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  1. Article: First report on sepsis caused by Porphyromonas pogonae

    Schröttner, Percy / Enno Jacobs / Florian Gunzer / Friedrich Stölzel / Katharina Heidrich / Wolfram W. Rudolph

    Anaerobe. 2017 Apr., v. 44

    2017  

    Abstract: We report on a 62 year old patient who developed sepsis due to an infection caused by Porphyromonas pogonae, a recently described species of the bacterial genus Porphyromonas. This is the first case of an invasive infection with this pathogen. ...

    Abstract We report on a 62 year old patient who developed sepsis due to an infection caused by Porphyromonas pogonae, a recently described species of the bacterial genus Porphyromonas. This is the first case of an invasive infection with this pathogen.
    Keywords pathogens ; patients ; Porphyromonas ; sepsis (infection)
    Language English
    Dates of publication 2017-04
    Size p. 96-98.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1237621-8
    ISSN 1075-9964
    ISSN 1075-9964
    DOI 10.1016/j.anaerobe.2017.02.016
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Germline POT1 Deregulation Can Predispose to Myeloid Malignancies in Childhood

    Pia Michler / Anne Schedel / Martha Witschas / Ulrike Anne Friedrich / Rabea Wagener / Juha Mehtonen / Triantafyllia Brozou / Maria Menzel / Carolin Walter / Dalileh Nabi / Glen Pearce / Miriam Erlacher / Gudrun Göhring / Martin Dugas / Merja Heinäniemi / Arndt Borkhardt / Friedrich Stölzel / Julia Hauer / Franziska Auer

    International Journal of Molecular Sciences, Vol 22, Iss 11572, p

    2021  Volume 11572

    Abstract: While the shelterin complex guards and coordinates the mechanism of telomere regulation, deregulation of this process is tightly linked to malignant transformation and cancer. Here, we present the novel finding of a germline stop-gain variant (p.Q199*) ... ...

    Abstract While the shelterin complex guards and coordinates the mechanism of telomere regulation, deregulation of this process is tightly linked to malignant transformation and cancer. Here, we present the novel finding of a germline stop-gain variant (p.Q199*) in the shelterin complex gene POT1 , which was identified in a child with acute myeloid leukemia. We show that the cells overexpressing the mutated POT1 display increased DNA damage and chromosomal instabilities compared to the wildtype counterpart. Protein and mRNA expression analyses in the primary patient cells further confirm that, physiologically, the variant leads to a nonfunctional POT1 allele in the patient. Subsequent telomere length measurements in the primary cells carrying heterozygous POT1 p.Q199* as well as POT1 knockdown AML cells revealed telomeric elongation as the main functional effect. These results show a connection between POT1 p.Q199* and telomeric dysregulation and highlight POT1 germline deficiency as a predisposition to myeloid malignancies in childhood.
    Keywords acute myeloid leukemia ; pediatric ; trio sequencing ; germline cancer predisposition ; POT1 ; shelterin complex ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 612
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Biallelic TET2 mutations confer sensitivity to 5′-azacitidine in acute myeloid leukemia

    Friedrich Stölzel / Sarah E. Fordham / Devi Nandana / Wei-Yu Lin / Helen Blair / Claire Elstob / Hayden L. Bell / Brigitte Mohr / Leo Ruhnke / Desiree Kunadt / Claudia Dill / Daniel Allsop / Rachel Piddock / Emmanouela-Niki Soura / Catherine Park / Mohd Fadly / Thahira Rahman / Abrar Alharbi / Manja Wobus /
    Heidi Altmann / Christoph Röllig / Lisa Wagenführ / Gail L. Jones / Tobias Menne / Graham H. Jackson / Helen J. Marr / Jude Fitzgibbon / Kenan Onel / Manja Meggendorfer / Amber Robinson / Zuzanna Bziuk / Emily Bowes / Olaf Heidenreich / Torsten Haferlach / Sara Villar / Beñat Ariceta / Rosa Ayala Diaz / Steven J. Altschuler / Lani F. Wu / Felipe Prosper / Pau Montesinos / Joaquin Martinez-Lopez / Martin Bornhäuser / James M. Allan

    JCI Insight, Vol 8, Iss

    2023  Volume 2

    Abstract: Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 ... ...

