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  1. Conference proceedings: Die Rekonstruktion des vorderen Augenabschnitts durch eine künstliche Iris und/oder eine Hornhauttransplantation

    Fuchsluger, Thomas A.

    2023  , Page(s) 23vnda05

    Event/congress 72. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); Osnabrück; Vereinigung Norddeutscher Augenärzte; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-06-01
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23vnda05
    Database German Medical Science

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  2. Conference proceedings: Das HH-Ulcus am Freitagnachmittag: notwendige und optionale Maßnahmen

    Fuchsluger, Thomas A.

    2022  , Page(s) 22vnda15

    Event/congress 71. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); Bremen; Vereinigung Norddeutscher Augenärzte; 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-10-31
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22vnda15
    Database German Medical Science

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  3. Article ; Online: Neuartige Konzepte zur Behandlung des Hornhautendothels mittels Nanopartikel.

    Fuchsluger, Thomas A

    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

    2018  Volume 115, Issue 3, Page(s) 190–194

    Abstract: Background: The number of corneal transplantations has increased in Germany in recent years. One reason is an earlier time point of surgery due to less invasive posterior lamellar grafting techniques. To date, penetrating and lamellar corneal ... ...

    Title translation Novel concepts for treatment of the corneal endothelium with nanoparticles.
    Abstract Background: The number of corneal transplantations has increased in Germany in recent years. One reason is an earlier time point of surgery due to less invasive posterior lamellar grafting techniques. To date, penetrating and lamellar corneal transplantations are the only established therapeutic options to treat corneal diseases resulting from endothelial cell pathologies.
    Aim: This review article provides an insight into nanoparticle-related translational strategies to improve or to avoid corneal transplantation.
    Results: Nanoparticle-based strategies for optimization of the corneal endothelium have different fields of application: 1. during donor cornea cultivation in culture medium, 2. for single cell injection therapies and 3. to treat the patients' own endothelium in an effort to avoid transplantation.
    Conclusion: Several translational concepts exist to improve or to avoid grafting of a donor cornea. The coming decade will provide established alternatives to conventional corneal transplantation.
    MeSH term(s) Corneal Diseases ; Corneal Transplantation ; Endothelium, Corneal ; Germany ; Humans ; Nanoparticles
    Language German
    Publishing date 2018-01-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1105167-x
    ISSN 1433-0423 ; 0941-293X
    ISSN (online) 1433-0423
    ISSN 0941-293X
    DOI 10.1007/s00347-017-0640-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Wundheilung der Kornea – Pharmakologische Therapie.

    Brockmann, Tobias / Simon, Alexander / Brockmann, Claudia / Fuchsluger, Thomas A / Pleyer, Uwe / Walckling, Marcus

    Die Ophthalmologie

    2024  Volume 121, Issue 3, Page(s) 245–258

    Abstract: Physiological wound healing of the cornea is a complex process and involves numerous multifactorial tissue processes. A proper wound healing, especially without the formation of light-scattering scars, is essential to preserve the integrity and function ... ...

    Title translation Corneal wound healing-Pharmacological treatment.
    Abstract Physiological wound healing of the cornea is a complex process and involves numerous multifactorial tissue processes. A proper wound healing, especially without the formation of light-scattering scars, is essential to preserve the integrity and function of the cornea. Misdirected wound healing is of vast clinical relevance as it can lead to corneal fibrosis and the loss of optical transparency with subsequent reduction of visual acuity, up to blindness. In addition to the understanding of the pathophysiological mechanisms, the knowledge of therapeutic concepts and options for treating corneal wound healing disorders and fibrosis is essential to counteract a permanent damage of the cornea as early as possible. Nowadays, various pharmacological and surgical options are available for treatment. The decision, appropriate selection and indication for the optimal treatment depend primarily on the genesis and clinical appearance of the corneal wound, fibrosis or scar. The treatment of wound healing disorders ranges from the use of topical therapy and supportive measures up to tissue replacement procedures. As long as the mechanical stability of the cornea is intact and wound healing processes are still ongoing, a pharmacological modulation is reasonable, which is discussed in this article.
    MeSH term(s) Humans ; Cornea/pathology ; Corneal Injuries/therapy ; Wound Healing/physiology ; Cicatrix/therapy ; Fibrosis
    Language German
    Publishing date 2024-02-27
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ISSN 2731-7218
    ISSN (online) 2731-7218
    DOI 10.1007/s00347-024-02021-9
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  5. Conference proceedings: Kaltplasma: Eine neuartige Behandlungsmethode für schwere Hornhautinfektionen

    Fuchsluger, Thomas A.

