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  1. Article: The role of commercial non-related living kidney transplants.

    Friedlaender, Michael M

    Journal of nephrology

    2003  Volume 16 Suppl 7, Page(s) S10–5

    Abstract: The motivation for dialysis patients to seek early, even pre-emptive, kidney transplantation from living donors is discussed. In most countries both the waiting time and the numbers of patients awaiting kidney transplantation are increasing. Local ... ...

    Abstract The motivation for dialysis patients to seek early, even pre-emptive, kidney transplantation from living donors is discussed. In most countries both the waiting time and the numbers of patients awaiting kidney transplantation are increasing. Local geopolitics in Jerusalem have produced a unique window to observe present transplant practices which include widespread international marketing of kidneys from paid living donors. These have been subject of media admonitions and total rejection by professional organizations. In a modern world, traditional medical paternalism to both donors and patients should be balanced by rights for individual autonomy. Since patients, donors and medical professionals are already participating in illicit organ trading, is it not time for us to seriously consider the ethical and logistic implications of legalizing financial remuneration for kidney donation?
    MeSH term(s) Aged ; Commerce ; Ethics, Medical ; Fees and Charges ; Female ; Humans ; Israel ; Kidney Transplantation ; Living Donors ; Male ; Middle Aged ; Paternalism ; Personal Autonomy ; Tissue Donors/supply & distribution ; Tissue and Organ Procurement/economics
    Language English
    Publishing date 2003-11
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1121-8428 ; 1120-3625
    ISSN (online) 1724-6059
    ISSN 1121-8428 ; 1120-3625
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  2. Article: A protocol for paid kidney donation in Israel.

    Friedlaender, Michael M

    The Israel Medical Association journal : IMAJ

    2003  Volume 5, Issue 9, Page(s) 611–614

    MeSH term(s) Clinical Protocols ; Consent Forms/standards ; Direct Service Costs ; Ethics, Institutional ; Health Care Costs/standards ; Humans ; Israel ; Kidney Transplantation/standards ; Living Donors ; Nursing Assessment/standards ; Organizational Policy ; Postoperative Care/standards ; Quality Control ; Tissue and Organ Procurement/economics ; Tissue and Organ Procurement/organization & administration
    Language English
    Publishing date 2003-09
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  3. Article: The right to sell or buy a kidney: are we failing our patients?

    Friedlaender, Michael M

    Lancet (London, England)

    2002  Volume 359, Issue 9310, Page(s) 971–973

    MeSH term(s) Adult ; Attitude of Health Personnel ; Costs and Cost Analysis ; Humans ; Israel ; Kidney Transplantation/economics ; Kidney Transplantation/statistics & numerical data ; Living Donors ; Male ; Time Factors ; United States
    Language English
    Publishing date 2002-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/S0140-6736(02)08030-3
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  4. Article: Immunohistochemical staining for proliferation antigen as a predictor of chronic graft dysfunction and renal graft loss.

    Pizov, Galina / Friedlaender, Michael M

    Nephron

    2002  Volume 92, Issue 3, Page(s) 738–742

    Abstract: Background: Assessment of proliferation rate (PR%) using monoclonal antibody for Ki-67 antigen has recently been found to have prognostic importance in lung and cardiac allografts. We ascertained whether the same might be true for renal allografts.: ... ...

    Abstract Background: Assessment of proliferation rate (PR%) using monoclonal antibody for Ki-67 antigen has recently been found to have prognostic importance in lung and cardiac allografts. We ascertained whether the same might be true for renal allografts.
    Methods: Newly cut sections from 20 archival paraffin blocks of renal allograft biopsy material showing acute cellular rejection and/or acute tubular necrosis (ATN) and absence of other pathology were stained using MIB-1 antibody and were further double-stained with anti-CD3, anti-CD20 or anti-CD68 antibodies. Counts of staining of mononuclear interstitial cells were correlated with clinical and pathological data.
    Results: Mean PR% was significantly greater than that in control renal allografts (13.23 +/- 1.94 vs. 2.84 +/- 1.66, p < 0.01). PR% of cases with ATN and no or borderline rejection was significantly lower than that of the remaining cases with acute rejection pathology (6.68 +/- 1.15 vs. 14.31 +/- 1.62, p < 0.05). However, PR% was neither correlated to histological rejection grade nor to long-term graft outcome. Double labelling failed to identify the cell type of most infiltrating MIB-1 positive cells.
    Conclusions: Positive MIB-1 staining helps to identify the presence of rejection but does not appear to predict prognosis or correlate with the Banff classification of rejection pathology.
    MeSH term(s) Antibodies, Monoclonal ; Cell Division ; Graft Rejection/pathology ; Graft Survival ; Humans ; Immunohistochemistry ; Ki-67 Antigen/analysis ; Ki-67 Antigen/immunology ; Kidney Transplantation ; Predictive Value of Tests ; Prognosis ; Transplantation, Homologous
    Chemical Substances Antibodies, Monoclonal ; Ki-67 Antigen
    Language English
    Publishing date 2002
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207121-6
    ISSN 1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
    ISSN (online) 1423-0186 ; 2235-3186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000064104
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  5. Article: Legalizing the sale of kidneys for transplantation: suggested guidelines.