    Abstract Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant to anthracycline and cytarabine but acutely sensitive to 5′-azacitidine (5′-Aza) hypomethylating monotherapy, resulting in long-term morphological remission. Given the role of TET2 as a regulator of genomic methylation, we hypothesized that mutant TET2 allele dosage affects response to 5′-Aza. Using an isogenic cell model system and an orthotopic mouse xenograft, we demonstrate that biallelic TET2 mutations confer sensitivity to 5′-Aza compared with cells with monoallelic mutations. Our data argue in favor of using hypomethylating agents for chemoresistant disease or as first-line therapy in patients with biallelic TET2-mutated AML and demonstrate the importance of considering mutant allele dosage in the implementation of precision medicine for patients with cancer.
    Keywords Hematology ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells

    Guruchandar Arulmozhivarman / Martin Kräter / Manja Wobus / Jens Friedrichs / Elham Pishali Bejestani / Katrin Müller / Katrin Lambert / Dimitra Alexopoulou / Andreas Dahl / Martin Stöter / Marc Bickle / Nona Shayegi / Jochen Hampe / Friedrich Stölzel / Michael Brand / Malte von Bonin / Martin Bornhäuser

    Scientific Reports, Vol 7, Iss 1, Pp 1-

    - Preclinical Validation in Human CD34+ Stem and Progenitor Cells

    2017  Volume 15

    Abstract: Abstract The identification of small molecules that either increase the number and/or enhance the activity of human hematopoietic stem and progenitor cells (hHSPCs) during ex vivo expansion remains challenging. We used an unbiased in vivo chemical screen ...

    Abstract Abstract The identification of small molecules that either increase the number and/or enhance the activity of human hematopoietic stem and progenitor cells (hHSPCs) during ex vivo expansion remains challenging. We used an unbiased in vivo chemical screen in a transgenic (c-myb:EGFP) zebrafish embryo model and identified histone deacetylase inhibitors (HDACIs), particularly valproic acid (VPA), as significant enhancers of the number of phenotypic HSPCs, both in vivo and during ex vivo expansion. The long-term functionality of these expanded hHSPCs was verified in a xenotransplantation model with NSG mice. Interestingly, VPA increased CD34+ cell adhesion to primary mesenchymal stromal cells and reduced their in vitro chemokine-mediated migration capacity. In line with this, VPA-treated human CD34+ cells showed reduced homing and early engraftment in a xenograft transplant model, but retained their long-term engraftment potential in vivo, and maintained their differentiation ability both in vitro and in vivo. In summary, our data demonstrate that certain HDACIs lead to a net expansion of hHSPCs with retained long-term engraftment potential and could be further explored as candidate compounds to amplify ex-vivo engineered peripheral blood stem cells.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2017-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

    Maddalena Noviello / Francesco Manfredi / Eliana Ruggiero / Tommaso Perini / Giacomo Oliveira / Filippo Cortesi / Pantaleo De Simone / Cristina Toffalori / Valentina Gambacorta / Raffaella Greco / Jacopo Peccatori / Monica Casucci / Giulia Casorati / Paolo Dellabona / Masahiro Onozawa / Takanori Teshima / Marieke Griffioen / Constantijn J. M. Halkes / J. H. F. Falkenburg /
    Friedrich Stölzel / Heidi Altmann / Martin Bornhäuser / Miguel Waterhouse / Robert Zeiser / Jürgen Finke / Nicoletta Cieri / Attilio Bondanza / Luca Vago / Fabio Ciceri / Chiara Bonini

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells ... ...

