uptake in 13(54%). Mean lesion size was 16.5 ± 6.8 mm; 8 at the penile root, 4 along the shaft, and 1 at the glans. CT detected loss of the penile texture in 15(63%). PSL were observed only during relapse or follow-up of disseminated disease. Among those with prostate cancer, PSA varied widely. Fifteen (62.5%) died, at a mean 13.3 ± 15.9 months following PSL demonstration, nine had non-prostate malignancies. PET/CT identified and characterized PSL in a fraction of cancer patients, most commonly those with prostate cancer. PSL universally surfaced in advanced disease, and signaled high mortality, especially in non-prostate cancers.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Biopsy ; Fluorodeoxyglucose F18 ; Humans ; Male ; Middle Aged ; Multimodal Imaging/methods ; Pelvic Neoplasms ; Penile Neoplasms/diagnostic imaging ; Penile Neoplasms/pathology ; Penile Neoplasms/secondary ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Retrospective Studies ; Tomography, X-Ray Computed ; Tumor Burden
    Chemical Substances Biomarkers, Tumor ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-85300-8
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  3. Article: Oncologic Outcomes Following Robot-Assisted Radical Prostatectomy for Clinical T3 Prostate Disease.

    Zilberman, Dorit E / Abu-Ghanem, Yasmin / Raviv, Gil / Rosenzweig, Barak / Fridman, Eddie / Portnoy, Orith / Dotan, Zohar A

    The Israel Medical Association journal : IMAJ

    2021  Volume 23, Issue 2, Page(s) 111–115

    Abstract: Background: Little is known about oncologic outcomes following robot-assisted-radical-prostatectomy (RALP) for clinical T3 (cT3) prostate cancer.: Objectives: To investigate oncologic outcomes of patients with cT3 prostate cancer treated by RALP.: ... ...

    Abstract Background: Little is known about oncologic outcomes following robot-assisted-radical-prostatectomy (RALP) for clinical T3 (cT3) prostate cancer.
    Objectives: To investigate oncologic outcomes of patients with cT3 prostate cancer treated by RALP.
    Methods: Medical records of patients who underwent RALP from 2010 to 2018 were retrieved. cT3 cases were reviewed. Demographic and pre/postoperative pathology data were analyzed. Patients were followed in 3-6 month intervals with repeat PSA analyses. Adjuvant/salvage treatments were monitored. Biochemical recurrence (BCR) meant PSA levels of ≥ 0.2 ng/ml.
    Results: Seventy-nine patients met inclusion criteria. Median age at surgery was 64 years. Preoperative PSA level was 7.14 ng/dl, median prostate weight was 54 grams, and 23 cases (29.1%) were down-staged to pathological stage T2. Positive surgical margin rate was 42%. Five patients were lost to follow-up. Median follow-up time for the remaining 74 patients was 24 months. Postoperative relapse in PSA levels occurred in 31 patients (42%), and BCR in 28 (38%). Median time to BCR was 9 months. The overall 5-year BCR-free survival rate was 61%. Predicting factors for BCR were age (hazard-ratio [HR] 0.85, 95% confidence interval [95%CI] 0.74-0.97, P = 0.017) and prostate weight (HR 1.04, 95%CI 1.01-1.08, P = 0.021). Twenty-six patients (35%) received adjuvant/salvage treatments. Three patients died from metastatic prostate cancer 31, 52, and 78 months post-surgery. Another patient died 6 months post-surgery of unknown reasons. The 5-year cancer-specific survival rate was 92.
    Conclusions: RALP is an oncologic effective procedure for cT3 prostate cancer. Adjuvant/salvage treatment is needed to achieve optimal disease-control.
    MeSH term(s) Aged ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prostate-Specific Antigen/analysis ; Prostatectomy/methods ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Salvage Therapy ; Survival Rate ; Treatment Outcome
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-02-17
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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    Zs.A 5470: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: GLI1 Gene Alterations in Neoplasms of the Genitourinary and Gynecologic Tract.

    Argani, Pedram / Boyraz, Baris / Oliva, Esther / Matoso, Andres / Gross, John / Fridman, Eddie / Zhang, Lei / Dickson, Brendan C / Antonescu, Cristina R

    The American journal of surgical pathology

    2021  Volume 46, Issue 5, Page(s) 677–687

    Abstract: We report 4 neoplasms of the kidney (2 cases) and uterus (2 cases) harboring rearrangements or amplifications of the GLI1 gene, which because of their unusual clinical presentation, morphology, and immunoprofile mimicked other neoplasms, causing ... ...

