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Article: Changes in Serum Irisin Levels and Their Significance in Carotid Atherosclerosis Associated with Obesity.

Fu, Shaohua / Xing, Guisheng

Alternative therapies in health and medicine

2024

Abstract: Objective: This study aims to comprehensively examine and assess the changes and significance of irisin levels in individuals with carotid atherosclerosis (CAS) who are concurrently dealing with obesity.: Method: A total of 156 CAS patients admitted ... ...

Abstract	Objective: This study aims to comprehensively examine and assess the changes and significance of irisin levels in individuals with carotid atherosclerosis (CAS) who are concurrently dealing with obesity. Method: A total of 156 CAS patients admitted between March 2020 and March 2022 were categorized into CAS normal weight (C1), CAS overweight (C2), and CAS obesity (C3) groups based on BMI. Simultaneously, 80 healthy adults from the same period comprised the control group (C0). The study conducted a comparative analysis of biochemical indexes, serum irisin levels, and carotid artery ultrasounds across all groups. Correlation analyses and diagnostic assessments for serum irisin in obesity with carotid atherosclerosis were executed using ROC curves. Results: Statistically significant differences were observed in cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), serum homocysteine (Hcy), and irisin levels among all groups (P < .05). Obese CAS patients exhibited higher levels of TC, TG, LDL-C, and Hcy, with notably lower levels of HDL-C and irisin compared to other groups (P < .05). Significant variations in carotid artery ultrasound intima-media thickness (IMT) and Crouse scores were also evident among all groups (P < .05). Specifically, IMT and Crouse scores were higher in obese CAS patients compared to other groups (P < .05). Correlation analysis results indicated a significant negative correlation between irisin and TC, TG, LDL-C, Hcy, IMT, and Crouse score (P < .05). Conversely, irisin exhibited a significant positive correlation with HDL-C levels (P < .05). The ROC curve analysis for the diagnostic value of irisin in obesity with CAS revealed an area under the curve of 0.957. Conclusions: Serum irisin levels are significantly reduced in CAS patients, particularly those with overweight and obese. Additionally, irisin levels are closely associated with patients' blood lipids, homocysteine levels, and the severity of atherosclerosis.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Anthocyanin extract from black rice attenuates chronic inflammation in DSS-induced colitis mouse model by modulating the gut microbiota

Li Yanmei / Yuan Fahu / He Xiaohong / Fu Shaohua / Fan Bolin

Open Chemistry, Vol 21, Iss 1, Pp e15687-

2023 Volume 65

Abstract: There is substantial evidence for the probiotic activity of anthocyanins, but the relationship between anthocyanins involved in the regulation of microbiota and intestinal inflammation has not been fully elucidated. The aim of this study was to ... ...

Abstract	There is substantial evidence for the probiotic activity of anthocyanins, but the relationship between anthocyanins involved in the regulation of microbiota and intestinal inflammation has not been fully elucidated. The aim of this study was to investigate the regulatory effects of black rice anthocyanin extract (BRAE) on intestinal microbiota imbalance in mice with dextran sulfate sodium (DSS)-induced chronic colitis. DSS was added into drinking water to induce a mouse model of chronic experimental colitis, and BRAE was given by gavage (200 mg/kg/day) for 4 weeks. Body weight, fecal viscosity, and hematochezia were monitored during administration. After mice were sacrificed, the serum concentrations of TNF-α and IL-6 were detected by enzyme-linked immunosorbent assay, and the composition of intestinal flora was analyzed by 16S rDNA sequencing. The results showed that BRAE significantly suppressed DSS-induced colonic inflammatory phenotypes and maintained colon length in mice. In addition, BRAE reduced intestinal permeability and improved intestinal barrier dysfunction in mice with colitis. Gut microbiota analysis showed that BRAE significantly improved the imbalance of intestinal microecological diversity caused by DSS, inhibited the increase in the relative abundance of inflammatory bacteria, and promoted the abundance of anti-inflammatory probiotics including Akkermansia spp.
Keywords	black rice anthocyanin ; inflammation ; inflammatory bowel disease ; microbiota ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
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Article ; Online: Relationship between chemical industrial environment and allergic skin diseases.

