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  1. Article ; Online: Optical coherence tomography: when a picture is worth a million words.

    Tzaridis, Simone / Friedlander, Martin

    The Journal of clinical investigation

    2023  

    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI174951
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  2. Article ; Online: Managing Adverse Effects Associated With Poly (ADP-ribose) Polymerase Inhibitors in Ovarian Cancer: A Synthesis of Clinical Trial and Real-World Data.

    Friedlander, Michael / Lee, Yeh Chen / Tew, William P

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2023  Volume 43, Page(s) e390876

    Abstract: The use of poly (ADP-ribose) polymerase (PARP) inhibitor therapy is standard care in the management of patients with various malignancies including ovarian, breast, prostate, and pancreatic cancers. PARP inhibitors have been approved in different ... ...

    Abstract The use of poly (ADP-ribose) polymerase (PARP) inhibitor therapy is standard care in the management of patients with various malignancies including ovarian, breast, prostate, and pancreatic cancers. PARP inhibitors have been approved in different settings for patients with specific hereditary pathogenic variants, most notably homologous recombination repair pathways such as
    MeSH term(s) Male ; Humans ; Female ; Poly(ADP-ribose) Polymerase Inhibitors/adverse effects ; Ribose/therapeutic use ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Genes, BRCA2 ; DNA Repair ; Poly(ADP-ribose) Polymerases/genetics ; Drug-Related Side Effects and Adverse Reactions
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; Ribose (681HV46001) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30)
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_390876
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  3. Article: Ammonia and CO2 enrichment of a Gracilaria cultivation pond through biofiltration of organic waste

    Friedlander, M / J. van Rijn

    Aquaculture. 2018 Jan. 01, v. 482

    2018  

    Abstract: Intensive pond cultivation of Gracilaria may achieve maximal yields by enrichment of seawater with ammonia and CO2. In the present study, we examined the use of organic waste material as a source of ammonia and inorganic carbon. A biofiltration system ... ...

    Abstract Intensive pond cultivation of Gracilaria may achieve maximal yields by enrichment of seawater with ammonia and CO2. In the present study, we examined the use of organic waste material as a source of ammonia and inorganic carbon. A biofiltration system was constructed, consisting of several fermentation tanks and a fluidized bed reactor for the required bioconversion of organic wastes. Gracilaria conferta was cultured in a 30m2 pond from which seawater was circulated through the biofiltration system for a period of nine months. As compared to the filtered seawater used for water supply, the outlets of the fermentation tanks and the fluidized bed reactor showed significant increases in dissolved inorganic carbon and ammonia concentrations and significant decreases in oxygen concentrations and redox potentials. The most efficient organic waste compound tested had the highest C/N ratio. No significant differences were found between the Gracilaria yields of the control and biofiltration pond systems. These results might contribute a fundamental improvement in the economy of Gracilaria pond cultivation by water recycling through such a biofiltration system.The system might contribute a fundamental improvement in the economy of Gracilaria pond cultivation.
    Keywords ammonia ; biofiltration ; biotransformation ; carbon ; carbon dioxide ; carbon dioxide enrichment ; carbon nitrogen ratio ; dissolved inorganic carbon ; fermentation ; fluidized beds ; Gracilaria ; organic wastes ; oxygen ; redox potential ; seawater ; tanks ; water reuse ; water supply
    Language English
    Dates of publication 2018-0101
    Size p. 45-48.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 185380-6
    ISSN 0044-8486 ; 0044-8516
    ISSN 0044-8486 ; 0044-8516
    DOI 10.1016/j.aquaculture.2017.08.041
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Reply.

    Tzaridis, Simone / Friedlander, Martin

    Retina (Philadelphia, Pa.)

    2021  Volume 42, Issue 3, Page(s) e23

    Language English
    Publishing date 2021-12-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003393
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  5. Article ; Online: Functional Relevance of Hyper-Reflectivity in Macular Telangiectasia Type 2.

    Tzaridis, Simone / Friedlander, Martin

    Investigative ophthalmology & visual science

    2021  Volume 62, Issue 3, Page(s) 6

    Abstract: Purpose: The purpose of this study was to quantify hyper-reflective lesions on en face optical coherence tomography (OCT) and study its functional relevance in macular telangiectasia type 2 (MacTel).: Design: This was a retrospective, cross-sectional ...

