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Article ; Online: Characterization of the complete chloroplast genome of

Zhou, Ning / Fu, Ai-Gen

Mitochondrial DNA. Part B, Resources

2021 Volume 6, Issue 8, Page(s) 2288–2290

Abstract: ... Murraya ... ...

Abstract	Murraya exotica
Language	English
Publishing date	2021-07-09
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2021.1942267
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Article: Positive Herpesvirus IgG Antibodies in Lung Cancer Patients Finally Proved as Drug-induced Pemphigus.

Jiang, Jiao / Yang, Wen / Ren, Hong Q / Zhao, Qian / Fu, Ai S / Ge, Yan L

Clinical laboratory

2024 Volume 70, Issue 1

Abstract: Background: Herpesvirus IgG antibody positivity can be a lifelong burden of disease replication and reinfection or recent viruses can be reactivated and play an important role in the diagnosis and monitoring of herpesvirus [1]. However, sometimes serum ... ...

Abstract	Background: Herpesvirus IgG antibody positivity can be a lifelong burden of disease replication and reinfection or recent viruses can be reactivated and play an important role in the diagnosis and monitoring of herpesvirus [1]. However, sometimes serum IgG antibody positivity is of limited help in determining the onset of disease. We reported a case of herpesvirus IgG antibody positive in a patient with lung cancer who was initially misdiagnosed as herpes simplex and later confirmed drug-induced pemphigus (DIP) by histological and immunofluorescence studies. Methods: Appropriate laboratory tests, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and histological tests were performed for diagnosis. Results: In lung cancer patients who were positive for herpesvirus IgG antibodies, were initially misdiagnosed as herpes simplex and eventually confirmed by histological and immunofluorescence examinations as DIP. Conclusions: Positive herpesvirus IgG antibody is not a specific manifestation of herpesvirus infection. For patients with unexplained skin blisters, we should improve histological examinations as soon as possible to clarify the type of lesion.
MeSH term(s)	Humans ; Pemphigus ; Immunoglobulin G ; Lung Neoplasms/drug therapy ; Herpes Simplex ; Fluorescent Antibody Technique ; Antibodies, Viral ; Enzyme-Linked Immunosorbent Assay
Chemical Substances	Immunoglobulin G ; Antibodies, Viral
Language	English
Publishing date	2024-01-12
Publishing country	Germany
Document type	Case Reports
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230722
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Article: Probiotic yogurt regulates gut microbiota homeostasis and alleviates hepatic steatosis and liver injury induced by high-fat diet in golden hamsters.

Zhu, Linwensi / Ying, Na / Hao, Liuyi / Fu, Ai / Ding, Qinchao / Cao, Feiwei / Ren, Daxi / Han, Qiang / Li, Songtao

Food science & nutrition

2024 Volume 12, Issue 4, Page(s) 2488–2501

Abstract: This study aimed to investigate the beneficial effects of probiotic yogurt on lipid metabolism and gut microbiota in metabolic-related fatty liver disease (MAFLD) golden hamsters fed on a high-fat diet (HFD). The results demonstrated that probiotic ... ...

Abstract	This study aimed to investigate the beneficial effects of probiotic yogurt on lipid metabolism and gut microbiota in metabolic-related fatty liver disease (MAFLD) golden hamsters fed on a high-fat diet (HFD). The results demonstrated that probiotic yogurt significantly reversed the adverse effects caused by HFD, such as body and liver weight gain, liver steatosis and damage, sterol deposition, and oxidative stress after 8 weeks of intervention. qRT-PCR analysis showed that golden hamsters fed HFD had upregulated genes related to adipogenesis, increased free fatty acid infiltration, and downregulated genes related to lipolysis and very low-density lipoprotein secretion. Probiotic yogurt supplements significantly inhibited HFD-induced changes in the expression of lipid metabolism-related genes. Furthermore, 16S rRNA gene sequencing of the intestinal content microbiota suggested that probiotic yogurt changed the diversity and composition of the gut microbiota in HFD-fed hamsters. Probiotic yogurt decreased the ratio of the
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3930
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Article: Neglected Right Hemidiaphragmatic Angle Soft Tissue Shadow in a Renal Transplant Recipient Diagnosed as Lymphoma.