Fu, Shaohua / Gong, Minli / Xing, Guisheng

Acta biochimica Polonica

2023 Volume 70, Issue 4, Page(s) 899–904

Abstract: Objective: This study is an exploration of the relationship between chemical industrial environment and allergic skin diseases.: Methods: In this retrospective analysis, 200 patients with allergic skin diseases who worked or lived in a chemical ... ...

Abstract	Objective: This study is an exploration of the relationship between chemical industrial environment and allergic skin diseases. Methods: In this retrospective analysis, 200 patients with allergic skin diseases who worked or lived in a chemical industrial zone and were admitted in our hospital between January 2018 and January 2020 were enrolled as Group A. Besides, 500 patients with allergic skin disease who lived in Zhenhai New District, five kilometers away from the chemical radiation zone, were selected as Group B. The specific immunoglobulin E (IgE) levels were determined by Western blotting. The allergen positivity, as well as allergen positivity between different age, sex and body mass index (BMI) were compared between the two groups. The positive food-specific allergen IgE antibody (sIgE) and positive inhalational sIgE were compared between the two groups. Results: The positive rate of total IgE and inhalational sIgE in Group A was higher than that in Group B (P<0.05), while there was no significant difference in positive rate in food sIgE between the two groups (P>0.05). In Group A, the differences in positive rates of total IgE, food-induced sIgE and inhalational sIgE were not significant between patients with different ages, sexes and BMI (P>0.05). There was no significant difference between the two groups in sIgE positive rates of wheat, mango, soybean/peanut/cashew nut combination, limb/beef combination, crab/shrimp/fish combination, milk and egg white (P>0.05). The positive rates of inhalational sIgE in tree combination and dust mites/household dust mites combination in Group A were higher than those in Group B (P<0.05), but had no significant difference between the two groups in the positive rates of inhalational sIgE in Humulus japonicus, mold combination 1, cockroach, cat/dog hair combination, and ragweed/artemisia combination (P>0.05). Conclusion: Chemical industrial environment is closely associated with allergic dermatosis, and the positive rate of total IgE and inhalational sIgE increases significantly in patients living there.
MeSH term(s)	Animals ; Dogs ; Cattle ; Humans ; Retrospective Studies ; Skin Tests ; Allergens ; Dermatitis, Atopic/etiology ; Immunoglobulin E ; Dust
Chemical Substances	Allergens ; Immunoglobulin E (37341-29-0) ; Dust
Language	English
Publishing date	2023-12-01
Publishing country	Poland
Document type	Journal Article
ZDB-ID	595762-x
ISSN	1734-154X ; 0001-527X
ISSN (online)	1734-154X
ISSN	0001-527X
DOI	10.18388/abp.2020_6797
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Article ; Online: Research and design of an intelligent fish tank system.

Fu, Shaohua / Xing, Wenjing / Wu, Juncheng / Chen, Jiangang / Liu, Shuangjiao

PloS one

2023 Volume 18, Issue 5, Page(s) e0285105

Abstract: In order to improve the hardware configuration and interaction mode of the fish tank system and realize the diversification of client functions, the purpose of real-time remote monitoring and management is achieved. A set of IoT intelligent fish tank ... ...