    Abstract We report 4 neoplasms of the kidney (2 cases) and uterus (2 cases) harboring rearrangements or amplifications of the GLI1 gene, which because of their unusual clinical presentation, morphology, and immunoprofile mimicked other neoplasms, causing significant diagnostic challenge. The neoplasms occurred in 4 female patients ages 33 to 88 years. Histologically they all demonstrated nodular growth, solid architecture, bland epithelioid to ovoid-spindle cells with pale cytoplasm set in a variably myxoid or hyalinized stroma. One uterine tumor also demonstrated a focal round cell pattern, while another demonstrated focal pleomorphism. Unlike most previously reported neoplasms with these genetic abnormalities, the neoplasms in the current series were negative for S100 protein and minimally reactive for actin. All labeled for CD10 and cyclin D1, while 2 labeled for estrogen receptor and BCOR and 1 labeled for desmin, raising consideration of endometrial stromal sarcoma, myxoid leiomyosarcoma, metastatic breast carcinoma, and glomus tumor. One renal neoplasm demonstrated a GLI1-FOXO4 gene fusion and the other harbored a GLI1 gene rearrangement (unknown partner). The 2 uterine neoplasms exhibited GLI1 gene amplifications. GLI1-altered neoplasms (particularly those with GLI1 amplification) show variable morphology and lack a consistent immunophenotype, and thus may trigger diagnostic challenges which can be resolved by molecular testing.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Endometrial Neoplasms/pathology ; Female ; Gene Fusion ; Glomus Tumor ; Humans ; Middle Aged ; Sarcoma, Endometrial Stromal/genetics ; Uterine Neoplasms/genetics ; Uterine Neoplasms/pathology ; Zinc Finger Protein GLI1/genetics
    Chemical Substances Biomarkers, Tumor ; GLI1 protein, human ; Zinc Finger Protein GLI1
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752964-8
    ISSN 1532-0979 ; 0147-5185
    ISSN (online) 1532-0979
    ISSN 0147-5185
    DOI 10.1097/PAS.0000000000001844
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1356: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Endoscopic management of upper tract urothelial carcinoma-tips and tricks.

    Shvero, Asaf / Zilberman, Dorit E / Dotan, Zohar A / Laufer, Maneham / Fridman, Eddie / Winkler, Harry / Kleinmann, Nir

    Translational andrology and urology

    2020  Volume 9, Issue 4, Page(s) 1815–1820

    Abstract: Ureteroscopic methods have been rapidly evolving in the last several decades. With advances in flexible devices, optics and laser technologies, the endourologic surgeon has now the tools to treat high-volume tumors, in difficult locations, with good ... ...

    Abstract Ureteroscopic methods have been rapidly evolving in the last several decades. With advances in flexible devices, optics and laser technologies, the endourologic surgeon has now the tools to treat high-volume tumors, in difficult locations, with good oncologic outcome. This makes radical nephroureterectomy unnecessary in some cases. Endoscopy in the setting of UTUC will surely continue to evolve and become applicable to a wider selection of patients. In this review we describe the surgical technique and provide tips and tricks which we use in our practice of endoscopic retrograde treatment of upper-tract urothelial carcinoma.
    Language English
    Publishing date 2020-08-29
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau.2020.01.07
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  6. Article: Viable triplet pregnancy coexisting with a complete molar pregnancy.

    Polonsky, Ariel / Olteanu, Ioana / Ben-David, Mordechai / Mamet, Jacob / Agranat, Avi / Fridman, Eddie

    Clinical case reports

    2016  Volume 4, Issue 3, Page(s) 247–249

    Abstract: This case is extraordinary because it was never before described in English literature. The case describes a long-standing debate about the safety of carrying this pregnancy to term. Some authors are for and some are against. The risks and benefits ... ...

    Abstract This case is extraordinary because it was never before described in English literature. The case describes a long-standing debate about the safety of carrying this pregnancy to term. Some authors are for and some are against. The risks and benefits should be thoroughly reviewed before a decision is made.
    Language English
    Publishing date 2016-01-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.417
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  7. Article: Tumor-infiltrating lymphocytes from human prostate tumors reveal anti-tumor reactivity and potential for adoptive cell therapy.

    Yunger, Sharon / Bar El, Assaf / Zeltzer, Li-At / Fridman, Eddie / Raviv, Gil / Laufer, Menachem / Schachter, Jacob / Markel, Gal / Itzhaki, Orit / Besser, Michal J

    Oncoimmunology

    2019  Volume 8, Issue 12, Page(s) e1672494

    Abstract: Advanced prostate cancer remains incurable and is the second leading cause of mortality in men. Immunotherapy based on the adoptive transfer of tumor-infiltrating lymphocytes (TIL) has demonstrated promising clinical results in patients with metastatic ... ...