Li, Xin R / Fu, Ai S / Luo, Jia F / Ji, Hong L / Nie, Cheng X / Ge, Yan L

Clinical laboratory

2024 Volume 70, Issue 5

Abstract: Background: Post-transplant lymphoproliferative disorders are characterized by atypical clinical manifestations, high mortality, and missed diagnosis rates.: Methods: We report a case of renal transplantation in a patient with unexplained soft-tissue ...

Abstract	Background: Post-transplant lymphoproliferative disorders are characterized by atypical clinical manifestations, high mortality, and missed diagnosis rates. Methods: We report a case of renal transplantation in a patient with unexplained soft-tissue nodular shadows, and the type of the post-transplant abnormal soft-tissue shadows was clarified by puncture biopsy. Results: The pathologic returns were consistent with the post-transplant lymphoproliferative disease, and the immunohistochemical returns supported a diffuse large B-cell lymphoma (non-growth center origin). Conclusions: In organ transplant patients, when unexplained soft tissue nodular shadows are present, the possibility of post-transplant lymphoproliferative disorders should be considered, and an aggressive puncture biopsy should be performed to clarify the diagnosis.
MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Male ; Middle Aged ; Biopsy
Language	English
Publishing date	2024-05-15
Publishing country	Germany
Document type	Case Reports
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.231140
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Article: A Case of Organizing Pneumonia Resembling Lung Cancer.

Yao, Xue X / Sun, Si Y / Zhang, Ling / Ren, Hong Q / Fu, Ai S / Ge, Yan L

Clinical laboratory

2024 Volume 70, Issue 5

Abstract: Background: Organizing pneumonia (OP) is a pathologic diagnosis with clinical and imaging manifestations that often resemble other diseases, such as infections and cancers, which can lead to delays in diagnosis and inappropriate management of the ... ...

Abstract	Background: Organizing pneumonia (OP) is a pathologic diagnosis with clinical and imaging manifestations that often resemble other diseases, such as infections and cancers, which can lead to delays in diagnosis and inappropriate management of the underlying disease. In this article, we present a case of organized pneumonia that resembles lung cancer. Methods: We report a case of initial suspicion of pulmonary malignancy, treated with anti-inflammatory medication and then reviewed with CT suggesting no improvement, and finally confirmed to be OP by pathological biopsy taken via transbronchoscopy. A joint literature analysis was performed to raise clinicians' awareness of the diagnosis and treatment of OP. Results: Initially, because of the atypical auxiliary findings, we thought that the disease turned out to be a lung tumor, which was eventually confirmed as OP by pathological diagnosis. Conclusions: The diagnosis and treatment of OP requires a combination of clinical information and radiological expertise, as well as biopsy to obtain histopathological evidence. That is, clinical-imaging-pathological tripartite cooperation and comprehensive analysis.
MeSH term(s)	Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Lung Neoplasms/diagnostic imaging ; Diagnosis, Differential ; Tomography, X-Ray Computed ; Cryptogenic Organizing Pneumonia/diagnosis ; Cryptogenic Organizing Pneumonia/pathology ; Cryptogenic Organizing Pneumonia/diagnostic imaging ; Biopsy ; Male ; Aged ; Middle Aged ; Lung/pathology ; Lung/diagnostic imaging ; Bronchoscopy ; Organizing Pneumonia
Language	English
Publishing date	2024-05-15
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.231216
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Article: A Prediction Model for Prolonged Hospital Length of Stay (ProLOS) in Coronavirus Disease 2019 (COVID-19) Patients.

