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  1. Book ; Thesis: Prävalenz einer kognitiven Beeinträchtigung oder Demenz bei Patienten mit akutem Schlaganfall oder transitorisch ischämischer Attacke unter besonderer Berücksichtigung von Vorhofflimmern

    Fuchs, Maximilian

    2016  

    Author's details vorgelegt von Maximilian Fuchs
    Language German
    Size 82 Seiten, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2017
    HBZ-ID HT019451223
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 E 1551 order for loan Magazin

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  2. Book ; Online ; Thesis: Die Allgemeine Rechtstheorie Santi Romanos.

    Fuchs, Maximilian [Verfasser]

    2019  

    Author's details Maximilian Fuchs
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Duncker & Humblot
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    ISBN 978-3-428-44539-4 ; 3-428-44539-2
    Database Digital theses on the web

    Full text online

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  3. Book: Gesundheit, Alter, Pflege, Rehabilitation - Recht und Praxis im interdisziplinären Dialog

    Igl, Gerhard / Welti, Felix / Fuchs, Maximilian / Fuchsloch, Christine / Naegele, Gerhard / Udsching, Peter

    Festschrift für Gerhard Igl

    2017  

    Author's details Welti/Fuchs/Fuchsloch/Naegele/Udsching (Hrsg.)
    Keywords Deutschland ; Gesundheitsrecht ; Igl, Gerhard
    Subject Gesundheitswesen
    Language German
    Size 750 Seiten, Porträt, Diagramme, 23 cm
    Edition 1. Auflage
    Publisher Nomos
    Publishing place Baden-Baden
    Publishing country Germany
    Document type Book
    HBZ-ID HT019554662
    ISBN 978-3-8487-3435-1 ; 3-8487-3435-4 ; 9783845277707 ; 384527770X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1391 available for loan (reading room) Lesesaal EG

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  4. Book: Europäisches Sozialrecht

    Fuchs, Maximilian

    (NomosKommentar)

    2013  

    Author's details Maximilian Fuchs (Hrsg.)
    Series title NomosKommentar
    Keywords Sozialrecht ; Europäische Union ; Europarecht. Sozialrecht
    Language German
    Size 1002 S., 25 cm
    Edition 6. Aufl.
    Publisher Nomos ; Helbing & Lichtenhahn ; Manz
    Publishing place Baden-Baden ; Basel ; Wien
    Document type Book
    Note Literaturangaben
    ISBN 3719033368 ; 3832977902 ; 9783214084400 ; 9783719033361 ; 9783832977900 ; 3214084402
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book: Europäisches Sozialrecht

    Fuchs, Maximilian

    (NomosKommentar)

    2013  

    Author's details Maximilian Fuchs (Hrsg.)
    Series title NomosKommentar
    Keywords Sozialrecht ; Europäische Union
    Language German
    Size 1002 S., 25 cm
    Edition 6. Aufl.
    Publisher Nomos ; Helbing & Lichtenhahn ; Manz
    Publishing place Baden-Baden ; Basel ; Wien
    Document type Book
    Note Literaturangaben
    ISBN 3719033368 ; 3832977902 ; 9783214084400 ; 9783719033361 ; 9783832977900 ; 3214084402
    Database Former special subject collection: coastal and deep sea fishing

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  6. Book: Themenheft: Ländlicher Wegebau, Gärfutter-Fahrsilos, Lebensmittelsilos

    Fuchs, Maximilian

    (Bauen für die Landwirtschaft ; 51,1)

    2013  

    Title variant Ländlicher Wegebau, Gärfutter-Fahrsilos, Lebensmittelsilos
    Author's details Maximilian Fuchs
    Series title Bauen für die Landwirtschaft ; 51,1
    Language German
    Size 23 S., Ill., graph. Darst., Tab.
    Publisher Verl. Bau + Technik
    Publishing place Düsseldorf
    Document type Book
    Database Max Rubner-Institute, Federal Research Institute of Nutrition and Food

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  7. Article ; Online: Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases.

    Vide, Uršula / Kasapović, Dženita / Fuchs, Maximilian / Heimböck, Martin P / Totaro, Massimo G / Zenzmaier, Elfriede / Winkler, Andreas

    Science advances

    2023  Volume 9, Issue 31, Page(s) eadh4721

    Abstract: Regulatory proteins play a crucial role in adaptation to environmental cues. Especially for lifestyle transitions, such as cell proliferation or apoptosis, switch-like characteristics are desirable. While nature frequently uses regulatory circuits to ... ...

    Abstract Regulatory proteins play a crucial role in adaptation to environmental cues. Especially for lifestyle transitions, such as cell proliferation or apoptosis, switch-like characteristics are desirable. While nature frequently uses regulatory circuits to amplify or dampen signals, stand-alone protein switches are interesting for applications like biosensors, diagnostic tools, or optogenetics. However, such stand-alone systems frequently feature limited dynamic and operational ranges and suffer from slow response times. Here, we characterize a LOV-activated diguanylate cyclase (LadC) that offers precise temporal and spatial control of enzymatic activity with an exceptionally high dynamic range over four orders of magnitude. To establish this pronounced activation, the enzyme exhibits a two-stage activation process in which its activity is inhibited in the dark by caging its effector domains and stimulated upon illumination by the formation of an extended coiled-coil. These switch-like characteristics of the LadC system can be used to develop new optogenetic tools with tight regulation.
    MeSH term(s) Light ; Phosphorus-Oxygen Lyases/genetics ; Escherichia coli Proteins ; Photic Stimulation ; Optogenetics
    Chemical Substances diguanylate cyclase (EC 4.6.1.-) ; Phosphorus-Oxygen Lyases (EC 4.6.-) ; Escherichia coli Proteins
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh4721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes.

