LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 14

Search options

  1. Article: Investigation of the Antibacterial Properties and Mode of Action of Compounds From Urtica dioica L.

    Du, Juan / Fu, Jingyun / Chen, Tao

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52083

    Abstract: In recent years, the issue of antimicrobial resistance has gained significant global attention. The prevalence of methicillin- ... ...

    Abstract In recent years, the issue of antimicrobial resistance has gained significant global attention. The prevalence of methicillin-resistant
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52083
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: X-linked recessive Kallmann syndrome: A case report.

    Zhang, Ping / Fu, Jing-Yun

    World journal of clinical cases

    2022  Volume 10, Issue 25, Page(s) 8990–8997

    Abstract: Background: Kallmann syndrome (KS), also known as hypogonadotropic hypogonadism (HH) or olfactory-gonadal dysplasia, is a genetic condition in which the primary symptom is a failure to begin puberty or a failure to fully complete it. It occurs in both ... ...

    Abstract Background: Kallmann syndrome (KS), also known as hypogonadotropic hypogonadism (HH) or olfactory-gonadal dysplasia, is a genetic condition in which the primary symptom is a failure to begin puberty or a failure to fully complete it. It occurs in both males and females and has the additional symptoms of hypogonadism and almost invariably infertility. The condition has a low prevalence that is estimated to be 1 in 4000 for male HH cases overall and 1:50000 for KS. It is three to five times more common in males than females. Whether this is a true sex imbalance or a reflection of how difficult KS/HH is to diagnose correctly in males
    Case summary: This article reports a 26-year-old male presenting with delayed puberty. The synthetic decapeptide luteinizing hormone-releasing hormone stimulation test showed that the secretion levels of follicle-stimulating hormone and luteinizing hormone were delayed. The eigengenes commonly associated with idiopathic HH (IHH) were screened, and an X-linked recessive (KAL-1) mutation was found. His gonadotropin and testosterone levels increased significantly after pulsatile gonadotropin-releasing hormone (GnRH) subcutaneous therapy by pump. A relevant literature review on the recent advances in the diagnosis and treatment of KS and genetic counseling was conducted.
    Conclusion: KS is caused by a KAL-1 mutation that follows an X-linked recessive inheritance pattern. Pulsatile GnRH subcutaneous therapy by pump was effective in this patient.
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i25.8990
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Characterization of vB_ValM_PVA8, a broad-host-range bacteriophage infecting

    Fu, Jingyun / Li, Ying / Zhao, Lihong / Wu, Chunguang / He, Zengguo

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1105924

    Abstract: Phage therapy was taken as an alternative strategy to antibiotics in shrimp farming for the control ... ...

    Abstract Phage therapy was taken as an alternative strategy to antibiotics in shrimp farming for the control of
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1105924
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Characterization and Genomic Analysis of a Bacteriophage with Potential in Lysing Vibrio alginolyticus

    Fu, Jingyun / Li, Ying / Zhao, Lihong / Wu, Chunguang / He, Zengguo

    Viruses

    2022  Volume 15, Issue 1

    Abstract: Vibrio alginolyticus is one of the major pathogens causing vibriosis to a variety of aquatic animals as well as bringing about severe food safety concerns. Nowadays, phage therapy has received increasing attention as an alternative to the antibiotics ... ...

