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  1. Article: Photoacoustic elasto-viscography and optical coherence microscopy for multi-parametric

    Yang, Fen / Ding, Wenguo / Fu, Xinlei / Chen, Wei / Tang, Jianbo

    Biomedical optics express

    2023  Volume 14, Issue 11, Page(s) 5615–5628

    Abstract: Optical coherence microscopy (OCM) has shown the importance of ... ...

    Abstract Optical coherence microscopy (OCM) has shown the importance of imaging
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.503847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metal-free synthesis of difluoro/trifluoromethyl carbinol-containing chromones

    Wu, Long-Hui / Liu, Xia / Liu, Zhao-Wen / Chen, Zhi-Xi / Fu, Xin-Lei / Yang, Kai

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 46, Page(s) 9236–9241

    Abstract: We herein propose a HFIP-promoted tandem cyclization reaction for the synthesis of difluoro/trifluoromethyl carbinol-containing chromones ... ...

    Abstract We herein propose a HFIP-promoted tandem cyclization reaction for the synthesis of difluoro/trifluoromethyl carbinol-containing chromones from
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01582c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Silencing of miR-486 alleviates LPS-stimulated inflammatory response of macrophages through targeting SIRT1.

    Huang, Jie / Fu, Xinlei / Chen, Xue / Xu, Shuang / Yu, Jian

    RSC advances

    2019  Volume 9, Issue 30, Page(s) 17057–17064

    Abstract: Previous studies identified that microRNAs (miRNAs) have promising diagnostic and prognostic value against sepsis. MiR-486 was demonstrated to be upregulated in sepsis. However, the detailed role and underlying mechanism of miR-486 in the inflammatory ... ...

    Abstract Previous studies identified that microRNAs (miRNAs) have promising diagnostic and prognostic value against sepsis. MiR-486 was demonstrated to be upregulated in sepsis. However, the detailed role and underlying mechanism of miR-486 in the inflammatory response of sepsis are still unclear. In this research, macrophages were stimulated with lipopolysaccharide (LPS) to establish a sepsis model
    Language English
    Publishing date 2019-05-31
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra01374a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Multi-Scale Label-free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy.

    Chang, Shuaibin / Yang, Jiarui / Novoseltseva, Anna / Fu, Xinlei / Li, Chenglin / Chen, Shih-Chi / Augustinack, Jean C / Magnain, Caroline / Fischl, Bruce / Mckee, Ann C / Boas, David A / Chen, Ichun Anderson / Wang, Hui

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The study of neurodegenerative processes in the human brain requires a comprehensive understanding of cytoarchitectonic, myeloarchitectonic, and vascular structures. Recent computational advances have enabled volumetric reconstruction of the human brain ... ...

    Abstract The study of neurodegenerative processes in the human brain requires a comprehensive understanding of cytoarchitectonic, myeloarchitectonic, and vascular structures. Recent computational advances have enabled volumetric reconstruction of the human brain using thousands of stained slices, however, tissue distortions and loss resulting from standard histological processing have hindered deformation-free reconstruction of the human brain. The development of a multi-scale and volumetric human brain imaging technique that can measure intact brain structure would be a major technical advance. Here, we describe the development of integrated serial sectioning Polarization Sensitive Optical Coherence Tomography (PSOCT) and Two Photon Microscopy (2PM) to provide label-free multi-contrast imaging, including scattering, birefringence and autofluorescence of human brain tissue. We demonstrate that high-throughput reconstruction of 4×4×2cm
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.22.541785
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Silencing of miR-486 alleviates LPS-stimulated inflammatory response of macrophages through targeting SIRT1

    Huang, Jie / Fu, Xinlei / Chen, Xue / Xu, Shuang / Yu, Jian

    RSC advances. 2019 May 31, v. 9, no. 30

    2019  

    Abstract: Previous studies identified that microRNAs (miRNAs) have promising diagnostic and prognostic value against sepsis. MiR-486 was demonstrated to be upregulated in sepsis. However, the detailed role and underlying mechanism of miR-486 in the inflammatory ... ...

    Abstract Previous studies identified that microRNAs (miRNAs) have promising diagnostic and prognostic value against sepsis. MiR-486 was demonstrated to be upregulated in sepsis. However, the detailed role and underlying mechanism of miR-486 in the inflammatory response of sepsis are still unclear. In this research, macrophages were stimulated with lipopolysaccharide (LPS) to establish a sepsis model in vitro. qRT-PCR was used to detect miR-486 expression and the mRNA levels of sirtuin (SIRT1), tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β. ELISA assay was performed to measure the levels of TNF-α, IL-6 and IL-1β. SIRT1 protein expression was determined by Western blot analysis. The targeted relationship of miR-486 and SIRT1 was confirmed by dual-luciferase reporter assay. Our data supported that miR-486 was upregulated in the serum of sepsis patients. MiR-486 expression and inflammatory response were elevated by LPS stimulation in macrophages. MiR-486 silencing or SIRT1 overexpression alleviated inflammatory response in LPS-stimulated macrophages. Moreover, SIRT1 was a direct target of miR-486. Anti-miR-486-mediated anti-inflammatory response in LPS-stimulated macrophages was antagonized by SIRT1 inhibition. Our data suggested that miR-486 silencing alleviated inflammatory response in macrophages under LPS stimulation at least partly through targeting SIRT1. Targeting miR-486 may provide a novel way to protect against dysregulated inflammatory response in sepsis patients.
    Keywords Western blotting ; blood serum ; enzyme-linked immunosorbent assay ; inflammation ; interleukin-1beta ; interleukin-6 ; lipopolysaccharides ; luciferase ; macrophages ; messenger RNA ; microRNA ; models ; nutritional status ; patients ; prognosis ; protein synthesis ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; sepsis (infection) ; tumor necrosis factor-alpha
    Language English
    Dates of publication 2019-0531
    Size p. 17057-17064.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c9ra01374a
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Technical Note: Performance evaluation of a small-animal PET/CT system based on NEMA NU 4-2008 standards.