    Chatterjee, Shambhabi / Leach-Mehrwald, Megan / Huang, Cheng-Kai / Xiao, Ke / Fuchs, Maximilian / Otto, Mandy / Lu, Dongchao / Dang, Vinh / Winkler, Thomas / Dunbar, Cynthia E / Thum, Thomas / Bär, Christian

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 196

    Abstract: Telomeres as the protective ends of linear chromosomes, are synthesized by the enzyme telomerase (TERT). Critically short telomeres essentially contribute to aging-related diseases and are associated with a broad spectrum of disorders known as ... ...

    Abstract Telomeres as the protective ends of linear chromosomes, are synthesized by the enzyme telomerase (TERT). Critically short telomeres essentially contribute to aging-related diseases and are associated with a broad spectrum of disorders known as telomeropathies. In cardiomyocytes, telomere length is strongly correlated with cardiomyopathies but it remains ambiguous whether short telomeres are the cause or the result of the disease. In this study, we employed an inducible CRISPRi human induced pluripotent stem cell (hiPSC) line to silence TERT expression enabling the generation of hiPSCs and hiPSC-derived cardiomyocytes with long and short telomeres. Reduced telomerase activity and shorter telomere lengths of hiPSCs induced global transcriptomic changes associated with cardiac developmental pathways. Consequently, the differentiation potential towards cardiomyocytes was strongly impaired and single cell RNA sequencing revealed a shift towards a more smooth muscle cell like identity in the cells with the shortest telomeres. Poor cardiomyocyte function and increased sensitivity to stress directly correlated with the extent of telomere shortening. Collectively our data demonstrates a TERT dependent cardiomyogenic differentiation defect, highlighting the CRISPRi TERT hiPSCs model as a powerful platform to study the mechanisms and consequences of short telomeres in the heart and also in the context of telomeropathies.
    MeSH term(s) Telomerase/metabolism ; Telomerase/genetics ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/cytology ; Humans ; Cell Differentiation ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/cytology ; Telomere/metabolism ; Telomere Shortening ; Cell Line
    Chemical Substances Telomerase (EC 2.7.7.49) ; TERT protein, human (EC 2.7.7.49)
    Language English
    Publishing date 2024-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05239-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo.

    Abbas, Naisam / Haas, Jonas A / Xiao, Ke / Fuchs, Maximilian / Just, Annette / Pich, Andreas / Perbellini, Filippo / Werlein, Christopher / Ius, Fabio / Ruhparwar, Arjang / Fiedler, Jan / Weber, Natalie / Thum, Thomas

    European heart journal

    2024  

    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 640: Show issues

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  10. Article ; Online: L-arginine metabolism inhibits arthritis and inflammatory bone loss.

    Cao, Shan / Li, Yixuan / Song, Rui / Meng, Xianyi / Fuchs, Maximilian / Liang, Chunguang / Kachler, Katerina / Meng, Xinyu / Wen, Jinming / Schlötzer-Schrehardt, Ursula / Taudte, Verena / Gessner, Arne / Kunz, Meik / Schleicher, Ulrike / Zaiss, Mario M / Kastbom, Alf / Chen, Xiaoxiang / Schett, Georg / Bozec, Aline

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 1, Page(s) 72–87

    Abstract: Objectives: To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss.: Methods: L-arginine was applied to three arthritis models (collagen-induced arthritis, serum-induced arthritis and human TNF ... ...

    Abstract Objectives: To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss.
    Methods: L-arginine was applied to three arthritis models (collagen-induced arthritis, serum-induced arthritis and human TNF transgenic mice). Inflammation was assessed clinically and histologically, while bone changes were quantified by μCT and histomorphometry. In vitro, effects of L-arginine on osteoclast differentiation were analysed by RNA-seq and mass spectrometry (MS). Seahorse, Single Cell ENergetIc metabolism by profilIng Translation inHibition and transmission electron microscopy were used for detecting metabolic changes in osteoclasts. Moreover, arginine-associated metabolites were measured in the serum of rheumatoid arthritis (RA) and pre-RA patients.
    Results: L-arginine inhibited arthritis and bone loss in all three models and directly blocked TNFα-induced murine and human osteoclastogenesis. RNA-seq and MS analyses indicated that L-arginine switched glycolysis to oxidative phosphorylation in inflammatory osteoclasts leading to increased ATP production, purine metabolism and elevated inosine and hypoxanthine levels. Adenosine deaminase inhibitors blocking inosine and hypoxanthine production abolished the inhibition of L-arginine on osteoclastogenesis in vitro and in vivo. Altered arginine levels were also found in RA and pre-RA patients.
    Conclusion: Our study demonstrated that L-arginine ameliorates arthritis and bone erosion through metabolic reprogramming and perturbation of purine metabolism in osteoclasts.
    MeSH term(s) Humans ; Mice ; Animals ; Osteoclasts ; Arthritis, Rheumatoid/pathology ; Arthritis, Experimental/pathology ; Inflammation/metabolism ; Mice, Transgenic ; Arginine/pharmacology ; Inosine/metabolism ; Inosine/pharmacology ; Hypoxanthines/metabolism ; Hypoxanthines/pharmacology ; Purines/pharmacology ; Bone Resorption
    Chemical Substances Arginine (94ZLA3W45F) ; Inosine (5A614L51CT) ; Hypoxanthines ; Purines
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2022-223626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.114: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 167: Show issues

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