    Abstract Advanced prostate cancer remains incurable and is the second leading cause of mortality in men. Immunotherapy based on the adoptive transfer of tumor-infiltrating lymphocytes (TIL) has demonstrated promising clinical results in patients with metastatic melanoma and lately also in other solid tumors. However, the ability to obtain TIL from patients with prostate cancer, considered poorly immunogenic, remains unknown. In this study, we investigate the feasibility of isolating and expanding TIL from primary prostate tumors. We collected tumor specimens from eight patients with diagnosed prostate adenocarcinoma undergoing radical prostatectomy and were able to successfully expand multiple autologous TIL cultures from all patients. Twenty-eight prostate-TIL cultures were further expanded using a standard rapid expansion procedure under Good Manufacturing Practice conditions. TIL cultures were phenotypically characterized for T cell subset composition, differentiation status and co-inhibitory/stimulatory markers such as PD-1, TIM-3, LAG-3, and CD28 and were found to have in general similarity to TIL obtained from patients with melanoma and lung carcinoma previously treated at our center. All analyzed TIL cultures were functional as determined by the capability to produce high level of IFNγ upon stimuli. Most importantly, co-culture assays of prostate-TIL with autologous tumors demonstrated anti-tumor reactivity. In conclusion, these findings demonstrate that functional and anti-tumor reactive TIL can be obtained, despite the immunosuppressive microenvironment of the cancer, thus this study supports the development of TIL therapy for prostate cancer patients.
    Language English
    Publishing date 2019-10-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2019.1672494
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  8. Article ; Online: Classic neurothekeoma (nerve sheath myxoma) and cellular neurothekeoma of the oral mucosa: immunohistochemical profiles.

    Vered, Marilena / Fridman, Eddie / Carpenter, William M / Buchner, Amos

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2011  Volume 40, Issue 2, Page(s) 174–180

    Abstract: Background: Classic neurothekeoma (nerve sheath myxoma) is regarded as being a true benign cutaneous tumor of nerve sheath origin. Cellular neurothekeoma was separated from the classic type by histogenesis, morphology and immunophenotype. Whether ... ...

    Abstract Background: Classic neurothekeoma (nerve sheath myxoma) is regarded as being a true benign cutaneous tumor of nerve sheath origin. Cellular neurothekeoma was separated from the classic type by histogenesis, morphology and immunophenotype. Whether cellular neurothekeoma represents a continuum within the spectrum of classic neurothekeoma or is an independent entity is controversial. Only a small number of classic neurothekeomas of the oral mucosa have been reported and there are even fewer publications on cellular neurothekeoma. We analyzed a series of oral neurothekeomas (classic and cellular) with a panel of neural and other mesenchymal markers to enhance their diagnosis and classification.
    Methods: One cellular and three classic neurothekeomas were submitted to a panel of immunohistochemical stains with antibodies against S100, S100A6, NSE, NKI/C3, PGP9.5, α-SMA, HHF-35, CD68 and vimentin. Two cases of neurofibroma (plexiform type), representing a true lesion of neural origin, served as control.
    Results: The cellular neurothekeoma yielded a positive immunoreaction for S100A6 and NKI/C3 and a negative immunoreaction for S-100. The classic neurothekeomas demonstrated a positive reaction for S-100 and S100A6, but a negative one for NKI/C3. Other markers were non-contributory to distinguishing between these types of lesions.
    Conclusions: The small number of reported oral neurothekeomas (classic and cellular) could be due, in part, to the lack of recognition of their particular morphologic and immunohistochemical features. Our results indicate that testing for NKI/C3 immunoreactivity may be of value in distinguishing between cellular and classic neurothekeoma.
    MeSH term(s) Adult ; Biomarkers, Tumor/analysis ; Cell Cycle Proteins/analysis ; Child ; Female ; Humans ; Immunohistochemistry ; Male ; Mouth Mucosa/pathology ; Mouth Neoplasms/chemistry ; Mouth Neoplasms/classification ; Mouth Neoplasms/pathology ; NK Cell Lectin-Like Receptor Subfamily B/analysis ; Neurothekeoma/chemistry ; Neurothekeoma/classification ; Neurothekeoma/pathology ; S100 Calcium Binding Protein A6 ; S100 Proteins/analysis ; Young Adult
    Chemical Substances Biomarkers, Tumor ; Cell Cycle Proteins ; NK Cell Lectin-Like Receptor Subfamily B ; S100 Calcium Binding Protein A6 ; S100 Proteins ; S100A6 protein, human (105504-00-5)
    Language English
    Publishing date 2011-02
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/j.1600-0714.2010.00952.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 825: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Oncologic Outcomes of Partial Nephrectomy for Stage T3a Renal Cell Cancer.

