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  1. Article: Ascorbate peroxidase plays an important role in photoacclimation in the extremophilic red alga

    Fu, Han-Yi / Wang, Ming-Wei

    Frontiers in plant science

    2023  Volume 14, Page(s) 1176985

    Abstract: Introduction: Acidothermophilic cyanidiophytes in natural habitats can survive under a wide variety of light regimes, and the exploration and elucidation of their long-term photoacclimation mechanisms promises great potential for further ... ...

    Abstract Introduction: Acidothermophilic cyanidiophytes in natural habitats can survive under a wide variety of light regimes, and the exploration and elucidation of their long-term photoacclimation mechanisms promises great potential for further biotechnological applications. Ascorbic acid was previously identified as an important protectant against high light stress in
    Methods: The significance of ascorbic acid and related ROS scavenging and antioxidant regenerating enzymes in photoacclimation in the extremophilic red alga
    Results and discussion: Accumulation of ascorbic acid and activation of the ascorbate-related enzymatic ROS scavenging system characterized the photoacclimation response after cells were transferred from a low light condition at 20 μmol photons m
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1176985
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  2. Article ; Online: Effect of molecular structure on the adsorption behavior of sulfanilamide antibiotics on crumpled graphene balls.

    Fu, Han / Gray, Kimberly A

    Water research

    2023  Volume 242, Page(s) 120177

    Abstract: Since the 1930s, sulfonamide(SA)-based antibiotics have served as important pharmaceuticals, but their widespread detection in water systems threatens aquatic organisms and human health. Adsorption via graphene, its modified form (graphene oxide, GO), ... ...

    Abstract Since the 1930s, sulfonamide(SA)-based antibiotics have served as important pharmaceuticals, but their widespread detection in water systems threatens aquatic organisms and human health. Adsorption via graphene, its modified form (graphene oxide, GO), and related nanocomposites is a promising method to remove SAs, owing to the strong and selective surface affinity of graphene/GO with aromatic compounds. However, a deeper understanding of the mechanisms of interaction between the chemical structure of SAs and the GO surface is required to predict the performance of GO-based nanostructured materials to adsorb the individual chemicals making up this large class of pharmaceuticals. In this research, we studied the adsorptive performance of 3D crumpled graphene balls (CGBs) to remove 10 SAs and 13 structural analogs from water. The maximum adsorption capacity q
    MeSH term(s) Humans ; Anti-Bacterial Agents/chemistry ; Sulfanilamide ; Graphite/chemistry ; Adsorption ; Molecular Structure ; Water ; Nanocomposites/chemistry ; Water Pollutants, Chemical/chemistry ; Pharmaceutical Preparations
    Chemical Substances Anti-Bacterial Agents ; Sulfanilamide (21240MF57M) ; Graphite (7782-42-5) ; Water (059QF0KO0R) ; Water Pollutants, Chemical ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2023.120177
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    In stock of ZB MED Bonn / Germany

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  3. Article: A qualitative study on the willingness and influencing factors of master of geriatric nursing specialist postgraduates to volunteer for home respite care for disabled elderly families.

    Chen, Bihui / Zhu, Haili / Fu, Han / Han, Qiannan / Chen, Lei

    BMC nursing

    2024  Volume 23, Issue 1, Page(s) 49

    Abstract: Background: As China's population ages, the demand for care for the disabled elderly is increasing, and family caregivers find it challenging to meet the comprehensive care needs of the disabled elderly. Through home respite services, families of the ... ...

    Abstract Background: As China's population ages, the demand for care for the disabled elderly is increasing, and family caregivers find it challenging to meet the comprehensive care needs of the disabled elderly. Through home respite services, families of the disabled elderly can receive help and support from specialized nursing professionals to ease the burden on family caregivers and provide high-quality services. This study explores the willingness and influencing factors of Master of Geriatric Nursing Specialist postgraduates in China to volunteer to provide home respite services for disabled elderly individuals.
    Methods: A qualitative study based on Grounded Theory used Strauss and Corbin's programmatic version. A purposive sampling method was employed to conduct semi-structured interviews with 12 Master of Geriatric Nursing Specialist postgraduates from a tertiary hospital in Changsha, Hunan Province, China.
    Results: The willingness of Master of Geriatric Nursing Specialist postgraduates to volunteer to provide home respite services for the disabled elderly was established as a core category, which was influenced by three main categories: personal factors, service object factors, and social factors, and nine categories formed from 39 initial concepts were included under the main category.
    Conclusions: Influenced by China's traditional cultural background, Master of Geriatric Nursing Specialist postgraduates in China have shown high motivation in volunteering to provide home respite services for the families of the disabled elderly but have been challenged by several challenges from China's healthcare environment and education system. Relevant departments need to adopt a series of policies and measures to increase volunteers' willingness to participate in respite care and promote its development.
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-024-01710-9
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  4. Article ; Online: Determination and Quantitation of Cytotoxic T Cell-Mediated Cell Death.