    Rapoport, Jayson / Kagan, Alexander / Friedlaender, Michael M

    The Israel Medical Association journal : IMAJ

    2002  Volume 4, Issue 12, Page(s) 1132–1134

    MeSH term(s) Commerce ; Humans ; Israel ; Kidney Transplantation/economics ; Kidney Transplantation/ethics ; Kidney Transplantation/legislation & jurisprudence ; Living Donors ; Public Policy ; Tissue and Organ Procurement/economics ; Tissue and Organ Procurement/ethics ; Tissue and Organ Procurement/legislation & jurisprudence
    Language English
    Publishing date 2002-12
    Publishing country Israel
    Document type Guideline ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
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  6. Article: The kidney in Fabry disease.

    Raas-Rothschild, Annick / Friedlaender, Michael M / Pizov, Galina / Backenroth, Rebecca

    The Journal of pediatrics

    2005  Volume 146, Issue 1, Page(s) 148

    MeSH term(s) Child ; Fabry Disease/complications ; Fabry Disease/genetics ; Fabry Disease/pathology ; Female ; Humans ; Kidney/pathology
    Language English
    Publishing date 2005-01
    Publishing country United States
    Document type Case Reports ; Comment ; Letter
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2004.08.024
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  7. Article: Immunohistochemical Staining for Proliferation Antigen as a Predictor of Chronic Graft Dysfunction and Renal Graft Loss

    Pizov, Galina / Friedlaender, Michael M.

    Nephron

    2002  Volume 92, Issue 3, Page(s) 738–742

    Abstract: Background: Assessment of proliferation rate (PR%) using monoclonal antibody for Ki-67 antigen has recently been found to have prognostic importance in lung and cardiac allografts. We ascertained whether the same might be true for renal allografts. ... ...

    Institution Departments of Pathology and Nephrology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Abstract Background: Assessment of proliferation rate (PR%) using monoclonal antibody for Ki-67 antigen has recently been found to have prognostic importance in lung and cardiac allografts. We ascertained whether the same might be true for renal allografts. Methods: Newly cut sections from 20 archival paraffin blocks of renal allograft biopsy material showing acute cellular rejection and/or acute tubular necrosis (ATN) and absence of other pathology were stained using MIB-1 antibody and were further double-stained with anti-CD3, anti-CD20 or anti-CD68 antibodies. Counts of staining of mononuclear interstitial cells were correlated with clinical and pathological data. Results: Mean PR% was significantly greater than that in control renal allografts (13.23 ± 1.94 vs. 2.84 ± 1.66, p < 0.01). PR% of cases with ATN and no or borderline rejection was significantly lower than that of the remaining cases with acute rejection pathology (6.68 ± 1.15 vs. 14.31 ± 1.62, p < 0.05). However, PR% was neither correlated to histological rejection grade nor to long-term graft outcome. Double labelling failed to identify the cell type of most infiltrating MIB-1 positive cells. Conclusion: Positive MIB-1 staining helps to identify the presence of rejection but does not appear to predict prognosis or correlate with the Banff classification of rejection pathology.
    Keywords MIB-1 antibody ; Ki-67 proliferation antigen ; Renal transplantation ; Rejection
    Language English
    Publishing date 2002-09-26
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Short Communication
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000064104
    Database Karger publisher's database

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  8. Article: Recovery of renal tubule phosphate reabsorption despite reduced levels of sodium-phosphate transporter.

    Friedlaender, Michael M / Wald, Hanna / Dranitzky-Elhalel, Michal / Levi, Moshe / Popovtzer, Mordecai M

    European journal of endocrinology

    2004  Volume 151, Issue 6, Page(s) 797–801

    Abstract: Background: The acute effect of parathyroid hormone (PTH) on phosphate transport has been reported to be mediated by rapid downregulation of sodium-phosphate transporter (NaPi-IIa) protein, but the association was observed with pharmacological doses of ... ...