    2019  , Page(s) 19vnda02

    Event/congress 69. Tagung der Vereinigung Norddeutscher Augenärzte (VNDA); Rostock; Vereinigung Norddeutscher Augenärzte; 2019
    Keywords Medizin, Gesundheit
    Publishing date 2019-06-12
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19vnda02
    Database German Medical Science

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  6. Article: Examining the Transmission of Visible Light through Electrospun Nanofibrous PCL Scaffolds for Corneal Tissue Engineering.

    Himmler, Marcus / Schubert, Dirk W / Fuchsluger, Thomas A

    Nanomaterials (Basel, Switzerland)

    2021  Volume 11, Issue 12

    Abstract: The transparency of nanofibrous scaffolds is of highest interest for potential applications like corneal wound dressings in corneal tissue engineering. In this study, we provide a detailed analysis of light transmission through electrospun ... ...

    Abstract The transparency of nanofibrous scaffolds is of highest interest for potential applications like corneal wound dressings in corneal tissue engineering. In this study, we provide a detailed analysis of light transmission through electrospun polycaprolactone (PCL) scaffolds. PCL scaffolds were produced via electrospinning, with fiber diameters in the range from (35 ± 13) nm to (167 ± 35) nm. Light transmission measurements were conducted using UV-vis spectroscopy in the range of visible light and analyzed with respect to the influence of scaffold thickness, fiber diameter, and surrounding medium. Contour plots were compiled for a straightforward access to light transmission values for arbitrary scaffold thicknesses. Depending on the fiber diameter, transmission values between 15% and 75% were observed for scaffold thicknesses of 10 µm. With a decreasing fiber diameter, light transmission could be improved, as well as with matching refractive indices of fiber material and medium. For corneal tissue engineering, scaffolds should be designed as thin as possible and fabricated from polymers with a matching refractive index to that of the human cornea. Concerning fiber diameter, smaller fiber diameters should be favored for maximizing graft transparency. Finally, a novel, semi-empirical formulation of light transmission through nanofibrous scaffolds is presented.
    Language English
    Publishing date 2021-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano11123191
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  7. Conference proceedings: Strategien in Diagnostik und Therapie des trockenen Auges

    Fuchsluger, Thomas A.

    2017  , Page(s) 17sag17

    Event/congress Jahrestagung 2017 der Sächsischen Augenärztlichen Gesellschaft; Glauchau; Sächsische Augenärztliche Gesellschaft; 2017
    Keywords Medizin, Gesundheit
    Publishing date 2017-11-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/17sag17
    Database German Medical Science

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  8. Article ; Online: Biomechanik in der Augenheilkunde.

    Zeitz, P Franko / Fuchsluger, Thomas A

    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

    2018  Volume 115, Issue 8, Page(s) 634

    Title translation Biomechanics in ophthalmology.
    MeSH term(s) Biomechanical Phenomena ; Cornea ; Ophthalmology
    Language German
    Publishing date 2018-05-18
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1105167-x
    ISSN 1433-0423 ; 0941-293X
    ISSN (online) 1433-0423
    ISSN 0941-293X
    DOI 10.1007/s00347-018-0728-7
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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Electrospun PCL Scaffolds as Drug Carrier for Corneal Wound Dressing Using Layer-by-Layer Coating of Hyaluronic Acid and Heparin.

    Himmler, Marcus / Schubert, Dirk W / Dähne, Lars / Egri, Gabriella / Fuchsluger, Thomas A

    International journal of molecular sciences

    2022  Volume 23, Issue 5

    Abstract: Due to its ability to reduce scarring and inflammation, human amniotic membrane is a widely used graft for wound dressings after corneal surgery. To overcome donor dependency and biological variances in the donor tissue, artificial nanofibrous grafts ... ...

