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Article ; Online: High-Resolution Quantitative Mapping of Macaque Cervicovaginal Epithelial Thickness: Implications for Mucosal Vaccine Delivery.

Vincent, Kathleen L / Frost, Patrice A / Motamedi, Massoud / Dick, Edward J / Wei, Jingna / Yang, Jinping / White, Robert / Gauduin, Marie-Claire

Frontiers in immunology

2021 Volume 12, Page(s) 660524

Abstract: Vaginal mucosal surfaces naturally offer some protection against sexually transmitted infections (STIs) including Human Immunodeficiency Virus-1, however topical preventative medications or vaccine designed to boost local immune responses can further ... ...

Abstract	Vaginal mucosal surfaces naturally offer some protection against sexually transmitted infections (STIs) including Human Immunodeficiency Virus-1, however topical preventative medications or vaccine designed to boost local immune responses can further enhance this protection. We previously developed a novel mucosal vaccine strategy using viral vectors integrated into mouse dermal epithelium to induce virus-specific humoral and cellular immune responses at the site of exposure. Since vaccine integration occurs at the site of cell replication (basal layer 100-400 micrometers below the surface), temporal epithelial thinning during vaccine application, confirmed with high resolution imaging, is desirable. In this study, strategies for vaginal mucosal thinning were evaluated noninvasively using optical coherence tomography (OCT) to map reproductive tract epithelial thickness (ET) in macaques to optimize basal layer access in preparation for future effective intravaginal mucosal vaccination studies. Twelve adolescent female rhesus macaques (5-7kg) were randomly assigned to interventions to induce vaginal mucosal thinning, including cytobrush mechanical abrasion, the chemical surfactant spermicide nonoxynol-9 (N9), the hormonal contraceptive depomedroxyprogesterone acetate (DMPA), or no intervention. Macaques were evaluated at baseline and after interventions using colposcopy, vaginal biopsies, and OCT imaging, which allowed for real-time
MeSH term(s)	Animals ; Cervix Uteri/cytology ; Drug Delivery Systems ; Epithelial Cells ; Epithelium/drug effects ; Epithelium/immunology ; Female ; Macaca mulatta ; Mice ; Mucous Membrane/anatomy & histology ; Mucous Membrane/drug effects ; Mucous Membrane/immunology ; Simian Immunodeficiency Virus/physiology ; Tomography, Optical Coherence/methods ; Vaccines/administration & dosage ; Vaccines/immunology ; Vagina/cytology ; Vagina/immunology
Chemical Substances	Vaccines
Language	English
Publishing date	2021-06-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.660524
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Article ; Online: Indices of muscle and liver dysfunction after surviving hemorrhage and prolonged hypotension.

Hinojosa-Laborde, Carmen / Shade, Robert E / Frost, Patrice A / Dutton, John W / Muniz, Gary W / Hudson, Ian L / Carter, Robert / Ryan, Kathy L

The journal of trauma and acute care surgery

2019 Volume 87, Issue 1S Suppl 1, Page(s) S101–S109

Abstract: Background: This study determined the long-term effects of prolonged hypotension (PH) on liver, muscle, and kidney dysfunction. The hypothesis was that longer duration of PH after hemorrhage will result in greater organ dysfunction.: Methods: Baboons ...

