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Article: Effects of natural products on skin inflammation caused by abnormal hormones secreted by the adrenal gland.

Xie, Wei / Zhang, Ce / Wang, Tian / Wang, Jianshe / Fu, Fenghua

2023 Volume 14, Page(s) 1156271

Abstract: The cortex of adrenal gland produces glucocorticoid, mineralocorticoid, and androgen. The medulla of adrenal gland secrets catecholamines. These hormones play an important role in regulating blood pressure, metabolism, and homeostasis of glucose or ... ...

Abstract	The cortex of adrenal gland produces glucocorticoid, mineralocorticoid, and androgen. The medulla of adrenal gland secrets catecholamines. These hormones play an important role in regulating blood pressure, metabolism, and homeostasis of glucose or electrolytes. Hypersecretion or hyposecretion by the adrenal gland will cause a complex cascade of hormone effects and lead to diseases, including Addison's disease, Cushing's syndrome, and congenital adrenal cortical hyperplasia. Skin is the largest organ of body. It provides protection and acts as a barrier against external damage factors like infectious organisms, chemicals, and allergens. Endocrinologic disorders often induce cutaneous abnormalities. According to the previous evidences, natural products have the potential properties for attenuating skin disorders and improving dermatologic symptoms by inhibiting inflammation through MAPK or PI3K/AKT-dependent NF-κB pathways. The natural products may also promote skin wound healing by inhibiting the production of matrix metalloproteinase-9. We systematically searched the relevant articles from databases, including PubMed, Embase, and Cochrane library databases, to review the effects of natural products on skin disorders. This article summarized the effects of natural products on skin inflammation caused by abnormal hormone secreted by adrenal gland. And the published papers indicated that natural products might be a potential source for treating skin diseases.
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1156271
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Article: The effect of triple reuptake inhibitor toludesvenlafaxine on neurological function in cerebral ischemic rats.

Sun, Xiaohui / Wang, Tian / Zhou, Lin / Zhang, Ce / Fu, Fenghua

Frontiers in pharmacology

2023 Volume 14, Page(s) 1073099

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1073099
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Article ; Online: Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats.

Li, Min / Wang, Shengguang / Zhang, Ce / Chi, Chenglin / Liu, Rongxia / Wang, Tian / Fu, Fenghua

International immunopharmacology

2023 Volume 115, Page(s) 109659

Abstract: Hyperactivity of HPA axis results in intestinal dysfunction, which may play a role in brain injury caused by ischemic stroke (IS). Escin shows a neuroprotective effect but it may not penetrate blood brain barrier (BBB). Previous work in our laboratory ... ...

Abstract	Hyperactivity of HPA axis results in intestinal dysfunction, which may play a role in brain injury caused by ischemic stroke (IS). Escin shows a neuroprotective effect but it may not penetrate blood brain barrier (BBB). Previous work in our laboratory showed that escin ameliorated intestinal injury in animals. The aim of this study is to investigate whether escin attenuates brain injury by improving intestinal dysfunction in middle cerebral artery occlusion (MCAO) rats, to mimic IS. MCAO rats and lipopolysaccharides (LPS)-induced Caco-2 cells were used to evaluate the effects of escin in vivo and in vitro. The results showed that escin could not penetrate BBB but reduced brain infarct volume, improved neurological function, inhibited neuroinflammation, ameliorated intestinal dysfunction and tissue integrity by increasing the expression of the tight junction protein in vivo and in vitro. Escin reduced the increased corticosterone and endotoxin level in blood of MCAO rats, regulated GR/p38 MAPK/NF-κB signaling pathway in ileal tissue and LPS/TLR4/NF-κB signaling pathway in ischemic brain tissue. These findings suggest that escin could attenuate ischemic brain injury by improving intestinal dysfunction, and it may be a promising way to protect brain injury by protecting intestine, instead of targeting the brain directly after IS.
MeSH term(s)	Humans ; Rats ; Animals ; NF-kappa B/metabolism ; Ischemic Stroke ; Escin ; Lipopolysaccharides/pharmacology ; Brain-Gut Axis ; Caco-2 Cells ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System ; Gastrointestinal Diseases ; Infarction, Middle Cerebral Artery/drug therapy ; Brain Ischemia/drug therapy ; Intestinal Diseases ; Reperfusion Injury ; Brain Injuries ; Stroke
Chemical Substances	NF-kappa B ; Escin (6805-41-0) ; Lipopolysaccharides
Language	English
Publishing date	2023-01-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2022.109659
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Zs.A 5408: Show issues

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Article: Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats.

Du, Yuan / Ruan, Jian / Zhang, Leiming / Fu, Fenghua

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 7469068

Abstract: Jieyu Anshen granule (JY) is a traditional Chinese medicine formula for treating depression and anxiety. The aim of the study was to observe the effects of JY on poststroke depression (PSD) and investigate the underlying mechanism. PSD rat model was ... ...