    Abstract Vibrio alginolyticus is one of the major pathogens causing vibriosis to a variety of aquatic animals as well as bringing about severe food safety concerns. Nowadays, phage therapy has received increasing attention as an alternative to the antibiotics that have being limited for use in aquaculture industries. In this work, a potent bacteriophage, vB_ValM_PVA23 (PVA23), which efficiently infects pathogenic strains of V. alginolyticus, was isolated from sewage water and characterized by microbiological and genomic analyses. Based on the transmission electronic observation, the phage was characterized to be the Myoviridae family. It has a latent period of 10 min and a burst size of 203 PFUs/infected bacterium, and was stable over a broad pH range (5.0−11.0) and a wide temperature span (−80 °C to 60 °C), respectively. Genome sequencing results show that PVA23 has a 246,962-bp double-stranded DNA with a G + C content of 41.25%. The lab and plant shrimp farming trials demonstrated that phage preparation derived from PVA23 out-performed the chemical disinfectant iodine treatment in the prevention of V. alginolyticus propagation, and the phage application could rapidly yet significantly reduce the level of V. alginolyticus in the pond within 12 h, with negligible rebound observed. These results suggests that phage PVA23 has the potential to be used as an anti-V. alginolyticus agent in aquaculture industries.
    MeSH term(s) Animals ; Bacteriophages/genetics ; Vibrio alginolyticus/genetics ; Genomics ; Myoviridae/genetics ; Vibrio Infections/microbiology ; Genome, Viral
    Language English
    Publishing date 2022-12-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15010135
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online: Rethinking Cross-Entropy Loss for Stereo Matching Networks

    Xu, Peng / Xiang, Zhiyu / Qiao, Chenyu / Fu, Jingyun / Zhao, Xijun

    2023  

    Abstract: Despite the great success of deep learning in stereo matching, recovering accurate and clearly-contoured disparity map is still challenging. Currently, L1 loss and cross-entropy loss are the two most widely used loss functions for training the stereo ... ...

    Abstract Despite the great success of deep learning in stereo matching, recovering accurate and clearly-contoured disparity map is still challenging. Currently, L1 loss and cross-entropy loss are the two most widely used loss functions for training the stereo matching networks. Comparing with the former, the latter can usually achieve better results thanks to its direct constraint to the the cost volume. However, how to generate reasonable ground-truth distribution for this loss function remains largely under exploited. Existing works assume uni-modal distributions around the ground-truth for all of the pixels, which ignores the fact that the edge pixels may have multi-modal distributions. In this paper, we first experimentally exhibit the importance of correct edge supervision to the overall disparity accuracy. Then a novel adaptive multi-modal cross-entropy loss which encourages the network to generate different distribution patterns for edge and non-edge pixels is proposed. We further optimize the disparity estimator in the inference stage to alleviate the bleeding and misalignment artifacts at the edge. Our method is generic and can help classic stereo matching models regain competitive performance. GANet trained by our loss ranks 1st on the KITTI 2015 and 2012 benchmarks and outperforms state-of-the-art methods by a large margin. Meanwhile, our method also exhibits superior cross-domain generalization ability and outperforms existing generalization-specialized methods on four popular real-world datasets.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2023-06-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: A Novel Bi-Functional Fibrinolytic Enzyme with Anticoagulant and Thrombolytic Activities from a Marine-Derived Fungus Aspergillus versicolor ZLH-1

    Zhao, Lihong / Lin, Xiuping / Fu, Jingyun / Zhang, Jun / Tang, Wei / He, Zengguo

    Marine drugs. 2022 May 27, v. 20, no. 6

    2022  

    Abstract: Fibrinolytic enzymes are important components in the treatment of thrombosis-associated disorders. A new bi-functional fibrinolytic enzyme, versiase, was identified from a marine-derived fungus Aspergillus versicolor ZLH-1. The enzyme was isolated from ... ...