Abstract	Background: This study determined the long-term effects of prolonged hypotension (PH) on liver, muscle, and kidney dysfunction. The hypothesis was that longer duration of PH after hemorrhage will result in greater organ dysfunction. Methods: Baboons were sedated and hemorrhaged (30% blood volume). Systolic blood pressure greater than 80 mm Hg was maintained for 1 hour (1 hr-PH; n = 5), 2 hours (2 hr-PH; n = 5), or 3 hours (3 hr-PH; n = 5). After PH, hemorrhage volume was replaced. Animals were recovered and monitored for 21 days. Control animals were hemorrhaged and immediately resuscitated (0 hr-PH, n = 3). Data are Mean ± Standard Deviation, and analyzed by 2-way repeated measures ANOVA and Holm-Sidak test. Results: Hemorrhage resulted in mild hypotension. Minimal resuscitation was required during the hypotensive phase, and survival rate was 100%. Significant increases (p < 0.001) in alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, and lactate dehydrogenase occurred on Day 1 after PH, and were significantly greater (p < 0.001) in the 2 hr- and 3 hr-PH groups than the 0 hr-PH group. Maximum alanine aminotransferase levels (U/L) were 140 ± 56 (0 hr-PH), 170 ± 130 (1 hr-PH), 322 ± 241 (2 hr-PH), and 387 ± 167 (3 hr-PH). Maximum aspartate aminotransferase levels (U/L) were 218 ± 44 (0 hr-PH), 354 ± 219 (1 hr-PH), 515 ± 424 (2 hr-PH), and 711 ± 278 (3 hr-PH). Maximum creatine phosphokinase values (U/L) were 7834 ± 3681 (0 hr-PH), 24336 ± 22268 (1 hr-PH), 50494 ± 67653 (2 hr-PH), and 59857 ± 32408 (3 hr-PH). Maximum lactic acid dehydrogenase values (U/L) were 890 ± 396 (0 hr-PH), 2055 ± 1520 (1 hr-PH), 3992 ± 4895 (2 hr-PH), and 4771 ± 1884 (3 hr-PH). Plasma creatinine and blood urea nitrogen were unaffected by PH (p > 0.10). Conclusion: These results indicate that PH up to 3 hours in duration results in transient liver and muscle dysfunction that was most severe after 2 hr-PH and 3 hr-PH. Prolonged hypotension produced minimal effects on the kidney. Level of evidence: Basic science research, Level of evidence not required for basic science research.
MeSH term(s)	Animals ; Hemorrhage/complications ; Hypotension/etiology ; Hypotension/physiopathology ; Kidney/physiopathology ; Liver/physiopathology ; Male ; Muscles/physiopathology ; Papio ; Time Factors
Language	English
Publishing date	2019-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000002311
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Article ; Online: Nonhuman primate model in clinical modeling of diseases for stem cell therapy.

Choudhury, Gourav R / Kim, Jeffrey / Frost, Patrice A / Bastarrachea, Raul A / Daadi, Marcel M

Brain circulation

2016 Volume 2, Issue 3, Page(s) 141–145

Abstract: Nonhuman primates (NHPs) are alike humans in size, behavior, physiology, biochemistry, and immunology. Given close similarities to humans, the NHP model offers exceptional opportunities to understand the biological mechanisms and translational ... ...

Abstract	Nonhuman primates (NHPs) are alike humans in size, behavior, physiology, biochemistry, and immunology. Given close similarities to humans, the NHP model offers exceptional opportunities to understand the biological mechanisms and translational applications with direct relevance to human conditions. Here, we evaluate the opportunities and limitations of NHPs as animal models for translational regenerative medicine. NHP models of human disease propose exceptional opportunities to advance stem cell-based therapy by addressing pertinent translational concerns related to this research. Nonetheless, the value of these primates must be carefully assessed, taking into account the expense of specialized equipment and requirement of highly specialized staff. Well-designed initial fundamental studies in small animal models are essential before translating research into NHP models and eventually into human trials. In addition, we suggest that applying a directed and collaborative approach, as seen in the evolution of stroke NHP models, will greatly benefit the translation of stem cell therapy in other NHP disease models.
Language	English
Publishing date	2016-10-18
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2950273-1
ISSN	2455-4626 ; 2394-8108
ISSN (online)	2455-4626
ISSN	2394-8108
DOI	10.4103/2394-8108.192524
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Article: Research methodology for in vivo measurements of resting energy expenditure, daily body temperature, metabolic heat and non-viral tissue-specific gene therapy in baboons

Frost, Patrice A / Chen, Shuyuan / Rodriguez-Ayala, Ernesto / Laviada-Molina, Hugo A / Vaquera, Zoila / Gaytan-Saucedo, Janeth F / Li, Wen-Hong / Haack, Karin / Grayburn, Paul A / Sayers, Ken / Cole, Shelley A / Bastarrachea, Raul A

Research in veterinary science. 2020 Dec., v. 133

2020

Abstract: A large number of studies have shown that the baboon is one of the most commonly used non-human primate (NHP) research model for the study of immunometabolic complex traits such as type 2 diabetes (T2D), insulin resistance (IR), adipose tissue ... ...