    Liu, Qiong / Li, Chaofan / Liu, Jiguo / Krish, Kishore / Fu, Xinlei / Zhao, Jie / Chen, Jyh-Cheng

    Medical physics

    2021  Volume 48, Issue 9, Page(s) 5272–5282

    Abstract: Purpose: The Metis: Methods: Energy resolution, spatial resolution, sensitivity, scatter fraction (SF), noise-equivalent count rate (NECR), and image quality (IQ) characteristics were measured. A micro Derenzo phantom experiment was performed to ... ...

    Abstract Purpose: The Metis
    Methods: Energy resolution, spatial resolution, sensitivity, scatter fraction (SF), noise-equivalent count rate (NECR), and image quality (IQ) characteristics were measured. A micro Derenzo phantom experiment was performed to evaluate the spatial resolution using three-dimensional ordered-subsets expectation maximization (3D-OSEM) and maximum likelihood expectation maximization (MLEM) reconstructed images. In addition, the CT imaging agent Ioverol 350 was mixed with fluorine-18 (
    Results: The mean energy resolution of the system was 15.3%. The tangential resolution was 0.82 mm full-width half-maximum (FWHM) at the center of the field of the view (FOV), and the radial and axial resolution were generally lower than 2.0 mm FWHM. The spatial resolution was significantly improved when using 3D-OSEM, especially the axial FWHM could be improved by up to about 57%. The system absolute sensitivity was 7.7% and 6.8% for an energy window of 200-750 and 350-750 keV respectively. The scatter fraction was 8.2% and 12.1% for the mouse- and rat-like phantom respectively. The peak NECR was 1343.72 kcps at 69 MBq and 640.32 kcps at 53 MBq for the mouse- and rat-like phantom respectively. The 1-mm fillable rod in the IQ phantom can be clearly observed. We can identify the 0.6-mm aperture of the micro Derenzo phantom image clearly using 3D-OSEM (10 subsets, 5 iterations). We also performed the fusion of the PET and CT images of the mouse and the brain imaging of the rat.
    Conclusions: The results show that the system has the characteristics of high-resolution, high-sensitivity, and excellent IQ and is suitable for rodent imaging-based research.
    MeSH term(s) Animals ; Fluorodeoxyglucose F18 ; Mice ; Phantoms, Imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Rats ; Reference Standards
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.15088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article ; Online: Multi-Scale Label-Free Human Brain Imaging with Integrated Serial Sectioning Polarization Sensitive Optical Coherence Tomography and Two-Photon Microscopy.

    Chang, Shuaibin / Yang, Jiarui / Novoseltseva, Anna / Abdelhakeem, Ayman / Hyman, Mackenzie / Fu, Xinlei / Li, Chenglin / Chen, Shih-Chi / Augustinack, Jean C / Magnain, Caroline / Fischl, Bruce / Mckee, Ann C / Boas, David A / Chen, Ichun Anderson / Wang, Hui

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 35, Page(s) e2303381

    Abstract: The study of aging and neurodegenerative processes in the human brain requires a comprehensive understanding of cytoarchitectonic, myeloarchitectonic, and vascular structures. Recent computational advances have enabled volumetric reconstruction of the ... ...

    Abstract The study of aging and neurodegenerative processes in the human brain requires a comprehensive understanding of cytoarchitectonic, myeloarchitectonic, and vascular structures. Recent computational advances have enabled volumetric reconstruction of the human brain using thousands of stained slices, however, tissue distortions and loss resulting from standard histological processing have hindered deformation-free reconstruction. Here, the authors describe an integrated serial sectioning polarization-sensitive optical coherence tomography (PSOCT) and two photon microscopy (2PM) system to provide label-free multi-contrast imaging of intact brain structures, including scattering, birefringence, and autofluorescence of human brain tissue. The authors demonstrate high-throughput reconstruction of 4 × 4 × 2cm
    MeSH term(s) Humans ; Tomography, Optical Coherence/methods ; Microscopy/methods ; Lipofuscin ; Brain/diagnostic imaging ; Neuroimaging
    Chemical Substances Lipofuscin
    Language English
    Publishing date 2023-10-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202303381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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