Zhang, Ling / Mi, Guo C / Yao, Xue X / Sun, Si Y / Fu, Ai S / Ge, Yan L

Clinical laboratory

2024 Volume 70, Issue 5

Abstract: Background: Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the normalization of COVID-19 globally, it is crucial to construct a prediction ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the normalization of COVID-19 globally, it is crucial to construct a prediction model that enables clinicians to identify patients at risk for ProLOS based on demographics and serum inflammatory biomarkers. Methods: The study included hospitalized patients with a confirmed diagnosis of COVID-19. These patients were randomly grouped into a training (80%) and a test (20%) cohort. The LASSO regression and ten-fold cross-validation method were applied to filter variables. The training cohort utilized multifactorial logistic regression analyses to identify the independent factors of ProLOS in COVID-19 patients. A 4-variable nomogram was created for clinical use. ROC curves were plotted, and the area under the curve (AUC) was calculated to evaluate the model's discrimination; calibration analysis was planned to assess the validity of the nomogram, and decision curve analysis (DCA) was used to evaluate the clinical usefulness of the model. Results: The results showed that among 310 patients with COVID-19, 80 had extended hospitalization (80/310). Four independent risk factors for COVID-19 patients were identified: age, coexisting chronic respiratory diseases, white blood cell count (WBC), and serum albumin (ALB). A nomogram based on these variables was created. The AUC in the training cohort was 0.808 (95% CI: 0.75 - 0.8671), and the AUC in the test cohort was 0.815 (95% CI: 0.7031 - 0.9282). The model demonstrates good calibration and can be used with threshold probabilities ranging from 0% to 100% to obtain clinical net benefits. Conclusions: A predictive model has been created to accurately predict whether the hospitalization duration of COVID-19 patients will be prolonged. This model incorporates serum WBC, ALB levels, age, and the presence of chronic respiratory system diseases.
MeSH term(s)	Humans ; COVID-19/diagnosis ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/complications ; Female ; Male ; Middle Aged ; Aged ; Length of Stay/statistics & numerical data ; Risk Factors ; Nomograms ; SARS-CoV-2 ; Adult ; ROC Curve ; Hospitalization ; Retrospective Studies
Language	English
Publishing date	2024-05-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.231203
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Article: Effect of 0.02% and 0.01% atropine on ocular biometrics: A two-year clinical trial.

Wang, Ming / Cui, Can / Yu, Shi-Ao / Liang, Ling-Ling / Ma, Jing-Xue / Fu, Ai-Cun

Frontiers in pediatrics

2023 Volume 11, Page(s) 1095495

Abstract: Background: Several studies have shown that various concentrations of low-concentration atropine can reduce myopia progression and control axial elongation safely and efficiently in children. The aim of this study was to evaluate the effects of 0.02% ... ...

Abstract	Background: Several studies have shown that various concentrations of low-concentration atropine can reduce myopia progression and control axial elongation safely and efficiently in children. The aim of this study was to evaluate the effects of 0.02% and 0.01% atropine on ocular biometrics. Methods: Cohort study. 138 and 142 children were randomized to use either 0.02% or 0.01% atropine eye drops, respectively. They wore single-vision (SV) spectacles, with one drop of atropine applied to both eyes nightly. Controls ( Results: The changes in cycloplegic spherical equivalent refraction (SER) and axial length (AL) were -0.81 ± 0.52D, -0.94 ± 0.59D, and -1.33 ± 0.72D; and 0.62 ± 0.29 mm, 0.72 ± 0.31 mm, and 0.89 ± 0.35 mm in the 0.02% and 0.01% atropine and control groups, respectively (all Conclusions: After 2 years, 0.02% and 0.01% atropine had no clinical effects on corneal and lens power, ocular and corneal astigmatism, ACD or IOP compared to the control group. 0.02% and 0.01% atropine helped to control myopia progression mainly by reducing AL elongation.
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1095495
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Article ; Online: Comparison of 0.02% atropine eye drops, peripheral myopia defocus design spectacle lenses, and orthokeratology for myopia control.

Wang, Ming / Ji, Na / Yu, Shi-Ao / Liang, Ling-Ling / Ma, Jing-Xue / Fu, Ai-Cun

Clinical & experimental optometry

2023 , Page(s) 1–7

Abstract: Clinical relevance: There are many methods to control the progression of myopia. However, it is currently unknown which method could better control myopia progression: 0.02% atropine eye drops, peripheral myopic defocus design spectacle lenses (PMDSL), ... ...