    Abstract Fibrinolytic enzymes are important components in the treatment of thrombosis-associated disorders. A new bi-functional fibrinolytic enzyme, versiase, was identified from a marine-derived fungus Aspergillus versicolor ZLH-1. The enzyme was isolated from the fungal culture through precipitation with ammonium sulfate at 90% saturation. Additionally, it was further purified by DEAE-based ion-exchange chromatography, with a recovery of 20.4%. The fibrinolytic enzyme presented as one band on both SDS-PAGE and fibrin-zymogram, with a molecular mass of 37.3 kDa. It was elucidated as a member of metalloprotease in M35 family by proteomic approaches. The homology-modeling analysis revealed that versiase shares significant structural homology wuth the zinc metalloendopeptidase. The enzyme displayed maximum activity at 40 °C and pH 5.0. The activity of versiase was strongly inhibited by the metalloprotease inhibitors EDTA and BGTA. Furthermore, versiase hydrolyzed fibrin directly and indirectly via the activation of plasminogen, and it was able to hydrolyze the three chains (α, β, γ) of fibrin(ogen). Additionally, versiase demonstrated promising thrombolytic and anticoagulant activities, without many side-effects noticed. In conclusion, versiase appears to be a potent fibrinolytic enzyme deserving further investigation.
    Keywords Aspergillus versicolor ; adverse effects ; ammonium sulfate ; anticoagulants ; fibrin ; fungal culture ; fungi ; hydrolysis ; ion exchange chromatography ; metalloproteinases ; molecular weight ; pH ; plasminogen ; polyacrylamide gel electrophoresis ; proteomics ; zinc
    Language English
    Dates of publication 2022-0527
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20060356
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Subclinical Hypothyroidism and Sperm DNA Fragmentation: A Cross-sectional Study of 5401 Men Seeking Infertility Care.

    Zhao, Shuhua / Tang, Li / Fu, Jingyun / Yang, Zexing / Su, Cunmei / Rao, Meng

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 10, Page(s) e4027–e4036

    Abstract: Context: Our previous study showed that paternal subclinical hypothyroidism (SCH) had a detrimental effect on the clinical outcomes of assisted reproductive technologies. However, it remains to be determined whether paternal SCH affects sperm DNA ... ...

    Abstract Context: Our previous study showed that paternal subclinical hypothyroidism (SCH) had a detrimental effect on the clinical outcomes of assisted reproductive technologies. However, it remains to be determined whether paternal SCH affects sperm DNA integrity.
    Objective: To investigate the association between SCH and sperm DNA fragmentation in men seeking infertility care.
    Methods: This cross-sectional study included 4983 men with euthyroidism and 418 men with SCH seeking infertility treatment in a tertiary care academic medical center between January 2017 and December 2021. The outcome measures were the absolute DNA fragmentation index (DFI) and the risk of abnormal DFI (defined as DFI ≥ 25% or ≥ 30%).
    Results: The mean (SD) age of men with euthyroidism and men with SCH was 34.20 (5.97) and 35.35 (6.48) years, respectively (P < 0.001). The difference in DFI was not statistically significant (adjusted mean: 19.7% vs 18.9% in the SCH and euthyroidism groups, respectively; P = 0.07) after confounder adjustment. A DFI ≥25% was significantly more frequent in men with SCH (20.57%) than in men with euthyroidism (14.49%) after confounder adjustment [odds ratio (OR) 1.43 (95% CI 1.09-1.88)]. DFI ≥ 30% was also significantly more common in men with SCH (11.72%) than in men with euthyroidism [6.74%; OR 1.84 (95% CI 1.34-2.52)]. In addition, thyroid-stimulating hormone concentration was significantly associated with an increased risk of having a DFI ≥25% (P < 0.001) or ≥30% (P = 0.011).
    Conclusion: SCH was significantly associated with an increased risk of an abnormal DFI.
    MeSH term(s) Cross-Sectional Studies ; DNA/therapeutic use ; DNA Fragmentation ; Humans ; Hypothyroidism/complications ; Hypothyroidism/epidemiology ; Infertility, Male/drug therapy ; Infertility, Male/therapy ; Male ; Semen ; Spermatozoa ; Thyrotropin/therapeutic use
    Chemical Substances Thyrotropin (9002-71-5) ; DNA (9007-49-2)
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac458
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: A Novel Bi-Functional Fibrinolytic Enzyme with Anticoagulant and Thrombolytic Activities from a Marine-Derived Fungus

    Zhao, Lihong / Lin, Xiuping / Fu, Jingyun / Zhang, Jun / Tang, Wei / He, Zengguo

    Marine drugs

    2022  Volume 20, Issue 6

    Abstract: Fibrinolytic enzymes are important components in the treatment of thrombosis-associated disorders. A new bi-functional fibrinolytic enzyme, versiase, was identified from a marine-derived ... ...