    Fu, Han-Hsuan / Qui, Harry

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2255, Page(s) 159–169

    Abstract: Cytotoxic T cell-induced cell death is well documented. Cytotoxic T cell releases various cytolytic proteins. The cytolytic proteins induce target cell death. T cell-induced cell death can be measured by the lytic assay. One of the well-known lytic ... ...

    Abstract Cytotoxic T cell-induced cell death is well documented. Cytotoxic T cell releases various cytolytic proteins. The cytolytic proteins induce target cell death. T cell-induced cell death can be measured by the lytic assay. One of the well-known lytic assays uses radioactive tracer, Chromium-51 (
    MeSH term(s) Adenocarcinoma/immunology ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Animals ; CD8-Positive T-Lymphocytes/immunology ; Cell Death ; Chromium Radioisotopes/analysis ; Colonic Neoplasms/immunology ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/pathology ; Cytotoxicity Tests, Immunologic/methods ; Flow Cytometry/methods ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/metabolism ; Lymphoma, B-Cell/pathology ; Mice ; T-Lymphocytes, Cytotoxic/immunology ; Tumor Cells, Cultured
    Chemical Substances Chromium Radioisotopes ; Chromium-51 (9QAU17N705)
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1162-3_14
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  5. Article: TiO

    Fu, Han / Gray, Kimberly A

    Nanomaterials (Basel, Switzerland)

    2021  Volume 11, Issue 8

    Abstract: The presence of pharmaceuticals and personal care products (PPCPs) in aquatic systems is a serious threat to human and ecological health. The photocatalytic degradation of PPCPs via titanium oxide ( ... ...

    Abstract The presence of pharmaceuticals and personal care products (PPCPs) in aquatic systems is a serious threat to human and ecological health. The photocatalytic degradation of PPCPs via titanium oxide (TiO
    Language English
    Publishing date 2021-08-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano11082087
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  6. Article: Preventive effect and mechanism of compound Danshen dripping pills on contrast-induced nephropathy after percutaneous coronary interventional.

    Fu, Han / Wang, Linrui / Ying, Shuo / Zhao, Zhicheng / Zhang, Peng

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1211982

    Abstract: Background: Contrast-induced nephropathy (CIN) is one of the most common complications after coronary stent implantation due to the extensive development of coronary catheterization technology. Compound Danshen dripping pills (CDDP) are clinically used ... ...

    Abstract Background: Contrast-induced nephropathy (CIN) is one of the most common complications after coronary stent implantation due to the extensive development of coronary catheterization technology. Compound Danshen dripping pills (CDDP) are clinically used as cardiovascular drugs, relieving systemic inflammatory response. Previous studies have observed that CDDP can decrease CIN incidence after coronary stent implantation with uncertain effectiveness.
    Methods: We conducted a prospective, randomized, single-center, single-blind, controlled trial. We enrolled patients 18 years and older with unstable angina pectoris and NSTEMI who underwent PCI at the Tianjin Chest Hospital between November 1, 2021, and November 31, 2022, and followed for 30 days. Patients were randomized to CDDP and hydration therapy (10 capsules three times/day;
    Results: After 48 h of operation, the two groups had statistical significance in Scr and BUN values (80.0 ± 12.59 vs. 84.43 ± 13.49,
    Conclusions: CDDP pre-treatment could prevent contrast-induced nephropathy. Inflammatory response and oxidative stress could be significant in the CDDP mechanism.
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1211982
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  7. Article ; Online: Metal oxide encapsulated by 3D graphene oxide creates a nanocomposite with enhanced organic adsorption in aqueous solution.