Abstract	A large number of studies have shown that the baboon is one of the most commonly used non-human primate (NHP) research model for the study of immunometabolic complex traits such as type 2 diabetes (T2D), insulin resistance (IR), adipose tissue dysfunction (ATD), dyslipidemia, obesity (OB) and cardiovascular disease (CVD). This paper reports on innovative technologies and advanced research strategies for energetics and translational medicine with this NHP model. This includes the following: measuring resting energy expenditure (REE) with the mobile indirect calorimeter Breezing®; monitoring daily body temperature using subcutaneously implanted data loggers; quantifying metabolic heat with veterinary infrared thermography (IRT) imaging, and non-viral non-invasive, tissue-specific ultrasound-targeted microbubble destruction (UTMD) gene-based therapy. These methods are of broad utility; for example, they may facilitate the engineering of ectopic overexpression of brown adipose tissue (BAT) mUCP-1 via UTMD-gene therapy into baboon SKM to achieve weight loss, hypophagia and immunometabolic improvement. These methods will be valuable to basic and translational research, and human clinical trials, in the areas of metabolism, cardiovascular health, and immunometabolic and infectious diseases.
Keywords	Papio ; body temperature ; brown adipose tissue ; calorimeters ; cardiovascular diseases ; gene therapy ; heat ; humans ; hyperlipidemia ; insulin resistance ; metabolism ; microbubbles ; models ; noninsulin-dependent diabetes mellitus ; obesity ; thermography ; translational medical research ; undereating ; veterinary medicine ; weight loss
Language	English
Dates of publication	2020-12
Size	p. 136-145.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2020.09.020
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Article ; Online: Research methodology for in vivo measurements of resting energy expenditure, daily body temperature, metabolic heat and non-viral tissue-specific gene therapy in baboons.

Research in veterinary science

2020 Volume 133, Page(s) 136–145

Abstract	A large number of studies have shown that the baboon is one of the most commonly used non-human primate (NHP) research model for the study of immunometabolic complex traits such as type 2 diabetes (T2D), insulin resistance (IR), adipose tissue dysfunction (ATD), dyslipidemia, obesity (OB) and cardiovascular disease (CVD). This paper reports on innovative technologies and advanced research strategies for energetics and translational medicine with this NHP model. This includes the following: measuring resting energy expenditure (REE) with the mobile indirect calorimeter Breezing®; monitoring daily body temperature using subcutaneously implanted data loggers; quantifying metabolic heat with veterinary infrared thermography (IRT) imaging, and non-viral non-invasive, tissue-specific ultrasound-targeted microbubble destruction (UTMD) gene-based therapy. These methods are of broad utility; for example, they may facilitate the engineering of ectopic overexpression of brown adipose tissue (BAT) mUCP-1 via UTMD-gene therapy into baboon SKM to achieve weight loss, hypophagia and immunometabolic improvement. These methods will be valuable to basic and translational research, and human clinical trials, in the areas of metabolism, cardiovascular health, and immunometabolic and infectious diseases.
MeSH term(s)	Animals ; Body Temperature ; Disease Models, Animal ; Energy Metabolism ; Genetic Therapy/methods ; Genetic Therapy/veterinary ; Monitoring, Physiologic/instrumentation ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/veterinary ; Papio/physiology ; Research Design ; Thermography/veterinary
Language	English
Publishing date	2020-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2020.09.020
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Article ; Online: Anti-HIV IgM protects against mucosal SHIV transmission.