Abstract	In order to improve the hardware configuration and interaction mode of the fish tank system and realize the diversification of client functions, the purpose of real-time remote monitoring and management is achieved. A set of IoT intelligent fish tank system composed of sensor unit, signal processing unit and wireless transmission unit was designed. The system improves the algorithm of the data collected by the sensor, and proposes an improved first-order lag average filtering algorithm. The system uses composite collection information, intelligent processing, chart data analysis and other methods to transmit the processed data to the cloud server through the WIFI communication module. An APP is designed on the remote monitoring and control end, and a visual data interface of the smart fish tank is made, and the user can modify the environmental parameters conducive to the biological survival inside the fish tank through the APP, it brings great convenience to the family fish tank, and the test shows that the system network is stable and fast in response, and the overall purpose of the intelligent fish tank system is achieved.
MeSH term(s)	Animals ; Wireless Technology ; Algorithms ; Signal Processing, Computer-Assisted
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285105
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Article: Acute and subchronic oral toxicity study of

Xia, Ying / Zhu, Jie / Qu, Min / Yang, Wenxiang / Fu, Shaohua / Yu, Liqin / Fan, Bolin

Heliyon

2023 Volume 10, Issue 1, Page(s) e23654

Abstract: Objective: The aim of these studies was to ascertain if : Methods: Wistar rats of both sexes were used in an acute toxicity test, and the fatal dosage (LD50) of oral : Results: There were no observable toxicity-related changes in any of the three ... ...

Abstract	Objective: The aim of these studies was to ascertain if Methods: Wistar rats of both sexes were used in an acute toxicity test, and the fatal dosage (LD50) of oral Results: There were no observable toxicity-related changes in any of the three dosage groups. There is no toxicological relevance to the change in the high-dose hematological indicator PLT at the conclusion of the recovery period because it was within the usual range for this strain in our laboratory. The test material did not result in any pathological alterations, according to a pathological examination. Conclusion: Since the results of the current study, the no-observed-adverse-effect-level (NOAEL) for
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e23654
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Article ; Online: From Euler disk to phonon bottleneck effect: Excited state physics.

Lin, Xinnian / Fu, Shaohua / Zhai, Yanni / Wang, Wenhui / Li, Haochen / Zhang, Ruizhi / Meng, Sheng / Zhao, Jimin

Innovation (Cambridge (Mass.))

2024 Volume 5, Issue 3, Page(s) 100614

Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2666-6758
ISSN (online)	2666-6758
DOI	10.1016/j.xinn.2024.100614
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Article ; Online: Directly Probing Interfacial Coupling in a Monolayer MoSe

Fu, Shaohua / Wang, Rui / Tang, Dongsheng / Zhang, Xiaoxian / He, Dawei

ACS applied materials & interfaces

2021 Volume 13, Issue 15, Page(s) 18372–18379

Abstract: It is of great importance to develop useful methods to evaluate interfacial coupling strength noninvasively for exploring and optimizing heterointerface functionality. Recently, organic-inorganic van der Waals (vdW) heterostructures (HSs) composed of ... ...

Abstract	It is of great importance to develop useful methods to evaluate interfacial coupling strength noninvasively for exploring and optimizing heterointerface functionality. Recently, organic-inorganic van der Waals (vdW) heterostructures (HSs) composed of organic semiconductors and transition-metal dichalcogenides (TMD) have shown great potential for developing next-generation flexible optical, electrical, and optoelectrical devices. Since vdW coupling dominates the property of such a vdW HS, it is crucial to develop a method to evaluate its interfacial coupling strength noninvasively. In this work, by combining electrical force microscopy (EFM) and Raman and photoluminescence spectroscopic measurements, we were able to directly probe the coupling strength between monolayer MoSe
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c03779
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Article: Tibetan Medicine Shi-Wei-Gan-Ning-San Alleviates Carbon Tetrachloride-Induced Chronic Liver Injury by Inhibiting TGF-

Jia, Ziming / Zheng, Yanhua / Fu, Shaohua / Qu, Jingjing / Tian, Jie / Qu, Wen / Mei, Zhinan

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 2011876

Abstract: Background: Shi-Wei-Gan-Ning-San (SWGNS) is a classic Tibetan prescription, which has obvious clinical effects in the treatment of viral hepatitis, fatty liver, liver fibrosis, liver cirrhosis, liver cancer, and other liver injuries. However, animal ... ...

