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  1. Book ; Online ; E-Book: Systems neuroscience in depression

    Frodl, Thomas

    2016  

    Author's details edited by Thomas Frodl
    Keywords Depression / physiopathology ; Depressive Disorder / physiopathology ; Brain / physiopathology ; Neuronal Plasticity / physiology
    Subject code 616.8/527
    Language English
    Size 1 Online-Ressource (xxxvi, 383 Seiten), Illustrationen, Diagramme
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019395503
    ISBN 978-0-12-802628-1 ; 9780128024560 ; 0-12-802628-6 ; 0128024569
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Adaptive and maladaptive emotion regulation in bipolar disorder.

    Frodl, Thomas

    Acta psychiatrica Scandinavica

    2023  Volume 148, Issue 6, Page(s) 469–471

    MeSH term(s) Humans ; Bipolar Disorder/psychology ; Emotional Regulation ; Emotions/physiology
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.141: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Thesis: Dipolquellenanlyse der akustisch evozierten P300 bei gesunden Probanden und schizophrenen Patienten

    Frodl, Thomas

    2000  

    Author's details vorgelegt von Thomas Frodl
    Language German
    Size III, 147 S. : graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 2000
    HBZ-ID HT012867833
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 D 2443 order for loan Magazin

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  4. Article ; Online: Time-sensitive changes in the maternal brain and their influence on mother-child attachment.

    Nehls, Susanne / Losse, Elena / Enzensberger, Christian / Frodl, Thomas / Chechko, Natalia

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 84

    Abstract: Pregnancy and the postpartum period are characterized by an increased neuroplasticity in the maternal brain. To explore the dynamics of postpartum changes in gray matter volume (GMV), magnetic resonance imaging was performed on 20 healthy postpartum ... ...

    Abstract Pregnancy and the postpartum period are characterized by an increased neuroplasticity in the maternal brain. To explore the dynamics of postpartum changes in gray matter volume (GMV), magnetic resonance imaging was performed on 20 healthy postpartum women immediately after childbirth and at 3-week intervals for 12 postpartum weeks. The control group comprised 20 age-matched nulliparous women. The first 6 postpartum weeks (constituting the subacute postpartum period) are associated with decreasing progesterone levels and a massive restructuring in GMV, affecting the amygdala/hippocampus, the prefrontal/subgenual cortex, and the insula, which approach their sizes in nulliparous women only around weeks 3-6 postpartum. Based on the amygdala volume shortly after delivery, the maternal brain can be reliably distinguished from the nulliparous brain. Even 12 weeks after childbirth, the GMV in the dorsomedial prefrontal cortex, and the cortical thickness of the subgenual and lateral prefrontal cortices do not reach the pre-pregnancy levels. During this period, a volume decrease is seen in the cerebellum, the thalamus, and the dorsal striatum. A less hostile behavior toward the child at 6-12 weeks postpartum is predicted by the GMV change in the amygdala, the temporal pole, the olfactory gyrus, the anterior cingulate, the thalamus and the cerebellum in the same period. In summary, the restructuring of the maternal brain follows time-dependent trajectories. The fact that the volume changes persist at 12 weeks postpartum indicates that the maternal brain does not fully revert to pre-pregnancy physiology. Postpartum neuroplasticity suggests that these changes may be particularly significant in the regions important for parenting.
    MeSH term(s) Pregnancy ; Humans ; Female ; Brain/diagnostic imaging ; Brain/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Prefrontal Cortex/pathology ; Temporal Lobe/pathology ; Magnetic Resonance Imaging ; Mother-Child Relations
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02805-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Recent advances in predicting responses to antidepressant treatment.

    Frodl, Thomas

    F1000Research

    2017  Volume 6

    Abstract: Major depressive disorder is one of the leading causes of disability in the world since depression is highly frequent and causes a strong burden. In order to reduce the duration of depressive episodes, clinicians would need to choose the most effective ... ...