Gong, Siqi / Tomusange, Khamis / Kulkarni, Viraj / Adeniji, Opeyemi S / Lakhashe, Samir K / Hariraju, Dinesh / Strickland, Amanda / Plake, Elizabeth / Frost, Patrice A / Ratcliffe, Sarah J / Wang, Liping / Lafer, Eileen M / Ruprecht, Ruth M

AIDS (London, England)

2018 Volume 32, Issue 11, Page(s) F5–F13

Abstract: Objective: Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin M (IgM) is the first antibody class generated in response to infectious agents; IgM is present in the systemic circulation and in mucosal fluids as secretory ... ...

Abstract	Objective: Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin M (IgM) is the first antibody class generated in response to infectious agents; IgM is present in the systemic circulation and in mucosal fluids as secretory IgM. We sought to investigate for the first time the role of IgM in preventing AIDS virus acquisition in vivo. Design: Recombinant polymeric monoclonal IgM was generated from the neutralizing monoclonal IgG1 antibody 33C6-IgG1, tested in vitro, and given by passive intrarectal immunization to rhesus macaques 30 min before intrarectal challenge with simian-human immunodeficiency virus (SHIV) that carries an HIV-1 envelope gene. Results: In vitro, 33C6-IgM captured virions more efficiently and neutralized the challenge SHIV with a 50% inhibitory molar concentration (IC50) that was 1 log lower than that for 33C6-IgG1. The IgM form also exhibited significantly higher affinity and avidity compared with 33C6-IgG1. After intrarectal administration, 33C6-IgM prevented viremia in four out of six rhesus macaques after high-dose intrarectal SHIV challenge. Five out of six rhesus macaques given 33C6-IgG1 were protected at a five times higher molar concentration compared with the IgM form; all untreated controls became highly viremic. Rhesus macaques passively immunized with 33C6-IgM with breakthrough infection had notably early development of autologous neutralizing antibody responses. Conclusion: Our primate model data provide the first proof-of-concept that mucosal IgM can prevent mucosal HIV transmission and have implications for HIV prevention and vaccine development.
MeSH term(s)	Administration, Rectal ; Animals ; Antibodies, Monoclonal/genetics ; Disease Transmission, Infectious/prevention & control ; HIV Antibodies/administration & dosage ; HIV Antibodies/genetics ; Immunization, Passive ; Immunoglobulin M/administration & dosage ; Immunoglobulin M/genetics ; Macaca mulatta ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/genetics ; Simian Acquired Immunodeficiency Syndrome/prevention & control ; Simian Acquired Immunodeficiency Syndrome/transmission ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; HIV Antibodies ; Immunoglobulin M ; Recombinant Proteins
Language	English
Publishing date	2018-05-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000001857
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Article ; Online: Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1.

Chen, Shuyuan / Bastarrachea, Raul A / Roberts, Brad J / Voruganti, V Saroja / Frost, Patrice A / Nava-Gonzalez, Edna J / Arriaga-Cazares, Hector E / Chen, Jiaxi / Huang, Pintong / DeFronzo, Ralph A / Comuzzie, Anthony G / Grayburn, Paul A

Cell cycle (Georgetown, Tex.)

2014 Volume 13, Issue 7, Page(s) 1145–1151

Abstract: Both major forms of diabetes mellitus (DM) involve β-cell destruction and dysfunction. New treatment strategies have focused on replenishing the deficiency of β-cell mass common to both major forms of diabetes by islet transplantation or β-cell ... ...

