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  1. Book: Angewandte Pharmakotherapie

    Benndorf, Ralf / Rose, Olaf / Friedland, Kristina

    2019  

    Author's details Rose / Friedland ; herausgegeben von Dr. Olaf Rose, Pharm D. und Prof. Dr. Kristina Friedland ; mit Beiträgen von Prof. Dr. Ralf Benndorf [und vielen weiteren]
    Keywords Arzneimittelanwendung ; Patientenorientierte Pharmazie ; Angewandte Pharmakotherapie ; Behandlungsstrategien ; Medikationsmanagement ; Arzneimitteltherapie ; Arzneitherapie ; Pharmakotherapie ; Apotheker ; Patientenorientierte Medizin ; Individualisierte Medizin
    Subject Personalisierte Medizin ; Individualmedizin ; Patientenindividuelle Medizin ; Patientenindividuelle Therapie ; Maßgeschneiderte Pharmakotherapie ; Personalised medicine ; Präzisionsmedizin ; Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie
    Subject code 610
    Language German
    Size XX, 774 Seiten, Illustrationen, Diagramme, 27 cm x 19.3 cm
    Edition 2., aktualisierte und erweiterte Auflage
    Publisher Wissenschaftliche Verlagsgesellschaft
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020191510
    ISBN 978-3-8047-3736-5 ; 3-8047-3736-6 ; 9783804740334 ; 3804740332
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 423 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Talk to Me-Interplay between Mitochondria and Microbiota in Aging.

    Endres, Kristina / Friedland, Kristina

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: The existence of mitochondria in eukaryotic host cells as a remnant of former microbial organisms has been widely accepted, as has their fundamental role in several diseases and physiological aging. In recent years, it has become clear that the health, ... ...

    Abstract The existence of mitochondria in eukaryotic host cells as a remnant of former microbial organisms has been widely accepted, as has their fundamental role in several diseases and physiological aging. In recent years, it has become clear that the health, aging, and life span of multicellular hosts are also highly dependent on the still-residing microbiota, e.g., those within the intestinal system. Due to the common evolutionary origin of mitochondria and these microbial commensals, it is intriguing to investigate if there might be a crosstalk based on preserved common properties. In the light of rising knowledge on the gut-brain axis, such crosstalk might severely affect brain homeostasis in aging, as neuronal tissue has a high energy demand and low tolerance for according functional decline. In this review, we summarize what is known about the impact of both mitochondria and the microbiome on the host's aging process and what is known about the aging of both entities. For a long time, bacteria were assumed to be immortal; however, recent evidence indicates their aging and similar observations have been made for mitochondria. Finally, we present pathways by which mitochondria are affected by microbiota and give information about therapeutic anti-aging approaches that are based on current knowledge.
    MeSH term(s) Gastrointestinal Microbiome/physiology ; Microbiota ; Mitochondria ; Bacteria/metabolism
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Serotonin 5-HT2A - Dopamine D2 Receptor Heterodimers: Characterization and Functional Evaluation

    Plach, Michael [Verfasser] / Friedland, Kristina [Akademischer Betreuer] / Friedland, Kristina [Gutachter]

    2020  

    Author's details Michael Plach ; Gutachter: Kristina Friedland ; Betreuer: Kristina Friedland
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Book ; Online ; Thesis: Der Einfluss einer elektronischen Patientenkurve mit Dosierungsunterstützung auf die Arzneimittelsicherheit in einer Kinder- und Jugendklinik

    Wimmer, Stefan [Verfasser] / Neubert, Antje [Akademischer Betreuer] / Friedland, Kristina [Gutachter]

    2022  

    Author's details Stefan Wimmer ; Gutachter: Kristina Friedland ; Betreuer: Antje Neubert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: Interaction of the Acid Sphingomyelinase/Ceramide System and TRPC6 Ion Channels in neuronal cells

    Zeitler, Stefanie [Verfasser] / Friedland, Kristina [Akademischer Betreuer] / Friedland, Kristina [Gutachter]

    2019  

    Author's details Stefanie Zeitler ; Gutachter: Kristina Friedland ; Betreuer: Kristina Friedland
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  6. Article ; Online: Preventive Care in Type 2 Diabetes: Results of a Randomized, Controlled Trial in Community Pharmacies.

    Prax, Katja / Schmiedel, Karin / Hepp, Tobias / Schlager, Helmut / Friedland, Kristina

    Diabetes care

    2021  Volume 44, Issue 8, Page(s) e157–e159

    MeSH term(s) Community Pharmacy Services ; Diabetes Mellitus, Type 2/prevention & control ; Humans ; Medication Adherence ; Pharmacies ; Pharmacists
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Letter ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc20-2319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1434: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 365: Show issues

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  7. Article ; Online: Mitochondrial Dysfunction as a Causative Factor in Alzheimer's Disease-Spectrum Disorders: Lymphocytes as a Window to the Brain.

