Article ; Online: Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype.
2020 Volume 10, Issue 1, Page(s) 2924
Abstract: Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation. The apolipoprotein E (APOE) ε4 allele is the most common genetic risk factor for AD and is related ... ...
| Abstract | Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation. The apolipoprotein E (APOE) ε4 allele is the most common genetic risk factor for AD and is related to a pro-inflammatory state. To test the hypothesis that microglia and AD-implicated cytokines were differentially associated with AD pathology based on the presence of APOE ε4, we examined the dorsolateral frontal cortex from deceased participants within a community-based aging cohort (n = 154). Cellular density of Iba1, a marker of microglia, was positively associated with tau pathology only in APOE ε4 positive participants (p = 0.001). The cytokines IL-10, IL-13, IL-4, and IL-1α were negatively associated with tau pathology, independent of Aβ |
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| MeSH term(s) | Aged, 80 and over ; Alleles ; Amyloid beta-Peptides/metabolism ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Apolipoprotein E4/genetics ; Biomarkers/metabolism ; Brain/pathology ; Calcium-Binding Proteins/metabolism ; Cell Count ; Cohort Studies ; Cytokines/metabolism ; Dementia/pathology ; Female ; Genotype ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Male ; Microfilament Proteins/metabolism ; Microglia/metabolism ; Microglia/pathology ; Models, Biological ; tau Proteins/metabolism |
| Chemical Substances | AIF1 protein, human ; Amyloid beta-Peptides ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Apolipoprotein E4 ; Biomarkers ; CD68 antigen, human ; Calcium-Binding Proteins ; Cytokines ; Microfilament Proteins ; tau Proteins |
| Language | English |
| Publishing date | 2020-02-19 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-020-59869-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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