Abstract	Both major forms of diabetes mellitus (DM) involve β-cell destruction and dysfunction. New treatment strategies have focused on replenishing the deficiency of β-cell mass common to both major forms of diabetes by islet transplantation or β-cell regeneration. The pancreas, not the liver, is the ideal organ for islet regeneration, because it is the natural milieu for islets. Since islet mass is known to increase during obesity and pregnancy, the concept of stimulating pancreatic islet regeneration in vivo is both rational and physiologic. This paper proposes a novel approach in which non-viral gene therapy is targeted to pancreatic islets using ultrasound targeted microbubble destruction (UTMD) in a non-human primate model (NHP), the baboon. Treated baboons received a gene cocktail comprised of cyclinD2, CDK, and GLP1, which in rats results in robust and durable islet regeneration with normalization of blood glucose, insulin, and C-peptide levels. We were able to generate important preliminary data indicating that gene therapy by UTMD can achieve in vivo normalization of the intravenous (IV) glucose tolerance test (IVGTT) curves in STZ hyperglycemic-induced conscious tethered baboons. Immunohistochemistry clearly demonstrated evidence of islet regeneration and restoration of β-cell mass.
MeSH term(s)	Animals ; Cyclin D2/genetics ; Cyclin-Dependent Kinase 4/genetics ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Experimental/therapy ; Genetic Therapy ; Glucagon-Like Peptide-1 Receptor/genetics ; Insulin-Secreting Cells/metabolism ; Islets of Langerhans/metabolism ; Islets of Langerhans/physiopathology ; Papio ; Pilot Projects ; Regeneration ; Streptozocin ; Ultrasonic Waves
Chemical Substances	Cyclin D2 ; Glucagon-Like Peptide-1 Receptor ; Streptozocin (5W494URQ81) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22)
Language	English
Publishing date	2014-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.27997
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Article ; Online: Successful pharmaceutical-grade streptozotocin (STZ)-induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model.

Frost, Patrice A / Chen, Shuyuan / Mezzles, Marguerite J / Voruganti, Venkata Saroja / Nava-Gonzalez, Edna J / Arriaga-Cazares, Hector E / Freed, Katy A / Comuzzie, Anthony G / DeFronzo, Ralph A / Kent, Jack W / Grayburn, Paul A / Bastarrachea, Raul A

Journal of medical primatology

2015 Volume 44, Issue 4, Page(s) 202–217

Abstract: Background: Non-human primate (NHP) diabetic models using chemical ablation of β-cells with STZ have been achieved by several research groups. Chemotherapeutic STZ could lead to serious adverse events including nephrotoxicity, hepatotoxicity, and ... ...

Abstract	Background: Non-human primate (NHP) diabetic models using chemical ablation of β-cells with STZ have been achieved by several research groups. Chemotherapeutic STZ could lead to serious adverse events including nephrotoxicity, hepatotoxicity, and mortality. Methods: We implemented a comprehensive therapeutic strategy that included the tether system, permanent indwelling catheter implants, an aggressive hydration protocol, management for pain with IV nubain and anxiety with IV midazolam, moment-by-moment monitoring of glucose levels post-STZ administration, and continuous intravenous insulin therapy. Results: A triphasic response in blood glucose after STZ administration was fully characterized. A dangerous hypoglycemic phase was also detected in all baboons. Other significant findings were hyperglycemia associated with low levels of plasma leptin, insulin and C-peptide concentrations, hyperglucagonemia, and elevated non-esterified fatty acids (NEFA) concentrations. Conclusions: We successfully induced frank diabetes by IV administering a single dose of pharmaceutical-grade STZ safely and without adverse events in conscious tethered baboons.
MeSH term(s)	Administration, Intravenous ; Animals ; Blood Glucose/analysis ; Catheters, Indwelling ; Diabetes Mellitus, Experimental/etiology ; Disease Models, Animal ; Hyperglycemia/chemically induced ; Male ; Papio hamadryas/metabolism ; Streptozocin/administration & dosage ; Streptozocin/pharmacology
Chemical Substances	Blood Glucose ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2015-08
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	121206-0
ISSN	1600-0684 ; 0047-2565
ISSN (online)	1600-0684
ISSN	0047-2565
DOI	10.1111/jmp.12182
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Article ; Online: Author Correction: Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets.