    Abstract Major depressive disorder is one of the leading causes of disability in the world since depression is highly frequent and causes a strong burden. In order to reduce the duration of depressive episodes, clinicians would need to choose the most effective therapy for each individual right away. A prerequisite for this would be to have biomarkers at hand that would predict which individual would benefit from which kind of therapy (for example, pharmacotherapy or psychotherapy) or even from which kind of antidepressant class. In the past, neuroimaging, electroencephalogram, genetic, proteomic, and inflammation markers have been under investigation for their utility to predict targeted therapies. The present overview demonstrates recent advances in all of these different methodological areas and concludes that these approaches are promising but also that the aim to have such a marker available has not yet been reached. For example, the integration of markers from different systems needs to be achieved. With ongoing advances in the accuracy of sensing techniques and improvement of modelling approaches, this challenge might be achievable.
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.10300.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Baby blues, premenstrual syndrome and postpartum affective disorders: intersection of risk factors and reciprocal influences.

    Chechko, Natalia / Losse, Elena / Frodl, Thomas / Nehls, Susanne

    BJPsych open

    2023  Volume 10, Issue 1, Page(s) e3

    Abstract: Background: The aetiology and consequences of 'baby blues' (lower mood following childbirth) are yet to be sufficiently investigated with respect to an individual's clinical history.: Aims: The primary aim of the study was to assess the symptoms of ... ...

    Abstract Background: The aetiology and consequences of 'baby blues' (lower mood following childbirth) are yet to be sufficiently investigated with respect to an individual's clinical history.
    Aims: The primary aim of the study was to assess the symptoms of baby blues and the relevant risk factors, their associations with clinical history and premenstrual syndrome (PMS), and their possible contribution to the early recognition of postpartum depression (PPD).
    Method: Beginning shortly after childbirth, 369 mothers were followed up for 12 weeks. Information related to their clinical history, PMS, depression, stress and mother-child attachment was collected. At 12 weeks, mothers were classified as non-depressed, or with either PPD or adjustment disorder.
    Results: A correlation was found between the severity of baby blues and PMS (
    Conclusions: Baby blues are linked to a number of risk factors and a history of PMS, with both conditions adding to the risk of PPD. The neuroendocrine effects on mood need be understood in the context of individual risk factors. The assessment of both baby blues and PMS symptoms within the first postpartum days may contribute to an early identification of PPD.
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2829557-2
    ISSN 2056-4724
    ISSN 2056-4724
    DOI 10.1192/bjo.2023.612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Systems neuroscience in depression

    Frodl, Thomas

    2016  

    Author's details edited by Thomas Frodl
    MeSH term(s) Depression/physiopathology ; Depressive Disorder/physiopathology ; Brain/physiopathology ; Neuronal Plasticity/physiology
    Language English
    Size xxxvi., 383 pages :, illustrations,, 24 cm
    Document type Book
    ISBN 9780128024560 ; 0128024569
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Pharmacokinetic correlates of clinical response in a naturalistic sample of escitalopram-treated patients.

    Kasperk, Nicholas / Haen, Ekkehard / Hiemke, Christoph / Frodl, Thomas / Schoretsanitis, Georgios / Paulzen, Michael / Kuzo, Nazar

    Expert review of clinical pharmacology

    2024  Volume 17, Issue 3, Page(s) 247–253

    Abstract: Objective: We assessed pharmacokinetic correlates of treatment response to escitalopram using a large therapeutic drug monitoring database.: Methods: A large naturalistic sample of patients receiving escitalopram was analyzed. Responders were defined ...

    Abstract Objective: We assessed pharmacokinetic correlates of treatment response to escitalopram using a large therapeutic drug monitoring database.
    Methods: A large naturalistic sample of patients receiving escitalopram was analyzed. Responders were defined as 'very much improved' or 'much improved' based on the Clinical Global Impression - Improvement score, CGI-I. We compared responders (
    Results: There were no statistically significant differences in clinical and demographic characteristics between responders vs. non-responders. There were also no differences between escitalopram daily doses or plasma concentrations, while C/D ratios were significantly higher in non-responders than in responders (1.6 ± 1.7 vs. 1.2 ± 0.9 (ng/mL)/(mg/day),
    Conclusions: Patients with low clearance of escitalopram as reflected upon high C/D ratios may be less likely respond to escitalopram. Identifying these patients during dose titration may support clinical decision-making, including switching to a different antidepressant instead of increasing daily dose.
    MeSH term(s) Humans ; Citalopram/adverse effects ; Escitalopram ; Antidepressive Agents/therapeutic use ; Treatment Outcome
    Chemical Substances Citalopram (0DHU5B8D6V) ; Escitalopram (4O4S742ANY) ; Antidepressive Agents
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2024.2314211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dynamic Stability of Volatile Organic Compounds in Respiratory Air in Schizophrenic Patients and Its Potential Predicting Efficacy of TAAR Agonists.