    Abstract Purpose: The purpose of this study was to quantify hyper-reflective lesions on en face optical coherence tomography (OCT) and study its functional relevance in macular telangiectasia type 2 (MacTel).
    Design: This was a retrospective, cross-sectional cohort study.
    Methods: Baseline image and functional data from participants of a phase II clinical trial (NCT01949324) that studied the effect of Ciliary Neurotrophic Factor in patients with MacTel were analyzed. The projection of hyper-reflectivity within different layers on OCT was used to generate an en face view and measure the en face size of hyper-reflectivity. Ellipsoid zone (EZ)-loss was additionally evaluated, and en face images were superimposed onto microperimetry sensitivity maps, allowing to estimate mean retinal sensitivity within areas displaying hyper-reflectivity and EZ-loss, respectively. Best-corrected visual acuity (BCVA) and reading speed were also analyzed.
    Results: Fifty-two eyes from 52 patients were analyzed. Hyper-reflectivity was present in 32 eyes (62%), and EZ-loss in 50 (96%) eyes. Mean lesion size was 0.11 mm² (range = 0.01-0.26) for hyper-reflectivity and 0.51 mm² (range = 0.02-1.34) for EZ-loss, and lesion sizes correlated strongly (Spearman r = 0.79, P < 0.001). Although both hyper-reflectivity and EZ-loss were associated with a significant decrease in retinal sensitivity, mean sensitivity thresholds differed significantly between lesions (0.9 dB vs. 16.3 dB; P < 0.001), indicating an almost complete loss of sensitivity in hyper-reflective areas. No correlations were found between the size of hyper-reflectivity and BCVA (r = 0.09) or reading speed (r = -0.17).
    Conclusions: En face OCT can be used to quantify the area of hyper-reflective lesions in MacTel. Hyper-reflectivity in MacTel is associated with severe functional impairment, leading to an almost complete loss of retinal sensitivity as observed on microperimetry.
    MeSH term(s) Aged ; Cross-Sectional Studies ; Female ; Fluorescein Angiography ; Humans ; Male ; Middle Aged ; Retina/diagnostic imaging ; Retina/physiopathology ; Retinal Telangiectasis/diagnostic imaging ; Retinal Telangiectasis/physiopathology ; Retrospective Studies ; Scotoma/diagnostic imaging ; Scotoma/physiopathology ; Telangiectasia, Hereditary Hemorrhagic/diagnostic imaging ; Telangiectasia, Hereditary Hemorrhagic/physiopathology ; Tomography, Optical Coherence ; Visual Acuity/physiology ; Visual Field Tests ; Visual Fields/physiology
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.62.3.6
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    Zs.A 45: Show issues Location:
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  6. Article ; Online: Pregnancy induced hyperplasia of residual breast tissue following risk reducing contralateral mastectomy - simply interesting or a clinically important observation.

    Pitiyarachchi, Omali / Phillips, Kelly-Anne / Friedlander, Michael

    Cancer treatment and research communications

    2022  Volume 30, Page(s) 100504

    Abstract: After a diagnosis of breast cancer women with increased genetic risk often have a risk reducing contralateral mastectomy, and may opt for a nipple or skin sparing mastectomy with immediate reconstruction. A variable amount of residual breast tissue ... ...

    Abstract After a diagnosis of breast cancer women with increased genetic risk often have a risk reducing contralateral mastectomy, and may opt for a nipple or skin sparing mastectomy with immediate reconstruction. A variable amount of residual breast tissue remains which may substantially increase in volume during pregnancy. Whether this increases later risk of breast cancer is unknown. We describe the clinical details of 3 patients with a history of unilateral breast cancer, including 2 with a BRCA mutation, who developed hyperplasia of residual breast tissue in the 3rd trimester of a later pregnancy. They all had a delayed contralateral risk reducing skin sparing mastectomy and immediate reconstruction. Pregnancy occurred some years later. We summarise their management, review the literature and raise questions for discussion. All developed prominent hyperplasia of breast tissue in the 3rd trimester that was clinically obvious asymmetrical breast swelling in the reconstructed contralateral breast. MRI demonstrated substantial breast tissue. The risk of breast cancer, particularly in those at high genetic risk developing in the residual breast tissue is unknown but in view of the volume, breast tissue was excised postpartum. This phenomenon of pregnancy induced hyperplasia of breast tissue after risk reducing mastectomy is not well described .There is residual breast tissue following a risk reducing subcutaneous mastectomy. The risk factors include age and skin flap thickness. MRI can demonstrate the residual breast tissue. Pregnancy induced hyperplasia of residual breast tissue may occur after risk reducing mastectomy with a hypothetical increased risk of subsequent breast cancer.
    Language English
    Publishing date 2022-01-01
    Publishing country England
    Document type Journal Article
    ISSN 2468-2942
    ISSN (online) 2468-2942
    DOI 10.1016/j.ctarc.2021.100504
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  7. Book ; Online: Die Aktiengesellschaft