Abstract	Clinical relevance: There are many methods to control the progression of myopia. However, it is currently unknown which method could better control myopia progression: 0.02% atropine eye drops, peripheral myopic defocus design spectacle lenses (PMDSL), or orthokeratology (OK). Background: To compare the efficacy of 0.02% atropine, PMDSL, and OK to control axial length (AL) elongation in children with myopia. Methods: This study was analysed based on a previous cohort study (0.02% atropine group) and retrospective data (PMDSL and OK group). Overall, 387 children aged 6-14 years with myopia - 1.00D to - 6.00D in the three groups were divided into four subgroups according to age and spherical equivalent refraction (SER). The primary outcome was changed in AL over 1-year. Results: The mean axial elongation was 0.30 ± 0.21 mm, 0.23 ± 0.16 mm, and 0.17 ± 0.19 mm in the 0.02% atropine, PMDSL, and OK groups, respectively. Multivariate linear regression analyses showed significant differences in axial elongation among the three groups, especially in children aged 6-10, but not in children aged 10.1-14; the corresponding axial elongation was 0.35 ± 0.21 mm, 0.23 ± 0.17 mm, and 0.21 ± 0.20 mm ( Conclusions: Within the limits of this study design and using only the current brand of PMDSL, OK appeared to be the best method, followed by PMDSL and then 0.02% atropine, for controlling AL elongation over one year. However, different effects were found in the various age and SER subgroups.
Language	English
Publishing date	2023-12-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	639275-1
ISSN	1444-0938 ; 0816-4622
ISSN (online)	1444-0938
ISSN	0816-4622
DOI	10.1080/08164622.2023.2288180
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Article: Pulmonary Tuberculosis with Elevated CEA and Positive PET-CT.

Ren, Hong Q / Zhao, Qian / Yang, Wen / Jiang, Jiao / Fu, Ai S / Ge, Yan L

Clinical laboratory

2023 Volume 69, Issue 4

Abstract: Background: Pulmonary tuberculosis presenting as solitary pulmonary nodules in imaging is sometimes difficult to differentiate from lung cancer and is more likely to be misdiagnosed when accompanied by elevated CEA and positive PET-CT findings.: ... ...

Abstract	Background: Pulmonary tuberculosis presenting as solitary pulmonary nodules in imaging is sometimes difficult to differentiate from lung cancer and is more likely to be misdiagnosed when accompanied by elevated CEA and positive PET-CT findings. Methods: By reporting a case of misdiagnosed lung cancer, which was confirmed to be pulmonary tuberculosis by lung biopsy, a joint literature analysis was performed to raise clinicians' awareness of isolated nodules in the lung. Results: With a series of ancillary tests, we initially considered the nodule to be malignant, and the lung biopsy pathology eventually confirmed pulmonary tuberculosis. Conclusions: When chest imaging suggests the presence of malignant features in solitary pulmonary nodules, invasive procedures can be performed appropriately to clarify the nature of the lesion. The diagnosis cannot be made blindly to ensure that no incorrect diagnosis is made nor wrong treatment given.
MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography/methods ; Solitary Pulmonary Nodule/diagnosis ; Solitary Pulmonary Nodule/pathology ; Fluorodeoxyglucose F18 ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Tuberculosis, Pulmonary/diagnostic imaging
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-04-14
Publishing country	Germany
Document type	Case Reports
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2022.220716
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Article: Connective Tissue Disease-Associated Pulmonary Interstitial Fibrosis with Mycobacterium Paraintracellulare Infection: a Case Report.

Ren, Hong Q / Zhao, Qian / Yang, Wen / Jiang, Jiao / Fu, Ai S / Ge, Yan L

Clinical laboratory

2023 Volume 69, Issue 5

Abstract: Background: Infectious pulmonary diseases caused by nontuberculous mycobacteria (NTM) are becoming more common in clinical work, and early detection of the bacterium and its early identification are prerequisites for accurate treatment.: Methods: By ... ...

Abstract	Background: Infectious pulmonary diseases caused by nontuberculous mycobacteria (NTM) are becoming more common in clinical work, and early detection of the bacterium and its early identification are prerequisites for accurate treatment. Methods: By reporting a case of confirmed NTM infection in a patient with connective tissue disease-associated interstitial lung fibrosis, a joint literature analysis was performed to improve clinicians' understanding of NTM and the clinical application of targeted next-generation sequencing (tNGS). Results: Chest CT suggested a partially enlarged cavitary lesion in the upper lobe of the right lung, combined with positive sputum antacid staining, and sputum tNGS was sent to confirm the final diagnosis of Mycobacterium paraintracellulare infection. Conclusions: The successful application of tNGS helps in the rapid diagnosis of NTM infection. It also reminds medical practitioners to consider the presence of NTM infection in advance in the presence of many NTM infection factors, combined with imaging manifestations.
MeSH term(s)	Humans ; Mycobacterium Infections, Nontuberculous/complications ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium ; Nontuberculous Mycobacteria ; Connective Tissue Diseases ; Fibrosis
Language	English
Publishing date	2023-05-05
Publishing country	Germany
Document type	Case Reports
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2022.220847
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