Singh, Dhiraj Kumar / Singh, Bindu / Ganatra, Shashank R / Gazi, Michal / Cole, Journey / Thippeshappa, Rajesh / Alfson, Kendra J / Clemmons, Elizabeth / Gonzalez, Olga / Escobedo, Ruby / Lee, Tae-Hyung / Chatterjee, Ayan / Goez-Gazi, Yenny / Sharan, Riti / Gough, Maya / Alvarez, Cynthia / Blakley, Alyssa / Ferdin, Justin / Bartley, Carmen /

Staples, Hilary / Parodi, Laura / Callery, Jessica / Mannino, Amanda / Klaffke, Benjamin / Escareno, Priscilla / Platt, Roy N / Hodara, Vida / Scordo, Julia / Gautam, Shalini / Vilanova, Andreu G / Olmo-Fontanez, Angelica / Schami, Alyssa / Oyejide, Adelekan / Ajithdoss, Dharani K / Copin, Richard / Baum, Alina / Kyratsous, Christos / Alvarez, Xavier / Ahmed, Mushtaq / Rosa, Bruce / Goodroe, Anna / Dutton, John / Hall-Ursone, Shannan / Frost, Patrice A / Voges, Andra K / Ross, Corinna N / Sayers, Ken / Chen, Christopher / Hallam, Cory / Khader, Shabaana A / Mitreva, Makedonka / Anderson, Timothy J C / Martinez-Sobrido, Luis / Patterson, Jean L / Turner, Joanne / Torrelles, Jordi B / Dick, Edward J / Brasky, Kathleen / Schlesinger, Larry S / Giavedoni, Luis D / Carrion, Ricardo / Kaushal, Deepak

Nature microbiology

2021 Volume 6, Issue 3, Page(s) 413

Language	English
Publishing date	2021-01-16
Publishing country	England
Document type	Published Erratum
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-021-00867-2
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Article: Nephroblastomatosis and nephroblastoma in nonhuman primates.

Goens, S Denise / Moore, Charleen M / Brasky, Kathleen M / Frost, Patrice A / Leland, M Michelle / Hubbard, Gene B

Journal of medical primatology

2005 Volume 34, Issue 4, Page(s) 165–170

Abstract: Wilms' tumors, or nephroblastomas, are renal embryonal malignancies with a high incidence in humans. Nephroblastomas are uncommon in nonhuman primates. This report describes three cases of spontaneous proliferative renal tumors in young monkeys: two ... ...

Abstract	Wilms' tumors, or nephroblastomas, are renal embryonal malignancies with a high incidence in humans. Nephroblastomas are uncommon in nonhuman primates. This report describes three cases of spontaneous proliferative renal tumors in young monkeys: two cases of unilateral kidney nephroblastomas in baboons and a nephroblastomatosis in a cynomolgus macaque. Histologically, both baboon tumors were typical of Wilms' tumors found in humans, with proliferative epithelial cells forming tubules and aborted glomeruli, nephrogenic rests and proliferative fibrovascular tissue. The left kidney of the macaque was markedly enlarged and histologically similar to the baboon tumors, although normal kidney architecture was completely effaced by primitive tubules and occasional glomeruli surrounded by edematous stromal tissue. Cytogenetic analysis did not detect any macaque or baboon equivalents to human Wilms' tumor chromosomal abnormalities. By human pathology classification, the diffuse nature of the macaque tumor is more consistent with nephroblastomatosis than nephroblastoma. This differentiation is the first to be reported in a species other than human. The nephroblastomas described here are the first nephroblastomas to be reported in baboons. Our observations indicate that nonhuman primate nephroblastomatosis and nephroblastomas develop in a similar way to Wilms' tumors in humans, although no genetic marker has been associated with nephroblastomas of nonhuman primates thus far.
MeSH term(s)	Animals ; Cytogenetic Analysis/veterinary ; Fatal Outcome ; Female ; Kidney Neoplasms/pathology ; Kidney Neoplasms/veterinary ; Macaca fascicularis ; Male ; Monkey Diseases/pathology ; Papio ; Wilms Tumor/pathology ; Wilms Tumor/veterinary
Language	English
Publishing date	2005-08
Publishing country	Denmark
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	121206-0
ISSN	1600-0684 ; 0047-2565
ISSN (online)	1600-0684
ISSN	0047-2565
DOI	10.1111/j.1600-0684.2005.00113.x
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