    Held, Anna / Henning, Dariush / Jiang, Carina / Hoeschen, Christoph / Frodl, Thomas

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 11

    Abstract: Objectives: Volatile organic compounds (VOCs) in the breathing air were found to be altered in schizophrenia patients compared to healthy participants. The aim of this study was to confirm these findings and to examine for the first time whether these ... ...

    Abstract Objectives: Volatile organic compounds (VOCs) in the breathing air were found to be altered in schizophrenia patients compared to healthy participants. The aim of this study was to confirm these findings and to examine for the first time whether these VOCs are stable or change in concentration during the early treatment course. Moreover, it was investigated whether there is a correlation of the VOCs with the existing psychopathology of schizophrenia patients, i.e., whether the concentration of masses detected in the breath gas changes when the psychopathology of the participants changes.
    Methods: The breath of a total of 22 patients with schizophrenia disorder was examined regarding the concentration of VOCs using proton transfer reaction mass spectrometry. The measurements were carried out at baseline and after two weeks at three different time points, the first time immediately after waking up in the morning, after 30 min, and then after 60 min. Furthermore, 22 healthy participants were investigated once as a control group.
    Results: Using bootstrap mixed model analyses, significant concentration differences were found between schizophrenia patients and healthy control participants (
    Conclusion: Breath gas analysis is an easy-to-use method to detect differences in VOCs in the breath of schizophrenia patients with high temporal stability.
    MeSH term(s) Humans ; Volatile Organic Compounds/analysis ; Gas Chromatography-Mass Spectrometry/methods ; Mass Spectrometry ; Biomarkers ; Breath Tests/methods
    Chemical Substances Volatile Organic Compounds ; Biomarkers
    Language English
    Publishing date 2023-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28114385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article ; Online: Longitudinal hippocampal subfield development associated with psychotic experiences in young people.

    O'Neill, Aisling / Dooley, Niamh / Roddy, Darren / Healy, Colm / Carey, Eleanor / Frodl, Thomas / O'Hanlon, Erik / Cannon, Mary

    Translational psychiatry

    2024  Volume 14, Issue 1, Page(s) 44

    Abstract: Hippocampal volumetric reductions are observed across the psychosis spectrum, with interest in the localisation of these reductions within the hippocampal subfields increasing. Deficits of the CA1 subfield in particular have been implicated in the ... ...

    Abstract Hippocampal volumetric reductions are observed across the psychosis spectrum, with interest in the localisation of these reductions within the hippocampal subfields increasing. Deficits of the CA1 subfield in particular have been implicated in the neuropathophysiology of psychotic disorders. Investigating the trajectory of these abnormalities in healthy adolescents reporting sub-threshold psychotic experiences (PE) can provide insight into the neural mechanisms underlying psychotic symptoms without the potentially confounding effects of a formal disorder, or antipsychotic medication. In this novel investigation, a sample of 211 young people aged 11-13 participated initially in the Adolescent Brain Development study. PE classification was determined by expert consensus at each timepoint. Participants underwent neuroimaging at 3 timepoints, over 6 years. 78 participants with at least one scan were included in the final sample; 33 who met criteria for a definite PE at least once across all the timepoints (PE group), and 45 controls. Data from bilateral subfields of interest (CA1, CA2/3, CA4/DG, presubiculum and subiculum) were extracted for Linear Mixed Effects analyses. Before correction, subfield volumes were found to increase in the control group and decrease in the PE group for the right CA2 and CA2/3 subfields, with moderate to large effect sizes (d = -0.61, and d = -0.79, respectively). Before correction, right subiculum and left presubiculum volumes were reduced in the PE group compared to controls, regardless of time, with moderate effect sizes (d = -0.52, and d = -0.59, respectively). However, none of these effects survived correction. Severity of symptoms were not associated with any of the noted subfields. These findings provide novel insight to the discussion of the role of hippocampal subfield abnormalities in the pathophysiology underlying psychotic experiences.
    MeSH term(s) Adolescent ; Humans ; Organ Size ; Hippocampus/diagnostic imaging ; Psychotic Disorders/diagnostic imaging ; Neuroimaging/methods ; Antipsychotic Agents ; Magnetic Resonance Imaging/methods
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-024-02746-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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