    Abstract Fibrinolytic enzymes are important components in the treatment of thrombosis-associated disorders. A new bi-functional fibrinolytic enzyme, versiase, was identified from a marine-derived fungus
    MeSH term(s) Anticoagulants/pharmacology ; Aspergillus ; Fibrin ; Fibrinolytic Agents/chemistry ; Fungi ; Hydrogen-Ion Concentration ; Metalloproteases ; Molecular Weight ; Proteomics ; Temperature
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Fibrin (9001-31-4) ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20060356
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Purification, characterization of Chondroitinase ABC from Sphingomonas paucimobilis and in vitro cardiocytoprotection of the enzymatically degraded CS-A

    Fu, Jingyun / Zhiwen Jiang / Jing Chang / Baoqin Han / Wanshun Liu / Yanfei Peng

    International journal of biological macromolecules. 2018 Aug., v. 115

    2018  

    Abstract: An extracellular chondroitinase ABC (ChSase ABC) produced by Sphingomonas paucimobilis was purified to homogeneity through ammonium sulfate precipitation, DEAE-Sepharose Fast Flow and Sephadex G-100 chromatography. The molecular weight was 82.3 kDa. It ... ...

    Abstract An extracellular chondroitinase ABC (ChSase ABC) produced by Sphingomonas paucimobilis was purified to homogeneity through ammonium sulfate precipitation, DEAE-Sepharose Fast Flow and Sephadex G-100 chromatography. The molecular weight was 82.3 kDa. It showed specific lyase activity toward chondroitin sulfate A (CS-A), CS-B, CS-C and hyaluronan (HA). Using CS-A as substrate, the specific activity was 98.04 U/mg, the maximal reaction rate (Vmax) and Michaelis-Menten constant (Km) were 0.49 μmol/min/ml and 0.79 mg/ml, respectively. Highest activity was obtained at pH 6.5 and 40 °C, and Hg2+ could strongly inhibit the enzyme activity. Mass spectrometry analysis indicated CS-A was degraded to unsaturated disaccharides by ChSase ABC. In vitro cytotoxic tests showed that CS-A oligosaccharide at the concentration of 50 and 100 μg/ml could promote the proliferation of normal H9c2 myocardial cells, decrease the damage induced by isoproterenol (ISO) and accelerate the recovery of cells injured by ISO. These findings suggested that ChSase ABC from Sphingomonas paucimobilis could be a promising tool for the structural analysis and bioactive oligosaccharide preparation of glucosaminoglycans.
    Keywords Sphingomonas paucimobilis ; ammonium sulfate ; chondroitin sulfate ; chromatography ; cytotoxicity ; disaccharides ; enzyme activity ; enzyme kinetics ; hyaluronic acid ; isoproterenols ; mass spectrometry ; mercury ; molecular weight ; pH
    Language English
    Dates of publication 2018-08
    Size p. 737-745.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2018.04.117
    Database NAL-Catalogue (AGRICOLA)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Integrated bioinformatics analysis for novel miRNAs markers and ceRNA network in diabetic retinopathy.

    Li, Jingru / Li, Chaozhong / Zhao, Yulan / Wu, Xinyu / Yu, Shuai / Sun, Guihu / Ding, Peng / Lu, Si / Zhang, Lijiao / Yang, Ping / Peng, Yunzhu / Fu, Jingyun / Wang, Luqiao

    Frontiers in genetics

    2022  Volume 13, Page(s) 874885

    Abstract: In order to seek a more outstanding diagnosis and treatment of diabetic retinopathy (DR), we predicted the miRNA biomarkers of DR and explored the pathological mechanism of DR through bioinformatics analysis. ...

    Abstract In order to seek a more outstanding diagnosis and treatment of diabetic retinopathy (DR), we predicted the miRNA biomarkers of DR and explored the pathological mechanism of DR through bioinformatics analysis.
    Language English
    Publishing date 2022-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.874885
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top