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  1. Article ; Online: H

    Chang, Kaiwen / Sun, Xiaolin / Fu, Mingying / Han, Bing / Jiang, Xiaopeng / Qi, Qiaofang / Zhang, Yang / Ni, Tianjun / Ge, Chunpo / Yang, Zhijun

    Journal of materials chemistry. B

    2024  Volume 12, Issue 11, Page(s) 2737–2745

    Abstract: Carbon monoxide (CO) gas therapy has shown great potential as a very promising approach in the ongoing fight against tumors. However, delivering unstable CO to the tumor site and safely releasing it for maximum efficacy still have unsatisfactory outcomes. ...

    Abstract Carbon monoxide (CO) gas therapy has shown great potential as a very promising approach in the ongoing fight against tumors. However, delivering unstable CO to the tumor site and safely releasing it for maximum efficacy still have unsatisfactory outcomes. In this study, we've developed nanotheranostics (IN-DPPCO NPs) based on conjugated polymer IN-DPP and carbon monoxide (CO) carrier polymer mPEG(CO) for photothermal augmented gas therapy. The IN-DPPCO NPs can release CO with the hydrogen peroxide (H
    MeSH term(s) Humans ; Hydrogen Peroxide ; Carbon Monoxide ; Phototherapy ; Neoplasms/therapy ; Polymers ; Tumor Microenvironment
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Carbon Monoxide (7U1EE4V452) ; Polymers
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02399k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy.

    Chang, Kaiwen / Sun, Xiaolin / Qi, Qiaofang / Fu, Mingying / Han, Bing / Zhang, Yang / Zhao, Wei / Ni, Tianjun / Li, Qiong / Yang, Zhijun / Ge, Chunpo

    Biosensors

    2023  Volume 13, Issue 6

    Abstract: Photothermal therapy (PTT) has received constant attention as a promising cancer treatment. However, PTT-induced inflammation can limit its effectiveness. To address this shortcoming, we developed second near-infrared (NIR-II) light-activated ... ...

    Abstract Photothermal therapy (PTT) has received constant attention as a promising cancer treatment. However, PTT-induced inflammation can limit its effectiveness. To address this shortcoming, we developed second near-infrared (NIR-II) light-activated nanotheranostics (CPNPBs), which include a thermosensitive nitric oxide (NO) donor (BNN6) to enhance PTT. Under a 1064 nm laser irradiation, the conjugated polymer in CPNPBs serves as a photothermal agent for photothermal conversion, and the generated heat triggers the decomposition of BNN6 to release NO. The combination of hyperthermia and NO generation under single NIR-II laser irradiation allows enhanced thermal ablation of tumors. Consequently, CPNPBs can be exploited as potential candidates for NO-enhanced PTT, holding great promise for their clinical translational development.
    MeSH term(s) Photothermal Therapy ; Phototherapy ; Nitric Oxide ; Theranostic Nanomedicine ; Polymers ; Cell Line, Tumor ; Nanoparticles
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Polymers
    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13060642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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