Abstract	Background: Shi-Wei-Gan-Ning-San (SWGNS) is a classic Tibetan prescription, which has obvious clinical effects in the treatment of viral hepatitis, fatty liver, liver fibrosis, liver cirrhosis, liver cancer, and other liver injuries. However, animal studies and mechanism studies are still lacking. This study aimed to investigate its hepatoprotective efficacy and pharmacological mechanism in animal experiments. Methods: Chronic liver injury was induced by oral administration of carbon tetrachloride (CCl Results: SWGNS reversed weight loss is induced by CCl Conclusions: In conclusion, SWGNS alleviated CCl
Language	English
Publishing date	2022-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/2011876
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Article ; Online: Separated Electron-Phonon and Phonon-Phonon Scatterings Across Interface in Thin Film LaCoO

Hao, Wenjie / Gu, Minghui / Tian, Zhenyun / Fu, Shaohua / Meng, Meng / Zhang, Hong / Guo, Jiandong / Zhao, Jimin

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 11, Issue 2, Page(s) e2305900

Abstract: Electron-phonon coupling (EPC) and phonon-phonon scattering (PPS) are at the core of the microscopic physics mechanisms of vast quantum materials. However, to date, there are rarely reports that these two processes can be spatially separated, although ... ...

Abstract	Electron-phonon coupling (EPC) and phonon-phonon scattering (PPS) are at the core of the microscopic physics mechanisms of vast quantum materials. However, to date, there are rarely reports that these two processes can be spatially separated, although they are usually temporally detached with different characteristic lifetimes. Here, by employing ultrafast spectroscopy to investigate the photo-carrier ultrafast dynamics in a LaCoO
Language	English
Publishing date	2023-11-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202305900
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Article ; Online: Single-Atom Site SERS Chip for Rapid, Ultrasensitive, and Reproducible Direct-Monitoring of RNA Binding.

Feng, Ran / Fu, Shaohua / Liu, Hongyang / Wang, Ying / Liu, Simiao / Wang, Kaiwen / Chen, Binbin / Zhang, Xiaoxian / Hu, Liming / Chen, Qian / Cai, Ting / Han, Xiaodong / Wang, Cong

Advanced healthcare materials

2024 Volume 13, Issue 7, Page(s) e2301146

Abstract: Ribonucleic acids (RNA) play active roles within cells or viruses by catalyzing biological reactions, controlling gene expression, and communicating responses to cellular signals. Rapid monitoring RNA variation has become extremely important for ... ...

Abstract	Ribonucleic acids (RNA) play active roles within cells or viruses by catalyzing biological reactions, controlling gene expression, and communicating responses to cellular signals. Rapid monitoring RNA variation has become extremely important for appropriate clinical decisions and frontier biological research. However, the most widely used method for RNA detection, nucleic acid amplification, is restricted by a mandatory temperature cycling period of ≈1 h required to reach target detection criteria. Herein, a direct detection approach via single-atom site integrated surface-enhanced Raman scattering (SERS) monitoring nucleic acid pairing reaction, can be completed within 3 min and reaches high sensitivity and extreme reproducibility for COVID-19 and two other influenza viruses' detection. The mechanism is that a single-atom site on SERS chip, enabled by positioning a single-atom oxide coordinated with a specific complementary RNA probe on chip nanostructure hotspots, can effectively bind target RNA analytes to enrich them at designed sites so that the binding reaction can be detected through Raman signal variation. This ultrafast, sensitive, and reproducible single-atom site SERS chip approach paves the route for an alternative technique of immediate RNA detection. Moreover, single-atom site SERS is a novel surface enrichment strategy for SERS active sites for other analytes at ultralow concentrations.
MeSH term(s)	Reproducibility of Results ; Limit of Detection ; Metal Nanoparticles/chemistry ; RNA ; Nucleic Acids ; Spectrum Analysis, Raman/methods ; Gold/chemistry
Chemical Substances	RNA (63231-63-0) ; Nucleic Acids ; Gold (7440-57-5)
Language	English
Publishing date	2024-01-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202301146
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