    Abstract Background: The acute effect of parathyroid hormone (PTH) on phosphate transport has been reported to be mediated by rapid downregulation of sodium-phosphate transporter (NaPi-IIa) protein, but the association was observed with pharmacological doses of PTH.
    Objective: To explore the effects of physiological doses of PTH on NaPi-IIa protein and its relationship to phosphate transport.
    Methods: Acute clearance studies were performed in parathyroidectomized rats given a bolus i.v. physiological dose (1 microg) of bovine PTH(1-34) and NaPi-IIa protein concentrations were examined at different time intervals.
    Results: Fractional excretion of phosphate increased from 0.031+/-0.006 (mean+/-S.E.) to 0.238+/-0.059 (P<0.01 compared with baseline and compared with controls) at 40 min and returned to control values by 120 min. Urinary cAMP concentrations were increased at 20 min only. Superficial cortex brush-border membrane (BBM) NaPi-IIa protein was decreased from baseline at both 40 and 120 min (P<0.01) and did not recover at 240 min (P<0.01 compared with baseline and compared with controls).
    Conclusion: These results confirm that PTH, even in physiological dosage, causes a rapid decrease in BBM NaPi-IIa, but subsequent recovery of phosphate reabsorption is poorly correlated with BBM concentrations of NaPi-IIa protein. This suggests that transport mechanisms other than NaPi-IIa are important in renal phosphate reabsorption.
    MeSH term(s) Absorption ; Animals ; Calcium/blood ; Creatinine/metabolism ; Cyclic AMP/urine ; Electrophoresis, Polyacrylamide Gel ; Immunoblotting ; Kidney Tubules/metabolism ; Male ; Microvilli/drug effects ; Parathyroid Hormone/pharmacology ; Parathyroidectomy ; Phosphates/blood ; Phosphates/metabolism ; Rats ; Sodium-Phosphate Cotransporter Proteins ; Sodium-Phosphate Cotransporter Proteins, Type IIa ; Symporters/metabolism
    Chemical Substances Parathyroid Hormone ; Phosphates ; Slc34a1 protein, rat ; Sodium-Phosphate Cotransporter Proteins ; Sodium-Phosphate Cotransporter Proteins, Type IIa ; Symporters ; Creatinine (AYI8EX34EU) ; Cyclic AMP (E0399OZS9N) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2004-09-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/eje.0.1510797
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  9. Article: Temporary regression of Merkel cell carcinoma metastases after cessation of cyclosporine.

    Friedlaender, Michael M / Rubinger, Dvora / Rosenbaum, Eli / Amir, Gail / Siguencia, Edgar

    Transplantation

    2002  Volume 73, Issue 11, Page(s) 1849–1850

    MeSH term(s) Carcinoma, Merkel Cell/secondary ; Cyclosporine/administration & dosage ; Fatal Outcome ; Humans ; Immunosuppressive Agents/administration & dosage ; Kidney Transplantation ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Postoperative Complications/pathology ; Skin Neoplasms/pathology
    Chemical Substances Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2002-06-15
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/00007890-200206150-00028
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  10. Article: End-Stage Renal Interstitial Fibrosis in an Adult Ten Years after Ifosfamide Therapy

    Friedlaender, Michael M. / Haviv, Yosef S. / Rosenmann, Eliezer / Peylan-Ramu, Nili

    American Journal of Nephrology

    1998  Volume 18, Issue 2, Page(s) 131–133

    Abstract: A 33-year-old male presented with end-stage renal failure. Renal biopsy showed severe interstitial fibrosis without glomerulopathy or vasculopathy. More than 10 years previously the patient had been successfully treated for recurrent rhabdomyosarcoma. ... ...

    Institution Nephrology and Hypertension Services and Departments of Pathology and Oncology, Hadassah University Hospital, Jerusalem, Israel
    Abstract A 33-year-old male presented with end-stage renal failure. Renal biopsy showed severe interstitial fibrosis without glomerulopathy or vasculopathy. More than 10 years previously the patient had been successfully treated for recurrent rhabdomyosarcoma. The treatment included ifosfamide, a drug known to cause acute tubular dysfunction. Though a possible synergistic effect of previous radiation which was well within accepted tolerance limits cannot be excluded, it would appear that ifosfamide was almost certainly the major cause of the late onset chronic renal disease.
    Keywords Ifosfamide ; Chronic renal failure ; Renal biopsy ; Interstitial fibrosis
    Language English
    Publishing date 1998-04-01
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Case Report
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000013321
    Database Karger publisher's database

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