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Article ; Online: Effectiveness of online HIV treatment services in the context of the COVID‐19 pandemic

Jing Han / Hanxi Zhang / Ye Su / Fujie Zhang

Health Care Science, Vol 2, Iss 3, Pp 164-

2023 Volume 172

Abstract: Abstract Background The COVID‐19 pandemic has created challenges with respect to HIV care services. Remote online services might provide an effective method for health service delivery to people living with HIV (PLHIV). Few studies have focused on the ... ...

Abstract	Abstract Background The COVID‐19 pandemic has created challenges with respect to HIV care services. Remote online services might provide an effective method for health service delivery to people living with HIV (PLHIV). Few studies have focused on the efficacy of telemedical services for PLHIV and the effect of antiretroviral treatment via online services in China. Methods We developed a platform called the “No. 8 Health” for online antiretroviral drug collection and delivery services in Beijing from January 21 to June 30, 2022. We evaluated the online treatment service according to viral load suppression rates and compared differences in social characteristics between PLHIV who received antiretroviral drugs through online or offline treatment services. Results By June 2022, 9528 PLHIV had received outpatient treatment services, among which 44.6% (4031/9528) used the online treatment and drug delivery services for a total of 5590 person‐times. The satisfaction rate was 100%. Rates of viral load suppression among PLHIV who initiated antiretroviral therapy (ART) in 2020 and 2021 were 96.4% and 93.1%, respectively. Results showed that the viral load suppression rate was 97.9%. Regarding HIV rapid self‐testing, 4513 men who have sex with men used the online HIV rapid testing service. The number of users was approximately the same as in 2021, but both were slightly lower than those in 2020. Conclusion This study was the first to evaluate the effect of online drug collection and delivery services and virologic outcomes among PLHIV in China. The online service helped with maintenance of ART services, but the COVID‐19 pandemic still had some impacts on viral load suppression.
Keywords	HIV ; online service ; efficacy ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hierarchical Detection of Gastrodia elata Based on Improved YOLOX

Xingwei Duan / Yuhao Lin / Lixia Li / Fujie Zhang / Shanshan Li / Yuxin Liao

Agronomy, Vol 13, Iss 1477, p

2023 Volume 1477

Abstract: Identifying the grade of Gastrodia elata in the market has low efficiency and accuracy. To address this issue, an I-YOLOX object detection algorithm based on deep learning and computer vision is proposed in this paper. First, six types of Gastrodia elata ...

Abstract	Identifying the grade of Gastrodia elata in the market has low efficiency and accuracy. To address this issue, an I-YOLOX object detection algorithm based on deep learning and computer vision is proposed in this paper. First, six types of Gastrodia elata images of different grades in the Gastrodia elata planting cooperative were collected for image enhancement and labeling as the model training dataset. Second, to improve feature information extraction, an ECA attention mechanism module was inserted between the backbone network CSPDarknet and the neck enhancement feature extraction network FPN in the YOLOX model. Then, the impact of the attention mechanism and application position on model improvement was investigated. Third, the 3 × 3 convolution in the neck enhancement feature extraction network FPN and the head network was replaced by depthwise separable convolution (DS Conv) to reduce the model size and computation amount. Finally, the EIoU loss function was used to predict boundary frame regression at the output prediction end to improve the convergence speed of the model. The experimental results indicated that compared with the original YOLOX model, the mean average precision of the improved I-YOLOX network model was increased by 4.86% (97.83%), the model computation was reduced by 5.422 M (reaching 3.518 M), the model size was reduced by 20.6 MB (reaching 13.7 MB), and the image frames detected per second increased by 3 (reaching 69). Compared with other target detection algorithms, the improved model outperformed Faster R-CNN, SSD-VGG, YOLOv3s, YOLOv4s, YOLOv5s, and YOLOv7 algorithms in terms of mean average precision, model size, computation amount, and frames per second. The lightweight model improved the detection accuracy and speed of different grades of Gastrodia elata and provided a theoretical basis for the development of online identification systems of different grades of Gastrodia elata in practical production.
Keywords	Gastrodia elata ; YOLOX ; target detection ; ECA ; DS Conv ; EIoU ; Agriculture ; S
Subject code	006
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Thirteen-year viral suppression and immunologic recovery of LPV/r-based regimens in pediatric HIV treatment

Xiaojie Lao / Hanxi Zhang / Liting Yan / Hongxin Zhao / Qingxia Zhao / Hongyan Lu / Yuewu Chen / Huiqin Li / Jinfeng Chen / Fuxiu Ye / Fengting Yu / Qing Xiao / Qun Li / Xuelei Liang / Xiaojie Yang / Chang Yan / Fujie Zhang

Frontiers in Medicine, Vol

a multicenter cohort study in resource-constrained settings of China

2023 Volume 10

Abstract: BackgroundAntiretroviral Therapy (ART) in children remains challenging due to resource-constrained settings. We conducted a 13-year, prospective, multicenter cohort study on the effectiveness and safety of LPV/r-based regimens in ART-naive and ART- ... ...

