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  1. Book: Hepatic stellate cells

    Weiskirchen, Ralf / Friedman, Scott L.

    methods and protocols

    (Methods in molecular biology ; 2669 ; Springer protocols)

    2023  

    Author's details edited by Ralf Weiskirchen, Scott L. Friedman
    Series title Methods in molecular biology ; 2669
    Springer protocols
    Collection
    Keywords Kupffer cells
    Subject code 612.352
    Language English
    Size xiii, 309 Seiten, Illustrationen, Diagramme, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT030043667
    ISBN 978-1-0716-3206-2 ; 9781071632079 ; 1-0716-3206-X ; 1071632078
    Database Catalogue ZB MED Medicine, Health

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    Zs A 7042 -2669- not available for loan Lesesaal EG

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  2. Article ; Online: Hepatic Fibrosis and Cancer: The Silent Threats of Metabolic Syndrome.

    Friedman, Scott L

    Diabetes & metabolism journal

    2024  Volume 48, Issue 2, Page(s) 161–169

    Abstract: Metabolic dysfunction-associated steatotic (fatty) liver disease (MASLD), previously termed non-alcoholic fatty liver disease, is a worldwide epidemic that can lead to hepatic inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The ... ...

    Abstract Metabolic dysfunction-associated steatotic (fatty) liver disease (MASLD), previously termed non-alcoholic fatty liver disease, is a worldwide epidemic that can lead to hepatic inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The disease is typically a component of the metabolic syndrome that accompanies obesity, and is often overlooked because the liver manifestations are clinically silent until late-stage disease is present (i.e., cirrhosis). Moreover, Asian populations, including Koreans, have a higher fraction of patients who are lean, yet their illness has the same prognosis or worse than those who are obese. Nonetheless, ongoing injury can lead to hepatic inflammation and ballooning of hepatocytes as classic features. Over time, fibrosis develops following activation of hepatic stellate cells, the liver's main fibrogenic cell type. The disease is usually more advanced in patients with type 2 diabetes mellitus, indicating that all diabetic patients should be screened for liver disease. Although there has been substantial progress in clarifying pathways of injury and fibrosis, there no approved therapies yet, but current research seeks to uncover the pathways driving hepatic inflammation and fibrosis, in hopes of identifying new therapeutic targets. Emerging molecular methods, especially single cell sequencing technologies, are revolutionizing our ability to clarify mechanisms underlying MASLD-associated fibrosis and HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Diabetes Mellitus, Type 2/complications ; Liver Neoplasms/epidemiology ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Liver Cirrhosis/complications ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Obesity/complications ; Inflammation/complications
    Language English
    Publishing date 2024-01-26
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2023.0240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fighting Cardiac Fibrosis with CAR T Cells.

    Friedman, Scott L

    The New England journal of medicine

    2022  Volume 386, Issue 16, Page(s) 1576–1578

    MeSH term(s) Fibrosis/therapy ; Heart Diseases/pathology ; Heart Diseases/therapy ; Humans ; Immunotherapy, Adoptive/methods ; Receptors, Chimeric Antigen/therapeutic use ; T-Lymphocytes
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcibr2201182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Regression of Fibrosis Following Hepatitis C Eradication.

    Friedman, Scott L

    Gastroenterology & hepatology

    2022  Volume 18, Issue 10, Page(s) 599–601

    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6543: Show issues Location:
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    Zs.MO 517: Show issues

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  5. Book: Hepatic fibrosis

    Friedman, Scott L.

    pathogenesis, diagnosis, and emerging therapies

    (Clinics in liver disease ; 12,4)

    2008  

    Author's details guest ed. Scott L. Friedman
    Series title Clinics in liver disease ; 12,4
    Collection
    Language English
    Size XIV S., S. 733 - 972 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015920267
    ISBN 1-4160-6315-3 ; 978-1-4160-6315-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1870 -12,4- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH).

    Wang, Shuang / Friedman, Scott L

    Science translational medicine

    2023  Volume 15, Issue 716, Page(s) eadi0759

    Abstract: Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of liver disease that poses a global health threat because of its potential to progress to advanced fibrosis, leading to cirrhosis and liver cancer. Recent advances in single-cell ... ...

    Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of liver disease that poses a global health threat because of its potential to progress to advanced fibrosis, leading to cirrhosis and liver cancer. Recent advances in single-cell methodologies, refined disease models, and genetic and epigenetic insights have provided a nuanced understanding of MASH fibrogenesis, with substantial cellular heterogeneity in MASH livers providing potentially targetable cell-cell interactions and behavior. Unlike fibrogenesis, mechanisms underlying fibrosis regression in MASH are still inadequately understood, although antifibrotic targets have been recently identified. A refined antifibrotic treatment framework could lead to noninvasive assessment and targeted therapies that preserve hepatocellular function and restore the liver's architectural integrity.
    MeSH term(s) Humans ; Liver Cirrhosis/metabolism ; Fatty Liver/complications ; Cell Communication ; Liver Neoplasms
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.adi0759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  7. Article ; Online: Working with Immortalized Hepatic Stellate Cell Lines.

