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  1. AU="Fuentes, Gabriela Cárdenas"
  2. AU="Supekar, Mrudul V"
  3. AU=Benson M T AU=Benson M T
  4. AU="Chrysos, E"
  5. AU="Zhihong Long"
  6. AU=Stratil J
  7. AU="Furse, Cynthia M"
  8. AU="Andres, S. Bernet" AU="Andres, S. Bernet"
  9. AU="Lee, Sang Mok"
  10. AU="Wang, Fei-Yao"
  11. AU="Kanta, Josephine M"
  12. AU="Hatfield, Disa L"
  13. AU="Kalima, Pota"
  14. AU="Charisi, Martha"
  15. AU="Carrie L. Byington"
  16. AU="Weakland, Leo F"
  17. AU="Johannes Müller"
  18. AU="Yu, Jieh-Juen"

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  1. Artikel: Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome

    Fuentes, Gabriela Cárdenas / Castañer, Olga / Warnberg, Julia / Subirana, Isaac / Buil-Cosiales, Pilar / Salas-Salvadó, Jordi / Corella, Dolores / Serra-Majem, Lluis / Romaguera, Dora / Estruch, Ramón / Martínez, J. Alfredo / Pintó, Xavier / Vázquez, Clotilde / Vidal, Josep / Tur, Josep A / Arós, Fernando / Bullo, Mònica / Fitó, Montserrat / Schröder, Helmut

    Clinical nutrition. 2020 Jan. 22,

    2020  

    Abstract: There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are ... ...

    Abstract There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese.This prospective study included 489 men and women, aged 55–75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up.Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006).Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies.Clinical trial identifier: International Standard Randomized Controlled Trial 89898870.
    Schlagwörter C-reactive protein ; T-lymphocytes ; biomarkers ; blood sampling ; c-peptide ; chemokine CCL5 ; elderly ; fasting ; inflammation ; interleukin-18 ; interleukin-6 ; interleukin-8 ; leptin ; men ; metabolic syndrome ; monocytes ; obesity ; physical activity ; prospective studies ; public health ; questionnaires ; randomized clinical trials ; regression analysis ; women
    Sprache Englisch
    Erscheinungsverlauf 2020-0122
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2020.01.015
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome.

    Fuentes, Gabriela Cárdenas / Castañer, Olga / Warnberg, Julia / Subirana, Isaac / Buil-Cosiales, Pilar / Salas-Salvadó, Jordi / Corella, Dolores / Serra-Majem, Lluis / Romaguera, Dora / Estruch, Ramón / Martínez, J Alfredo / Pintó, Xavier / Vázquez, Clotilde / Vidal, Josep / Tur, Josep A / Arós, Fernando / Bullo, Mònica / Fitó, Montserrat / Schröder, Helmut

    Clinical nutrition (Edinburgh, Scotland)

    2020  Band 39, Heft 10, Seite(n) 3092–3098

    Abstract: Background: There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older ... ...

    Abstract Background: There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese.
    Methods: This prospective study included 489 men and women, aged 55-75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up.
    Results: Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006).
    Conclusions: Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies.
    Clinical trial registry: Clinical trial identifier: International Standard Randomized Controlled Trial 89898870.
    Mesh-Begriff(e) Age Factors ; Aged ; Biomarkers/blood ; Cytokines/blood ; Diet, Healthy ; Diet, Mediterranean ; Exercise ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Inflammation Mediators/blood ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/therapy ; Middle Aged ; Obesity/blood ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/therapy ; Patient Education as Topic ; Prospective Studies ; Risk Assessment ; Risk Factors ; Spain/epidemiology ; Time Factors ; Treatment Outcome
    Chemische Substanzen Biomarkers ; Cytokines ; Inflammation Mediators
    Sprache Englisch
    Erscheinungsdatum 2020-02-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2020.01.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1774: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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