Abstract	BackgroundAntiretroviral Therapy (ART) in children remains challenging due to resource-constrained settings. We conducted a 13-year, prospective, multicenter cohort study on the effectiveness and safety of LPV/r-based regimens in ART-naive and ART-experienced children.MethodsFrom January 2008 to May 2021, children living with HIV-1 were recruited with LPV/r-based regimens from 8 clinical research sites in 6 provinces in China. Effectiveness outcomes were virologic failure (defined as at least two consecutive measurements of VL > 200 copies/mL after 6 months of ART) and immune response (defined as CD4% recovered to more than 25% after 12 months of treatment). The safety outcomes were treatment-related grade 2–4 adverse events and abnormal laboratory test results.ResultsA total of 345 ART-naïve children and 113 ART-experienced children were included in this cohort study. The median follow-up time was 7.3 (IQR 5.5–10.5) years. The incidence density of virologic failure was 4.1 (95% CI 3.3–4.9) per 100 person-years in ART-naïve children and 5.0 (95% CI 3.5–6.5) per 100 person-years in ART-experienced children. Kaplan Meyer (KM) curve analysis showed children with ART experience were at a higher risk of virologic failure (p < 0.05). The risk factors of virologic failure in ART-naïve children were clinic setting in rural hospitals (aHR = 2.251, 1.108–4.575), annual missed dose times >5 days of LPV intake (aHR = 1.889, 1.004–3.554); The risk factor of virologic failure in ART-experienced children was missed dose times >5 days (aHR = 2.689, 1.299–5.604) and mother as caregivers for ART administration (aHR = 0.475, 0.238–0.948). However, during long-term treatment, viral suppression rates between ART-naïve and ART-experienced children remained similar. No significant differences were observed in the immune response, treatment-related grade 2–4 events, and abnormal laboratory test results between ART-naïve children and ART-experienced children.ConclusionOur research underscores that with consistent, long-term ...
Keywords	HIV ; lopinavir/ritonavir ; LPV/r ; children ; effectiveness ; safety ; Medicine (General) ; R5-920
Subject code	700
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Concentration Method for HIV Drug Resistance Testing in Low-Level Viremia Samples

Qun Li / Fengting Yu / Chuan Song / Hongxin Zhao / Liting Yan / Qing Xiao / Xiaojie Lao / Siyuan Yang / Yunxia Tang / Jiang Xiao / Fujie Zhang

BioMed Research International, Vol

2022 Volume 2022

Abstract: Background. Drug resistance testing in HIV-1 low-level viremia (LLV) samples is challenging yet critical. Our study is aimed at assessing the performance of lentivirus concentration reagent (LCR) in combination with a validated Sanger sequencing (SS) for ...

Abstract	Background. Drug resistance testing in HIV-1 low-level viremia (LLV) samples is challenging yet critical. Our study is aimed at assessing the performance of lentivirus concentration reagent (LCR) in combination with a validated Sanger sequencing (SS) for monitoring drug resistance mutations (DRMs) in LLV samples. Methods. A series of clinical samples were diluted and amplified for genotypic resistance testing (GRT) to prove the performance of the LCR. The Stanford HIV-1 drug resistance database (HIVdb version 8.9) was used to analyze the mutations. HIV-1 subtypes and CRFs were determined using the COMET online tool. The overall success rate of genotyping was compared with ultracentrifugation combined with SS. Furthermore, the success rates at varied VL of the two concentration methods were evaluated, and the DRMs of diluted samples were compared with those undiluted samples. Results. When LCR was used, the overall success rate was 90% (72/80) in the PR and RT regions and 60% (48/80) in the IN region. In addition, when HIV RNA was 1000 copies/ml, 400 copies/ml, 200 copies/ml, and 100 copies/ml, the success rates of PR and RT regions were 100%, 100%, 95%, and 65%, respectively, while the success rates of IN region were 85%, 60%, 45%, and 50%, respectively. We found that the sample DR-387A2 missed the E138A mutation, and mutations in other samples were consistent with undiluted samples using LCR. Conclusions. LCR will support monitoring DRMs in HIV-1 patients with LLV and can be an effective alternative for small- and medium-sized laboratories that cannot afford an ultracentrifuge.
Keywords	Medicine ; R
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-respondersResearch in context

Qing Xiao / Liting Yan / Junyan Han / Siyuan Yang / Yunxia Tang / Qun Li / Xiaojie Lao / Zhen Chen / Jiang Xiao / Hongxin Zhao / Fengting Yu / Fujie Zhang

EBioMedicine, Vol 86, Iss , Pp 104382- (2022)

2022

Abstract: Summary: Background: HIV immune non-responders (INRs) are described as a failure to reestablish a pool of CD4+ T lymphocytes (CD4 cells) after antiretroviral therapy (ART), which is related to poor clinical results. Ferroptosis is a newly discovered form ...