    Jörg, Marko / Plehn, Johanna E / Friedland, Kristina / Müller, Walter E

    Current Alzheimer research

    2021  Volume 18, Issue 10, Page(s) 733–752

    Abstract: Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. Today, AD affects millions of people worldwide and the number of AD cases will further increase with longer life expectancy. The AD brain is marked by severe ... ...

    Abstract Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. Today, AD affects millions of people worldwide and the number of AD cases will further increase with longer life expectancy. The AD brain is marked by severe neurodegeneration, such as the loss of synapses and neurons, atrophy and depletion of neurotransmitter systems, especially in the hippocampus and cerebral cortex. Recent findings highlight the important role of mitochondrial dysfunction and increased oxidative stress in the pathophysiology of late-onset alzheimer's disease (LOAD). These alterations are not only observed in the brain of AD patients but also in the periphery. In this review, we discuss the potential role of elevated apoptosis, increased oxidative stress and mitochondrial dysfunction as peripheral markers for the detection of AD in blood cells e.g. lymphocytes. We evaluate recent findings regarding impaired mitochondrial function comprising mitochondrial respiration, reduced complex activities of the respiratory chain and altered Mitochondrial Membrane Potential (MMP) in lymphocytes as well as in neurons. Finally, we will question whether these mitochondrial parameters might be suitable as an early peripheral marker for the detection of LOAD but also for the transitional stage between normal aging and Dementia, "Mild Cognitive Impairment" (MCI).
    MeSH term(s) Alzheimer Disease ; Brain ; Cognitive Dysfunction ; Humans ; Lymphocytes ; Mitochondria ; Neurodegenerative Diseases
    Language English
    Publishing date 2021-12-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2205170-3
    ISSN 1875-5828 ; 1567-2050
    ISSN (online) 1875-5828
    ISSN 1567-2050
    DOI 10.2174/1567205018666211208141512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Pharmacological basis of the anxiolytic and antidepressant properties of Silexan®, an essential oil from the flowers of lavender.

    Müller, Walter E / Sillani, Giacomo / Schuwald, Anita / Friedland, Kristina

    Neurochemistry international

    2020  Volume 143, Page(s) 104899

    Abstract: Silexan®, a proprietary essential oil manufactured by steam distillation from Lavandula angustifolia flowers showed pronounced anxiolytic effects in patients with subthreshold anxiety disorders and was also efficacious in patients with Generalized ... ...

    Abstract Silexan®, a proprietary essential oil manufactured by steam distillation from Lavandula angustifolia flowers showed pronounced anxiolytic effects in patients with subthreshold anxiety disorders and was also efficacious in patients with Generalized Anxiety disorder (GAD). Moreover, evidences for antidepressant-like properties of Silexan® have been observed in anxious patients suffering from comorbid depressive symptoms and in patients with mixed anxiety-depression disorder (ICD-10 F41.2). In accordance with the clinical data Silexan® is active in several behavioral models in rodents at rather low concentrations indicating potent anxiolytic and antidepressive properties. As possible mechanism of action a moderate inhibition of voltage dependent calcium channels (VDCC) has been found showing some similarities to the anxiolytic drug pregabalin. However, while pregabalin mainly inhibits P/Q-type channels by binding to a modulatory subunit, Silexan® moderately inhibits mainly T-type and N-type channels and to some extent P/Q-type channels. Unlike pregabalin Silexan® is free of hypnotic or sedative side effects and seems to be devoid of any abuse potential. With respect to its specific antidepressant like properties Silexan® improves several aspects of neuroplasticity which seems to be the common final pathway of all antidepressant drugs. As a potential mechanism of its effects on neuroplasticity an activation of the transcription factor CREB via activation of intracellular signaling kinases like PKA and MAPK has been found. Since the concentrations of Silexan® needed to inhibit VDCC function and to improve neuroplasticity are quite similar, the effects of Silexan® on PKA or MAPK could constitute a common intracellular signaling cascade leading to VDCC modulation as well as CREB activation and improved neuroplasticity.
    MeSH term(s) Animals ; Anti-Anxiety Agents/isolation & purification ; Anti-Anxiety Agents/pharmacology ; Anti-Anxiety Agents/therapeutic use ; Antidepressive Agents/isolation & purification ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Anxiety/drug therapy ; Calcium Channel Blockers/isolation & purification ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Calcium Channels/physiology ; Depression/drug therapy ; Flowers ; Humans ; Lavandula ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology ; Oils, Volatile/therapeutic use ; Plant Oils/isolation & purification ; Plant Oils/pharmacology ; Plant Oils/therapeutic use
    Chemical Substances Anti-Anxiety Agents ; Antidepressive Agents ; Calcium Channel Blockers ; Calcium Channels ; Oils, Volatile ; Plant Oils ; lavender oil (ZBP1YXW0H8)
    Language English
    Publishing date 2020-11-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 283190-9
    ISSN 1872-9754 ; 0197-0186
    ISSN (online) 1872-9754
    ISSN 0197-0186
    DOI 10.1016/j.neuint.2020.104899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1610: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid.