Abstract	Jieyu Anshen granule (JY) is a traditional Chinese medicine formula for treating depression and anxiety. The aim of the study was to observe the effects of JY on poststroke depression (PSD) and investigate the underlying mechanism. PSD rat model was developed by middle cerebral artery occlusion following chronic unpredictable mild stress in conjunction with isolation rearing. We performed behavioral tests, Western blot, ELISA, and BrdU/NeuN staining. Treatment with JY showed significant antidepressant effect in open-field and sucrose preference tests, as well as significant improvement in beam-walking, cylinder, grip strength, and water maze tests. In addition, treatment with JY could restore the levels of neurotransmitters and decrease the levels of hormone and inflammation cytokines in serum and brain. Treatment with JY also showed significant regulation in the expression of neurotransmitter receptors and NF-
Language	English
Publishing date	2020-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/7469068
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Zs.A 5995: Show issues

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Article ; Online: Severe Acute Lung Injury Related to COVID-19 Infection: A Review and the Possible Role for Escin.

Gallelli, Luca / Zhang, Leiming / Wang, Tian / Fu, Fenghua

Journal of clinical pharmacology

2020 Volume 60, Issue 7, Page(s) 815–825

Abstract: Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a ...

Abstract	Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that induce intra-alveolar fibrin accumulation that reduces the gas exchange. Therefore, an add-on therapy with drugs able to reduce inflammation, edema, and cell activation has been proposed as well as a treatment with interferon, corticosteroids or monoclonal antibodies (eg, tocilizumab). In this article reviewing literature data related to the use of escin, an agent having potent anti-inflammatory and anti-viral effects in lung injury, we suggest that it could represent a therapeutic opportunity as add-on therapy in ALI related to COVID-19 infection.
MeSH term(s)	Acute Lung Injury/etiology ; Acute Lung Injury/physiopathology ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/physiopathology ; Drug Therapy, Combination ; Escin/administration & dosage ; Escin/pharmacology ; Escin/therapeutic use ; Humans ; Immunologic Factors/therapeutic use ; Inflammation Mediators/metabolism ; Lung/pathology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/physiopathology ; SARS-CoV-2
Chemical Substances	Anti-Inflammatory Agents ; Antiviral Agents ; Immunologic Factors ; Inflammation Mediators ; Escin (6805-41-0)
Keywords	covid19
Language	English
Publishing date	2020-05-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.1644
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Article: The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis.

Zhang, Leiming / Li, Xiaoli / Ying, Tianhao / Wang, Tian / Fu, Fenghua

Frontiers in endocrinology

2021 Volume 12, Page(s) 744647

Abstract: Glucocorticoids are drugs that are widely used to suppress inflammation and the activation of the immune system. However, the prolonged use or at high doses of glucocorticoid can result in adverse side effects including osteoporosis, bone loss, and an ... ...

Abstract	Glucocorticoids are drugs that are widely used to suppress inflammation and the activation of the immune system. However, the prolonged use or at high doses of glucocorticoid can result in adverse side effects including osteoporosis, bone loss, and an increased risk of fracture. A number of compounds derived from natural plant sources have been reported to exert anti-inflammatory activity by interacting with the glucocorticoid receptor (GR), likely owing to their chemical similarity to glucocorticoids, or by regulating GR, without a concomitant risk of treatment-related side effects such as osteoporosis. Other herbal compounds can counteract the pathogenic processes underlying glucocorticoid-induced osteoporosis (GIOP) by regulating homeostatic bone metabolic processes. Herein, we systematically searched the PubMed, Embase, and Cochrane library databases to identify articles discussing such compounds published as of May 01, 2021. Compounds reported to exert anti-inflammatory glucocorticoid-like activity without inducing GIOP include escin, ginsenosides, and glycyrrhizic acid, while compounds reported to alleviate GIOP by improving osteoblast function or modulating steroid hormone synthesis include tanshinol and icariin.
MeSH term(s)	Animals ; Bone Density/drug effects ; Bone Density Conservation Agents ; Female ; Glucocorticoids/adverse effects ; Herbal Medicine/methods ; Humans ; Male ; Osteoporosis/chemically induced ; Osteoporosis/prevention & control ; Plant Preparations/therapeutic use
Chemical Substances	Bone Density Conservation Agents ; Glucocorticoids ; Plant Preparations
Language	English
Publishing date	2021-11-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.744647
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Article ; Online: Preparation of Long-Acting Somatostatin and GnRH Analogues and Their Applications in Tumor Therapy.

Yu, Fang / Zhang, Tingting / Fu, Fenghua / Wang, Aiping / Liu, Xinyong

Current drug delivery

2021 Volume 19, Issue 1, Page(s) 5–16

Abstract: Hormonal drugs are essential treatment options for some hormone-dependent or hormone- sensitive tumors. The common dosage forms of hormonal drugs have a short half-life. Hence, frequent administration is needed, which results in poor patient compliance. ... ...