Abstract	Summary: Background: HIV immune non-responders (INRs) are described as a failure to reestablish a pool of CD4+ T lymphocytes (CD4 cells) after antiretroviral therapy (ART), which is related to poor clinical results. Ferroptosis is a newly discovered form of cell death characterised by iron-dependent lipid peroxidation and the accumulation of reactive oxygen species (ROS). The mechanism of unrecoverable CD4 cells in INRs and whether ferroptosis plays a role are not fully understood. Methods: Ninety-two people living with HIV (PLHIVs) who experienced four-year ART with sustained viral suppression, including 27 INRs, 34 partial responders (PRs), and 31 complete responders (CRs); and 26 uninfected control participants (UCs) were analysed for 16 immune parameters with flow cytometry. Then plasma lipid, iron and oxidation, and antioxidant indicators were detected by ELISA, and CD4 cells were sorted out and visualised under transmission electron microscopy. Finally, ferroptosis inhibitors were added, and alterations in CD4 cell phenotype and function were observed. Findings: We found decreased recent thymic emigrants (RTE), over-activation and over-proliferation phenotypes, diminished killing function, decreased IL-7R and more severe inflammation; increased lipid peroxidation in the mitochondria and disruptions of the mitochondrial structure, showing typical features of ferroptosis in CD4 cells in INRs. Additionally, ferroptosis inhibitors could reduce inflammation and repair mitochondrial damage. Meanwhile, ELISA results showed increased plasma free fatty acids (FFA) and an imbalance of oxidative and antioxidant systems in INRs. Flow cytometry results displayed alterations of both transferrin receptor (CD71) and lipid transporter (CD36) expressions on the surface of CD4 cells. Mechanistically, there was a stronger correlation between CD36 expression and mitochondrial lipid peroxidation production, ferroptosis makers, and inflammation indicators; while amino acid transporter (CD98) was more related to killing ...
Keywords	Human immunodeficiency virus (HIV) ; Poor immune reconstitution (PIR) ; Immune non-responder (INR) ; Ferroptosis ; Metabolism ; Inflammation ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	570
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak

Ju Zhang / Nan Ding / Yangzi Song / Rui Song / Yang Pan / Linghang Wang / Shuo Yan / Qi Wang / Shanfang Ma / Lirong Wei / Fengting Yu / Lianhe Lu / Fujie Zhang / Chen Chen / Hui Zeng

The Innovation, Vol 2, Iss 2, Pp 100099- (2021)

2021

Abstract: SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more ... ...

Abstract	SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world. Asymptomatic transmission of SARS-CoV-2 is the Achilles’ heel of COVID-19 public health control measures. Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission. In this study, using a novel MINERVA sequencing technology, we traced asymptomatic transmission of COVID-19 patients in Beijing, China. One hundred and seventy-eight close contacts were quarantined, and 14 COVID-19 patients were laboratory confirmed by RT-PCR. We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.
Keywords	SARS-CoV-2 ; COVID-19 ; asymptomatic transmission ; outbreak ; phylogenomic ; Science (General) ; Q1-390
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A retrospective study of distribution of HIV associated malignancies among inpatients from 2007 to 2020 in China

Fang Wang / Pan Xiang / Hongxin Zhao / Guiju Gao / Di Yang / Jiang Xiao / Ning Han / Liang Wu / Hongyuan Liang / Liang Ni / Yujiao Duan / Qiuhua Xu / Meiling Chen / Fujie Zhang

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract HIV-associated malignancies are responsible for morbidity and mortality increasingly in the era of potent antiretroviral therapy. This study aimed to investigate the distribution of HIV-associated malignancies among inpatients, the ... ...