    Friedländer, Martin

    ie Rechte der Aktionäre, die Pflichten des Vorstands und des Aufsichtsrats

    2017  

    Author's details von Dr. jur. Martin Friedlaender
    Language German
    Dates of publication 2017-1913
    Size 1 Online-Ressource (VIII, 110 Seiten)
    Publisher ZBW
    Publishing place Kiel ; Hamburg
    Document type Book ; Online
    Database ECONomics Information System

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  8. Article ; Online: Anti-VEGF therapy: higher potency and long-lasting antagonism are not necessarily better.

    Usui-Ouchi, Ayumi / Friedlander, Martin

    The Journal of clinical investigation

    2019  Volume 129, Issue 8, Page(s) 3032–3034

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Humans ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Angiogenesis Inhibitors ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V)
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI129862
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  9. Article ; Online: Rates of paclitaxel hypersensitivity reactions using a modified Markman's infusion protocol as primary prophylaxis.

    Symons, Rebecca / Heath, Fiona / Duggan, Jennifer / Bui, Kim Tam / Byun, Lily / Friedlander, Michael / Lee, Yeh Chen

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2024  Volume 32, Issue 5, Page(s) 292

    Abstract: Purpose: Markman's desensitisation protocol allows successful retreatment of patients who have had significant paclitaxel hypersensitivity reactions. We aimed to reduce the risk and severity of paclitaxel hypersensitivity reactions by introducing this ... ...

    Abstract Purpose: Markman's desensitisation protocol allows successful retreatment of patients who have had significant paclitaxel hypersensitivity reactions. We aimed to reduce the risk and severity of paclitaxel hypersensitivity reactions by introducing this protocol as primary prophylaxis.
    Methods: We evaluated all patients with a gynaecological malignancy receiving paclitaxel before (December 2018 to September 2019) and after (October 2019 to July 2020) the implementation of a modified Markman's desensitisation protocol. The pre-implementation group received paclitaxel over a gradually up-titrated rate from 60 to 180 ml/h. The post-implementation group received paclitaxel via 3 fixed-dose infusion bags in the first 2 cycles. Rates and severity of paclitaxel hypersensitivity reactions were compared.
    Results: A total of 426 paclitaxel infusions were administered to 78 patients. The median age was 64 years (range 34-81), and the most common diagnosis was ovarian, fallopian tube and primary peritoneal cancer (67%, n = 52/78). Paclitaxel hypersensitivity reaction rates were similar in the pre-implementation (8%, n = 16/195) and post-implementation groups (9%, n = 20/231; p = 0.87). Most paclitaxel hypersensitivity reactions occurred within 30 min (pre- vs. post-implementation, 88% [n = 14/16] vs. 75% [n = 15/20]; p = 0.45) and were grade 2 in severity (pre- vs. post-implementation, 81% [n = 13/16] vs. 75% [n = 15/20]; p = 0.37). There was one grade 3 paclitaxel hypersensitivity reaction in the pre-implementation group. All patients were successfully rechallenged in the post-implementation group compared to 81% (n = 13/16) in the pre-implementation group (p = 0.43).
    Conclusion: The modified Markman's desensitisation protocol as primary prophylaxis did not reduce the rate or severity of paclitaxel hypersensitivity reactions, although all patients could be successfully rechallenged.
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Retrospective Studies ; Drug Hypersensitivity/prevention & control ; Paclitaxel/adverse effects ; Genital Neoplasms, Female/drug therapy
    Chemical Substances Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2024-04-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-024-08460-z
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    Zs.A 3697: Show issues Location:
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  10. Article ; Online: Advances in treatment and management: immunologic and cell-based regenerative therapies.

    Friedlander, Martin

    Investigative ophthalmology & visual science

    2012  Volume 53, Issue 5, Page(s) 2511–2514

    MeSH term(s) Bone Marrow Cells ; Fetal Blood/cytology ; Glaucoma/therapy ; Humans ; Neuroprotective Agents/administration & dosage ; Ocular Hypertension/genetics ; Ocular Hypertension/immunology ; Optic Nerve Diseases/therapy ; Pluripotent Stem Cells/transplantation ; Stem Cell Transplantation/methods
    Chemical Substances Neuroprotective Agents
    Language English
    Publishing date 2012-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.12-9483p
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