    Fu, Han / Cai, Haotian / Gray, Kimberly A

    Journal of hazardous materials

    2022  Volume 444, Issue Pt A, Page(s) 130340

    Abstract: The presence of organic contaminants (OCs) in aquatic systems is a threat to ecological and human health. Adsorption by graphene-based adsorbent is a promising technique for OC removal and we previously fabricated crumpled graphene balls (CGBs), via a ... ...

    Abstract The presence of organic contaminants (OCs) in aquatic systems is a threat to ecological and human health. Adsorption by graphene-based adsorbent is a promising technique for OC removal and we previously fabricated crumpled graphene balls (CGBs), via a novel nano-spray drying technique, which show robust adsorptive performance. Yet, since CGBs contain non-accessible surface area due to 2D graphene stacking, the goal of this research was to investigate the efficacy of maximizing the accessible CGB surface by synthesizing a nanocomposite composed of metal oxide nanoparticles encapsulated by crumpled graphene oxide (MGC). The metal oxides reduce graphene oxide stacking, expand the internal adsorptive surface area, and boost the adsorptive capacity of the MGC. MGC (fumed SiO
    MeSH term(s) Humans ; Graphite ; Adsorption ; Charcoal ; Silicon Dioxide ; Oxides ; Nanocomposites ; Water ; Methylene Blue ; Powders ; Metal Nanoparticles
    Chemical Substances graphene oxide ; Graphite (7782-42-5) ; Charcoal (16291-96-6) ; Silicon Dioxide (7631-86-9) ; Oxides ; Water (059QF0KO0R) ; Methylene Blue (T42P99266K) ; Powders
    Language English
    Publishing date 2022-11-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2022.130340
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  8. Article ; Online: Identification of multiple nonphotochemical quenching processes in the extremophilic red alga Cyanidioschyzon merolae.

    Chiang, Yu-Hao / Huang, Yu-Jia / Fu, Han-Yi

    Photosynthesis research

    2022  Volume 154, Issue 2, Page(s) 125–141

    Abstract: Nonphotochemical quenching acts as a frontline response to prevent excitation energy from reaching the photochemical reaction center of photosystem II before photodamage occurs. Strong fluorescence quenching after merely one multi-turnover saturating ... ...

    Abstract Nonphotochemical quenching acts as a frontline response to prevent excitation energy from reaching the photochemical reaction center of photosystem II before photodamage occurs. Strong fluorescence quenching after merely one multi-turnover saturating light pulse characterizes a unique feature of nonphotochemical quenching in red algae. Several mechanisms underlying red algal nonphotochemical quenching have been proposed, yet which process(es) dominantly account for the strong fluorescence quenching is still under discussion. Here we assessed multiple nonphotochemical quenching processes in the extremophilic red alga Cyanidioschyzon merolae under light pulse and continuous illumination conditions. To assess the nonphotochemical quenching processes that might display different kinetics, fluorescence emission spectra at 77 K were measured after different periods of light treatments, and external fluorophores were added for normalization of the fluorescence level. The phycobilisome- and photosystem II-related nonphotochemical quenching processes were distinguished by light preferentially absorbed by phycobilisomes and photosystems, respectively. Multiple nonphotochemical quenching processes, including the energetic decoupling of phycobilisomes from photosystem II, the energy spillover from phycobilisomes to photosystem I and from photosystem II to photosystem I, were identified along with the previously identified intrinsic quenching within photosystem II. The ability to use multiple nonphotochemical quenching processes appears to maximize the light harvesting efficiency for photochemistry and to provide the flexibility of the energy redistribution between photosystem II and photosystem I. The effect of the various ionophores on the nonphotochemical quenching level suggests that nonphotochemical quenching is modulated by transmembrane gradients of protons and other cations.
    MeSH term(s) Photosystem I Protein Complex/metabolism ; Photosystem II Protein Complex/metabolism ; Phycobilisomes/metabolism ; Extremophiles/metabolism ; Rhodophyta/metabolism
    Chemical Substances Photosystem I Protein Complex ; Photosystem II Protein Complex ; Phycobilisomes
    Language English
    Publishing date 2022-09-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1475688-2
    ISSN 1573-5079 ; 0166-8595
    ISSN (online) 1573-5079
    ISSN 0166-8595
    DOI 10.1007/s11120-022-00963-2
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  9. Article ; Online: Analysis and Design of Single-Ended Resonant Converter for Wireless Power Transfer Systems.