    Shvero, Asaf / Nativ, Ofer / Abu-Ghanem, Yasmin / Zilberman, Dorit / Zaher, Bahouth / Levitt, Max / Fridman, Eddie / Portnoy, Orith / Ramon, Jacob / Dotan, Zohar A

    Clinical genitourinary cancer

    2017  Volume 16, Issue 3, Page(s) e613–e617

    Abstract: Background: Partial nephrectomy (PN) for clinical stage T3 tumors is controversial. Radical nephrectomy (RN) has been associated with a greater rate of chronic kidney disease, an increased risk of cardiovascular disease, and increased mortality compared ...

    Abstract Background: Partial nephrectomy (PN) for clinical stage T3 tumors is controversial. Radical nephrectomy (RN) has been associated with a greater rate of chronic kidney disease, an increased risk of cardiovascular disease, and increased mortality compared with PN. We present our long-term 2-center experience with PN for stage pT3a tumors and compare the oncologic outcomes with those of similar patients treated with RN.
    Materials and methods: We reviewed the data from all patients who had undergone nephrectomy for renal cell carcinoma from 1987 to 2015 in 2 medical centers. The study included 134 patients with pathologic stage T3a tumors, of whom 48 and 86 underwent PN and RN, respectively. We compared the 2 groups (PN and RN) using univariate and multivariate analyses.
    Results: The tumors of all patients with pathologic stage T3a who had undergone PN had been pathologically upstaged from clinical stage T1 or T2. Univariate and multivariate analyses revealed tumor size was significantly different statistically between the study groups (median, 7.0 cm in RN group vs. 4.0 cm in PN group; P < .001). Surgery type was not a predictor of local recurrence (P = .978), metastatic progression (P = .972), death from renal cancer (P = .626), or death from all causes (P = .974) at the 5-year follow-up point.
    Conclusion: The results of the present study have shown similar oncologic outcomes between 48 patients with stage pT3a renal cancer who underwent PN and 86 patients who underwent RN. Although PN was not performed on clinical T3a tumors, our findings suggest that PN can also be considered for these tumors and, thus, avoid the long-term complications of RN. However, strict follow-up protocols are mandatory.
    MeSH term(s) Aged ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/physiopathology ; Carcinoma, Renal Cell/surgery ; Disease Progression ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/physiopathology ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Staging ; Nephrectomy ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2017-11-07
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 2225121-2
    ISSN 1938-0682 ; 1558-7673
    ISSN (online) 1938-0682
    ISSN 1558-7673
    DOI 10.1016/j.clgc.2017.10.016
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    Zs.A 6168: Show issues Location:
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  10. Article ; Online: AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.

    Cohen, Yoram / Shalmon, Bruria / Korach, Jacob / Barshack, Iris / Fridman, Eddie / Rechavi, Gideon

    Gynecologic oncology

    2010  Volume 116, Issue 1, Page(s) 88–91

    Abstract: Objectives: The PI3K/AKT pathway is frequently activated in endometrial carcinoma (EC) mainly due to mutations in the PIK3CA and PTEN genes. These events are common and believed to be the key to endometrial carcinogenesis. Recently, a somatic activating ...

    Abstract Objectives: The PI3K/AKT pathway is frequently activated in endometrial carcinoma (EC) mainly due to mutations in the PIK3CA and PTEN genes. These events are common and believed to be the key to endometrial carcinogenesis. Recently, a somatic activating mutation in the AKT1 gene (E17K) was identified in several cancer types. In this study we explored the frequency of this AKT1 mutation in endometrial carcinoma.
    Methods: Tumor DNA, extracted from 73 EC was analyzed for AKT1 E17K mutation (G49A) using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). In addition, the tumors were screened for coexisting common mutations in PTEN, PIK3CA and KRAS.
    Results: The AKT1 E17K mutation was detected in 4% of EC. One of the AKT1-mutated tumors showed coexisting PTEN loss-of-function mutation.
    Conclusion: We identified the AKT1 E17K mutation in 4% of endometrial carcinomas. The presence of double AKT1/ PTEN mutants is in accord with the hypothesis that in EC more than one hit is required to completely activate the PI3K pathway. Furthermore, AKT1 mutations were limited to high grade, advanced stage tumors suggesting that this mutation confers a more aggressive tumor behavior.
    MeSH term(s) Aged ; Blood Proteins/genetics ; DNA, Neoplasm/genetics ; Endometrial Neoplasms/enzymology ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/pathology ; Female ; Humans ; Mutation ; Neoplasm Staging ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphoproteins/genetics ; Protein Structure, Tertiary ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
    Chemical Substances Blood Proteins ; DNA, Neoplasm ; Phosphoproteins ; platelet protein P47 ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2009.09.038
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