    Gąssowska-Dobrowolska, Magdalena / Kolasa-Wołosiuk, Agnieszka / Cieślik, Magdalena / Dominiak, Agnieszka / Friedland, Kristina / Adamczyk, Agata

    International journal of molecular sciences

    2021  Volume 22, Issue 6

    Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficient social interaction and communication besides repetitive, stereotyped behaviours. A characteristic feature of ASD is altered dendritic spine density and morphology ...

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficient social interaction and communication besides repetitive, stereotyped behaviours. A characteristic feature of ASD is altered dendritic spine density and morphology associated with synaptic plasticity disturbances. Since microtubules (MTs) regulate dendritic spine morphology and play an important role in spine development and plasticity the aim of the present study was to investigate the alterations in the content of neuronal α/β-tubulin and Tau protein level as well as phosphorylation state in the valproic acid (VPA)-induced rat model of autism. Our results indicated that maternal exposure to VPA induces: (1) decrease the level of α/β-tubulin along with Tau accumulation in the hippocampus and cerebral cortex; (2) excessive Tau phosphorylation and activation of Tau-kinases: CDK5, ERK1/2, and p70S6K in the cerebral cortex; (3) up-regulation of mTOR kinase-dependent signalling in the hippocampus and cerebral cortex of adolescent rat offspring. Moreover, immunohistochemical staining showed histopathological changes in neurons (chromatolysis) in both analysed brain structures of rats prenatally exposed to VPA. The observed changes in Tau protein together with an excessive decrease in α/β-tubulin level may suggest destabilization and thus dysfunction of the MT cytoskeleton network, which in consequence may lead to the disturbance in synaptic plasticity and the development of autistic-like behaviours.
    MeSH term(s) Animals ; Autistic Disorder/etiology ; Autistic Disorder/metabolism ; Autistic Disorder/pathology ; Biomarkers ; Brain/metabolism ; Brain/pathology ; Disease Susceptibility ; Enzyme Activation ; Female ; Immunohistochemistry ; Maternal Exposure/adverse effects ; Phosphorylation ; Pregnancy ; Prenatal Exposure Delayed Effects ; Rats ; Signal Transduction ; Tubulin/metabolism ; Valproic Acid/adverse effects ; tau Proteins/metabolism
    Chemical Substances Biomarkers ; Tubulin ; tau Proteins ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2021-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22063209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Beers-Criteria: Translation of the recent update.

    Prax, Katja / Abbas, Zahra / Friedland, Kristina / Smollich, Martin

    Medizinische Monatsschrift fur Pharmazeuten

    2018  Volume 39, Issue 10, Page(s) 406–420

    Abstract: The Beers criteria are an important instrument to improve medication safety in geriatrics. In 2015, the American Geriatrics Society (AGS) updated the Beers criteria and extended the list regarding important aspects. Our translation into German aims to ... ...

    Title translation Aktuelles Update der Beers-Kriterien Deutsche Übersetzung und Anpassung an den deutschen Arzneimittelmarkt.
    Abstract The Beers criteria are an important instrument to improve medication safety in geriatrics. In 2015, the American Geriatrics Society (AGS) updated the Beers criteria and extended the list regarding important aspects. Our translation into German aims to simplify the application in German health care and to improve medication safety. The list was adapted to the German health care market to ensure its suitability for daily clinical use. The updated Beers lists is extended regarding clinical relevant drug-drug interactions and advice for dose titration in patients with renal insufficiency. Thereby, we hope that the updated Beers criteria will help to optimize geriatric pharmacotherapy.
    MeSH term(s) Adverse Drug Reaction Reporting Systems ; Aged ; Biomarkers, Pharmacological ; Cross-Cultural Comparison ; Drug Therapy/standards ; Drug Therapy/trends ; Evidence-Based Medicine ; Female ; Geriatrics/standards ; Geriatrics/trends ; Germany ; Humans ; Male ; Potentially Inappropriate Medication List ; Translating ; United States
    Chemical Substances Biomarkers, Pharmacological
    Language German
    Publishing date 2018-07-30
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 132805-0
    ISSN 0342-9601
    ISSN 0342-9601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1374: Show issues Location:
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