Abstract	Abstract HIV-associated malignancies are responsible for morbidity and mortality increasingly in the era of potent antiretroviral therapy. This study aimed to investigate the distribution of HIV-associated malignancies among inpatients, the immunodeficiency and the effect of antiretroviral therapy (ART) on spectrum of HIV-associated malignancies. A total of 438 cases were enrolled from 2007 to 2020 in Beijing Ditan Hospital. Demographic, clinical and laboratory data, managements, and outcomes were collected and analyzed retrospectively. Of 438 cases, 433 were assigned to non-AIDS-defining cancers (NADCs) (n = 200, 45.7%) and AIDS-defining cancers (ADCs) (n = 233, 53.2%), 5 (1.1%) with lymphoma were not specified further. No significant change was observed in the proportion of NADCs and ADCs as time goes on. Of NADCs, lung cancer (n = 38, 19%) was the most common type, followed by thyroid cancer (n = 17, 8.5%). Patients with ADCs had lower CD4 counts(104.5/μL vs. 314/μL), less suppression of HIVRNA(OR 0.23, 95%CI 0.16–0.35) compared to those with NADCs. ART did not affect spectrum of NADCs, but affect that of ADCs (between patients with detectable and undetectable HIVRNA). ADCs remain frequent in China, and NADCs play an important role in morbidity and mortality of HIV positive population.
Keywords	Medicine ; R ; Science ; Q
Subject code	310
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Function Point Estimation and Demonstration on Website Projects

Jingchun Feng / Fujie Zhang / Dandan Zhu / Fei Zhang

Computer and Information Science , Vol 5, Iss

2012 Volume 3

Abstract: Compared with software projects, the estimation of website projects is not mature enough without any methods for size or workload estimation. This paper researched Function Point Analysis (FPA), the most important size estimation method in software ... ...

Abstract	Compared with software projects, the estimation of website projects is not mature enough without any methods for size or workload estimation. This paper researched Function Point Analysis (FPA), the most important size estimation method in software projects and then constructed Commerce Website Function Point Analysis (CWFPA) by introducing principles of FPA into commerce website projects. The paper reserved the basic definitions of software FPA for CWFPA and researched some key factors combined with characteristics of commerce website projects including the functional complexity, function point weight and value adjustment factor. In the end, a commerce website project PET was given as a demonstration of CWFPA.
Keywords	Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Language	English
Publishing date	2012-04-01T00:00:00Z
Publisher	Canadian Center of Science and Education
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification and Calculation Method of the Financial Benefits of IT Projects for Better Financial Evaluation

Jingchun Feng / Fujie Zhang / Lei Li

Intelligent Information Management, Vol 02, Iss 09, Pp 552-

2010 Volume 558

Abstract: To financially evaluate an IT projects is to assess its financial feasibility, while the financial benefits are the core parameters of financial evaluation of IT projects. Therefore, correctly identifying the financial benefits of IT projects is the ... ...

Abstract	To financially evaluate an IT projects is to assess its financial feasibility, while the financial benefits are the core parameters of financial evaluation of IT projects. Therefore, correctly identifying the financial benefits of IT projects is the precondition to ensure the validity of the financial evaluation. Essentially, IT projects can be divided into productive IT projects and supportive IT projects. The paper analyzes the importance of identifying the financial benefits and introduces the meaning, characteristics and classification of financial benefits of IT projects. On this basis, the paper identifies the financial benefits of both productive IT projects and supportive IT projects and emphasizes the formation and specific calculation method of the two types of IT projects. For productive IT projects and supportive IT projects, the calculation of financial benefits should employ different methods.
Keywords	Productive IT Projects ; Supportive IT Projects ; Financial Evaluation ; Financial Benefits ; Benefit Identification ; Information technology ; T58.5-58.64 ; Industrial engineering. Management engineering ; T55.4-60.8 ; Technology (General) ; T1-995 ; Technology ; T ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
Subject code	690
Language	English
Publishing date	2010-10-01T00:00:00Z
Publisher	Scientific Research Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Late or Lack of Vaccination Linked to Importation of Yellow Fever from Angola to China

Rui Song / Shengcan Guan / Shui Shan Lee / Zhihai Chen / Chen Chen / Lifen Han / Yanli Xu / Ang Li / Hui Zeng / Hanhui Ye / Fujie Zhang

Emerging Infectious Diseases, Vol 24, Iss 7, Pp 1383-

2018 Volume 1386

Abstract: During March and April 2016, 11 yellow fever cases were identified in China. We report epidemic and viral information for 10 of these patients, 6 of whom had been vaccinated before travel. Phylogenetic analyses suggest these viruses nested within the ... ...

Abstract	During March and April 2016, 11 yellow fever cases were identified in China. We report epidemic and viral information for 10 of these patients, 6 of whom had been vaccinated before travel. Phylogenetic analyses suggest these viruses nested within the diversity of strains endemic to Angola, where an outbreak began in 2015.
Keywords	yellow fever ; virus ; outbreak ; vaccination ; viscerotropic ; jaundice ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	Centers for Disease Control and Prevention
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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