    Friedman, Scott L / Weiskirchen, Ralf

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2669, Page(s) 129–162

    Abstract: Hepatic stellate cells (HSCs) are the major cellular source of extracellular matrix production in the liver. Therefore, this cell population has received considerable attention in studies investigating fundamental features of hepatic fibrosis. However, ... ...

    Abstract Hepatic stellate cells (HSCs) are the major cellular source of extracellular matrix production in the liver. Therefore, this cell population has received considerable attention in studies investigating fundamental features of hepatic fibrosis. However, the limited supply and ever-increasing demand for these cells, combined with the additional tightening of formal standards in animal welfare policy, make working with these primary cells increasingly difficult. Moreover, researchers working in biomedical research are challenged to implement the 3R principle of "replacement," "reduction," and "refinement" in their work. This principle, originally proposed in 1959 by William M. S. Russell and Rex L. Burch, is now widely endorsed by legislators and regulatory bodies in many countries as a roadmap to tackle the ethical dilemma associated with animal experimentation. As such, working with immortalized HSC lines is a good alternative to limit the number of animals and their suffering in biomedical research. This article summarizes issues that need to be considered when working with established HSC cell lines and provides general guidelines for the maintenance and storage of HSC lines from mouse, rat, and humans.
    MeSH term(s) Humans ; Rats ; Mice ; Animals ; Hepatic Stellate Cells/metabolism ; Liver Cirrhosis/metabolism ; Kupffer Cells ; Cell Line
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3207-9_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The future of hepatology.

    Friedman, Scott L / Sanyal, Arun J

    Hepatology (Baltimore, Md.)

    2023  Volume 78, Issue 2, Page(s) 637–648

    Abstract: The field of hepatology has made impressive progress over its ~75 years of existence. Advances in understanding liver function and its dysregulation in disease, genetic determinants of disease, antiviral therapy, and transplantation have transformed the ... ...

    Abstract The field of hepatology has made impressive progress over its ~75 years of existence. Advances in understanding liver function and its dysregulation in disease, genetic determinants of disease, antiviral therapy, and transplantation have transformed the lives of patients. However, there are still significant challenges that require ongoing creativity and discipline, particularly with the emergence of fatty liver diseases, as well as managing autoimmune disease, cancer, and liver disease in children. Diagnostic advances are urgently needed to accelerate risk stratification and efficient testing of new agents with greater precision in enriched populations. Integrated, holistic care models should be extended beyond liver cancer to diseases like NAFLD with systemic manifestations or extrahepatic comorbidities such as cardiovascular disease, diabetes, addiction, and depressive disorders. To meet the growing burden of asymptomatic liver disease, the workforce will need to be expanded by incorporating more advanced practice providers and educating other specialists. The training of future hepatologists will benefit from incorporating emerging skills in data management, artificial intelligence, and precision medicine. Continued investment in basic and translational science is crucial for further progress. The challenges ahead are significant, but with collective effort, the field of hepatology will continue to make progress and overcome obstacles.
    MeSH term(s) Child ; Humans ; Gastroenterology ; Artificial Intelligence ; Non-alcoholic Fatty Liver Disease ; Liver Neoplasms
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
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  9. Book: Current diagnosis & treatment in gastroenterology

    Friedman, Scott L.

    (A Lange medical book)

    2003  

    Title variant Diagnosis & treatment in gastroenterology ; Gastroenterology
    Author's details ed. by Scott L. Friedman
    Series title A Lange medical book
    Keywords Gastrointestinal Diseases
    Language English
    Size XV, 867 S. : Ill., graph. Darst.
    Edition 2. ed., internat. ed.
    Publisher Lange Medical Books/McGraw-Hill
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013529031
    ISBN 0-07-121228-0 ; 0-8385-1551-7 ; 978-0-07-121228-1 ; 978-0-8385-1551-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 5785 order for loan Magazin

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  10. Article: Hepatic Stellate Cell-Immune Interactions in NASH.

    Carter, James K / Friedman, Scott L

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 867940

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide. Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is characterized by severe hepatocellular injury, inflammation, and fibrosis. Chronic ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide. Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is characterized by severe hepatocellular injury, inflammation, and fibrosis. Chronic inflammation and heightened immune cell activity have emerged as hallmark features of NASH and key drivers of fibrosis through the activation of hepatic stellate cells (HSCs). Recent advances in our understanding of the molecular and cellular pathways in NASH have highlighted extensive crosstalk between HSCs and hepatic immune populations that strongly influences disease activity. Here, we review these findings, emphasizing the roles of HSCs in liver immunity and inflammation, key cell-cell interactions, and exciting areas for future investigation.
    MeSH term(s) Fibrosis ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Inflammation/metabolism ; Non-alcoholic Fatty Liver Disease/pathology
    Language English
    Publishing date 2022-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.867940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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