    Li, Qiqi / Duan, Shanxu / Fu, Han

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 15

    Abstract: Single-ended resonant converters such as Class-E inverters have been widely considered as a potential topology for small- and medium-power wireless power transfer (WPT) applications, which feature compact circuits, low switching losses, and cost benefits, ...

    Abstract Single-ended resonant converters such as Class-E inverters have been widely considered as a potential topology for small- and medium-power wireless power transfer (WPT) applications, which feature compact circuits, low switching losses, and cost benefits, as they only use a low-side switch with a simple gate driver. However, there remains a practical challenge in the design of voltage stress, efficiency, and power density. In this paper, a single-ended resonant converter with a primary parallel resonant-matching network is investigated to absorb the bulky input-choke inductors of the Class-E inverters into the coil inductance. The analytical expressions for all the converter parameters are derived based on time-domain resonant waveforms, including: (1) analysis of critical zero-voltage switching (ZVS) conditions and (2) power transfer capabilities under the given maximum switch voltage stress. Furthermore, this paper elaborates on the design methodology of the proposed single-ended resonant converters, and an optimal operating point is chosen to ensure soft-switching operation and rated power. Finally, the accuracy of the proposed model is verified by simulation and experimental results.
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22155617
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  10. Article ; Online: [Expression of HOX transcript antisense intergenic RNA in salivary adenoid cystic carcinoma and its influence on prognosis].

    Fu, Han-Bin / Luo, Lin

    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

    2020  Volume 38, Issue 5, Page(s) 509–512

    Abstract: Objective: This study aimed to investigate the expression of HOX transcript antisense intergenic RNA (HOTAIR) in salivary adenoid cystic carcinoma (SACC) and explore its influence on prognosis.: Methods: A total of 86 cases of patients with SACC who ... ...

    Abstract Objective: This study aimed to investigate the expression of HOX transcript antisense intergenic RNA (HOTAIR) in salivary adenoid cystic carcinoma (SACC) and explore its influence on prognosis.
    Methods: A total of 86 cases of patients with SACC who underwent surgical resection treatment from March 2007 to March 2014 were selected. In the same period, 45 cases of normal salivary gland tissues were obtained. The expression of HOTAIR was detected via real-time fluorescent quantitative polymerase chain reaction. The patients were followed up after the surgery, and the follow-up deadline was March 31, 2019. The deaths and survival times of patients were recorded. Based on the quartile value of the relative expression level of HOTAIR in SACC patients, the patients were divided into low expression group and high expression group. Kaplan-Meier method and Log-Rank test were used to compare the survival time of the two groups. Taking the age, sex, tumor location, pathological type, tumor diameter, TNM stage, nerve invasion and lymph node metastasis as independent variables, Cox proportional hazards regression model was used to analyze the multiple factors affecting survival time.
    Results: The relative expression of HOTAIR in SACC tissue was 2.48±0.22, which was higher than that in normal salivary gland tissue at 1.03±0.13, and the difference was statistically significant (t=39.812, P<0.001). No nerve invasion and lymph node metastasis were observed in these patients compared with those patients with TNM stages Ⅰ or Ⅱ, while the relative expression of HOTAIR in the tissues of patients with TNM stages Ⅲ or Ⅳ, nerve invasion, and lymph node metastasis increased (P<0.05). Kaplan-Meier survival analysis showed that the average survival time and cumulative survival rate in the low expression group were higher than those in the high expression group [(113.32±10.77) months vs. (59.75±6.50) months and 72.73% vs. 39.06%, respectively, P=0.004]. Cox proportional hazard regression analysis showed that nerve invasion, lymph node metastasis, and the high expression of HOTAIR were the inde-pendent risk factors for the prognosis of patients with SACC (HR=3.274, 2.971, and 2.911, respectively, P<0.05).
    Conclusions: HOTAIR was highly expressed in patients with SACC tissues and associated with poor prognosis. It is a risk factor for prog-nosis, and it is expected to be a potential marker for the prognostic assessment of patients with SACC.
    MeSH term(s) Carcinoma, Adenoid Cystic ; Humans ; Lymphatic Metastasis ; Prognosis ; Salivary Gland Neoplasms ; Survival Rate
    Language Chinese
    Publishing date 2020-10-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 1202342-5
    ISSN 2618-0456 ; 1000-1182
    ISSN (online) 2618-0456
    ISSN 1000-1182
    DOI 10.7518/hxkq.2020.05.006
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