Abstract	Hormonal drugs are essential treatment options for some hormone-dependent or hormone- sensitive tumors. The common dosage forms of hormonal drugs have a short half-life. Hence, frequent administration is needed, which results in poor patient compliance. Nevertheless, using drug delivery technology, somatostatin analogues (SSAs) and gonadotropin-releasing hormone (GnRH) analogues are prepared into long-acting formulations that can significantly prolong the action time of these drugs, reducing medication frequency and increasing patient compliance. Such drugs are advantageous when treating acromegaly, gastroenteropancreatic neuroendocrine tumors (GEP-NETs), breast cancer, prostate cancer, and other diseases having a relatively long course. SSAs and GnRH analogues are two typical hormonal drugs, the long-acting formulations of which are essential in clinical practice. This review summarized the preparation methods and clinical application of long-acting formulations in cancer. Further, the action mechanism and new research of SSAs and GnRH analogues were discussed, and suggestions related to the development of long-acting SSAs and GnRH analogues were provided.
MeSH term(s)	Gonadotropin-Releasing Hormone ; Humans ; Intestinal Neoplasms/drug therapy ; Neuroendocrine Tumors/drug therapy ; Neuroendocrine Tumors/pathology ; Pancreatic Neoplasms/drug therapy ; Somatostatin/therapeutic use
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2) ; Somatostatin (51110-01-1)
Language	English
Publishing date	2021-12-24
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/1567201819666211224113311
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Article ; Online: Role of calcitonin gene-related peptide in pain regulation in the parabrachial nucleus of naive rats and rats with neuropathic pain.

Wang, Lin-Lin / Wang, Hong-Bo / Fu, Feng-Hua / Yu, Long-Chuan

Toxicology and applied pharmacology

2021 Volume 414, Page(s) 115428

Abstract: Researches have shown that calcitonin gene-related peptide (CGRP) plays a pivotal role in pain modulation. Nociceptive information from the periphery is relayed from parabrachial nucleus (PBN) to brain regions implicated involved in pain. This study ... ...

Abstract	Researches have shown that calcitonin gene-related peptide (CGRP) plays a pivotal role in pain modulation. Nociceptive information from the periphery is relayed from parabrachial nucleus (PBN) to brain regions implicated involved in pain. This study investigated the effects and mechanisms of CGRP and CGRP receptors in pain regulation in the PBN of naive and neuropathic pain rats. Chronic sciatic nerve ligation was used to model neuropathic pain, CGRP and CGRP 8-37 were injected into the PBN of the rats, and calcitonin receptor-like receptor (CLR), a main structure of CGRP receptor, was knocked down by lentivirus-coated CLR siRNA. The hot plate test (HPT) and the Randall Selitto Test (RST) was used to determine the latency of the rat hindpaw response. The expression of CLR was detected with RT-PCR and western blotting. We found that intra-PBN injecting of CGRP induced an obvious anti-nociceptive effect in naive and neuropathic pain rats in a dose-dependent manner, the CGRP-induced antinociception was significantly reduced after injection of CGRP 8-37, Moreover, the mRNA and protein levels of CLR, in PBN decreased significantly and the antinociception CGRP-induced was also significantly lower in neuropathic pain rats than that in naive rats. Knockdown CLR in PBN decreased the expression of CLR and the antinociception induced by CGRP was observably decreased. Our results demonstrate that CGRP induced antinociception in PBN of naive or neuropathic pain rats, CGRP receptor mediates this effect. Neuropathic pain induced decreases in the expression of CGRP receptor, as well as in CGRP-induced antinociception in PBN.
MeSH term(s)	Analgesics/pharmacology ; Animals ; Calcitonin Gene-Related Peptide/pharmacology ; Calcitonin Receptor-Like Protein/agonists ; Calcitonin Receptor-Like Protein/genetics ; Calcitonin Receptor-Like Protein/metabolism ; Disease Models, Animal ; Gene Expression Regulation ; Male ; Nociceptive Pain/genetics ; Nociceptive Pain/metabolism ; Nociceptive Pain/physiopathology ; Nociceptive Pain/prevention & control ; Pain Threshold/drug effects ; Parabrachial Nucleus/drug effects ; Parabrachial Nucleus/metabolism ; Parabrachial Nucleus/physiopathology ; Peptide Fragments/pharmacology ; Rats, Sprague-Dawley ; Receptors, Calcitonin Gene-Related Peptide/agonists ; Receptors, Calcitonin Gene-Related Peptide/genetics ; Receptors, Calcitonin Gene-Related Peptide/metabolism ; Sciatica/genetics ; Sciatica/metabolism ; Sciatica/physiopathology ; Sciatica/prevention & control ; Rats
Chemical Substances	Analgesics ; Calcitonin Receptor-Like Protein ; Calcrl protein, rat ; Peptide Fragments ; Receptors, Calcitonin Gene-Related Peptide ; calcitonin gene-related peptide (8-37) (119911-68-1) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2021-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2021.115428
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Zs.B 14: Show issues

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Article: Continuous Activation of Dopamine Receptors Alleviates LPS-Induced Liver Injury in Mice via β-arrestin2 Dependent Akt/NF-κB Pathway.