    Abstract Due to its ability to reduce scarring and inflammation, human amniotic membrane is a widely used graft for wound dressings after corneal surgery. To overcome donor dependency and biological variances in the donor tissue, artificial nanofibrous grafts acting as drug carrier systems are promising substitutes. Electrospun nanofibrous scaffolds seem to be an appropriate approach as they offer the properties of permeable scaffolds with a high specific surface, the latter one depending on the fiber diameter. Electrospun scaffolds with fiber diameter of 35 nm, 113 nm, 167 nm and 549 nm were manufactured and coated by the layer-by-layer (LbL) technology with either hyaluronic acid or heparin for enhanced regeneration of corneal tissue after surgery. Studies on drug loading capacity and release kinetics defined a lower limit for nanofibrous scaffolds for effective drug loading. Additionally, scaffold characteristics and resulting mechanical properties from the application-oriented characterization of suture pullout from suture retention tests were examined. Finally, scaffolds consisting of nanofibers with a mean fiber diameter of 113 nm were identified as the best-performing scaffolds, concerning drug loading efficiency and resistance against suture pullout.
    MeSH term(s) Bandages ; Drug Carriers ; Heparin/pharmacology ; Humans ; Hyaluronic Acid/pharmacology ; Nanofibers/therapeutic use ; Polyesters ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Drug Carriers ; Polyesters ; Hyaluronic Acid (9004-61-9) ; Heparin (9005-49-6)
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23052765
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  10. Article: Anatomical and functional results after vitrectomy with conventional ILM peeling versus inverted ILM flap technique in large full-thickness macular holes.

    Dera, Adrianna U / Stoll, Doerte / Schoeneberger, Verena / Walckling, Marcus / Brockmann, Claudia / Fuchsluger, Thomas A / Schaub, Friederike

    International journal of retina and vitreous

    2023  Volume 9, Issue 1, Page(s) 68

    Abstract: Background: Aim of the study was to compare success rate and functional outcome following pars plana vitrectomy (PPV) with conventional internal limiting membrane (ILM) peeling versus ILM flap technique for full-thickness idiopathic macular holes (FTMH). ...

    Abstract Background: Aim of the study was to compare success rate and functional outcome following pars plana vitrectomy (PPV) with conventional internal limiting membrane (ILM) peeling versus ILM flap technique for full-thickness idiopathic macular holes (FTMH).
    Methods: Retrospective analysis of consecutive eyes with FTMH having undergone vitrectomy with sulfur hexafluoride (SF6) endotamponade 25% at the University Medical Center Rostock, Germany (2009-2020). Eyes were divided according to applied surgical technique (ILM peeling [group P] versus ILM flap [group F]). Inclusion criteria were macular hole base diameters (MH-BD) ≥ 400 μm plus axial length ≤ 26.0 mm. Each group was divided into two subgroups based on macular hole minimum linear diameter (MH-MLD): ≤ 400 μm and > 400 μm. Exclusion criteria were FTMH with MH-BD < 400 μm, trauma, myopia with axial length > 26.0 mm or macular schisis. Demographic, functional, and anatomical data were obtained pre- and postoperatively. Preoperative MH-BD and MH-MLD were measured using optical coherence tomography (OCT; Spectralis®, Heidelberg Engineering GmbH, Heidelberg, Germany). Main outcome parameter were: primary closure rate, best-corrected visual acuity (BCVA), and re-surgery rate.
    Results: Overall 117 eyes of 117 patients with FTMH could be included, thereof 52 eyes underwent conventional ILM peeling (group P) and 65 additional ILM flap (group F) technique. Macular hole closure was achieved in 31 eyes (59.6%) in group P and in 59 eyes (90.8%) in group F (p < 0.001). Secondary PPV was required in 21 eyes (40.4%) in group P and in 6 eyes (9.2%) in group F. Postoperative BCVA at first follow-up in eyes with surgical closure showed no significant difference for both groups (MH-MLD ≤ 400 μm: p = 0.740); MH-MLD > 400 μm: p = 0.241).
    Conclusion: Anatomical results and surgical closure rate following ILM flap technique seems to be superior to conventional ILM peeling for treatment of FTMH.
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2836254-8
    ISSN 2056-9920
    ISSN 2056-9920
    DOI 10.1186/s40942-023-00509-1
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