    Abstract Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse.
    Keywords Science ; Q
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

    Maddalena Noviello / Francesco Manfredi / Eliana Ruggiero / Tommaso Perini / Giacomo Oliveira / Filippo Cortesi / Pantaleo De Simone / Cristina Toffalori / Valentina Gambacorta / Raffaella Greco / Jacopo Peccatori / Monica Casucci / Giulia Casorati / Paolo Dellabona / Masahiro Onozawa / Takanori Teshima / Marieke Griffioen / Constantijn J. M. Halkes / J. H. F. Falkenburg /
    Friedrich Stölzel / Heidi Altmann / Martin Bornhäuser / Miguel Waterhouse / Robert Zeiser / Jürgen Finke / Nicoletta Cieri / Attilio Bondanza / Luca Vago / Fabio Ciceri / Chiara Bonini

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 15

    Abstract: Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells ... ...

    Abstract Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse.
    Keywords Science ; Q
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Author Correction

    Wei-Yu Lin / Sarah E. Fordham / Eric Hungate / Nicola J. Sunter / Claire Elstob / Yaobo Xu / Catherine Park / Anne Quante / Konstantin Strauch / Christian Gieger / Andrew Skol / Thahira Rahman / Lara Sucheston-Campbell / Junke Wang / Theresa Hahn / Alyssa I. Clay-Gilmour / Gail L. Jones / Helen J. Marr / Graham H. Jackson /
    Tobias Menne / Mathew Collin / Adam Ivey / Robert K. Hills / Alan K. Burnett / Nigel H. Russell / Jude Fitzgibbon / Richard A. Larson / Michelle M. Le Beau / Wendy Stock / Olaf Heidenreich / Abrar Alharbi / David J. Allsup / Richard S. Houlston / Jean Norden / Anne M. Dickinson / Elisabeth Douglas / Clare Lendrem / Ann K. Daly / Louise Palm / Kim Piechocki / Sally Jeffries / Martin Bornhäuser / Christoph Röllig / Heidi Altmann / Leo Ruhnke / Desiree Kunadt / Lisa Wagenführ / Heather J. Cordell / Rebecca Darlay / Mette K. Andersen / Maria C. Fontana / Giovanni Martinelli / Giovanni Marconi / Miguel A. Sanz / José Cervera / Inés Gómez-Seguí / Thomas Cluzeau / Chimène Moreilhon / Sophie Raynaud / Heinz Sill / Maria Teresa Voso / Francesco Lo-Coco / Hervé Dombret / Meyling Cheok / Claude Preudhomme / Rosemary E. Gale / David Linch / Julia Gaal-Wesinger / Andras Masszi / Daniel Nowak / Wolf-Karsten Hofmann / Amanda Gilkes / Kimmo Porkka / Jelena D. Milosevic Feenstra / Robert Kralovics / David Grimwade / Manja Meggendorfer / Torsten Haferlach / Szilvia Krizsán / Csaba Bödör / Friedrich Stölzel / Kenan Onel / James M. Allan

    Nature Communications, Vol 13, Iss 1, Pp 1-

    Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

    2022  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation

    Luise Hartmann / Sayantanee Dutta / Sabrina Opatz / Sebastian Vosberg / Katrin Reiter / Georg Leubolt / Klaus H. Metzeler / Tobias Herold / Stefanos A. Bamopoulos / Kathrin Bräundl / Evelyn Zellmeier / Bianka Ksienzyk / Nikola P. Konstandin / Stephanie Schneider / Karl-Peter Hopfner / Alexander Graf / Stefan Krebs / Helmut Blum / Jan Moritz Middeke /
    Friedrich Stölzel / Christian Thiede / Stephan Wolf / Stefan K. Bohlander / Caroline Preiss / Linping Chen-Wichmann / Christian Wichmann / Maria Cristina Sauerland / Thomas Büchner / Wolfgang E. Berdel / Bernhard J. Wörmann / Jan Braess / Wolfgang Hiddemann / Karsten Spiekermann / Philipp A. Greif

    Nature Communications, Vol 7, Iss 1, Pp 1-

    2016  Volume 7

    Abstract: The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that the ...

    Abstract The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that the mutations reduce DNA binding activity.
    Keywords Science ; Q
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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