Li, Mingan / Zhang, Ce / Zhou, Lin / Sun, Xiaohui / Wang, Tian / Fu, Fenghua

Frontiers in pharmacology

2022 Volume 13, Page(s) 853834

Abstract: Many studies showed that dopamine receptors (DRs) agonists have anti-inflammatory effects. Rotigotine, a non-ergot dopamine receptor agonist, mainly actives DRD2/DRD3/DRD1. Rotigotine extended-release microspheres (RoMS) are a sustained-release ... ...

Abstract	Many studies showed that dopamine receptors (DRs) agonists have anti-inflammatory effects. Rotigotine, a non-ergot dopamine receptor agonist, mainly actives DRD2/DRD3/DRD1. Rotigotine extended-release microspheres (RoMS) are a sustained-release formulation that can release sustainably rotigotine for more than 7 days after a single dose of RoMS. This study aimed to investigate whether RoMS can attenuate the lipopolysaccharide (LPS)-induced liver injury of mice. The liver injury was evaluated by assaying serum transaminase and observing histopathological changes. The levels of pro-inflammatory cytokines in serum were also detected. Western blot was employed to assay the expression of proteins in the Akt/NF-κB pathway. The results showed that pre-administration with a single dose of RoMS could inhibit the increase of serum transaminase induced by LPS, alleviate the pathological damage of liver tissue, and decrease the levels of tumor necrosis factor-α and interleukin-6. In addition, RoMS decreased Toll-like receptor 4 protein expression in liver tissue. RoMS mitigated liver injury by activating DRs and negatively regulating the β-arrestin2-dependent Akt/NF-κB signaling pathway. The effects of RoMS could be weakened or abolished by the specific DRD2 antagonist, R121. In conclusion, activation of DRs inhibited the releases of pro-inflammatory cytokines and alleviated the immune-mediated liver injury induced by LPS in mice. The anti-inflammatory mechanism of RoMS may be related to the regulation of the β-arrestin2-dependent Akt/NF-κB signaling pathway.
Language	English
Publishing date	2022-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.853834
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Article ; Online: Administration of Huperzine A microspheres ameliorates myocardial ischemic injury via α7nAChR-dependent JAK2/STAT3 signaling pathway.

Zhang, Ce / Li, Mingan / Xie, Wei / Li, Min / You, Chunna / Wang, Tian / Fu, Fenghua

European journal of pharmacology

2022 Volume 940, Page(s) 175478

Abstract: Acetylcholinesterase (AChE) inhibitor (AChEI) is well established as ﬁrst-line agents for relieving the symptoms of Alzheimer's disease (AD). Injectable sustained-release formulation of AChEI may be suitable for treating AD patients. However, it needs to ...

Abstract	Acetylcholinesterase (AChE) inhibitor (AChEI) is well established as ﬁrst-line agents for relieving the symptoms of Alzheimer's disease (AD). Injectable sustained-release formulation of AChEI may be suitable for treating AD patients. However, it needs to know whether continuous inhibition of AChE could deteriorate or attenuate myocardial damage if myocardial ischemia (MI) occurs. Huperzine A microspheres (HAM) are a sustained-release formulation releasing sustainably huperzine A (an AChEI) for more than 7 days after a single dose of HAM. This study aimed to investigate the myocardial damage in an isoprenaline (ISO)-induced MI mice model during HAM treatment. The heart injury was evaluated by assaying serum CK-MB, Tn-I and observing histopathological changes. The levels of proinflammatory cytokines in serum were detected. The level of p-P65 and the expression of proteins in the JAK2/STAT3 signaling pathway were assayed with Western blot. Administration with a single dose of HAM resulted in inhibiting the MI-induced increases of CK-MB and Tn-I, alleviating the damage of heart tissue, and decreasing the levels of TNF-α and IL-6. In addition, HAM decreased the levels of p-P65, p-JAK2, and p-STAT3 in heart tissue. The effects of HAM could be weakened or abolished by the specific α7nAChR antagonist. These findings suggest that continuous AChE inhibition could protect the heart from ischemic damage during administration of sustained-release formulation of AChEI, which is associated with the anti-inflammatory effect of HAM by regulating α7nAChR-dependent JAK2/STAT3 signaling pathway.
Language	English
Publishing date	2022-12-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2022.175478
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